Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable transporter MCH1

Gene

MCH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter. Does not act in the transport of monocarboxylic acids across the plasma membrane.

GO - Molecular functioni

  • transporter activity Source: SGD

GO - Biological processi

  • transmembrane transport Source: InterPro
  • transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29471-MONOMER.

Protein family/group databases

TCDBi2.A.1.75.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transporter MCH1
Alternative name(s):
Monocarboxylate transporter homolog 1
Gene namesi
Name:MCH1
Ordered Locus Names:YDL054C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL054C.
SGDiS000002212. MCH1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicSequence analysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Topological domaini51 – 6717VacuolarSequence analysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Topological domaini89 – 935CytoplasmicSequence analysis
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Topological domaini115 – 13319VacuolarSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Topological domaini155 – 1639CytoplasmicSequence analysis
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Topological domaini185 – 21228VacuolarSequence analysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST
Topological domaini234 – 27946CytoplasmicSequence analysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence analysisAdd
BLAST
Topological domaini301 – 32020VacuolarSequence analysisAdd
BLAST
Transmembranei321 – 34323HelicalSequence analysisAdd
BLAST
Topological domaini344 – 3474CytoplasmicSequence analysis
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Topological domaini369 – 38517VacuolarSequence analysisAdd
BLAST
Transmembranei386 – 40621HelicalSequence analysisAdd
BLAST
Topological domaini407 – 4137CytoplasmicSequence analysis
Transmembranei414 – 43421HelicalSequence analysisAdd
BLAST
Topological domaini435 – 45622VacuolarSequence analysisAdd
BLAST
Transmembranei457 – 47721HelicalSequence analysisAdd
BLAST
Topological domaini478 – 4869CytoplasmicSequence analysis

GO - Cellular componenti

  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Probable transporter MCH1PRO_0000084877Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence analysis
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis
Modified residuei255 – 2551PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ07376.

PTM databases

iPTMnetiQ07376.

Interactioni

Protein-protein interaction databases

BioGridi32005. 31 interactions.
DIPiDIP-5410N.
MINTiMINT-530873.

Structurei

3D structure databases

ProteinModelPortaliQ07376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000246467.
InParanoidiQ07376.
OMAiIWGIDIM.
OrthoDBiEOG092C3ADJ.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSKVEHYL SYHTRLLLPH VLSLQSSHRV AYIFSLLSAV STGFITLISL
60 70 80 90 100
YSQPWQKHLN YSSWQINTIA SMTNLGMYLT PPILGMIADS HGPITLSLLA
110 120 130 140 150
IIGFIPSYSY LAYVFNHPEL SLGGNGDSSF NLSIICFVFI GISTSALYFS
160 170 180 190 200
ALLTCTKLYP HTKLLSISLP TTCYGISSVV GSQLLRIKWF WSSNASSSSS
210 220 230 240 250
NSDLNLGRVF QTFALVYVVI GLLAWIATSV VSLLHFNEEQ DNQKRLDDQT
260 270 280 290 300
DVEQSPLLER SNHVQEKFTQ TMLRIFSDPV TYILAVSILL SLGPLEMFIA
310 320 330 340 350
NMGSLTNLLV QLDAPTLSTK LLSTYALSST FTRLLTGIVA DFFAKKKISI
360 370 380 390 400
KWILLTFLSL GVCAQLFLLK MTSSASPWGL VPTGSLVGIV YGGLFTVYPT
410 420 430 440 450
LVLLVWGERS FGTVYGSLLI APAIGSMIFC MLYAKFYDSR CMSGGGDLRN
460 470 480
PSCISAVYKY SSIAFVVSAV LSAVVFWKLK SRKLRI
Length:486
Mass (Da):53,566
Last modified:November 1, 1996 - v1
Checksum:iF233A3FE854C53DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74102 Genomic DNA. Translation: CAA98616.1.
BK006938 Genomic DNA. Translation: DAA11802.1.
PIRiS67589.
RefSeqiNP_010229.1. NM_001180113.1.

Genome annotation databases

EnsemblFungiiYDL054C; YDL054C; YDL054C.
GeneIDi851506.
KEGGisce:YDL054C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74102 Genomic DNA. Translation: CAA98616.1.
BK006938 Genomic DNA. Translation: DAA11802.1.
PIRiS67589.
RefSeqiNP_010229.1. NM_001180113.1.

3D structure databases

ProteinModelPortaliQ07376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32005. 31 interactions.
DIPiDIP-5410N.
MINTiMINT-530873.

Protein family/group databases

TCDBi2.A.1.75.1. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ07376.

Proteomic databases

MaxQBiQ07376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL054C; YDL054C; YDL054C.
GeneIDi851506.
KEGGisce:YDL054C.

Organism-specific databases

EuPathDBiFungiDB:YDL054C.
SGDiS000002212. MCH1.

Phylogenomic databases

HOGENOMiHOG000246467.
InParanoidiQ07376.
OMAiIWGIDIM.
OrthoDBiEOG092C3ADJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-29471-MONOMER.

Miscellaneous databases

PROiQ07376.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMCH1_YEAST
AccessioniPrimary (citable) accession number: Q07376
Secondary accession number(s): D6VRU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.