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Protein

Contactin-3

Gene

Cntn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-3
Alternative name(s):
Brain-derived immunoglobulin superfamily protein 1
Short name:
BIG-1
Plasmacytoma-associated neuronal glycoprotein
Gene namesi
Name:Cntn3
Synonyms:Pang, Pcs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:99534. Cntn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001470720 – 1002Contactin-3Add BLAST983
PropeptideiPRO_00000147081003 – 1028Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi249 ↔ 297PROSITE-ProRule annotation
Disulfide bondi339 ↔ 386PROSITE-ProRule annotation
Glycosylationi377N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi431 ↔ 479PROSITE-ProRule annotation
Glycosylationi468N-linked (GlcNAc...)Sequence analysis1
Glycosylationi489N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi521 ↔ 577PROSITE-ProRule annotation
Glycosylationi765N-linked (GlcNAc...)Sequence analysis1
Glycosylationi860N-linked (GlcNAc...)Sequence analysis1
Glycosylationi895N-linked (GlcNAc...)Sequence analysis1
Glycosylationi913N-linked (GlcNAc...)Sequence analysis1
Glycosylationi931N-linked (GlcNAc...)Sequence analysis1
Glycosylationi956N-linked (GlcNAc...)Sequence analysis1
Lipidationi1002GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ07409.
PeptideAtlasiQ07409.
PRIDEiQ07409.

PTM databases

PhosphoSitePlusiQ07409.

Expressioni

Tissue specificityi

Specifically expressed in brain. Ectopically expressed in tumors expressing endogenous intracisternal A-type particles (IAPs).1 Publication

Gene expression databases

BgeeiENSMUSG00000030075.
CleanExiMM_CNTN3.
GenevisibleiQ07409. MM.

Interactioni

Subunit structurei

Interacts with PTPRG.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032159.

Structurei

Secondary structure

11028
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi132 – 134Combined sources3
Beta strandi140 – 142Combined sources3
Beta strandi153 – 161Combined sources9
Beta strandi172 – 174Combined sources3
Turni176 – 178Combined sources3
Beta strandi181 – 185Combined sources5
Helixi188 – 190Combined sources3
Beta strandi192 – 200Combined sources9
Beta strandi206 – 208Combined sources3
Beta strandi212 – 216Combined sources5
Beta strandi225 – 232Combined sources8
Beta strandi235 – 240Combined sources6
Beta strandi245 – 255Combined sources11
Beta strandi258 – 263Combined sources6
Beta strandi273 – 276Combined sources4
Helixi277 – 279Combined sources3
Beta strandi281 – 284Combined sources4
Helixi289 – 291Combined sources3
Beta strandi293 – 301Combined sources9
Beta strandi304 – 315Combined sources12
Beta strandi406 – 409Combined sources4
Beta strandi411 – 413Combined sources3
Beta strandi417 – 422Combined sources6
Beta strandi427 – 429Combined sources3
Beta strandi434 – 437Combined sources4
Beta strandi440 – 445Combined sources6
Beta strandi454 – 458Combined sources5
Beta strandi464 – 466Combined sources3
Helixi471 – 473Combined sources3
Beta strandi475 – 483Combined sources9
Beta strandi486 – 497Combined sources12
Beta strandi501 – 504Combined sources4
Beta strandi509 – 512Combined sources4
Beta strandi517 – 519Combined sources3
Beta strandi522 – 524Combined sources3
Beta strandi532 – 537Combined sources6
Beta strandi540 – 542Combined sources3
Helixi545 – 547Combined sources3
Beta strandi550 – 553Combined sources4
Beta strandi562 – 564Combined sources3
Helixi569 – 571Combined sources3
Beta strandi573 – 581Combined sources9
Beta strandi584 – 595Combined sources12
Beta strandi602 – 608Combined sources7
Beta strandi614 – 619Combined sources6
Beta strandi628 – 636Combined sources9
Beta strandi638 – 642Combined sources5
Beta strandi647 – 654Combined sources8
Beta strandi659 – 664Combined sources6
Beta strandi670 – 679Combined sources10
Beta strandi716 – 720Combined sources5
Helixi726 – 728Combined sources3
Beta strandi731 – 733Combined sources3
Beta strandi735 – 742Combined sources8
Beta strandi749 – 753Combined sources5
Beta strandi760 – 765Combined sources6
Beta strandi773 – 782Combined sources10
Beta strandi785 – 789Combined sources5
Beta strandi793 – 796Combined sources4
Beta strandi810 – 813Combined sources4
Beta strandi815 – 817Combined sources3
Beta strandi819 – 822Combined sources4
Helixi830 – 832Combined sources3
Beta strandi837 – 843Combined sources7
Beta strandi853 – 857Combined sources5
Beta strandi863 – 866Combined sources4
Beta strandi874 – 883Combined sources10
Beta strandi894 – 897Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E4QX-ray2.82A604-900[»]
5E5RX-ray2.60B/D124-316[»]
5I99X-ray2.40A406-801[»]
ProteinModelPortaliQ07409.
SMRiQ07409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 117Ig-like C2-type 1Add BLAST86
Domaini122 – 209Ig-like C2-type 2Add BLAST88
Domaini227 – 313Ig-like C2-type 3Add BLAST87
Domaini318 – 402Ig-like C2-type 4Add BLAST85
Domaini408 – 497Ig-like C2-type 5Add BLAST90
Domaini499 – 593Ig-like C2-type 6Add BLAST95
Domaini600 – 698Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini703 – 800Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini805 – 901Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini902 – 998Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ07409.
KOiK06761.
OMAiPQINWRR.
OrthoDBiEOG091G00X7.
TreeFamiTF351103.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032995. Contactin-3.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF695. PTHR10489:SF695. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSWKQLIL LSFIGCLAGE LLLQGPVFIK EPSNSIFPVD SEDKKITLNC
60 70 80 90 100
EARGNPSPHY RWQLNGSDID TSLDHRYKLN GGNLIVINPN RNWDTGSYQC
110 120 130 140 150
FATNSLGTIV SREAKLQFAY LENFKTRMRS TVSVREGQGV VLLCGPPPHS
160 170 180 190 200
GELSYAWVFN EYPSFVEEDS RRFVSQETGH LYIAKVEPSD VGNYTCVVTS
210 220 230 240 250
TVTNTRVLGS PTPLVLRSDG VMGEYEPKIE VQFPETLPAA KGSTVRLECF
260 270 280 290 300
ALGNPVPQIN WRRSDGMPFP NKIKLRKFNG MLEIQNFQQE DTGSYECIAE
310 320 330 340 350
NSRGKNVARG RLTYYAKPYW LQLLRDVEIA VEDSLYWECR ASGKPKPSYR
360 370 380 390 400
WLKNGDALVL EERIQIENGA LTITNLNVTD SGMFQCIAEN KHGLIYSSAE
410 420 430 440 450
LKVVASAPDF SRNPMKKMVQ VQVGSLVILD CKPRASPRAL SFWKKGDMMV
460 470 480 490 500
REQARVSFLN DGGLKIMNVT KADAGTYTCT AENQFGKANG TTHLVVTEPT
510 520 530 540 550
RIILAPSNMD VAVGESVILP CQVQHDPLLD IMFAWYFNGA LTDFKKDGSH
560 570 580 590 600
FEKVGGSSSG DLMIRNIQLK HSGKYVCMVQ TGVDSVSSAA ELIVRGSPGP
610 620 630 640 650
PENVKVDEIT DTTAQLSWTE GTDSHSPVIS YAVQARTPFS VGWQSVRTVP
660 670 680 690 700
EVIDGKTHTA TVVELNPWVE YEFRIVASNK IGGGEPSLPS EKVRTEEAAP
710 720 730 740 750
EIAPSEVSGG GGSRSELVIT WDPVPEELQN GGGFGYVVAF RPLGVTTWIQ
760 770 780 790 800
TVVTSPDNPR YVFRNESIVP FSPYEVKVGV YNNKGEGPFS PVTTVFSAEE
810 820 830 840 850
EPTVAPSHIS AHSLSSSEIE VSWNTIPWKL SNGHLLGYEV RYWNNGGEEE
860 870 880 890 900
SSRKVKVAGN QTSAVLRGLK SNLAYYTAVR AYNSAGAGPF SATVNATTKK
910 920 930 940 950
TPPSQPPGNV VWNATDTKVL LNWEQVKAME NESEVTGYKV FYRTSSQNNV
960 970 980 990 1000
HVLNTNKTSA ELLLPIKEDY IIEVKATTDG GDGTSSEQIR IPRITSMDAR
1010 1020
GSTSAISNIH PLSGYMSVLL FFIVNALW
Length:1,028
Mass (Da):113,232
Last modified:October 3, 2012 - v2
Checksum:i73EBC0C7EB661078
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173F → L in AAA17403 (PubMed:8108413).Curated1
Sequence conflicti297C → G in AAA17403 (PubMed:8108413).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01991 mRNA. Translation: AAA17403.1.
AC114423 Genomic DNA. No translation available.
AC153597 Genomic DNA. No translation available.
AC153600 Genomic DNA. No translation available.
AC155328 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99385.1.
CCDSiCCDS39581.1.
PIRiA53449.
RefSeqiNP_032805.2. NM_008779.2.
XP_006505788.1. XM_006505725.3.
XP_006505790.1. XM_006505727.3.
XP_006505791.1. XM_006505728.3.
XP_017176937.1. XM_017321448.1.
UniGeneiMm.435479.

Genome annotation databases

EnsembliENSMUST00000032159; ENSMUSP00000032159; ENSMUSG00000030075.
ENSMUST00000203619; ENSMUSP00000145176; ENSMUSG00000030075.
GeneIDi18488.
KEGGimmu:18488.
UCSCiuc009dch.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01991 mRNA. Translation: AAA17403.1.
AC114423 Genomic DNA. No translation available.
AC153597 Genomic DNA. No translation available.
AC153600 Genomic DNA. No translation available.
AC155328 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99385.1.
CCDSiCCDS39581.1.
PIRiA53449.
RefSeqiNP_032805.2. NM_008779.2.
XP_006505788.1. XM_006505725.3.
XP_006505790.1. XM_006505727.3.
XP_006505791.1. XM_006505728.3.
XP_017176937.1. XM_017321448.1.
UniGeneiMm.435479.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E4QX-ray2.82A604-900[»]
5E5RX-ray2.60B/D124-316[»]
5I99X-ray2.40A406-801[»]
ProteinModelPortaliQ07409.
SMRiQ07409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032159.

PTM databases

PhosphoSitePlusiQ07409.

Proteomic databases

PaxDbiQ07409.
PeptideAtlasiQ07409.
PRIDEiQ07409.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032159; ENSMUSP00000032159; ENSMUSG00000030075.
ENSMUST00000203619; ENSMUSP00000145176; ENSMUSG00000030075.
GeneIDi18488.
KEGGimmu:18488.
UCSCiuc009dch.1. mouse.

Organism-specific databases

CTDi5067.
MGIiMGI:99534. Cntn3.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ07409.
KOiK06761.
OMAiPQINWRR.
OrthoDBiEOG091G00X7.
TreeFamiTF351103.

Miscellaneous databases

PROiQ07409.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030075.
CleanExiMM_CNTN3.
GenevisibleiQ07409. MM.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032995. Contactin-3.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF695. PTHR10489:SF695. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN3_MOUSE
AccessioniPrimary (citable) accession number: Q07409
Secondary accession number(s): G5E878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.