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Protein

Probable transporter MCH1

Gene

MCH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter. Does not act in the transport of monocarboxylic acids across the plasma membrane.

GO - Molecular functioni

  • transporter activity Source: SGD

GO - Biological processi

  • transmembrane transport Source: InterPro
  • transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29471-MONOMER.

Protein family/group databases

TCDBi2.A.1.75.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transporter MCH1
Alternative name(s):
Monocarboxylate transporter homolog 1
Gene namesi
Name:MCH1
Ordered Locus Names:YDL054C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL054C.
SGDiS000002212. MCH1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 67VacuolarSequence analysisAdd BLAST17
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 93CytoplasmicSequence analysis5
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 133VacuolarSequence analysisAdd BLAST19
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155 – 163CytoplasmicSequence analysis9
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 212VacuolarSequence analysisAdd BLAST28
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 279CytoplasmicSequence analysisAdd BLAST46
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Topological domaini301 – 320VacuolarSequence analysisAdd BLAST20
Transmembranei321 – 343HelicalSequence analysisAdd BLAST23
Topological domaini344 – 347CytoplasmicSequence analysis4
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 385VacuolarSequence analysisAdd BLAST17
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 413CytoplasmicSequence analysis7
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 456VacuolarSequence analysisAdd BLAST22
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Topological domaini478 – 486CytoplasmicSequence analysis9

GO - Cellular componenti

  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848771 – 486Probable transporter MCH1Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Glycosylationi131N-linked (GlcNAc...)Sequence analysis1
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1
Modified residuei255PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ07376.
PRIDEiQ07376.

PTM databases

iPTMnetiQ07376.

Interactioni

Protein-protein interaction databases

BioGridi32005. 31 interactors.
DIPiDIP-5410N.
MINTiMINT-530873.

Structurei

3D structure databases

ProteinModelPortaliQ07376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000246467.
InParanoidiQ07376.
OMAiIWGIDIM.
OrthoDBiEOG092C3ADJ.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSKVEHYL SYHTRLLLPH VLSLQSSHRV AYIFSLLSAV STGFITLISL
60 70 80 90 100
YSQPWQKHLN YSSWQINTIA SMTNLGMYLT PPILGMIADS HGPITLSLLA
110 120 130 140 150
IIGFIPSYSY LAYVFNHPEL SLGGNGDSSF NLSIICFVFI GISTSALYFS
160 170 180 190 200
ALLTCTKLYP HTKLLSISLP TTCYGISSVV GSQLLRIKWF WSSNASSSSS
210 220 230 240 250
NSDLNLGRVF QTFALVYVVI GLLAWIATSV VSLLHFNEEQ DNQKRLDDQT
260 270 280 290 300
DVEQSPLLER SNHVQEKFTQ TMLRIFSDPV TYILAVSILL SLGPLEMFIA
310 320 330 340 350
NMGSLTNLLV QLDAPTLSTK LLSTYALSST FTRLLTGIVA DFFAKKKISI
360 370 380 390 400
KWILLTFLSL GVCAQLFLLK MTSSASPWGL VPTGSLVGIV YGGLFTVYPT
410 420 430 440 450
LVLLVWGERS FGTVYGSLLI APAIGSMIFC MLYAKFYDSR CMSGGGDLRN
460 470 480
PSCISAVYKY SSIAFVVSAV LSAVVFWKLK SRKLRI
Length:486
Mass (Da):53,566
Last modified:November 1, 1996 - v1
Checksum:iF233A3FE854C53DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74102 Genomic DNA. Translation: CAA98616.1.
BK006938 Genomic DNA. Translation: DAA11802.1.
PIRiS67589.
RefSeqiNP_010229.1. NM_001180113.1.

Genome annotation databases

EnsemblFungiiYDL054C; YDL054C; YDL054C.
GeneIDi851506.
KEGGisce:YDL054C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74102 Genomic DNA. Translation: CAA98616.1.
BK006938 Genomic DNA. Translation: DAA11802.1.
PIRiS67589.
RefSeqiNP_010229.1. NM_001180113.1.

3D structure databases

ProteinModelPortaliQ07376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32005. 31 interactors.
DIPiDIP-5410N.
MINTiMINT-530873.

Protein family/group databases

TCDBi2.A.1.75.1. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ07376.

Proteomic databases

MaxQBiQ07376.
PRIDEiQ07376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL054C; YDL054C; YDL054C.
GeneIDi851506.
KEGGisce:YDL054C.

Organism-specific databases

EuPathDBiFungiDB:YDL054C.
SGDiS000002212. MCH1.

Phylogenomic databases

HOGENOMiHOG000246467.
InParanoidiQ07376.
OMAiIWGIDIM.
OrthoDBiEOG092C3ADJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-29471-MONOMER.

Miscellaneous databases

PROiQ07376.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMCH1_YEAST
AccessioniPrimary (citable) accession number: Q07376
Secondary accession number(s): D6VRU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.