Reviewed, UniProtKB/Swiss-Prot Q07440 (B2LA1_MOUSE)

Names and origin

Protein names

Recommended name:
    Bcl-2-related protein A1
Alternative name(s):
    Protein BFL-1
    Hemopoietic-specific early response protein
    A1-A

Gene names

Name:	Bcl2a1
Synonyms:	A1, Bcl2a1a, Bfl1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection.
Subunit structure	Interacts directly with BCL2L11/BIM By similarity. Interacts directly with BAK1, BID, BMF and BBC3.
Subcellular location	Cytoplasm.
Tissue specificity	Expressed in hemopoietic tissues, including bone marrow, spleen and thymus.
Induction	By granulocyte-macrophage colony-stimulating factor and LPS in macrophages.
Sequence similarities	Belongs to the Bcl-2 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Technical term	3D-structure
Gene Ontology (GO)
Biological process	B cell homeostasis Inferred from direct assay. Source: MGI negative regulation of apoptosis Inferred from direct assay. Source: MGI
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BBC3	Q9BXH1	1	EBI-707754,EBI-519884	From a different organism.
BCL2L11	O43521	1	EBI-707754,EBI-526406	From a different organism.
Bcl2l11	O54918	1	EBI-707754,EBI-526067
BID	P55957	1	EBI-707754,EBI-519672	From a different organism.
BIK	Q13323	1	EBI-707754,EBI-700794	From a different organism.
HRK	O00198	1	EBI-707754,EBI-701322	From a different organism.
PMAIP1	Q13794	1	EBI-707754,EBI-707392	From a different organism.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 172

172

Bcl-2-related protein A1

PRO_0000143095

Regions

Motif

77 – 97

21

BH1

Motif

132 – 147

16

BH2

Compositional bias

24 – 33

10

Ala/Pro-rich

Secondary structure

1

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172

Helix Strand Turn

Details...

Helix

1 – 21

21

Helix

32 – 51

20

Helix

53 – 56

4

Helix

64 – 79

16

Helix

86 – 105

20

Helix

114 – 136

23

Turn

137 – 142

6

Helix

143 – 147

5

Sequences

	Sequence		Length	Mass (Da)
	Q07440-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 37AD35818E756488	FASTA	172	19,914
	10 20 30 40 50 60 MAESELMHIH SLAEHYLQYV LQVPAFESAP SQACRVLQRV AFSVQKEVEK NLKSYLDDFH 70 80 90 100 110 120 VESIDTARII FNQVMEKEFE DGIINWGRIV TIFAFGGVLL KKLPQEQIAL DVCAYKQVSS 130 140 150 160 170 FVAEFIMNNT GEWIRQNGGW EDGFIKKFEP KSGWLTFLQM TGQIWEMLFL LK

References

[1]	"Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2." Lin E.Y., Orlofsky A., Berger M.S., Prystowsky M.B. J. Immunol. 151:1979-1988(1993) [PubMed: 8345191] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CBA/J. Tissue: Bone marrow.
[2]	"Multiple gene duplication and expression of mouse bcl-2-related genes, A1." Hatakeyama S., Hamasaki A., Negishi I., Loh D.Y., Sendo F., Nakayama K., Nakayama K. Int. Immunol. 10:631-637(1998) [PubMed: 9645611] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv. Tissue: Liver.
[3]	"Structural plasticity underpins promiscuous binding of the prosurvival protein A1." Smits C., Czabotar P.E., Hinds M.G., Day C.L. Structure 16:818-829(2008) [PubMed: 18462686] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1-152 IN COMPLEXES WITH BAK1; BID; BMF AND BBC3.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

L16462 mRNA. Translation: AAA16886.1.
U23774, U23773 Genomic DNA. Translation: AAB97953.1.

PIR

I49449.

RefSeq

NP_033872.1.

UniGene

Mm.196770
Mm.425593

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2VOF	X-ray	1.80	A/C	1-152	[»]
2VOG	X-ray	1.90	A	1-152	[»]
2VOH	X-ray	1.90	A	1-152	[»]
2VOI	X-ray	2.10	A	1-152	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q07440.

Genome annotation databases

Ensembl

ENSMUSG00000074147. Mus musculus. [Contig view]

GeneID

12044.

KEGG

mmu:12044.

Organism-specific databases

MGI

MGI:102687. Bcl2a1a.

Phylogenomic databases

HOVERGEN

Q07440.

Gene expression databases

CleanEx

MM_BCL2A1A.

GermOnline

ENSMUSG00000074147. Mus musculus.

Family and domain databases

InterPro

IPR013282. Apop_reg_Bcl2Rel.
IPR002475. BCL2_apoptsis.
IPR000712. Bcl2_BH.
[Graphical view]

Pfam

PF00452. Bcl-2. 1 hit.
[Graphical view]

PRINTS

PR01862. BCL2FAMILY.
PR01867. BCL2RLATEDA1.

SMART

SM00337. BCL. 1 hit.
[Graphical view]

PROSITE

PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

280319.

SOURCE

Search...

Entry information

Entry name

B2LA1_MOUSE

Accession

Primary (citable) accession number: Q07440

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 25, 2008
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)