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Protein

Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Gene

Acads

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Introduces a double bond at position 2 in saturated acyl-CoA's of short chain length, i.e. less than 6 carbon atoms.By similarity

Catalytic activityi

A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.By similarity

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Pathwayi: mitochondrial fatty acid beta-oxidation

This protein is involved in the pathway mitochondrial fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway mitochondrial fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei161Substrate; via carbonyl oxygenBy similarity1
Binding sitei297FADBy similarity1
Binding sitei297FAD; shared with dimeric partnerBy similarity1
Binding sitei308FADBy similarity1
Active sitei392Proton acceptorBy similarity1
Binding sitei393Substrate; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi152 – 161FADBy similarity10
Nucleotide bindingi185 – 187FADBy similarity3
Nucleotide bindingi365 – 369FADBy similarity5
Nucleotide bindingi394 – 396FADBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-77350. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
R-MMU-77352. Beta oxidation of butanoyl-CoA to acetyl-CoA.
UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.1)
Short name:
SCAD
Alternative name(s):
Butyryl-CoA dehydrogenase
Gene namesi
Name:Acads
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:87868. Acads.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionBy similarityAdd BLAST24
ChainiPRO_000000049925 – 412Short-chain specific acyl-CoA dehydrogenase, mitochondrialAdd BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphothreonineCombined sources1
Modified residuei51N6-acetyllysine; alternateCombined sources1
Modified residuei51N6-succinyllysine; alternateCombined sources1
Modified residuei72N6-acetyllysineCombined sources1
Modified residuei129N6-acetyllysine; alternateCombined sources1
Modified residuei129N6-succinyllysine; alternateCombined sources1
Modified residuei208N6-acetyllysineCombined sources1
Modified residuei262N6-acetyllysine; alternateCombined sources1
Modified residuei262N6-succinyllysine; alternateCombined sources1
Modified residuei292N6-acetyllysineCombined sources1
Modified residuei306N6-acetyllysine; alternateCombined sources1
Modified residuei306N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ07417.
MaxQBiQ07417.
PaxDbiQ07417.
PeptideAtlasiQ07417.
PRIDEiQ07417.

2D gel databases

REPRODUCTION-2DPAGEQ07417.

PTM databases

iPTMnetiQ07417.
PhosphoSitePlusiQ07417.
SwissPalmiQ07417.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029545.
CleanExiMM_ACADS.
GenevisibleiQ07417. MM.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi197915. 1 interactor.
IntActiQ07417. 5 interactors.
MINTiMINT-4086625.
STRINGi10090.ENSMUSP00000031524.

Structurei

3D structure databases

ProteinModelPortaliQ07417.
SMRiQ07417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni269 – 272Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0139. Eukaryota.
COG1960. LUCA.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131659.
HOVERGENiHBG000224.
InParanoidiQ07417.
KOiK00248.
OMAiMRCRAVK.
OrthoDBiEOG091G04BS.
TreeFamiTF105019.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALLARAR GPLRRALGVR DWRRLHTVYQ SVELPETHQM LRQTCRDFAE
60 70 80 90 100
KELVPIAAQL DREHLFPTAQ VKKMGELGLL AMDVPEELSG AGLDYLAYSI
110 120 130 140 150
ALEEISRACA STGVIMSVNN SLYLGPILKF GSAQQKQQWI TPFTNGDKIG
160 170 180 190 200
CFALSEPGNG SDAGAASTTA REEGDSWVLN GTKAWITNSW EASATVVFAS
210 220 230 240 250
TDRSRQNKGI SAFLVPMPTP GLTLGKKEDK LGIRASSTAN LIFEDCRIPK
260 270 280 290 300
ENLLGEPGMG FKIAMQTLDM GRIGIASQAL GIAQASLDCA VKYAENRNAF
310 320 330 340 350
GAPLTKLQNI QFKLADMALA LESARLLTWR AAMLKDNKKP FTKESAMAKL
360 370 380 390 400
AASEAATAIS HQAIQILGGM GYVTEMPAER YYRDARITEI YEGTSEIQRL
410
VIAGHLLRSY RS
Length:412
Mass (Da):44,890
Last modified:July 27, 2011 - v2
Checksum:i53DDE98661DF6333
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94D → G in AAA16714 (PubMed:8276399).Curated1
Sequence conflicti348A → R in AAA16714 (PubMed:8276399).Curated1
Sequence conflicti369G → S in AAA16714 (PubMed:8276399).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11163 mRNA. Translation: AAA16714.1.
AK155361 mRNA. Translation: BAE33217.1.
AK169428 mRNA. Translation: BAE41170.1.
CH466529 Genomic DNA. Translation: EDL19883.1.
BC016259 mRNA. Translation: AAH16259.1.
CCDSiCCDS19579.1.
PIRiI49605.
RefSeqiNP_031409.2. NM_007383.3.
UniGeneiMm.18759.

Genome annotation databases

EnsembliENSMUST00000031524; ENSMUSP00000031524; ENSMUSG00000029545.
GeneIDi11409.
KEGGimmu:11409.
UCSCiuc008zdb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11163 mRNA. Translation: AAA16714.1.
AK155361 mRNA. Translation: BAE33217.1.
AK169428 mRNA. Translation: BAE41170.1.
CH466529 Genomic DNA. Translation: EDL19883.1.
BC016259 mRNA. Translation: AAH16259.1.
CCDSiCCDS19579.1.
PIRiI49605.
RefSeqiNP_031409.2. NM_007383.3.
UniGeneiMm.18759.

3D structure databases

ProteinModelPortaliQ07417.
SMRiQ07417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197915. 1 interactor.
IntActiQ07417. 5 interactors.
MINTiMINT-4086625.
STRINGi10090.ENSMUSP00000031524.

PTM databases

iPTMnetiQ07417.
PhosphoSitePlusiQ07417.
SwissPalmiQ07417.

2D gel databases

REPRODUCTION-2DPAGEQ07417.

Proteomic databases

EPDiQ07417.
MaxQBiQ07417.
PaxDbiQ07417.
PeptideAtlasiQ07417.
PRIDEiQ07417.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031524; ENSMUSP00000031524; ENSMUSG00000029545.
GeneIDi11409.
KEGGimmu:11409.
UCSCiuc008zdb.2. mouse.

Organism-specific databases

CTDi35.
MGIiMGI:87868. Acads.

Phylogenomic databases

eggNOGiKOG0139. Eukaryota.
COG1960. LUCA.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131659.
HOVERGENiHBG000224.
InParanoidiQ07417.
KOiK00248.
OMAiMRCRAVK.
OrthoDBiEOG091G04BS.
TreeFamiTF105019.

Enzyme and pathway databases

UniPathwayiUPA00660.
ReactomeiR-MMU-77350. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
R-MMU-77352. Beta oxidation of butanoyl-CoA to acetyl-CoA.

Miscellaneous databases

PROiQ07417.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029545.
CleanExiMM_ACADS.
GenevisibleiQ07417. MM.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACADS_MOUSE
AccessioniPrimary (citable) accession number: Q07417
Secondary accession number(s): Q91W85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.