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Q07434

- COX1_PHYPO

UniProt

Q07434 - COX1_PHYPO

Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Physarum polycephalum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871Iron (heme A axial ligand)Curated
    Metal bindingi266 – 2661Copper BCurated
    Metal bindingi270 – 2701Copper BCurated
    Metal bindingi315 – 3151Copper BCurated
    Metal bindingi316 – 3161Copper BCurated
    Metal bindingi401 – 4011Iron (heme A3 axial ligand)Curated
    Metal bindingi403 – 4031Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COX1
    Encoded oniMitochondrion
    OrganismiPhysarum polycephalum (Slime mold)
    Taxonomic identifieri5791 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaMyxogastriaMyxogastromycetidaePhysariidaPhysaraceaePhysarum

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594Cytochrome c oxidase subunit 1PRO_0000183390Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki266 ↔ 2701'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ07434.
    SMRiQ07434. Positions 26-520.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei333 – 35321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei363 – 38321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei405 – 42521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei467 – 48721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei508 – 52821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 2 hits.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 2 hits.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q07434-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSIPFDQKT ISLLGMKMDT SDFYTFADRW LFSTNHKYIG TLYLLFSIGA    50
    GLAGLALSVI MRMELASCGD LILNSNYQLY NTIVTAHALI MIFFFVMPAL 100
    IGGFGNWFVP LLMGAPDMAF PRLNNISLWL LPSSLILLLL SSYVEIGAGT 150
    GWTVYPPLSS ITGHSGPSVD LAIFSLHLAG VSSMLGAINF ICTIKNMRLK 200
    GLTGERLSLF VWAVLVTVIL LLLSLPVLAG AITMLLTDRN FNTSFFDATG 250
    GGDPILYQHL FWFFGHPEVY ILILPGFGIV SIIIQAYANK AIFGYLGMVY 300
    AMLSIGILGF MVWAHHMYTV GLDVDTRAYF TAATMIIAVP TGIKIFSWLA 350
    TLFGSYLKLR TPLLFILGFL ILFTLGGLSG VVLANSGLDI AFHDTYYVVA 400
    HFHYVLSMGA VFAAFAAFYH WFSIIKSFTT YEPHEWEFVY NPFELRKKIP 450
    YRRTDFSYLE TAGILHFITT FIGVNLTFFP MHLLGLAGMP RRIPDYPDAY 500
    LHFNLISSYG SFVTLVSTIM FFMFGVVFNY NLFINGFPSM FYIIKPLIKI 550
    TFFRIKQIIQ GNNECLNSIS KELTILILHV KRLSKLSVNN WSIA 594
    Length:594
    Mass (Da):66,514
    Last modified:August 14, 2001 - v2
    Checksum:i8D8A60C44620D5FF
    GO

    RNA editingi

    Some positions are modified by RNA editing via nucleotide insertion and conversion.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14769 mRNA. Translation: AAA71993.1.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14769 mRNA. Translation: AAA71993.1 .

    3D structure databases

    ProteinModelPortali Q07434.
    SMRi Q07434. Positions 26-520.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 2 hits.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 2 hits.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Substitutional and insertional RNA editing of the cytochrome c oxidase subunit 1 mRNA of Physarum polycephalum."
      Gott J.M., Visomirski L.M., Hunter J.L.
      J. Biol. Chem. 268:25483-25486(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], RNA EDITING.
      Strain: M3C.

    Entry informationi

    Entry nameiCOX1_PHYPO
    AccessioniPrimary (citable) accession number: Q07434
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3