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Q07352

- TISB_HUMAN

UniProt

Q07352 - TISB_HUMAN

Protein

Zinc finger protein 36, C3H1 type-like 1

Gene

ZFP36L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Probable regulatory protein involved in regulating the response to growth factors.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri114 – 14229C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri152 – 18029C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. mRNA binding Source: MGI
    4. poly(A) RNA binding Source: UniProtKB
    5. protein binding Source: IntAct
    6. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. gene expression Source: Reactome
    2. mRNA metabolic process Source: Reactome
    3. nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: Ensembl
    4. regulation of mRNA stability Source: MGI
    5. regulation of transcription, DNA-templated Source: GOC
    6. regulation of translation Source: Ensembl
    7. RNA metabolic process Source: Reactome
    8. T cell differentiation in thymus Source: Ensembl
    9. vasculogenesis Source: Ensembl

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_24915. Butyrate Response Factor 1 (BRF1) destabilizes mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 36, C3H1 type-like 1
    Alternative name(s):
    Butyrate response factor 1
    EGF-response factor 1
    Short name:
    ERF-1
    Protein TIS11B
    Gene namesi
    Name:ZFP36L1
    Synonyms:BERG36, BRF1, ERF1, RNF162B, TIS11B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:1107. ZFP36L1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Shuttles between the nucleus and the cytoplasm.By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35027.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Zinc finger protein 36, C3H1 type-like 1PRO_0000089167Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 541Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ07352.
    PaxDbiQ07352.
    PeptideAtlasiQ07352.
    PRIDEiQ07352.

    PTM databases

    PhosphoSiteiQ07352.

    Expressioni

    Gene expression databases

    ArrayExpressiQ07352.
    BgeeiQ07352.
    CleanExiHS_BRF1.
    HS_ZFP36L1.
    GenevestigatoriQ07352.

    Organism-specific databases

    HPAiHPA001301.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAPK14Q165392EBI-721823,EBI-73946

    Protein-protein interaction databases

    BioGridi107144. 12 interactions.
    IntActiQ07352. 4 interactions.
    MINTiMINT-1375566.
    STRINGi9606.ENSP00000337386.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1W0VX-ray2.27C325-333[»]
    1W0WX-ray2.10C325-333[»]
    ProteinModelPortaliQ07352.
    SMRiQ07352. Positions 112-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ07352.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi307 – 31610Poly-Ser

    Sequence similaritiesi

    Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri114 – 14229C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri152 – 18029C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5063.
    HOGENOMiHOG000233479.
    HOVERGENiHBG008483.
    InParanoidiQ07352.
    OMAiWPSSNPF.
    PhylomeDBiQ07352.
    TreeFamiTF315463.

    Family and domain databases

    Gene3Di4.10.1000.10. 2 hits.
    InterProiIPR007635. Tis11B_N.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PfamiPF04553. Tis11B_N. 1 hit.
    PF00642. zf-CCCH. 2 hits.
    [Graphical view]
    SMARTiSM00356. ZnF_C3H1. 2 hits.
    [Graphical view]
    PROSITEiPS50103. ZF_C3H1. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q07352-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP    50
    RRHSVTLPSS KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP 100
    TQKQPGGGQV NSSRYKTELC RPFEENGACK YGDKCQFAHG IHELRSLTRH 150
    PKYKTELCRT FHTIGFCPYG PRCHFIHNAE ERRALAGARD LSADRPRLQH 200
    SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS PTLPDGTNNP 250
    FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 300
    DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD 338
    Length:338
    Mass (Da):36,314
    Last modified:February 1, 1996 - v1
    Checksum:i98236CD40C4531D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti63 – 631H → R in CAA67781. (PubMed:8898945)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79066, X79067 mRNA. Translation: CAA55670.1.
    X99404 mRNA. Translation: CAA67781.1.
    BT019468 mRNA. Translation: AAV38275.1.
    BC018340 mRNA. Translation: AAH18340.1.
    CCDSiCCDS9791.1.
    PIRiS34854.
    RefSeqiNP_001231627.1. NM_001244698.1.
    NP_001231630.1. NM_001244701.1.
    NP_004917.2. NM_004926.3.
    UniGeneiHs.707091.
    Hs.85155.

    Genome annotation databases

    EnsembliENST00000336440; ENSP00000337386; ENSG00000185650.
    ENST00000439696; ENSP00000388402; ENSG00000185650.
    GeneIDi677.
    KEGGihsa:677.
    UCSCiuc001xkh.2. human.

    Polymorphism databases

    DMDMi1351254.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79066 , X79067 mRNA. Translation: CAA55670.1 .
    X99404 mRNA. Translation: CAA67781.1 .
    BT019468 mRNA. Translation: AAV38275.1 .
    BC018340 mRNA. Translation: AAH18340.1 .
    CCDSi CCDS9791.1.
    PIRi S34854.
    RefSeqi NP_001231627.1. NM_001244698.1.
    NP_001231630.1. NM_001244701.1.
    NP_004917.2. NM_004926.3.
    UniGenei Hs.707091.
    Hs.85155.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1W0V X-ray 2.27 C 325-333 [» ]
    1W0W X-ray 2.10 C 325-333 [» ]
    ProteinModelPortali Q07352.
    SMRi Q07352. Positions 112-181.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107144. 12 interactions.
    IntActi Q07352. 4 interactions.
    MINTi MINT-1375566.
    STRINGi 9606.ENSP00000337386.

    PTM databases

    PhosphoSitei Q07352.

    Polymorphism databases

    DMDMi 1351254.

    Proteomic databases

    MaxQBi Q07352.
    PaxDbi Q07352.
    PeptideAtlasi Q07352.
    PRIDEi Q07352.

    Protocols and materials databases

    DNASUi 677.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336440 ; ENSP00000337386 ; ENSG00000185650 .
    ENST00000439696 ; ENSP00000388402 ; ENSG00000185650 .
    GeneIDi 677.
    KEGGi hsa:677.
    UCSCi uc001xkh.2. human.

    Organism-specific databases

    CTDi 677.
    GeneCardsi GC14M069254.
    HGNCi HGNC:1107. ZFP36L1.
    HPAi HPA001301.
    MIMi 601064. gene.
    neXtProti NX_Q07352.
    PharmGKBi PA35027.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5063.
    HOGENOMi HOG000233479.
    HOVERGENi HBG008483.
    InParanoidi Q07352.
    OMAi WPSSNPF.
    PhylomeDBi Q07352.
    TreeFami TF315463.

    Enzyme and pathway databases

    Reactomei REACT_24915. Butyrate Response Factor 1 (BRF1) destabilizes mRNA.

    Miscellaneous databases

    ChiTaRSi ZFP36L1. human.
    EvolutionaryTracei Q07352.
    GeneWikii ZFP36L1.
    GenomeRNAii 677.
    NextBioi 2790.
    PROi Q07352.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q07352.
    Bgeei Q07352.
    CleanExi HS_BRF1.
    HS_ZFP36L1.
    Genevestigatori Q07352.

    Family and domain databases

    Gene3Di 4.10.1000.10. 2 hits.
    InterProi IPR007635. Tis11B_N.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    Pfami PF04553. Tis11B_N. 1 hit.
    PF00642. zf-CCCH. 2 hits.
    [Graphical view ]
    SMARTi SM00356. ZnF_C3H1. 2 hits.
    [Graphical view ]
    PROSITEi PS50103. ZF_C3H1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes."
      Barnard R.C., Pascall J.C., Brown K.D., McKay I.A., Williams N.S., Bustin S.A.
      Nucleic Acids Res. 21:3580-3580(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes."
      Bustin S.A., Nie X.F., Barnard R.C., Kumar V., Pascall J.C., Brown K.D., Leigh I.M., Williams N.S., McKay L.A.
      DNA Cell Biol. 13:449-459(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36."
      Ning Z.Q., Norton J.D., Li J., Murphy J.J.
      Eur. J. Immunol. 26:2356-2363(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Thermodynamic and structural equivalence of two HLA-B27 subtypes complexed with a self-peptide."
      Hulsmeyer M., Welfle K., Pohlmann T., Misselwitz R., Alexiev U., Welfle H., Saenger W., Uchanska-Ziegler B., Ziegler A.
      J. Mol. Biol. 346:1367-1379(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 325-333 IN COMPLEX WITH MAJOR HISTOCOMPATIBILITY COMPLEX HLA.

    Entry informationi

    Entry nameiTISB_HUMAN
    AccessioniPrimary (citable) accession number: Q07352
    Secondary accession number(s): Q13851
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3