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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Simian immunodeficiency virus (SIV)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ApoptosisUniRule annotationSAAS annotation, Fusion of virus membrane with host membraneUniRule annotationSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Cleaved into the following 2 chains:
Surface protein gp120UniRule annotation
Short name:
SUUniRule annotation
Alternative name(s):
Glycoprotein 120UniRule annotation
Short name:
gp120UniRule annotation
Transmembrane protein gp41UniRule annotation
Short name:
TMUniRule annotation
Gene namesi
Name:envImported
OrganismiSimian immunodeficiency virus (SIV)Imported
Taxonomic identifieri11723 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiPan troglodytes (Chimpanzee) [TaxID: 9598]

Subcellular locationi

  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei692 – 714HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host endosomeUniRule annotationSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
GlycosylationiCAR_500538976070N-linked (GlcNAc...)Combined sources1
Disulfide bondi101 ↔ 219Combined sources
Disulfide bondi108 ↔ 210Combined sources
GlycosylationiCAR_5005389768211N-linked (GlcNAc...)Combined sources1
Disulfide bondi232 ↔ 262Combined sources
Disulfide bondi242 ↔ 254Combined sources
GlycosylationiCAR_5005389765243N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5005389767277N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5005389763294N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5005389762305N-linked (GlcNAc...)Combined sources1
Disulfide bondi310 ↔ 343Combined sources
Disulfide bondi394 ↔ 458Combined sources
Disulfide bondi401 ↔ 431Combined sources
GlycosylationiCAR_5005389764459N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5005389766475N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5005389761478N-linked (GlcNAc...)Combined sources1

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Subunit structurei

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BF1X-ray4.00A66-109[»]
A209-311[»]
A342-502[»]
3FUSX-ray4.00A66-109[»]
A209-311[»]
A342-502[»]
ProteinModelPortaliQ07374.
SMRiQ07374.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07374.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 524GP120InterPro annotationAdd BLAST501
Domaini542 – 737GP41InterPro annotationAdd BLAST196

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili636 – 663Sequence analysisAdd BLAST28

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiIPR000328. GP41-like.
IPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07374-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCLGNQLLI AILLLSVYGI YCTQYVTVFY GVPAWRNATI PLFCATENRD
60 70 80 90 100
TWGTTQCLPD NGDYSELALN VTESFDAWEN TVTEQAIEDV WQLFETSIKP
110 120 130 140 150
CVKLSPLCIT MRCNKSETDK WGLTKSLTTT APTAPTAASK IDMVNETSSC
160 170 180 190 200
ITHDNCTGLE QEQMIGCKFN MTGLKRDKTK EYNETWYSTD LVCEQGNSTD
210 220 230 240 250
NESRCYMNHC NTSIIQESCD KHYWDTIRFR YCAPPGYALL RCNDTNYSGF
260 270 280 290 300
MPKCSKVVVS SCTRMMETQT STWFGFNGTR AENRTYIYWH GRDNRTIISL
310 320 330 340 350
NKYYNLTMKC RRPGNKTVLP VTIMSGLVFH SQPINDRPKQ AWCWFGGNWK
360 370 380 390 400
DAIKEMKQTI VKHPRYTGTN NTDKINLTAP RGGDPEVTFM WTNCRGEFLY
410 420 430 440 450
CKMNWFLNWV EDRDVTNQRP KERHRRNYVP CHIRQIINTW HKVGKNVYLP
460 470 480 490 500
PREGDLTCNS TVTSLIANID WTDGNQTNIT MSAEVAELYR LELGDYKLVE
510 520 530 540 550
ITPIGLAPTD VKRYTTGGTS RNKRGVFVLG FLGFLATAGS AMGAASLTLT
560 570 580 590 600
AQSRTLLAGI VQQQQQLLDV VKRQQELLRL TVWGTKNLQT RVTAIEKYLK
610 620 630 640 650
DQAQLNAWGC AFRQVCHTTV PWPNASLTPD WNNDTWQEWE RKVDFLEENI
660 670 680 690 700
TALLEEAQIQ QEKNMYELQK LNSWDVFGNW FDLASWIKYI QYGVYIVVGV
710 720 730 740 750
ILLRIVIYIV QMLAKLRQGY RPVFSSPPSY FQQTHIQQDP ALPTREGKEG
760 770 780 790 800
DGGEGGGNSS WPWQIEYIHF LIRQLIRLLT WLFSNCRTLL SRAYQILQPI
810 820 830 840 850
LQRLSAALQR IREVLRTELT YLQYGWSYFQ EAVQVGWRSA TETLAGAWGD
860 870
LWETLRRGGR WILAIPRRIR QGLELTLL
Length:878
Mass (Da):100,992
Last modified:November 1, 1996 - v1
Checksum:i210D7E30B417262A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01065 Genomic DNA. Translation: BAA00871.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01065 Genomic DNA. Translation: BAA00871.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BF1X-ray4.00A66-109[»]
A209-311[»]
A342-502[»]
3FUSX-ray4.00A66-109[»]
A209-311[»]
A342-502[»]
ProteinModelPortaliQ07374.
SMRiQ07374.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ07374.

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiIPR000328. GP41-like.
IPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ07374_SIV
AccessioniPrimary (citable) accession number: Q07374
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.