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Protein

Nitrogen regulatory PII-like protein

Gene

nrgB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for full induction of the nrgAB operon under conditions of ammonium limitation.1 Publication

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciBSUB:BSU36520-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrogen regulatory PII-like protein
Gene namesi
Name:nrgB
Ordered Locus Names:BSU36520
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells show no growth phenotype even at acidic pH.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001398141 – 116Nitrogen regulatory PII-like proteinAdd BLAST116

Proteomic databases

PaxDbiQ07428
PRIDEiQ07428

Expressioni

Inductioni

The nrgAB operon is activated by TnrA under nitrogen-limited conditions.1 Publication

Interactioni

Subunit structurei

Needs to interact with NrgA in order to localize correctly to the membrane.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100019741

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Helixi17 – 27Combined sources11
Beta strandi33 – 46Combined sources14
Helixi48 – 50Combined sources3
Beta strandi53 – 72Combined sources20
Helixi74 – 85Combined sources12
Beta strandi88 – 90Combined sources3
Beta strandi94 – 99Combined sources6
Beta strandi101 – 105Combined sources5
Turni106 – 108Combined sources3
Helixi112 – 114Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4R25X-ray2.52A5-116[»]
4RX6X-ray2.60A/B/D1-116[»]
ProteinModelPortaliQ07428
SMRiQ07428
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P(II) protein family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0347 LUCA
HOGENOMiHOG000017847
InParanoidiQ07428
KOiK04751
OMAiHQIEVNF
PhylomeDBiQ07428

Family and domain databases

Gene3Di3.30.70.120, 1 hit
InterProiView protein in InterPro
IPR002187 N-reg_PII
IPR011322 N-reg_PII-like_a/b
IPR015867 N-reg_PII/ATP_PRibTrfase_C
IPR017918 N-reg_PII_CS
PANTHERiPTHR30115 PTHR30115, 1 hit
PfamiView protein in Pfam
PF00543 P-II, 1 hit
PRINTSiPR00340 PIIGLNB
SMARTiView protein in SMART
SM00938 P-II, 1 hit
SUPFAMiSSF54913 SSF54913, 1 hit
PROSITEiView protein in PROSITE
PS00638 PII_GLNB_CTER, 1 hit
PS51343 PII_GLNB_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q07428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQMFKVEI VTRPANFEKL KQELGKIGVT SLTFSNVHGC GLQKAHTELY
60 70 80 90 100
RGVKIESNVY ERLKIEIVVS KVPVDQVTET AKRVLKTGSP GDGKIFVYEI
110
SNTINIRTGE EGPEAL
Length:116
Mass (Da):12,822
Last modified:October 1, 1994 - v1
Checksum:i386FCB5C1133CC59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03216 Unassigned DNA Translation: AAA17400.1
Z82987 Genomic DNA Translation: CAB05373.1
AL009126 Genomic DNA Translation: CAB15669.1
PIRiB36865
RefSeqiNP_391533.1, NC_000964.3
WP_003221829.1, NZ_JNCM01000034.1

Genome annotation databases

EnsemblBacteriaiCAB15669; CAB15669; BSU36520
GeneIDi936937
KEGGibsu:BSU36520
PATRICifig|224308.179.peg.3952

Similar proteinsi

Entry informationi

Entry nameiNRGB_BACSU
AccessioniPrimary (citable) accession number: Q07428
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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