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Q07412 (TPIS_PLAFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Triosephosphate isomerase

Short name=TIM
EC=5.3.1.1
Alternative name(s):
Triose-phosphate isomerase
Gene names
Name:TPI
OrganismPlasmodium falciparum
Taxonomic identifier5833 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself5EBI-7086711,EBI-7086711

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Triosephosphate isomerase HAMAP-Rule MF_00147_B
PRO_0000090138

Sites

Active site951Electrophile
Active site1651Proton acceptor
Binding site101Substrate
Binding site121Substrate

Secondary structure

.................................................. 248
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q07412 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: EFC8A4373EA9BED1

FASTA24827,935
        10         20         30         40         50         60 
MARKYFVAAN WKCNGTLESI KSLTNSFNNL DFDPSKLDVV VFPVSVHYDH TRKLLQSKFS 

        70         80         90        100        110        120 
TGIQNVSKFG NGSYTGEVSA EIAKDLNIEY VIIGHFERRK YFHETDEDVR EKLQASLKNN 

       130        140        150        160        170        180 
LKAVVCFGES LEQREQNKTI EVITKQVKAF VDLIDNFDNV ILAYEPLWAI GTGKTATPEQ 

       190        200        210        220        230        240 
AQLVHKEIRK IVKDTCGEKQ ANQIRILYGG SVNTENCSSL IQQEDIDGFL VGNASLKESF 


VDIIKSAM 

« Hide

References

[1]"Cloning of the triosephosphate isomerase gene of Plasmodium falciparum and expression in Escherichia coli."
Ranie J., Kumar V.P., Balaram H.
Mol. Biochem. Parasitol. 61:159-169(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Palo Alto.
[2]"Triosephosphate isomerase from Plasmodium falciparum: the crystal structure provides insights into antimalarial drug design."
Velanker S.S., Ray S.S., Gokhale R.S., Suma S., Balaram H., Balaram P., Murthy M.R.N.
Structure 5:751-761(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS), HOMODIMERIZATION.
[3]"Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: observation of the catalytic loop in the open conformation in the ligand-bound state."
Parthasarathy S., Balaram H., Balaram P., Murthy M.R.N.
Acta Crystallogr. D 58:1992-2000(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOGS, HOMODIMERIZATION.
[4]"Structure of the Plasmodium falciparum triosephosphate isomerase-phosphoglycolate complex in two crystal forms: characterization of catalytic loop open and closed conformations in the ligand-bound state."
Parthasarathy S., Ravindra G., Balaram H., Balaram P., Murthy M.R.N.
Biochemistry 41:13178-13188(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOG, HOMODIMERIZATION.
[5]"Structure of Plasmodium falciparum triose-phosphate isomerase-2-phosphoglycerate complex at 1.1-A resolution."
Parthasarathy S., Eaazhisai K., Balaram H., Balaram P., Murthy M.R.N.
J. Biol. Chem. 278:52461-52470(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.1 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOG.
[6]"Structures of unliganded and inhibitor complexes of W168F, a Loop6 hinge mutant of Plasmodium falciparum triosephosphate isomerase: observation of an intermediate position of loop6."
Eaazhisai K., Balaram H., Balaram P., Murthy M.R.N.
J. Mol. Biol. 343:671-684(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOG.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L01654 mRNA. Translation: AAA18799.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LYXX-ray1.90A1-248[»]
1LZOX-ray2.80A/B/C/D1-248[»]
1M7OX-ray2.40A/B1-248[»]
1M7PX-ray2.40A/B1-248[»]
1O5XX-ray1.10A/B1-248[»]
1VGAX-ray1.80A/B/C/D1-248[»]
1WOAX-ray2.80A/B/C/D1-248[»]
1WOBX-ray2.80A/B/C/D1-248[»]
1YDVX-ray2.20A/B1-248[»]
2FI6model-A1-248[»]
2VFDX-ray1.40A/B1-248[»]
2VFEX-ray2.20A/B1-248[»]
2VFFX-ray1.70A/B1-248[»]
2VFGX-ray1.95A/B/C/D1-248[»]
2VFHX-ray2.00A/B1-248[»]
2VFIX-ray2.25A/B1-248[»]
3PSVX-ray2.00A/B1-248[»]
3PSWX-ray1.99A/B1-248[»]
3PVFX-ray1.73A1-248[»]
3PWAX-ray2.04A/B1-248[»]
3PY2X-ray1.93A/B1-248[»]
DisProtDP00614.
ProteinModelPortalQ07412.
SMRQ07412. Positions 3-248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-7137584.

Proteomic databases

PRIDEQ07412.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0149.

Enzyme and pathway databases

UniPathwayUPA00109; UER00189.
UPA00138.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00147_B. TIM_B.
InterProIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERPTHR21139. PTHR21139. 1 hit.
PfamPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMSSF51351. SSF51351. 1 hit.
TIGRFAMsTIGR00419. tim. 1 hit.
PROSITEPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ07412.

Entry information

Entry nameTPIS_PLAFA
AccessionPrimary (citable) accession number: Q07412
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways