Reviewed, UniProtKB/Swiss-Prot Q07417 (ACADS_MOUSE)

Names and origin

Protein names

Recommended name:
    Short-chain specific acyl-CoA dehydrogenase, mitochondrial
      Short name=SCAD
    EC=1.3.99.2
Alternative name(s):
    Butyryl-CoA dehydrogenase

Gene names

Name:

Acads

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor.
Cofactor	FAD.
Pathway	Lipid metabolism; mitochondrial fatty acid beta-oxidation.
Subunit structure	Homotetramer.
Subcellular location	Mitochondrion matrix.
Miscellaneous	A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro butyryl-CoA dehydrogenase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 24	24	Mitochondrion By similarity
	Chain	25 – 412	388	Short-chain specific acyl-CoA dehydrogenase, mitochondrial		PRO_0000000499
Regions
	Nucleotide binding	152 – 161	10	FAD By similarity
	Nucleotide binding	185 – 187	3	FAD By similarity
	Nucleotide binding	365 – 369	5	FAD By similarity
	Nucleotide binding	394 – 396	3	FAD By similarity
Sites
	Active site	392	1	Proton acceptor By similarity
	Binding site	297	1	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q07417-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: F78485BC764B79E3	FASTA	412	44,947
	10 20 30 40 50 60 MAAALLARAR GPLRRALGVR DWRRLHTVYQ SVELPETHQM LRQTCRDFAE KELVPIAAQL 70 80 90 100 110 120 DREHLFPTAQ VKKMGELGLL AMDVPEELSG AGLGYLAYSI ALEEISRACA STGVIMSVNN 130 140 150 160 170 180 SLYLGPILKF GSAQQKQQWI TPFTNGDKIG CFALSEPGNG SDAGAASTTA REEGDSWVLN 190 200 210 220 230 240 GTKAWITNSW EASATVVFAS TDRSRQNKGI SAFLVPMPTP GLTLGKKEDK LGIRASSTAN 250 260 270 280 290 300 LIFEDCRIPK ENLLGEPGMG FKIAMQTLDM GRIGIASQAL GIAQASLDCA VKYAENRNAF 310 320 330 340 350 360 GAPLTKLQNI QFKLADMALA LESARLLTWR AAMLKDNKKP FTKESAMRKL AASEAATAIS 370 380 390 400 410 HQAIQILGSM GYVTEMPAER YYRDARITEI YEGTSEIQRL VIAGHLLRSY RS

References

[1]	"Cloning and characterization of the mouse short-chain acyl-CoA dehydrogenase cDNA." Kelly C.L., Hinsdale M.E., Wood P.A. Genomics 18:137-140(1993) [PubMed: 8276399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L11163 mRNA. Translation: AAA16714.1.
PIR	I49605.
UniGene	Mm.18759
3D structure databases
HSSP	HSSP built from PDB template 1JQI based on UniProtKB P15651.
SMR	Q07417. Positions 28-411.
ModBase	Search...
PTM databases
PhosphoSite	Q07417.
2-D gel databases
REPRODUCTION-2DPAGE	Q07417.
Genome annotation databases
Ensembl	ENSMUSG00000029545. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:87868. Acads.
Phylogenomic databases
HOGENOM	Q07417.
HOVERGEN	Q07417.
Gene expression databases
ArrayExpress	Q07417.
CleanEx	MM_ACADS.
GermOnline	ENSMUSG00000029545. Mus musculus.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_DHase/Oxase_M. IPR006089. Acyl-CoA_DHase_CS. IPR006092. Acyl-CoA_DHase_N. IPR006090. Acyl-CoA_Oxase/DHase_1. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

ACADS_MOUSE

Accession

Primary (citable) accession number: Q07417

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	November 25, 2008
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)