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Protein

Bcl-2-related protein A1

Gene

Bcl2a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (PubMed:11888890).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-related protein A1
Alternative name(s):
A1-A
Hemopoietic-specific early response protein
Protein BFL-1
Gene namesi
Name:Bcl2a1
Synonyms:A1, Bcl2a1a, Bfl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:102687. Bcl2a1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1293239.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430951 – 172Bcl-2-related protein A1Add BLAST172

Proteomic databases

PaxDbiQ07440.
PRIDEiQ07440.

PTM databases

PhosphoSitePlusiQ07440.

Expressioni

Tissue specificityi

Expressed in hemopoietic tissues, including bone marrow, spleen and thymus.

Inductioni

By granulocyte-macrophage colony-stimulating factor and LPS in macrophages.

Gene expression databases

BgeeiENSMUSG00000093809.
CleanExiMM_BCL2A1A.
GenevisibleiQ07440. MM.

Interactioni

Subunit structurei

Interacts directly with BCL2L11/BIM and PMAIP1 (By similarity). Interacts directly with BAK1, BID, BMF and BBC3. Interacts with BOP (By similarity). Interacts with isoform 3, isoform 4 and isoform 5 of ING4.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L11O435212EBI-707754,EBI-526406From a different organism.
BIDP559573EBI-707754,EBI-519672From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198319. 1 interactor.
DIPiDIP-29804N.
IntActiQ07440. 7 interactors.
STRINGi10090.ENSMUSP00000096086.

Chemistry databases

BindingDBiQ07440.

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 21Combined sources21
Helixi32 – 51Combined sources20
Helixi53 – 56Combined sources4
Helixi64 – 79Combined sources16
Helixi86 – 105Combined sources20
Helixi114 – 136Combined sources23
Turni137 – 142Combined sources6
Helixi143 – 147Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VOFX-ray1.80A/C1-152[»]
2VOGX-ray1.90A1-152[»]
2VOHX-ray1.90A1-152[»]
2VOIX-ray2.10A1-152[»]
ProteinModelPortaliQ07440.
SMRiQ07440.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07440.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi77 – 97BH1Add BLAST21
Motifi132 – 147BH2Add BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 33Ala/Pro-rich10

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00510000048456.
HOGENOMiHOG000059278.
HOVERGENiHBG004840.
InParanoidiQ07440.
KOiK02162.
OrthoDBiEOG091G0N5N.
PhylomeDBiQ07440.
TreeFamiTF315834.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR013282. Bcl2A1.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF10. PTHR11256:SF10. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PR01867. BCL2RLATEDA1.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESELMHIH SLAEHYLQYV LQVPAFESAP SQACRVLQRV AFSVQKEVEK
60 70 80 90 100
NLKSYLDDFH VESIDTARII FNQVMEKEFE DGIINWGRIV TIFAFGGVLL
110 120 130 140 150
KKLPQEQIAL DVCAYKQVSS FVAEFIMNNT GEWIRQNGGW EDGFIKKFEP
160 170
KSGWLTFLQM TGQIWEMLFL LK
Length:172
Mass (Da):19,914
Last modified:February 1, 1995 - v1
Checksum:i37AD35818E756488
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16462 mRNA. Translation: AAA16886.1.
U23774, U23773 Genomic DNA. Translation: AAB97953.1.
CCDSiCCDS23391.1.
PIRiI49449.
RefSeqiNP_033872.1. NM_009742.3.
UniGeneiMm.425593.
Mm.479217.

Genome annotation databases

EnsembliENSMUST00000098485; ENSMUSP00000096086; ENSMUSG00000102037.
GeneIDi12044.
KEGGimmu:12044.
UCSCiuc009qzh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16462 mRNA. Translation: AAA16886.1.
U23774, U23773 Genomic DNA. Translation: AAB97953.1.
CCDSiCCDS23391.1.
PIRiI49449.
RefSeqiNP_033872.1. NM_009742.3.
UniGeneiMm.425593.
Mm.479217.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VOFX-ray1.80A/C1-152[»]
2VOGX-ray1.90A1-152[»]
2VOHX-ray1.90A1-152[»]
2VOIX-ray2.10A1-152[»]
ProteinModelPortaliQ07440.
SMRiQ07440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198319. 1 interactor.
DIPiDIP-29804N.
IntActiQ07440. 7 interactors.
STRINGi10090.ENSMUSP00000096086.

Chemistry databases

BindingDBiQ07440.
ChEMBLiCHEMBL1293239.

PTM databases

PhosphoSitePlusiQ07440.

Proteomic databases

PaxDbiQ07440.
PRIDEiQ07440.

Protocols and materials databases

DNASUi12044.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098485; ENSMUSP00000096086; ENSMUSG00000102037.
GeneIDi12044.
KEGGimmu:12044.
UCSCiuc009qzh.1. mouse.

Organism-specific databases

CTDi12044.
MGIiMGI:102687. Bcl2a1a.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00510000048456.
HOGENOMiHOG000059278.
HOVERGENiHBG004840.
InParanoidiQ07440.
KOiK02162.
OrthoDBiEOG091G0N5N.
PhylomeDBiQ07440.
TreeFamiTF315834.

Miscellaneous databases

EvolutionaryTraceiQ07440.
PROiQ07440.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000093809.
CleanExiMM_BCL2A1A.
GenevisibleiQ07440. MM.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR013282. Bcl2A1.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF10. PTHR11256:SF10. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PR01867. BCL2RLATEDA1.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2LA1_MOUSE
AccessioniPrimary (citable) accession number: Q07440
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.