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Q07434

- COX1_PHYPO

UniProt

Q07434 - COX1_PHYPO

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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Physarum polycephalum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Iron (heme A axial ligand)Curated
Metal bindingi266 – 2661Copper BCurated
Metal bindingi270 – 2701Copper BCurated
Metal bindingi315 – 3151Copper BCurated
Metal bindingi316 – 3161Copper BCurated
Metal bindingi401 – 4011Iron (heme A3 axial ligand)Curated
Metal bindingi403 – 4031Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Encoded oniMitochondrion
OrganismiPhysarum polycephalum (Slime mold)
Taxonomic identifieri5791 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaMyxogastriaMyxogastromycetidaePhysariidaPhysaraceaePhysarum

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Cytochrome c oxidase subunit 1PRO_0000183390Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki266 ↔ 2701'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ07434.
SMRiQ07434. Positions 26-520.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121HelicalSequence AnalysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence AnalysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence AnalysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST
Transmembranei292 – 31221HelicalSequence AnalysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence AnalysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence AnalysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence AnalysisAdd
BLAST
Transmembranei467 – 48721HelicalSequence AnalysisAdd
BLAST
Transmembranei508 – 52821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 2 hits.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 2 hits.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07434-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSIPFDQKT ISLLGMKMDT SDFYTFADRW LFSTNHKYIG TLYLLFSIGA
60 70 80 90 100
GLAGLALSVI MRMELASCGD LILNSNYQLY NTIVTAHALI MIFFFVMPAL
110 120 130 140 150
IGGFGNWFVP LLMGAPDMAF PRLNNISLWL LPSSLILLLL SSYVEIGAGT
160 170 180 190 200
GWTVYPPLSS ITGHSGPSVD LAIFSLHLAG VSSMLGAINF ICTIKNMRLK
210 220 230 240 250
GLTGERLSLF VWAVLVTVIL LLLSLPVLAG AITMLLTDRN FNTSFFDATG
260 270 280 290 300
GGDPILYQHL FWFFGHPEVY ILILPGFGIV SIIIQAYANK AIFGYLGMVY
310 320 330 340 350
AMLSIGILGF MVWAHHMYTV GLDVDTRAYF TAATMIIAVP TGIKIFSWLA
360 370 380 390 400
TLFGSYLKLR TPLLFILGFL ILFTLGGLSG VVLANSGLDI AFHDTYYVVA
410 420 430 440 450
HFHYVLSMGA VFAAFAAFYH WFSIIKSFTT YEPHEWEFVY NPFELRKKIP
460 470 480 490 500
YRRTDFSYLE TAGILHFITT FIGVNLTFFP MHLLGLAGMP RRIPDYPDAY
510 520 530 540 550
LHFNLISSYG SFVTLVSTIM FFMFGVVFNY NLFINGFPSM FYIIKPLIKI
560 570 580 590
TFFRIKQIIQ GNNECLNSIS KELTILILHV KRLSKLSVNN WSIA
Length:594
Mass (Da):66,514
Last modified:August 14, 2001 - v2
Checksum:i8D8A60C44620D5FF
GO

RNA editingi

Some positions are modified by RNA editing via nucleotide insertion and conversion.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14769 mRNA. Translation: AAA71993.1.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14769 mRNA. Translation: AAA71993.1 .

3D structure databases

ProteinModelPortali Q07434.
SMRi Q07434. Positions 26-520.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 2 hits.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 2 hits.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Substitutional and insertional RNA editing of the cytochrome c oxidase subunit 1 mRNA of Physarum polycephalum."
    Gott J.M., Visomirski L.M., Hunter J.L.
    J. Biol. Chem. 268:25483-25486(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], RNA EDITING.
    Strain: M3C.

Entry informationi

Entry nameiCOX1_PHYPO
AccessioniPrimary (citable) accession number: Q07434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 14, 2001
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3