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Protein

Keratin, type I cytoskeletal 18

Gene

krt18

Organism
Carassius auratus (Goldfish)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

When phosphorylated, plays a role in filament reorganization.By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei339StutterSequence analysis1

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 18
Alternative name(s):
Cytokeratin-18
Short name:
CK-18
Keratin-18
Short name:
K18
Gene namesi
Name:krt18
OrganismiCarassius auratus (Goldfish)
Taxonomic identifieri7957 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002890712 – 435Keratin, type I cytoskeletal 18By similarityAdd BLAST434

Post-translational modificationi

Phosphorylated.By similarity
Proteolytically cleaved by caspases during epithelial cell apoptosis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei246 – 247Cleavage; by caspasesBy similarity2

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ07427

Expressioni

Tissue specificityi

Abundantly expressed in an even distribution throughout the optic nerve, localizing specifically to the astrocyte domains. Moderately expressed in spinal cord, brain, liver and oocytes.1 Publication

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ07427
SMRiQ07427
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 399IF rodPROSITE-ProRule annotationAdd BLAST311

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 88HeadSequence analysisAdd BLAST87
Regioni89 – 123Coil 1ASequence analysisAdd BLAST35
Regioni124 – 140Linker 1Sequence analysisAdd BLAST17
Regioni141 – 232Coil 1BSequence analysisAdd BLAST92
Regioni233 – 256Linker 12Sequence analysisAdd BLAST24
Regioni257 – 394Coil 2Sequence analysisAdd BLAST138
Regioni395 – 435TailSequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG013015

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRSSYSVR SSTSQVPVSQ MSQMSQMSIK RTTNVPTYRA ARSTAAAGQG
60 70 80 90 100
TRISSASYSG VRSGVGLPSM SSSIHVSATG ATGDIMGNEK MAMQNLNDRL
110 120 130 140 150
ASYLRSETLE QANSKLELKI REALEKKGPE VCDYSRFQPI IDDLRRKIFD
160 170 180 190 200
ATSNNARLVL QIDNARLAAD DFRVKYDSEL SIRQGVEADI AGLRKVIDDT
210 220 230 240 250
NMNRMNLESE IEALKEELIF LKKNHDNEVM ELRNQISHSG VQVDVDAPKG
260 270 280 290 300
QDLAKIMEEI RSKYEKMALK NQEELKAWHE SQITEVQVQV IQNTEALEGA
310 320 330 340 350
RTEVNELRRQ IQTLEIELES QRNLKGSLEA TLRDTEMRYN MEIESLNAVT
360 370 380 390 400
MQLEAELTQL RNNIQHQTQE YEALLNLKMK LEAEIATYRR LLDGGDFKLQ
410 420 430
DALEEQKRVK VMTVTQTLVD GKVVSSSTET KEKKF
Length:435
Mass (Da):49,179
Last modified:November 1, 1996 - v1
Checksum:iC5346F321732ABA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09744 mRNA Translation: AAC38007.1

Similar proteinsi

Entry informationi

Entry nameiK1C18_CARAU
AccessioniPrimary (citable) accession number: Q07427
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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