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Q07374

- Q07374_SIV

UniProt

Q07374 - Q07374_SIV

Protein
Submitted name:

Env polyprotein

Gene

env

Organism
Simian immunodeficiency virus (SIV)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.SAAS annotation
    The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Env polyproteinImported
    Gene namesi
    Name:envImported
    OrganismiSimian immunodeficiency virus (SIV)Imported
    Taxonomic identifieri11723 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiPan troglodytes (Chimpanzee) [TaxID: 9598]

    Subcellular locationi

    Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell endosome membrane Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral envelope Source: UniProtKB-KW
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinSAAS annotation, Virion

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi70 – 701N-linked (GlcNAc...)Imported
    Glycosylationi211 – 2111N-linked (GlcNAc...)Imported
    Glycosylationi243 – 2431N-linked (GlcNAc...)Imported
    Glycosylationi277 – 2771N-linked (GlcNAc...)Imported
    Glycosylationi294 – 2941N-linked (GlcNAc...)Imported
    Glycosylationi305 – 3051N-linked (GlcNAc...)Imported
    Glycosylationi459 – 4591N-linked (GlcNAc...)Imported
    Glycosylationi475 – 4751N-linked (GlcNAc...)Imported
    Glycosylationi478 – 4781N-linked (GlcNAc...)Imported

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BF1X-ray4.00A209-311[»]
    A342-502[»]
    A66-109[»]
    3FUSX-ray4.00A209-311[»]
    A342-502[»]
    A66-109[»]
    ProteinModelPortaliQ07374.
    SMRiQ07374. Positions 64-499, 551-673.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ07374.

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.170.40.20. 2 hits.
    InterProiIPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view]
    PfamiPF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view]
    SUPFAMiSSF56502. SSF56502. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q07374-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCLGNQLLI AILLLSVYGI YCTQYVTVFY GVPAWRNATI PLFCATENRD    50
    TWGTTQCLPD NGDYSELALN VTESFDAWEN TVTEQAIEDV WQLFETSIKP 100
    CVKLSPLCIT MRCNKSETDK WGLTKSLTTT APTAPTAASK IDMVNETSSC 150
    ITHDNCTGLE QEQMIGCKFN MTGLKRDKTK EYNETWYSTD LVCEQGNSTD 200
    NESRCYMNHC NTSIIQESCD KHYWDTIRFR YCAPPGYALL RCNDTNYSGF 250
    MPKCSKVVVS SCTRMMETQT STWFGFNGTR AENRTYIYWH GRDNRTIISL 300
    NKYYNLTMKC RRPGNKTVLP VTIMSGLVFH SQPINDRPKQ AWCWFGGNWK 350
    DAIKEMKQTI VKHPRYTGTN NTDKINLTAP RGGDPEVTFM WTNCRGEFLY 400
    CKMNWFLNWV EDRDVTNQRP KERHRRNYVP CHIRQIINTW HKVGKNVYLP 450
    PREGDLTCNS TVTSLIANID WTDGNQTNIT MSAEVAELYR LELGDYKLVE 500
    ITPIGLAPTD VKRYTTGGTS RNKRGVFVLG FLGFLATAGS AMGAASLTLT 550
    AQSRTLLAGI VQQQQQLLDV VKRQQELLRL TVWGTKNLQT RVTAIEKYLK 600
    DQAQLNAWGC AFRQVCHTTV PWPNASLTPD WNNDTWQEWE RKVDFLEENI 650
    TALLEEAQIQ QEKNMYELQK LNSWDVFGNW FDLASWIKYI QYGVYIVVGV 700
    ILLRIVIYIV QMLAKLRQGY RPVFSSPPSY FQQTHIQQDP ALPTREGKEG 750
    DGGEGGGNSS WPWQIEYIHF LIRQLIRLLT WLFSNCRTLL SRAYQILQPI 800
    LQRLSAALQR IREVLRTELT YLQYGWSYFQ EAVQVGWRSA TETLAGAWGD 850
    LWETLRRGGR WILAIPRRIR QGLELTLL 878
    Length:878
    Mass (Da):100,992
    Last modified:November 1, 1996 - v1
    Checksum:i210D7E30B417262A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D01065 Genomic DNA. Translation: BAA00871.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D01065 Genomic DNA. Translation: BAA00871.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BF1 X-ray 4.00 A 209-311 [» ]
    A 342-502 [» ]
    A 66-109 [» ]
    3FUS X-ray 4.00 A 209-311 [» ]
    A 342-502 [» ]
    A 66-109 [» ]
    ProteinModelPortali Q07374.
    SMRi Q07374. Positions 64-499, 551-673.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q07374.

    Family and domain databases

    Gene3Di 2.170.40.20. 2 hits.
    InterProi IPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view ]
    Pfami PF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56502. SSF56502. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Infectious molecular clones of SIVmac32H: Nef deletion controls ability to reisolate virus from rhesus macaques."
      Rud E.W., Yon J.R., Larder B.A., Clarke B.E., Cook N., Cranage M.P.
      (In) Brown F., Chanock R.M., Ginsberg H.S. (eds.); Vaccines 92: Modern Approaches to New Vaccines Including Prevention of AIDS, pp.229-235, Cold Spring Harbor Laboratory Press, New York (1992)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SIVmac32HImported.
    2. "Molecular cloning and sequence of the simian immunodeficiency virus, SIVmac32H."
      Rud E.W., Yon J.R., Cranage M.P., Larder B.A., Clarke B.E.
      J. Gen. Virol. 75:529-543(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SIVmac32HImported.
    3. "Structure of an unliganded simian immunodeficiency virus gp120 core."
      Chen B., Vogan E.M., Gong H., Skehel J.J., Wiley D.C., Harrison S.C.
      Nature 433:834-841(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.00 ANGSTROMS) OF 209-311; 342-502 AND 66-109, GLYCOSYLATION AT ASN-70; ASN-211; ASN-243; ASN-277; ASN-305; ASN-459 AND ASN-475.
    4. "Structural improvement of unliganded simian immunodeficiency virus gp120 core by normal-mode-based X-ray crystallographic refinement."
      Chen X., Lu M., Poon B.K., Wang Q., Ma J.
      Acta Crystallogr. D 65:339-347(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.00 ANGSTROMS) OF 209-311; 342-502 AND 66-109, GLYCOSYLATION AT ASN-70; ASN-211; ASN-243; ASN-277; ASN-294; ASN-305; ASN-459; ASN-475 AND ASN-478.

    Entry informationi

    Entry nameiQ07374_SIV
    AccessioniPrimary (citable) accession number: Q07374
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3