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Protein

Triosephosphate isomerase

Gene

TPI

Organism
Plasmodium falciparum
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (TIM), Triosephosphate isomerase (TPI), Triosephosphate isomerase (PowCR01_080027700)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10Substrate1
Binding sitei12Substrate1
Active sitei95Electrophile1
Active sitei165Proton acceptor1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • triose-phosphate isomerase activity Source: CACAO

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis, Pentose shunt

Enzyme and pathway databases

BRENDAi5.3.1.1. 4889.
SABIO-RKQ07412.
UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
Gene namesi
Name:TPI
OrganismiPlasmodium falciparum
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000901381 – 248Triosephosphate isomeraseAdd BLAST248

Proteomic databases

PaxDbiQ07412.

Interactioni

Subunit structurei

Homodimer.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-7086711,EBI-7086711

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

MINTiMINT-7137584.
STRINGi5833.PF14_0378.

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 10Combined sources6
Helixi17 – 28Combined sources12
Turni34 – 36Combined sources3
Beta strandi37 – 42Combined sources6
Helixi45 – 47Combined sources3
Helixi48 – 54Combined sources7
Beta strandi59 – 64Combined sources6
Beta strandi71 – 73Combined sources3
Helixi80 – 85Combined sources6
Beta strandi90 – 93Combined sources4
Helixi96 – 101Combined sources6
Helixi106 – 118Combined sources13
Beta strandi122 – 127Combined sources6
Helixi131 – 135Combined sources5
Helixi139 – 148Combined sources10
Helixi151 – 153Combined sources3
Beta strandi159 – 164Combined sources6
Helixi167 – 169Combined sources3
Beta strandi170 – 173Combined sources4
Helixi178 – 195Combined sources18
Helixi198 – 203Combined sources6
Beta strandi204 – 208Combined sources5
Turni214 – 216Combined sources3
Helixi217 – 221Combined sources5
Beta strandi228 – 231Combined sources4
Helixi233 – 236Combined sources4
Helixi240 – 246Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LYXX-ray1.90A1-248[»]
1LZOX-ray2.80A/B/C/D1-248[»]
1M7OX-ray2.40A/B1-248[»]
1M7PX-ray2.40A/B1-248[»]
1O5XX-ray1.10A/B1-248[»]
1VGAX-ray1.80A/B/C/D1-248[»]
1WOAX-ray2.80A/B/C/D1-248[»]
1WOBX-ray2.80A/B/C/D1-248[»]
1YDVX-ray2.20A/B1-248[»]
2FI6model-A1-248[»]
2VFDX-ray1.40A/B1-248[»]
2VFEX-ray2.20A/B1-248[»]
2VFFX-ray1.70A/B1-248[»]
2VFGX-ray1.95A/B/C/D1-248[»]
2VFHX-ray2.00A/B1-248[»]
2VFIX-ray2.25A/B1-248[»]
3PSVX-ray2.00A/B1-248[»]
3PSWX-ray1.99A/B1-248[»]
3PVFX-ray1.73A1-248[»]
3PWAX-ray2.04A/B1-248[»]
3PY2X-ray1.93A/B1-248[»]
4YWIX-ray1.85A/B1-248[»]
4YXGX-ray1.90A/B1-248[»]
4Z0JX-ray2.07A/B1-248[»]
4Z0SX-ray2.39A/B1-248[»]
4ZZ9X-ray1.81A/B1-248[»]
5BMWX-ray1.86A/B1-248[»]
5BMXX-ray1.80A/B/C/D1-248[»]
5BNKX-ray1.80A/B1-248[»]
5BRBX-ray2.53A/B1-248[»]
DisProtiDP00614.
ProteinModelPortaliQ07412.
SMRiQ07412.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07412.

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

eggNOGiKOG1643. Eukaryota.
COG0149. LUCA.

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKYFVAAN WKCNGTLESI KSLTNSFNNL DFDPSKLDVV VFPVSVHYDH
60 70 80 90 100
TRKLLQSKFS TGIQNVSKFG NGSYTGEVSA EIAKDLNIEY VIIGHFERRK
110 120 130 140 150
YFHETDEDVR EKLQASLKNN LKAVVCFGES LEQREQNKTI EVITKQVKAF
160 170 180 190 200
VDLIDNFDNV ILAYEPLWAI GTGKTATPEQ AQLVHKEIRK IVKDTCGEKQ
210 220 230 240
ANQIRILYGG SVNTENCSSL IQQEDIDGFL VGNASLKESF VDIIKSAM
Length:248
Mass (Da):27,935
Last modified:October 1, 1994 - v1
Checksum:iEFC8A4373EA9BED1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01654 mRNA. Translation: AAA18799.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01654 mRNA. Translation: AAA18799.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LYXX-ray1.90A1-248[»]
1LZOX-ray2.80A/B/C/D1-248[»]
1M7OX-ray2.40A/B1-248[»]
1M7PX-ray2.40A/B1-248[»]
1O5XX-ray1.10A/B1-248[»]
1VGAX-ray1.80A/B/C/D1-248[»]
1WOAX-ray2.80A/B/C/D1-248[»]
1WOBX-ray2.80A/B/C/D1-248[»]
1YDVX-ray2.20A/B1-248[»]
2FI6model-A1-248[»]
2VFDX-ray1.40A/B1-248[»]
2VFEX-ray2.20A/B1-248[»]
2VFFX-ray1.70A/B1-248[»]
2VFGX-ray1.95A/B/C/D1-248[»]
2VFHX-ray2.00A/B1-248[»]
2VFIX-ray2.25A/B1-248[»]
3PSVX-ray2.00A/B1-248[»]
3PSWX-ray1.99A/B1-248[»]
3PVFX-ray1.73A1-248[»]
3PWAX-ray2.04A/B1-248[»]
3PY2X-ray1.93A/B1-248[»]
4YWIX-ray1.85A/B1-248[»]
4YXGX-ray1.90A/B1-248[»]
4Z0JX-ray2.07A/B1-248[»]
4Z0SX-ray2.39A/B1-248[»]
4ZZ9X-ray1.81A/B1-248[»]
5BMWX-ray1.86A/B1-248[»]
5BMXX-ray1.80A/B/C/D1-248[»]
5BNKX-ray1.80A/B1-248[»]
5BRBX-ray2.53A/B1-248[»]
DisProtiDP00614.
ProteinModelPortaliQ07412.
SMRiQ07412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-7137584.
STRINGi5833.PF14_0378.

Proteomic databases

PaxDbiQ07412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1643. Eukaryota.
COG0149. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.
BRENDAi5.3.1.1. 4889.
SABIO-RKQ07412.

Miscellaneous databases

EvolutionaryTraceiQ07412.

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPIS_PLAFA
AccessioniPrimary (citable) accession number: Q07412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.