Env polyprotein - Simian immunodeficiency virus (SIV)

Preferred order of sections

Names and origin

Protein names

Submitted name:
Env polyprotein EMBL BAA00871.1

Gene names

Name:

env EMBL BAA00871.1

Organism

Simian immunodeficiency virus (SIV) EMBL BAA00871.1

Taxonomic identifier

11723 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group

Virus host

Pan troglodytes (Chimpanzee) [TaxID: 9598]

Protein attributes

Sequence length	878 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity. SAAS SAAS000328

The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity.

Ontologies

Keywords
Biological process	Apoptosis SAAS SAAS000328 Fusion of virus membrane with host membrane SAAS SAAS000328 Host-virus interaction Viral attachment to host cell SAAS SAAS000328 Viral penetration into host cytoplasm Virus entry into host cell
Cellular component	Host cell membrane SAAS SAAS000328 Host endosome SAAS SAAS000328 Host membrane Membrane Viral envelope protein SAAS SAAS000328 Virion
Domain	Transmembrane Transmembrane helix SAAS SAAS000328
PTM	Disulfide bond SAAS SAAS000328
Technical term	3D-structure PDB 3FUS PDB 2BF1
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell endosome Inferred from electronic annotation. Source: UniProtKB-KW host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Amino acid modifications

Glycosylation

70

1

N-linked (GlcNAc...) PDB 3FUS PDB 2BF1

Glycosylation

211

1

N-linked (GlcNAc...) PDB 3FUS PDB 2BF1

Glycosylation

243

1

N-linked (GlcNAc...) PDB 3FUS PDB 2BF1

Glycosylation

277

1

N-linked (GlcNAc...) PDB 3FUS PDB 2BF1

Glycosylation

294

1

N-linked (GlcNAc...) PDB 3FUS

Glycosylation

305

1

N-linked (GlcNAc...) PDB 3FUS PDB 2BF1

Glycosylation

459

1

N-linked (GlcNAc...) PDB 3FUS PDB 2BF1

Glycosylation

475

1

N-linked (GlcNAc...) PDB 3FUS PDB 2BF1

Glycosylation

478

1

N-linked (GlcNAc...) PDB 3FUS

Sequences

Sequence

Length

Mass (Da)

Tools

Q07374 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 210D7E30B417262A
Show »

FASTA

878

100,992

        10         20         30         40         50         60 
MGCLGNQLLI AILLLSVYGI YCTQYVTVFY GVPAWRNATI PLFCATENRD TWGTTQCLPD 

        70         80         90        100        110        120 
NGDYSELALN VTESFDAWEN TVTEQAIEDV WQLFETSIKP CVKLSPLCIT MRCNKSETDK 

       130        140        150        160        170        180 
WGLTKSLTTT APTAPTAASK IDMVNETSSC ITHDNCTGLE QEQMIGCKFN MTGLKRDKTK 

       190        200        210        220        230        240 
EYNETWYSTD LVCEQGNSTD NESRCYMNHC NTSIIQESCD KHYWDTIRFR YCAPPGYALL 

       250        260        270        280        290        300 
RCNDTNYSGF MPKCSKVVVS SCTRMMETQT STWFGFNGTR AENRTYIYWH GRDNRTIISL 

       310        320        330        340        350        360 
NKYYNLTMKC RRPGNKTVLP VTIMSGLVFH SQPINDRPKQ AWCWFGGNWK DAIKEMKQTI 

       370        380        390        400        410        420 
VKHPRYTGTN NTDKINLTAP RGGDPEVTFM WTNCRGEFLY CKMNWFLNWV EDRDVTNQRP 

       430        440        450        460        470        480 
KERHRRNYVP CHIRQIINTW HKVGKNVYLP PREGDLTCNS TVTSLIANID WTDGNQTNIT 

       490        500        510        520        530        540 
MSAEVAELYR LELGDYKLVE ITPIGLAPTD VKRYTTGGTS RNKRGVFVLG FLGFLATAGS 

       550        560        570        580        590        600 
AMGAASLTLT AQSRTLLAGI VQQQQQLLDV VKRQQELLRL TVWGTKNLQT RVTAIEKYLK 

       610        620        630        640        650        660 
DQAQLNAWGC AFRQVCHTTV PWPNASLTPD WNNDTWQEWE RKVDFLEENI TALLEEAQIQ 

       670        680        690        700        710        720 
QEKNMYELQK LNSWDVFGNW FDLASWIKYI QYGVYIVVGV ILLRIVIYIV QMLAKLRQGY 

       730        740        750        760        770        780 
RPVFSSPPSY FQQTHIQQDP ALPTREGKEG DGGEGGGNSS WPWQIEYIHF LIRQLIRLLT 

       790        800        810        820        830        840 
WLFSNCRTLL SRAYQILQPI LQRLSAALQR IREVLRTELT YLQYGWSYFQ EAVQVGWRSA 

       850        860        870 
TETLAGAWGD LWETLRRGGR WILAIPRRIR QGLELTLL

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References

[1]	"Infectious molecular clones of SIVmac32H: Nef deletion controls ability to reisolate virus from rhesus macaques." Rud E.W., Yon J.R., Larder B.A., Clarke B.E., Cook N., Cranage M.P. (In) Brown F., Chanock R.M., Ginsberg H.S. (eds.); Vaccines 92: Modern Approaches to New Vaccines Including Prevention of AIDS, pp.229-235, Cold Spring Harbor Laboratory Press, New York (1992) Cited for: NUCLEOTIDE SEQUENCE. Strain: SIVmac32H EMBL BAA00871.1.
[2]	"Molecular cloning and sequence of the simian immunodeficiency virus, SIVmac32H." Rud E.W., Yon J.R., Cranage M.P., Larder B.A., Clarke B.E. J. Gen. Virol. 75:529-543(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SIVmac32H EMBL BAA00871.1.
[3]	"Structure of an unliganded simian immunodeficiency virus gp120 core." Chen B., Vogan E.M., Gong H., Skehel J.J., Wiley D.C., Harrison S.C. Nature 433:834-841(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (4.00 ANGSTROMS) OF 66-502, GLYCOSYLATION AT ASN-70; ASN-211; ASN-243; ASN-277; ASN-305; ASN-459 AND ASN-475.
[4]	"Structural improvement of unliganded simian immunodeficiency virus gp120 core by normal-mode-based X-ray crystallographic refinement." Chen X., Lu M., Poon B.K., Wang Q., Ma J. Acta Crystallogr. D 65:339-347(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (4.00 ANGSTROMS) OF 66-502, GLYCOSYLATION AT ASN-70; ASN-211; ASN-243; ASN-277; ASN-294; ASN-305; ASN-459; ASN-475 AND ASN-478.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D01065 Genomic DNA. Translation: BAA00871.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3FUS	X-ray	4.00	A	66-502	[»]

ProteinModelPortal

Q07374.

SMR

Q07374. Positions 64-499, 551-673.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

2.170.40.20. 2 hits.

InterPro

IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]

Pfam

PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]

SUPFAM

SSF56502. GP120. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q07374.

Entry information

Entry name

Q07374_SIV

Accession

Primary (citable) accession number: Q07374

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)