Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q07434 (COX1_PHYPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COX1
Encoded onMitochondrion
OrganismPhysarum polycephalum (Slime mold)
Taxonomic identifier5791 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaMyxogastriaMyxogastromycetidaePhysariidaPhysaraceaePhysarum

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

RNA editing

Modified position: not applicable.
Some positions are modified by RNA editing via nucleotide insertion and conversion. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594Cytochrome c oxidase subunit 1
PRO_0000183390

Regions

Transmembrane41 – 6121Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane171 – 19121Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane260 – 28021Helical; Potential
Transmembrane292 – 31221Helical; Potential
Transmembrane333 – 35321Helical; Potential
Transmembrane363 – 38321Helical; Potential
Transmembrane405 – 42521Helical; Potential
Transmembrane467 – 48721Helical; Potential
Transmembrane508 – 52821Helical; Potential

Sites

Metal binding871Iron (heme A axial ligand) Probable
Metal binding2661Copper B Probable
Metal binding2701Copper B Probable
Metal binding3151Copper B Probable
Metal binding3161Copper B Probable
Metal binding4011Iron (heme A3 axial ligand) Probable
Metal binding4031Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link266 ↔ 2701'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07434 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: 8D8A60C44620D5FF

FASTA59466,514
        10         20         30         40         50         60 
MSSIPFDQKT ISLLGMKMDT SDFYTFADRW LFSTNHKYIG TLYLLFSIGA GLAGLALSVI 

        70         80         90        100        110        120 
MRMELASCGD LILNSNYQLY NTIVTAHALI MIFFFVMPAL IGGFGNWFVP LLMGAPDMAF 

       130        140        150        160        170        180 
PRLNNISLWL LPSSLILLLL SSYVEIGAGT GWTVYPPLSS ITGHSGPSVD LAIFSLHLAG 

       190        200        210        220        230        240 
VSSMLGAINF ICTIKNMRLK GLTGERLSLF VWAVLVTVIL LLLSLPVLAG AITMLLTDRN 

       250        260        270        280        290        300 
FNTSFFDATG GGDPILYQHL FWFFGHPEVY ILILPGFGIV SIIIQAYANK AIFGYLGMVY 

       310        320        330        340        350        360 
AMLSIGILGF MVWAHHMYTV GLDVDTRAYF TAATMIIAVP TGIKIFSWLA TLFGSYLKLR 

       370        380        390        400        410        420 
TPLLFILGFL ILFTLGGLSG VVLANSGLDI AFHDTYYVVA HFHYVLSMGA VFAAFAAFYH 

       430        440        450        460        470        480 
WFSIIKSFTT YEPHEWEFVY NPFELRKKIP YRRTDFSYLE TAGILHFITT FIGVNLTFFP 

       490        500        510        520        530        540 
MHLLGLAGMP RRIPDYPDAY LHFNLISSYG SFVTLVSTIM FFMFGVVFNY NLFINGFPSM 

       550        560        570        580        590 
FYIIKPLIKI TFFRIKQIIQ GNNECLNSIS KELTILILHV KRLSKLSVNN WSIA 

« Hide

References

[1]"Substitutional and insertional RNA editing of the cytochrome c oxidase subunit 1 mRNA of Physarum polycephalum."
Gott J.M., Visomirski L.M., Hunter J.L.
J. Biol. Chem. 268:25483-25486(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], RNA EDITING.
Strain: M3C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L14769 mRNA. Translation: AAA71993.1.

3D structure databases

ProteinModelPortalQ07434.
SMRQ07434. Positions 26-520.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 2 hits.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 2 hits.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_PHYPO
AccessionPrimary (citable) accession number: Q07434
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 14, 2001
Last modified: May 14, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways