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Protein

Bcl-2-related protein A1

Gene

Bcl2a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (PubMed:11888890).1 Publication

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • B cell homeostasis Source: MGI
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of B cell apoptotic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-related protein A1
Alternative name(s):
A1-A
Hemopoietic-specific early response protein
Protein BFL-1
Gene namesi
Name:Bcl2a1
Synonyms:A1, Bcl2a1a, Bfl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:102687. Bcl2a1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1293239.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Bcl-2-related protein A1PRO_0000143095Add
BLAST

Proteomic databases

PaxDbiQ07440.
PRIDEiQ07440.

Expressioni

Tissue specificityi

Expressed in hemopoietic tissues, including bone marrow, spleen and thymus.

Inductioni

By granulocyte-macrophage colony-stimulating factor and LPS in macrophages.

Gene expression databases

BgeeiQ07440.
CleanExiMM_BCL2A1A.
GenevisibleiQ07440. MM.

Interactioni

Subunit structurei

Interacts directly with BCL2L11/BIM and PMAIP1 (By similarity). Interacts directly with BAK1, BID, BMF and BBC3. Interacts with BOP (By similarity). Interacts with isoform 3, isoform 4 and isoform 5 of ING4.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L11O435212EBI-707754,EBI-526406From a different organism.
BIDP559573EBI-707754,EBI-519672From a different organism.

Protein-protein interaction databases

BioGridi198319. 1 interaction.
DIPiDIP-29804N.
IntActiQ07440. 7 interactions.
STRINGi10090.ENSMUSP00000096086.

Chemistry

BindingDBiQ07440.

Structurei

Secondary structure

172
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 2121Combined sources
Helixi32 – 5120Combined sources
Helixi53 – 564Combined sources
Helixi64 – 7916Combined sources
Helixi86 – 10520Combined sources
Helixi114 – 13623Combined sources
Turni137 – 1426Combined sources
Helixi143 – 1475Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VOFX-ray1.80A/C1-152[»]
2VOGX-ray1.90A1-152[»]
2VOHX-ray1.90A1-152[»]
2VOIX-ray2.10A1-152[»]
ProteinModelPortaliQ07440.
SMRiQ07440. Positions 1-150.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07440.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi77 – 9721BH1Add
BLAST
Motifi132 – 14716BH2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 3310Ala/Pro-rich

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00510000048456.
HOGENOMiHOG000059278.
HOVERGENiHBG004840.
InParanoidiQ07440.
KOiK02162.
OrthoDBiEOG70GMGD.
PhylomeDBiQ07440.
TreeFamiTF315834.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR013282. Bcl2A1.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF10. PTHR11256:SF10. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PR01867. BCL2RLATEDA1.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESELMHIH SLAEHYLQYV LQVPAFESAP SQACRVLQRV AFSVQKEVEK
60 70 80 90 100
NLKSYLDDFH VESIDTARII FNQVMEKEFE DGIINWGRIV TIFAFGGVLL
110 120 130 140 150
KKLPQEQIAL DVCAYKQVSS FVAEFIMNNT GEWIRQNGGW EDGFIKKFEP
160 170
KSGWLTFLQM TGQIWEMLFL LK
Length:172
Mass (Da):19,914
Last modified:February 1, 1995 - v1
Checksum:i37AD35818E756488
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16462 mRNA. Translation: AAA16886.1.
U23774, U23773 Genomic DNA. Translation: AAB97953.1.
CCDSiCCDS23391.1.
PIRiI49449.
RefSeqiNP_033872.1. NM_009742.3.
UniGeneiMm.425593.
Mm.479217.

Genome annotation databases

EnsembliENSMUST00000098485; ENSMUSP00000096086; ENSMUSG00000102037.
GeneIDi12044.
KEGGimmu:12044.
UCSCiuc009qzh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16462 mRNA. Translation: AAA16886.1.
U23774, U23773 Genomic DNA. Translation: AAB97953.1.
CCDSiCCDS23391.1.
PIRiI49449.
RefSeqiNP_033872.1. NM_009742.3.
UniGeneiMm.425593.
Mm.479217.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VOFX-ray1.80A/C1-152[»]
2VOGX-ray1.90A1-152[»]
2VOHX-ray1.90A1-152[»]
2VOIX-ray2.10A1-152[»]
ProteinModelPortaliQ07440.
SMRiQ07440. Positions 1-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198319. 1 interaction.
DIPiDIP-29804N.
IntActiQ07440. 7 interactions.
STRINGi10090.ENSMUSP00000096086.

Chemistry

BindingDBiQ07440.
ChEMBLiCHEMBL1293239.

Proteomic databases

PaxDbiQ07440.
PRIDEiQ07440.

Protocols and materials databases

DNASUi12044.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098485; ENSMUSP00000096086; ENSMUSG00000102037.
GeneIDi12044.
KEGGimmu:12044.
UCSCiuc009qzh.1. mouse.

Organism-specific databases

CTDi12044.
MGIiMGI:102687. Bcl2a1a.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00510000048456.
HOGENOMiHOG000059278.
HOVERGENiHBG004840.
InParanoidiQ07440.
KOiK02162.
OrthoDBiEOG70GMGD.
PhylomeDBiQ07440.
TreeFamiTF315834.

Miscellaneous databases

EvolutionaryTraceiQ07440.
NextBioi280319.
PROiQ07440.
SOURCEiSearch...

Gene expression databases

BgeeiQ07440.
CleanExiMM_BCL2A1A.
GenevisibleiQ07440. MM.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR013282. Bcl2A1.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF10. PTHR11256:SF10. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PR01867. BCL2RLATEDA1.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2."
    Lin E.Y., Orlofsky A., Berger M.S., Prystowsky M.B.
    J. Immunol. 151:1979-1988(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CBA/J.
    Tissue: Bone marrow.
  2. "Multiple gene duplication and expression of mouse bcl-2-related genes, A1."
    Hatakeyama S., Hamasaki A., Negishi I., Loh D.Y., Sendo F., Nakayama K., Nakayama K.
    Int. Immunol. 10:631-637(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Liver.
  3. "Mouse ING1 homologue, a protein interacting with A1, enhances cell death and is inhibited by A1 in mammary epithelial cells."
    Ha S., Lee S., Chung M., Choi Y.
    Cancer Res. 62:1275-1278(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ING4.
  4. "Structural plasticity underpins promiscuous binding of the prosurvival protein A1."
    Smits C., Czabotar P.E., Hinds M.G., Day C.L.
    Structure 16:818-829(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1-152 IN COMPLEXES WITH BAK1; BID; BMF AND BBC3.

Entry informationi

Entry nameiB2LA1_MOUSE
AccessioniPrimary (citable) accession number: Q07440
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.