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Q07421 (PMA1_AJECA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Plasma membrane ATPase
EC=3.6.3.6
Alternative name(s):
Proton pump
Gene names
Name:PMA1
OrganismAjellomyces capsulata (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifier5037 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Ajellomycetaceae › Ajellomyces

Protein attributes

Sequence length916 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 916916Plasma membrane ATPase
PRO_0000046265

Regions

Topological domain1 – 111111Cytoplasmic Potential
Transmembrane112 – 13423Helical; Name=1; Potential
Topological domain135 – 1362Extracellular Potential
Transmembrane137 – 15519Helical; Name=2; Potential
Topological domain156 – 279124Cytoplasmic Potential
Transmembrane280 – 30526Helical; Name=3; Potential
Topological domain306 – 32015Extracellular Potential
Transmembrane321 – 35030Helical; Name=4; Potential
Topological domain351 – 711361Cytoplasmic Potential
Transmembrane712 – 73423Helical; Name=5; Potential
Topological domain735 – 75420Extracellular Potential
Transmembrane755 – 77622Helical; Name=6; Potential
Topological domain777 – 81741Cytoplasmic Potential
Transmembrane818 – 84326Helical; Name=7; Potential
Topological domain844 – 8474Extracellular Potential
Transmembrane848 – 87427Helical; Name=8; Potential
Topological domain875 – 91642Cytoplasmic Potential
Compositional bias33 – 6230Asp/Glu-rich (acidic)

Sites

Active site37414-aspartylphosphate intermediate By similarity
Metal binding6301Magnesium By similarity
Metal binding6341Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07421 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 1B750ACE83F330AD

FASTA91698,885
        10         20         30         40         50         60 
MAHSAASGAA SAAHFEKKTP EVAHEEKKPP LPEEEDEDED MDALIEELES QDGHIDIEDD 

        70         80         90        100        110        120 
EDGEPGGARP VPDELLTTDT RHGLTDAEVV ARRKKYGLNQ MKEEKENLVL KFLSYFVGPI 

       130        140        150        160        170        180 
QFVMEAAAIL AAGLEDWVDF GVICALLLLN ACVGFVQEFQ AGSIVDELKK TLALKAVVLR 

       190        200        210        220        230        240 
NGRLTEVEAP EVVPGDILQV EEGTIIPADG RIVTEEAFLQ VDQSAITGES LAVDKHKGDT 

       250        260        270        280        290        300 
CYASSAVKRG EAFMVITATG DNTFVGRGPA LVNAASAGTG HFTEVLNGIG TVLLILVILT 

       310        320        330        340        350        360 
LLVVWVSSFY RSNSIVTILE FTLAITIIGV PVGLPAVVTT TMAVGAAYLA KKKAIVQKLS 

       370        380        390        400        410        420 
AIESLAGVEI LCSDKTGTLT KNKLSLAEPY CVSGVDPEDL MLTACLAASR KKKGIDAIDK 

       430        440        450        460        470        480 
AFLKSLRYYP RAKSVLTQYK VLEFHPFDPV SKKVSAVVLS PQGERITCVK GAPLSVLKTV 

       490        500        510        520        530        540 
EEDHPIPDEV DSAYKNKVAE FATRGFRSLG VARKRGEGSW EILGIMPCSD PPRHDTAKTI 

       550        560        570        580        590        600 
NEAKTLGLSI KMLTGDAVGI ARETSRQLGL GTNVYNAERL GLGGGGTMPG SEVYDFVEAA 

       610        620        630        640        650        660 
DGFAEVFPQH KYNVVEILQQ RGYLVAMTGD GVNDAPSLKK ADTGIAVEGA SDAARSAADI 

       670        680        690        700        710        720 
VFLAPGLSAI IDALKTSRQI FHRMYAYVVY RIALSLHLEI FLGLWIAILN TSLNLQLVVF 

       730        740        750        760        770        780 
IAIFADIATL AIAYDNAPFS KTPVKWNLPK LWGMSVLLGI VLAVGTWITL TTMLVGSENG 

       790        800        810        820        830        840 
GIVQNFGRTH PVLFLEISLT ENWLIFITRA NGPFWSSIPS WQLSGAILLV DIIATLFTIF 

       850        860        870        880        890        900 
GWFVGGQTSI VAVVRIWVFS FGCFCVLGGL YYLLQGSAGF DNMMHGKSPK KNQKQRSLED 

       910 
FVVSLQRVST QHEKSS

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References

[1]"Cloning and sequence analysis of an H(+)-ATPase-encoding gene from the human dimorphic pathogen Histoplasma capsulatum."
Schafer M.P., Dean G.E.
Gene 136:295-300(1993) [PubMed: 7916725] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L07305 Genomic DNA. Translation: AAB53772.1.

3D structure databases

ProteinModelPortalQ07421.
SMRQ07421. Positions 1-915.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR000695. ATPase_P-typ_H-transp.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006534. ATPase_P-typ_PM_proton-efflux.
IPR023298. ATPase_P-typ_TM_dom.
IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 2 hits.
G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 2 hits.
PANTHERPTHR24093:SF61. PTHR24093:SF61. 1 hit.
PfamPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePMA1_AJECA
AccessionPrimary (citable) accession number: Q07421
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 19, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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