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Protein

Contactin-3

Gene

Cntn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-3
Alternative name(s):
Brain-derived immunoglobulin superfamily protein 1
Short name:
BIG-1
Plasmacytoma-associated neuronal glycoprotein
Gene namesi
Name:Cntn3
Synonyms:Pang, Pcs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:99534. Cntn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 1002983Contactin-3PRO_0000014707Add
BLAST
Propeptidei1003 – 102826Removed in mature formSequence analysisPRO_0000014708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence analysis
Disulfide bondi249 ↔ 297PROSITE-ProRule annotation
Disulfide bondi339 ↔ 386PROSITE-ProRule annotation
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi431 ↔ 479PROSITE-ProRule annotation
Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence analysis
Glycosylationi489 – 4891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi521 ↔ 577PROSITE-ProRule annotation
Glycosylationi765 – 7651N-linked (GlcNAc...)Sequence analysis
Glycosylationi860 – 8601N-linked (GlcNAc...)Sequence analysis
Glycosylationi895 – 8951N-linked (GlcNAc...)Sequence analysis
Glycosylationi913 – 9131N-linked (GlcNAc...)Sequence analysis
Glycosylationi931 – 9311N-linked (GlcNAc...)Sequence analysis
Glycosylationi956 – 9561N-linked (GlcNAc...)Sequence analysis
Lipidationi1002 – 10021GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ07409.
PaxDbiQ07409.
PRIDEiQ07409.

PTM databases

PhosphoSiteiQ07409.

Expressioni

Tissue specificityi

Specifically expressed in brain. Ectopically expressed in tumors expressing endogenous intracisternal A-type particles (IAPs).1 Publication

Gene expression databases

CleanExiMM_CNTN3.
GenevisibleiQ07409. MM.

Interactioni

Subunit structurei

Interacts with PTPRG.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032159.

Structurei

3D structure databases

ProteinModelPortaliQ07409.
SMRiQ07409. Positions 23-996.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 11786Ig-like C2-type 1Add
BLAST
Domaini122 – 20988Ig-like C2-type 2Add
BLAST
Domaini227 – 31387Ig-like C2-type 3Add
BLAST
Domaini318 – 40285Ig-like C2-type 4Add
BLAST
Domaini408 – 49790Ig-like C2-type 5Add
BLAST
Domaini499 – 59395Ig-like C2-type 6Add
BLAST
Domaini600 – 69899Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini703 – 80098Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini805 – 90197Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini902 – 99897Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ07409.
KOiK06761.
OMAiPQINWRR.
OrthoDBiEOG7J17Z5.
TreeFamiTF351103.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR032995. Contactin-3.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF695. PTHR10489:SF695. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSWKQLIL LSFIGCLAGE LLLQGPVFIK EPSNSIFPVD SEDKKITLNC
60 70 80 90 100
EARGNPSPHY RWQLNGSDID TSLDHRYKLN GGNLIVINPN RNWDTGSYQC
110 120 130 140 150
FATNSLGTIV SREAKLQFAY LENFKTRMRS TVSVREGQGV VLLCGPPPHS
160 170 180 190 200
GELSYAWVFN EYPSFVEEDS RRFVSQETGH LYIAKVEPSD VGNYTCVVTS
210 220 230 240 250
TVTNTRVLGS PTPLVLRSDG VMGEYEPKIE VQFPETLPAA KGSTVRLECF
260 270 280 290 300
ALGNPVPQIN WRRSDGMPFP NKIKLRKFNG MLEIQNFQQE DTGSYECIAE
310 320 330 340 350
NSRGKNVARG RLTYYAKPYW LQLLRDVEIA VEDSLYWECR ASGKPKPSYR
360 370 380 390 400
WLKNGDALVL EERIQIENGA LTITNLNVTD SGMFQCIAEN KHGLIYSSAE
410 420 430 440 450
LKVVASAPDF SRNPMKKMVQ VQVGSLVILD CKPRASPRAL SFWKKGDMMV
460 470 480 490 500
REQARVSFLN DGGLKIMNVT KADAGTYTCT AENQFGKANG TTHLVVTEPT
510 520 530 540 550
RIILAPSNMD VAVGESVILP CQVQHDPLLD IMFAWYFNGA LTDFKKDGSH
560 570 580 590 600
FEKVGGSSSG DLMIRNIQLK HSGKYVCMVQ TGVDSVSSAA ELIVRGSPGP
610 620 630 640 650
PENVKVDEIT DTTAQLSWTE GTDSHSPVIS YAVQARTPFS VGWQSVRTVP
660 670 680 690 700
EVIDGKTHTA TVVELNPWVE YEFRIVASNK IGGGEPSLPS EKVRTEEAAP
710 720 730 740 750
EIAPSEVSGG GGSRSELVIT WDPVPEELQN GGGFGYVVAF RPLGVTTWIQ
760 770 780 790 800
TVVTSPDNPR YVFRNESIVP FSPYEVKVGV YNNKGEGPFS PVTTVFSAEE
810 820 830 840 850
EPTVAPSHIS AHSLSSSEIE VSWNTIPWKL SNGHLLGYEV RYWNNGGEEE
860 870 880 890 900
SSRKVKVAGN QTSAVLRGLK SNLAYYTAVR AYNSAGAGPF SATVNATTKK
910 920 930 940 950
TPPSQPPGNV VWNATDTKVL LNWEQVKAME NESEVTGYKV FYRTSSQNNV
960 970 980 990 1000
HVLNTNKTSA ELLLPIKEDY IIEVKATTDG GDGTSSEQIR IPRITSMDAR
1010 1020
GSTSAISNIH PLSGYMSVLL FFIVNALW
Length:1,028
Mass (Da):113,232
Last modified:October 3, 2012 - v2
Checksum:i73EBC0C7EB661078
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731F → L in AAA17403 (PubMed:8108413).Curated
Sequence conflicti297 – 2971C → G in AAA17403 (PubMed:8108413).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01991 mRNA. Translation: AAA17403.1.
AC114423 Genomic DNA. No translation available.
AC153597 Genomic DNA. No translation available.
AC153600 Genomic DNA. No translation available.
AC155328 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99385.1.
CCDSiCCDS39581.1.
PIRiA53449.
RefSeqiNP_032805.2. NM_008779.2.
XP_006505788.1. XM_006505725.2.
XP_006505789.1. XM_006505726.2.
XP_006505790.1. XM_006505727.2.
XP_006505791.1. XM_006505728.2.
UniGeneiMm.435479.

Genome annotation databases

EnsembliENSMUST00000032159; ENSMUSP00000032159; ENSMUSG00000030075.
ENSMUST00000203619; ENSMUSP00000145176; ENSMUSG00000030075.
GeneIDi18488.
KEGGimmu:18488.
UCSCiuc009dch.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01991 mRNA. Translation: AAA17403.1.
AC114423 Genomic DNA. No translation available.
AC153597 Genomic DNA. No translation available.
AC153600 Genomic DNA. No translation available.
AC155328 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99385.1.
CCDSiCCDS39581.1.
PIRiA53449.
RefSeqiNP_032805.2. NM_008779.2.
XP_006505788.1. XM_006505725.2.
XP_006505789.1. XM_006505726.2.
XP_006505790.1. XM_006505727.2.
XP_006505791.1. XM_006505728.2.
UniGeneiMm.435479.

3D structure databases

ProteinModelPortaliQ07409.
SMRiQ07409. Positions 23-996.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032159.

PTM databases

PhosphoSiteiQ07409.

Proteomic databases

MaxQBiQ07409.
PaxDbiQ07409.
PRIDEiQ07409.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032159; ENSMUSP00000032159; ENSMUSG00000030075.
ENSMUST00000203619; ENSMUSP00000145176; ENSMUSG00000030075.
GeneIDi18488.
KEGGimmu:18488.
UCSCiuc009dch.1. mouse.

Organism-specific databases

CTDi5067.
MGIiMGI:99534. Cntn3.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ07409.
KOiK06761.
OMAiPQINWRR.
OrthoDBiEOG7J17Z5.
TreeFamiTF351103.

Miscellaneous databases

NextBioi294202.
PROiQ07409.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CNTN3.
GenevisibleiQ07409. MM.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR032995. Contactin-3.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF695. PTHR10489:SF695. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PANG, a gene encoding a neuronal glycoprotein, is ectopically activated by intracisternal A-type particle long terminal repeats in murine plasmacytomas."
    Connelly M.A., Grady R.C., Mushinski J.F., Marcu K.B.
    Proc. Natl. Acad. Sci. U.S.A. 91:1337-1341(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Plasmacytoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
    Bouyain S., Watkins D.J.
    Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTPRG.

Entry informationi

Entry nameiCNTN3_MOUSE
AccessioniPrimary (citable) accession number: Q07409
Secondary accession number(s): G5E878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 3, 2012
Last modified: May 11, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.