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Q07374

- Q07374_SIV

UniProt

Q07374 - Q07374_SIV

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Protein

Endogenous retrovirus group K member 21 Env polyprotein

Gene

env

Organism
Simian immunodeficiency virus (SIV)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.SAAS annotation
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous retrovirus group K member 21 Env polyproteinSAAS annotation
Alternative name(s):
Endogenous retrovirus group K member 113 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 13-1 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 18 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 19 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 24 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 25 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 6 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 7 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 8 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 9 Env polyproteinSAAS annotation
Envelope glycoprotein gp160SAAS annotation
Gene namesi
Name:envImported
OrganismiSimian immunodeficiency virus (SIV)Imported
Taxonomic identifieri11723 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiPan troglodytes (Chimpanzee) [TaxID: 9598]

Subcellular locationi

Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

  1. host cell endosome membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinSAAS annotation, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...)Imported
Glycosylationi211 – 2111N-linked (GlcNAc...)Imported
Glycosylationi243 – 2431N-linked (GlcNAc...)Imported
Glycosylationi277 – 2771N-linked (GlcNAc...)Imported
Glycosylationi294 – 2941N-linked (GlcNAc...)
Glycosylationi305 – 3051N-linked (GlcNAc...)Imported
Glycosylationi459 – 4591N-linked (GlcNAc...)Imported
Glycosylationi475 – 4751N-linked (GlcNAc...)Imported
Glycosylationi478 – 4781N-linked (GlcNAc...)

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BF1X-ray4.00A66-109[»]
A209-311[»]
A342-502[»]
3FUSX-ray4.00A66-109[»]
A209-311[»]
A342-502[»]
ProteinModelPortaliQ07374.
SMRiQ07374. Positions 64-499, 551-673.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07374.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 3 hits.

Sequencei

Sequence statusi: Complete.

Q07374 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCLGNQLLI AILLLSVYGI YCTQYVTVFY GVPAWRNATI PLFCATENRD
60 70 80 90 100
TWGTTQCLPD NGDYSELALN VTESFDAWEN TVTEQAIEDV WQLFETSIKP
110 120 130 140 150
CVKLSPLCIT MRCNKSETDK WGLTKSLTTT APTAPTAASK IDMVNETSSC
160 170 180 190 200
ITHDNCTGLE QEQMIGCKFN MTGLKRDKTK EYNETWYSTD LVCEQGNSTD
210 220 230 240 250
NESRCYMNHC NTSIIQESCD KHYWDTIRFR YCAPPGYALL RCNDTNYSGF
260 270 280 290 300
MPKCSKVVVS SCTRMMETQT STWFGFNGTR AENRTYIYWH GRDNRTIISL
310 320 330 340 350
NKYYNLTMKC RRPGNKTVLP VTIMSGLVFH SQPINDRPKQ AWCWFGGNWK
360 370 380 390 400
DAIKEMKQTI VKHPRYTGTN NTDKINLTAP RGGDPEVTFM WTNCRGEFLY
410 420 430 440 450
CKMNWFLNWV EDRDVTNQRP KERHRRNYVP CHIRQIINTW HKVGKNVYLP
460 470 480 490 500
PREGDLTCNS TVTSLIANID WTDGNQTNIT MSAEVAELYR LELGDYKLVE
510 520 530 540 550
ITPIGLAPTD VKRYTTGGTS RNKRGVFVLG FLGFLATAGS AMGAASLTLT
560 570 580 590 600
AQSRTLLAGI VQQQQQLLDV VKRQQELLRL TVWGTKNLQT RVTAIEKYLK
610 620 630 640 650
DQAQLNAWGC AFRQVCHTTV PWPNASLTPD WNNDTWQEWE RKVDFLEENI
660 670 680 690 700
TALLEEAQIQ QEKNMYELQK LNSWDVFGNW FDLASWIKYI QYGVYIVVGV
710 720 730 740 750
ILLRIVIYIV QMLAKLRQGY RPVFSSPPSY FQQTHIQQDP ALPTREGKEG
760 770 780 790 800
DGGEGGGNSS WPWQIEYIHF LIRQLIRLLT WLFSNCRTLL SRAYQILQPI
810 820 830 840 850
LQRLSAALQR IREVLRTELT YLQYGWSYFQ EAVQVGWRSA TETLAGAWGD
860 870
LWETLRRGGR WILAIPRRIR QGLELTLL
Length:878
Mass (Da):100,992
Last modified:November 1, 1996 - v1
Checksum:i210D7E30B417262A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D01065 Genomic DNA. Translation: BAA00871.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D01065 Genomic DNA. Translation: BAA00871.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BF1 X-ray 4.00 A 66-109 [» ]
A 209-311 [» ]
A 342-502 [» ]
3FUS X-ray 4.00 A 66-109 [» ]
A 209-311 [» ]
A 342-502 [» ]
ProteinModelPortali Q07374.
SMRi Q07374. Positions 64-499, 551-673.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q07374.

Family and domain databases

Gene3Di 2.170.40.20. 2 hits.
InterProi IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view ]
Pfami PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view ]
SUPFAMi SSF56502. SSF56502. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "Infectious molecular clones of SIVmac32H: Nef deletion controls ability to reisolate virus from rhesus macaques."
    Rud E.W., Yon J.R., Larder B.A., Clarke B.E., Cook N., Cranage M.P.
    (In) Brown F., Chanock R.M., Ginsberg H.S. (eds.); Vaccines 92: Modern Approaches to New Vaccines Including Prevention of AIDS, pp.229-235, Cold Spring Harbor Laboratory Press, New York (1992)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SIVmac32HImported.
  2. "Molecular cloning and sequence of the simian immunodeficiency virus, SIVmac32H."
    Rud E.W., Yon J.R., Cranage M.P., Larder B.A., Clarke B.E.
    J. Gen. Virol. 75:529-543(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SIVmac32HImported.
  3. "Structure of an unliganded simian immunodeficiency virus gp120 core."
    Chen B., Vogan E.M., Gong H., Skehel J.J., Wiley D.C., Harrison S.C.
    Nature 433:834-841(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.00 ANGSTROMS) OF 66-109; 209-311 AND 342-502, GLYCOSYLATION AT ASN-70; ASN-211; ASN-243; ASN-277; ASN-305; ASN-459 AND ASN-475.
  4. "Structural improvement of unliganded simian immunodeficiency virus gp120 core by normal-mode-based X-ray crystallographic refinement."
    Chen X., Lu M., Poon B.K., Wang Q., Ma J.
    Acta Crystallogr. D 65:339-347(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.00 ANGSTROMS) OF 66-109; 209-311 AND 342-502, GLYCOSYLATION AT ASN-70; ASN-211; ASN-243; ASN-277; ASN-294; ASN-305; ASN-459; ASN-475 AND ASN-478.

Entry informationi

Entry nameiQ07374_SIV
AccessioniPrimary (citable) accession number: Q07374
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3