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Protein

Keratin, type I cytoskeletal 18

Gene

krt18

Organism
Carassius auratus (Goldfish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

When phosphorylated, plays a role in filament reorganization.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei339 – 3391StutterSequence analysis

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 18
Alternative name(s):
Cytokeratin-18
Short name:
CK-18
Keratin-18
Short name:
K18
Gene namesi
Name:krt18
OrganismiCarassius auratus (Goldfish)
Taxonomic identifieri7957 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 435434Keratin, type I cytoskeletal 18By similarityPRO_0000289071Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity
Proteolytically cleaved by caspases during epithelial cell apoptosis.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei246 – 2472Cleavage; by caspasesBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ07427.

Expressioni

Tissue specificityi

Abundantly expressed in an even distribution throughout the optic nerve, localizing specifically to the astrocyte domains. Moderately expressed in spinal cord, brain, liver and oocytes.1 Publication

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ07427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 8887HeadSequence analysisAdd
BLAST
Regioni89 – 394306RodSequence analysisAdd
BLAST
Regioni89 – 12335Coil 1ASequence analysisAdd
BLAST
Regioni124 – 14017Linker 1Sequence analysisAdd
BLAST
Regioni141 – 23292Coil 1BSequence analysisAdd
BLAST
Regioni233 – 25624Linker 12Sequence analysisAdd
BLAST
Regioni257 – 394138Coil 2Sequence analysisAdd
BLAST
Regioni395 – 43541TailSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG013015.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRSSYSVR SSTSQVPVSQ MSQMSQMSIK RTTNVPTYRA ARSTAAAGQG
60 70 80 90 100
TRISSASYSG VRSGVGLPSM SSSIHVSATG ATGDIMGNEK MAMQNLNDRL
110 120 130 140 150
ASYLRSETLE QANSKLELKI REALEKKGPE VCDYSRFQPI IDDLRRKIFD
160 170 180 190 200
ATSNNARLVL QIDNARLAAD DFRVKYDSEL SIRQGVEADI AGLRKVIDDT
210 220 230 240 250
NMNRMNLESE IEALKEELIF LKKNHDNEVM ELRNQISHSG VQVDVDAPKG
260 270 280 290 300
QDLAKIMEEI RSKYEKMALK NQEELKAWHE SQITEVQVQV IQNTEALEGA
310 320 330 340 350
RTEVNELRRQ IQTLEIELES QRNLKGSLEA TLRDTEMRYN MEIESLNAVT
360 370 380 390 400
MQLEAELTQL RNNIQHQTQE YEALLNLKMK LEAEIATYRR LLDGGDFKLQ
410 420 430
DALEEQKRVK VMTVTQTLVD GKVVSSSTET KEKKF
Length:435
Mass (Da):49,179
Last modified:November 1, 1996 - v1
Checksum:iC5346F321732ABA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09744 mRNA. Translation: AAC38007.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09744 mRNA. Translation: AAC38007.1.

3D structure databases

ProteinModelPortaliQ07427.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ07427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG013015.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C18_CARAU
AccessioniPrimary (citable) accession number: Q07427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.