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Protein

Zinc finger protein 36, C3H1 type-like 1

Gene

ZFP36L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable regulatory protein involved in regulating the response to growth factors.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri114 – 14229C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri152 – 18029C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB
  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • mRNA 3'-UTR AU-rich region binding Source: UniProtKB
  • mRNA binding Source: MGI
  • poly(A) RNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • 3'-UTR-mediated mRNA destabilization Source: UniProtKB
  • apoptotic process Source: Ensembl
  • cell proliferation Source: Ensembl
  • cellular response to cAMP Source: UniProtKB
  • cellular response to epidermal growth factor stimulus Source: UniProtKB
  • cellular response to fibroblast growth factor stimulus Source: UniProtKB
  • cellular response to glucocorticoid stimulus Source: UniProtKB
  • cellular response to hypoxia Source: UniProtKB
  • cellular response to insulin stimulus Source: UniProtKB
  • cellular response to peptide hormone stimulus Source: UniProtKB
  • cellular response to phorbol 13-acetate 12-myristate Source: UniProtKB
  • cellular response to raffinose Source: UniProtKB
  • cellular response to salt stress Source: UniProtKB
  • cellular response to transforming growth factor beta stimulus Source: UniProtKB
  • cellular response to tumor necrosis factor Source: UniProtKB
  • chorio-allantoic fusion Source: Ensembl
  • ERK1 and ERK2 cascade Source: UniProtKB
  • heart development Source: Ensembl
  • MAPK cascade Source: UniProtKB
  • mesendoderm development Source: UniProtKB
  • mRNA transport Source: UniProtKB
  • multicellular organism growth Source: Ensembl
  • negative regulation of erythrocyte differentiation Source: UniProtKB
  • neural tube development Source: Ensembl
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: Ensembl
  • nuclear-transcribed mRNA catabolic process, deadenylation-independent decay Source: UniProtKB
  • p38MAPK cascade Source: UniProtKB
  • phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • positive regulation of fat cell differentiation Source: UniProtKB
  • positive regulation of intracellular mRNA localization Source: UniProtKB
  • positive regulation of monocyte differentiation Source: UniProtKB
  • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: UniProtKB
  • proepicardium development Source: Ensembl
  • protein kinase B signaling Source: UniProtKB
  • regulation of gene expression Source: UniProtKB
  • regulation of keratinocyte apoptotic process Source: UniProtKB
  • regulation of keratinocyte differentiation Source: UniProtKB
  • regulation of keratinocyte proliferation Source: UniProtKB
  • regulation of mRNA 3'-end processing Source: UniProtKB
  • regulation of mRNA stability Source: UniProtKB
  • regulation of myoblast differentiation Source: UniProtKB
  • regulation of stem cell proliferation Source: UniProtKB
  • response to wounding Source: UniProtKB
  • spongiotrophoblast layer development Source: Ensembl
  • T cell differentiation in thymus Source: UniProtKB
  • vasculogenesis Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
SIGNORiQ07352.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 36, C3H1 type-like 1
Alternative name(s):
Butyrate response factor 1
EGF-response factor 1
Short name:
ERF-1
Protein TIS11B
Gene namesi
Name:ZFP36L1
Synonyms:BERG36, BRF1, ERF1, RNF162B, TIS11B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:1107. ZFP36L1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Shuttles between the nucleus and the cytoplasm.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic mRNA processing body Source: UniProtKB
  • cytosol Source: Reactome
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35027.

Polymorphism and mutation databases

BioMutaiZFP36L1.
DMDMi1351254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Zinc finger protein 36, C3H1 type-like 1PRO_0000089167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphoserineCombined sources
Modified residuei318 – 3181PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ07352.
MaxQBiQ07352.
PaxDbiQ07352.
PeptideAtlasiQ07352.
PRIDEiQ07352.

PTM databases

iPTMnetiQ07352.
PhosphoSiteiQ07352.

Expressioni

Gene expression databases

BgeeiENSG00000185650.
CleanExiHS_BRF1.
HS_ZFP36L1.
ExpressionAtlasiQ07352. baseline and differential.
GenevisibleiQ07352. HS.

Organism-specific databases

HPAiHPA001301.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAPK14Q165392EBI-721823,EBI-73946

GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107144. 12 interactions.
IntActiQ07352. 11 interactions.
MINTiMINT-1375566.
STRINGi9606.ENSP00000337386.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1W0VX-ray2.27C325-333[»]
1W0WX-ray2.10C325-333[»]
ProteinModelPortaliQ07352.
SMRiQ07352. Positions 112-181.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07352.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi307 – 31610Poly-Ser

Sequence similaritiesi

Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri114 – 14229C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri152 – 18029C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1677. Eukaryota.
COG5063. LUCA.
GeneTreeiENSGT00530000063262.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiQ07352.
KOiK18753.
OMAiLQHSYSF.
OrthoDBiEOG091G0957.
PhylomeDBiQ07352.
TreeFamiTF315463.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP
60 70 80 90 100
RRHSVTLPSS KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP
110 120 130 140 150
TQKQPGGGQV NSSRYKTELC RPFEENGACK YGDKCQFAHG IHELRSLTRH
160 170 180 190 200
PKYKTELCRT FHTIGFCPYG PRCHFIHNAE ERRALAGARD LSADRPRLQH
210 220 230 240 250
SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS PTLPDGTNNP
260 270 280 290 300
FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS
310 320 330
DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD
Length:338
Mass (Da):36,314
Last modified:February 1, 1996 - v1
Checksum:i98236CD40C4531D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631H → R in CAA67781 (PubMed:8898945).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79066, X79067 mRNA. Translation: CAA55670.1.
X99404 mRNA. Translation: CAA67781.1.
BT019468 mRNA. Translation: AAV38275.1.
BC018340 mRNA. Translation: AAH18340.1.
CCDSiCCDS9791.1.
PIRiS34854.
RefSeqiNP_001231627.1. NM_001244698.1.
NP_001231630.1. NM_001244701.1.
NP_004917.2. NM_004926.3.
UniGeneiHs.707091.
Hs.85155.

Genome annotation databases

EnsembliENST00000336440; ENSP00000337386; ENSG00000185650.
ENST00000439696; ENSP00000388402; ENSG00000185650.
GeneIDi677.
KEGGihsa:677.
UCSCiuc001xkh.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79066, X79067 mRNA. Translation: CAA55670.1.
X99404 mRNA. Translation: CAA67781.1.
BT019468 mRNA. Translation: AAV38275.1.
BC018340 mRNA. Translation: AAH18340.1.
CCDSiCCDS9791.1.
PIRiS34854.
RefSeqiNP_001231627.1. NM_001244698.1.
NP_001231630.1. NM_001244701.1.
NP_004917.2. NM_004926.3.
UniGeneiHs.707091.
Hs.85155.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1W0VX-ray2.27C325-333[»]
1W0WX-ray2.10C325-333[»]
ProteinModelPortaliQ07352.
SMRiQ07352. Positions 112-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107144. 12 interactions.
IntActiQ07352. 11 interactions.
MINTiMINT-1375566.
STRINGi9606.ENSP00000337386.

PTM databases

iPTMnetiQ07352.
PhosphoSiteiQ07352.

Polymorphism and mutation databases

BioMutaiZFP36L1.
DMDMi1351254.

Proteomic databases

EPDiQ07352.
MaxQBiQ07352.
PaxDbiQ07352.
PeptideAtlasiQ07352.
PRIDEiQ07352.

Protocols and materials databases

DNASUi677.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336440; ENSP00000337386; ENSG00000185650.
ENST00000439696; ENSP00000388402; ENSG00000185650.
GeneIDi677.
KEGGihsa:677.
UCSCiuc001xkh.3. human.

Organism-specific databases

CTDi677.
GeneCardsiZFP36L1.
HGNCiHGNC:1107. ZFP36L1.
HPAiHPA001301.
MIMi601064. gene.
neXtProtiNX_Q07352.
PharmGKBiPA35027.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1677. Eukaryota.
COG5063. LUCA.
GeneTreeiENSGT00530000063262.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiQ07352.
KOiK18753.
OMAiLQHSYSF.
OrthoDBiEOG091G0957.
PhylomeDBiQ07352.
TreeFamiTF315463.

Enzyme and pathway databases

ReactomeiR-HSA-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
SIGNORiQ07352.

Miscellaneous databases

ChiTaRSiZFP36L1. human.
EvolutionaryTraceiQ07352.
GeneWikiiZFP36L1.
GenomeRNAii677.
PROiQ07352.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185650.
CleanExiHS_BRF1.
HS_ZFP36L1.
ExpressionAtlasiQ07352. baseline and differential.
GenevisibleiQ07352. HS.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTISB_HUMAN
AccessioniPrimary (citable) accession number: Q07352
Secondary accession number(s): Q13851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.