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Reviewed, UniProtKB/Swiss-Prot Q07352 (TISB_HUMAN)

Last modified November 25, 2008. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Butyrate response factor 1
Alternative name(s):
    Protein TIS11B
    EGF-response factor 1
      Short name=ERF-1
Gene names
Name: ZFP36L1
Synonyms: BERG36, BRF1, ERF1, RNF162B, TIS11B
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Probable regulatory protein involved in regulating the response to growth factors.

Subcellular location

Nucleus.

Sequence similarities

Contains 2 C3H1-type zinc fingers.

Ontologies

Keywords

   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   PTMPhosphoprotein
   Technical term3D-structure

Gene Ontology (GO)

   Biological processregulation of mRNA stability

Inferred from direct assay. Source: MGI

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionmRNA binding

Inferred from direct assay. Source: MGI

protein binding

Inferred from physical interaction. Source: IntAct

transcription factor activity

Non-traceable author statement. Source: ProtInc

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MAPK14Q165391EBI-721823,EBI-73946

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Butyrate response factor 1
PRO_0000089167

Regions

Zinc finger114 – 14229C3H1-type 1
Zinc finger152 – 18029C3H1-type 2
Compositional bias307 – 31610Poly-Ser

Amino acid modifications

Modified residue541Phosphoserine By similarity
Modified residue921Phosphoserine By similarity

Experimental info

Sequence conflict631H → R in CAA67781. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q07352-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 98236CD40C4531D2

FASTA33836,314
        10         20         30         40         50         60 
MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS 

        70         80         90        100        110        120 
KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP TQKQPGGGQV NSSRYKTELC 

       130        140        150        160        170        180 
RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE 

       190        200        210        220        230        240 
ERRALAGARD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS 

       250        260        270        280        290        300 
PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 

       310        320        330 
DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD 

« Hide

References

« Hide 'large scale' references
[1]"Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes."
Barnard R.C., Pascall J.C., Brown K.D., McKay I.A., Williams N.S., Bustin S.A.
Nucleic Acids Res. 21:3580-3580(1993) [PubMed: 8346037] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes."
Bustin S.A., Nie X.F., Barnard R.C., Kumar V., Pascall J.C., Brown K.D., Leigh I.M., Williams N.S., McKay L.A.
DNA Cell Biol. 13:449-459(1994) [PubMed: 8024689] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36."
Ning Z.Q., Norton J.D., Li J., Murphy J.J.
Eur. J. Immunol. 26:2356-2363(1996) [PubMed: 8898945] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

X79066, X79067 mRNA. Translation: CAA55670.1.
X99404 mRNA. Translation: CAA67781.1.
BT019468 mRNA. Translation: AAV38275.1.
BC018340 mRNA. Translation: AAH18340.1.
PIRS34854.
RefSeqNP_004917.2.
UniGeneHs.699794
Hs.85155

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1W0VX-ray2.27C325-333[»]
1W0WX-ray2.11C325-333[»]
SMRQ07352. Positions 112-181.
ModBaseSearch...

Protein-protein interaction databases

IntActQ07352.

PTM databases

PhosphoSiteQ07352.

Proteomic databases

PeptideAtlasQ07352.

Genome annotation databases

EnsemblENSG00000185650. Homo sapiens. [Contig view]
GeneID677.
KEGGhsa:677.

Organism-specific databases

H-InvDBHIX0011759.
HGNCHGNC:1107. ZFP36L1.
HPAHPA001301.
MIM601064. gene.
PharmGKBPA35027.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ07352.
HOVERGENQ07352.

Gene expression databases

ArrayExpressQ07352.
CleanExHS_BRF1.
HS_ZFP36L1.
GermOnlineENSG00000185650. Homo sapiens.

Family and domain databases

InterProIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
PROSITEPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio2790.
SOURCESearch...

Entry information

Entry nameTISB_HUMAN
AccessionPrimary (citable) accession number: Q07352
Secondary accession number(s): Q13851
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 25, 2008
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents