Q07362 (PBP4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein PBP4

Alternative name(s):
PBP1-binding protein 4

Gene names

Name:	PBP4
Ordered Locus Names:	YDL053C
ORF Names:	D2574

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with IGO1, LSM12 and PBP1. Ref.5 Ref.6 Ref.8
Subcellular location	Cytoplasm. Nucleus Ref.3.
Miscellaneous	Present with 1560 molecules/cell in log phase SD medium.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasmic stress granule Inferred from direct assay PubMed 20368989. Source: SGD nucleus Inferred from direct assay Ref.3PubMed 22842922. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Protein PBP4		PRO_0000262746
Regions
	Compositional bias	56 – 62	7	Poly-Gln
Amino acid modifications
	Modified residue	2	1	Phosphothreonine Ref.7
	Modified residue	5	1	Phosphoserine Ref.7
	Modified residue	14	1	Phosphoserine Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q07362 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 516811BEF07EC37D	FASTA	185	19,881
	10 20 30 40 50 60 MTTTSTTSVD GRTSSTLKAT LSASGPNSNG PTPAVLPQKP KLTGWAQAAA KALPRQQQQQ 70 80 90 100 110 120 QQARKDDSVA VQPANTKTKT IASTAPPANI KGSSTANGSS TNKKFKRANK QPYNREEVRS 130 140 150 160 170 180 YMHKLFQSYT AGEKSHSMKT YKQVLSETAS GRVSTATDWG TVSSSKNKNK KYGCLSDIAK VLRNQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Identification of factors regulating poly(A) tail synthesis and maturation." Mangus D.A., Smith M.M., McSweeney J.M., Jacobson A. Mol. Cell. Biol. 24:4196-4206(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PBP1.
[6]	"Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes." Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J. Genes Dev. 20:1294-1307(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH LSM12 AND PBP1, IDENTIFICATION BY MASS SPECTROMETRY.
[7]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2; SER-5 AND SER-14, MASS SPECTROMETRY.
[8]	"Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway." Talarek N., Cameroni E., Jaquenoud M., Luo X., Bontron S., Lippman S., Devgan G., Snyder M., Broach J.R., De Virgilio C. Mol. Cell 38:345-355(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH IGO1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z74101 Genomic DNA. Translation: CAA98615.1. BK006938 Genomic DNA. Translation: DAA11803.1.
PIR	S67588.
RefSeq	NP_010230.1. NM_001180112.1.
3D structure databases
ProteinModelPortal	Q07362.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5229N.
IntAct	Q07362. 9 interactions.
MINT	MINT-536916.
STRING	4932.YDL053C.
Proteomic databases
PaxDb	Q07362.
PeptideAtlas	Q07362.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YDL053C; YDL053C; YDL053C.
GeneID	851507.
KEGG	sce:YDL053C.
Organism-specific databases
CYGD	YDL053c.
SGD	S000002211. PBP4.
Phylogenomic databases
eggNOG	NOG87662.
OMA	KLTGWAQ.
OrthoDB	EOG4CZFRS.
Gene expression databases
Genevestigator	Q07362.
GermOnline	YDL053C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	968863.

Entry information

Entry name

PBP4_YEAST

Accession

Primary (citable) accession number: Q07362
Secondary accession number(s): D6VRU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program