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Protein

mRNA decay activator protein ZFP36L1

Gene

ZFP36L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).By similarity16 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri114 – 142C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri152 – 180C3H1-type 2PROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB
  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • mRNA 3'-UTR AU-rich region binding Source: UniProtKB
  • mRNA 3'-UTR binding Source: GO_Central
  • mRNA binding Source: MGI
  • poly(A) RNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • 3'-UTR-mediated mRNA destabilization Source: UniProtKB
  • apoptotic process Source: Ensembl
  • cell proliferation Source: Ensembl
  • cellular response to cAMP Source: UniProtKB
  • cellular response to epidermal growth factor stimulus Source: UniProtKB
  • cellular response to fibroblast growth factor stimulus Source: UniProtKB
  • cellular response to glucocorticoid stimulus Source: UniProtKB
  • cellular response to hypoxia Source: UniProtKB
  • cellular response to insulin stimulus Source: UniProtKB
  • cellular response to peptide hormone stimulus Source: UniProtKB
  • cellular response to phorbol 13-acetate 12-myristate Source: UniProtKB
  • cellular response to raffinose Source: UniProtKB
  • cellular response to salt stress Source: UniProtKB
  • cellular response to transforming growth factor beta stimulus Source: UniProtKB
  • cellular response to tumor necrosis factor Source: UniProtKB
  • chorio-allantoic fusion Source: Ensembl
  • ERK1 and ERK2 cascade Source: UniProtKB
  • heart development Source: Ensembl
  • MAPK cascade Source: UniProtKB
  • mesendoderm development Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • mRNA transport Source: UniProtKB
  • multicellular organism growth Source: Ensembl
  • negative regulation of erythrocyte differentiation Source: UniProtKB
  • negative regulation of mitotic cell cycle phase transition Source: UniProtKB
  • neural tube development Source: Ensembl
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: Ensembl
  • nuclear-transcribed mRNA catabolic process, deadenylation-independent decay Source: UniProtKB
  • p38MAPK cascade Source: UniProtKB
  • phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • positive regulation of fat cell differentiation Source: UniProtKB
  • positive regulation of intracellular mRNA localization Source: UniProtKB
  • positive regulation of monocyte differentiation Source: UniProtKB
  • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: UniProtKB
  • proepicardium development Source: Ensembl
  • protein kinase B signaling Source: UniProtKB
  • regulation of B cell differentiation Source: UniProtKB
  • regulation of gene expression Source: UniProtKB
  • regulation of keratinocyte apoptotic process Source: UniProtKB
  • regulation of keratinocyte differentiation Source: UniProtKB
  • regulation of keratinocyte proliferation Source: UniProtKB
  • regulation of mRNA 3'-end processing Source: UniProtKB
  • regulation of mRNA stability Source: UniProtKB
  • regulation of myoblast differentiation Source: UniProtKB
  • regulation of stem cell proliferation Source: UniProtKB
  • response to wounding Source: UniProtKB
  • spongiotrophoblast layer development Source: Ensembl
  • T cell differentiation in thymus Source: UniProtKB
  • vasculogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA transport, Transport

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
SIGNORiQ07352.

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA decay activator protein ZFP36L1Curated
Alternative name(s):
Butyrate response factor 12 Publications
EGF-response factor 11 Publication
Short name:
ERF-11 Publication
TPA-induced sequence 11bBy similarity
Zinc finger protein 36, C3H1 type-like 1Imported
Short name:
ZFP36-like 1Imported
Gene namesi
Name:ZFP36L1Imported
Synonyms:BERG361 Publication, BRF12 Publications, ERF11 Publication, RNF162B, TIS11BBy similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:1107. ZFP36L1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic mRNA processing body Source: UniProtKB
  • cytosol Source: GO_Central
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi54S → A: Inhibits MAPKAPK2-mediated ARE-containing mRNA stabilization; when associated with A-92 and A-203. Combined sources1 Publication1
Mutagenesisi90S → A: Inhibits interaction with 14-3-3 proteins and AKT1-mediated ARE-containing mRNA stabilization, but does not affect ARE binding; when associated with A-92. 1 Publication1
Mutagenesisi92S → A: Inhibits MAPKAPK2-mediated ARE-containing mRNA stabilization; when associated with A-54 and A-203. Inhibits interaction with 14-3-3 proteins and AKT1-mediated ARE-containing mRNA stabilization; when associated with A-203. Inhibits interaction with 14-3-3 proteins and AKT1-mediated ARE-containing mRNA stabilization, but does not affect ARE binding; when associated with A-90. 3 Publications1
Mutagenesisi120C → R: Reduces binding to ARE-containing mRNAs and ARE-mediated mRNA decay. Inhibits binding to ARE-containing mRNAs and ARE-mediated mRNA decay; when associated with R-158. 2 Publications1
Mutagenesisi158C → R: Reduces binding to ARE-containing mRNAs and ARE-mediated mRNA decay. Inhibits binding to ARE-containing mRNAs and ARE-mediated mRNA decay; when associated with R-120. 2 Publications1
Mutagenesisi203S → A: Inhibits interaction with 14-3-3 proteins and AKT1-mediated ARE-containing mRNA stabilization; when associated with A-92. Inhibits MAPKAPK2-mediated ARE-containing mRNA stabilization; when associated with A-54 and A-92. 2 Publications1
Mutagenesisi334S → A: Inhibits p38 MAPK-mediated LDLR mRNA stabilization, but does not inhibit interaction with CNOT1 and CNOT7; when associated with A-336. 1 Publication1
Mutagenesisi336S → A: Inhibits p38 MAPK-mediated LDLR mRNA stabilization, but does not inhibit interaction with CNOT1 and CNOT7; when associated with A-334. 1 Publication1

Organism-specific databases

DisGeNETi677.
OpenTargetsiENSG00000185650.
PharmGKBiPA35027.

Polymorphism and mutation databases

BioMutaiZFP36L1.
DMDMi1351254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000891671 – 338mRNA decay activator protein ZFP36L1Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54Phosphoserine; by MAPKAPK2Combined sources1 Publication1
Modified residuei90Phosphoserine; by PKB/AKT11 Publication1
Modified residuei92Phosphoserine; by PKB/AKT1 and MAPKAPK22 Publications1
Modified residuei203Phosphoserine; by PKB/AKT1 and MAPKAPK22 Publications1
Modified residuei318PhosphoserineCombined sources1
Modified residuei334Phosphoserine; by RPS6KA11 Publication1

Post-translational modificationi

Phosphorylated (PubMed:19179481). Phosphorylated by RPS6KA1 at Ser-334 upon phorbol 12-myristate 13-acetate (PMA) treatment; this phosphorylation results in dissociation of the CCR4-NOT deadenylase complex and induces p38 MAPK-mediated stabilization of the low-density lipoprotein receptor LDLR mRNA (PubMed:25106868). Phosphorylated by protein kinase AKT1 at Ser-92 and Ser-203 in response to insulin; these phosphorylations stabilize ZFP36L1, increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization (PubMed:15538381, PubMed:17030608). AKT1-mediated phosphorylation at Ser-92 does not impair ARE-containing RNA-binding (PubMed:15538381). Phosphorylated at Ser-54, Ser-92 and Ser-203 by MAPKAPK2; these phosphorylations increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization in a protein kinase AKT1-independent manner (PubMed:18326031). MAPKAPK2-mediated phosphorylations at Ser-54, Ser-92 and Ser-203 do not impair ARE-containing RNA-binding (PubMed:18326031). Phosphorylations increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization during early adipogenesis in a p38 MAPK- and AKT-dependent manner (By similarity).By similarity5 Publications
Ubiquitinated. Ubiquitination leads to proteasomal degradation, a process inhibited by phosphorylations at Ser-90, Ser-92 and Ser-203 (PubMed:17030608).1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ07352.
MaxQBiQ07352.
PaxDbiQ07352.
PeptideAtlasiQ07352.
PRIDEiQ07352.

PTM databases

iPTMnetiQ07352.
PhosphoSitePlusiQ07352.

Expressioni

Tissue specificityi

Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009). Expressed in osteoblasts (PubMed:15465005).2 Publications

Inductioni

Down-regulated under hypoxic conditions in endothelial cells (at protein level) (PubMed:21832157). Up-regulated by growth factor (TGF-beta), cytokines, tumor necrosis factor (TNF-alpha) and epidermal growth factor (EGF) in keratinocytes (PubMed:20166898). Up-regulated also by glucocorticoid dexamethasone in keratinocytes (PubMed:20166898). Up-regulated in keratinocytes in response to wounding in a p38 MAPK-dependent manner (PubMed:20166898, PubMed:27182009). Up-regulated by the parathyroid hormone (PTH) in osteoblast-like cells in a cAMP/PKA-dependent manner (PubMed:15465005, PubMed:19179481). Up-regulated in response to adrenocorticotropic hormone (ACTH) (PubMed:19179481). Up-regulated during monocyte/macrophage differentiation in response to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (PubMed:26542173). Down-regulated by butyrate in colorectal cancer cells (PubMed:10367403).7 Publications

Gene expression databases

BgeeiENSG00000185650.
CleanExiHS_BRF1.
HS_ZFP36L1.
ExpressionAtlasiQ07352. baseline and differential.
GenevisibleiQ07352. HS.

Organism-specific databases

HPAiHPA001301.

Interactioni

Subunit structurei

Associates with the cytoplasmic CCR4-NOT deadenylase and RNA exosome complexes to trigger ARE-containing mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Interacts with CNOT1 (PubMed:25106868). Interacts (via N-terminus) with CNOT6 (PubMed:15687258, PubMed:18326031). Interacts with CNOT7; this interaction is inhibited in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Interacts with DCP1A (PubMed:15687258). Interacts (via N-terminus) with DCP2 (PubMed:15687258, PubMed:18326031). Interacts (via N-terminus) with EXOSC2 (PubMed:15687258, PubMed:18326031). Interacts with XRN1 (PubMed:15687258). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381, PubMed:17030608, PubMed:18326031). Interacts (via phosphorylated form) with YWHAZ; this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity).By similarity16 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAPK14Q165392EBI-721823,EBI-73946

GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107144. 12 interactors.
IntActiQ07352. 11 interactors.
MINTiMINT-1375566.
STRINGi9606.ENSP00000337386.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W0VX-ray2.27C325-333[»]
1W0WX-ray2.10C325-333[»]
ProteinModelPortaliQ07352.
SMRiQ07352.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07352.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 111Necessary and sufficient for the association with mRNA decay enzymes and mRNA decay activation1 PublicationAdd BLAST111
Regioni185 – 338Necessary for mRNA decay activation1 PublicationAdd BLAST154

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi307 – 316Poly-Ser10

Sequence similaritiesi

Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri114 – 142C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri152 – 180C3H1-type 2PROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1677. Eukaryota.
COG5063. LUCA.
GeneTreeiENSGT00530000063262.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiQ07352.
KOiK18753.
OMAiLQHSYSF.
OrthoDBiEOG091G0957.
PhylomeDBiQ07352.
TreeFamiTF315463.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP
60 70 80 90 100
RRHSVTLPSS KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP
110 120 130 140 150
TQKQPGGGQV NSSRYKTELC RPFEENGACK YGDKCQFAHG IHELRSLTRH
160 170 180 190 200
PKYKTELCRT FHTIGFCPYG PRCHFIHNAE ERRALAGARD LSADRPRLQH
210 220 230 240 250
SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS PTLPDGTNNP
260 270 280 290 300
FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS
310 320 330
DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD
Length:338
Mass (Da):36,314
Last modified:February 1, 1996 - v1
Checksum:i98236CD40C4531D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63H → R in CAA67781 (PubMed:8898945).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79066, X79067 mRNA. Translation: CAA55670.1.
X99404 mRNA. Translation: CAA67781.1.
BT019468 mRNA. Translation: AAV38275.1.
BC018340 mRNA. Translation: AAH18340.1.
CCDSiCCDS9791.1.
PIRiS34854.
RefSeqiNP_001231627.1. NM_001244698.1.
NP_001231630.1. NM_001244701.1.
NP_004917.2. NM_004926.3.
UniGeneiHs.707091.
Hs.85155.

Genome annotation databases

EnsembliENST00000336440; ENSP00000337386; ENSG00000185650.
ENST00000439696; ENSP00000388402; ENSG00000185650.
GeneIDi677.
KEGGihsa:677.
UCSCiuc001xkh.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79066, X79067 mRNA. Translation: CAA55670.1.
X99404 mRNA. Translation: CAA67781.1.
BT019468 mRNA. Translation: AAV38275.1.
BC018340 mRNA. Translation: AAH18340.1.
CCDSiCCDS9791.1.
PIRiS34854.
RefSeqiNP_001231627.1. NM_001244698.1.
NP_001231630.1. NM_001244701.1.
NP_004917.2. NM_004926.3.
UniGeneiHs.707091.
Hs.85155.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W0VX-ray2.27C325-333[»]
1W0WX-ray2.10C325-333[»]
ProteinModelPortaliQ07352.
SMRiQ07352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107144. 12 interactors.
IntActiQ07352. 11 interactors.
MINTiMINT-1375566.
STRINGi9606.ENSP00000337386.

PTM databases

iPTMnetiQ07352.
PhosphoSitePlusiQ07352.

Polymorphism and mutation databases

BioMutaiZFP36L1.
DMDMi1351254.

Proteomic databases

EPDiQ07352.
MaxQBiQ07352.
PaxDbiQ07352.
PeptideAtlasiQ07352.
PRIDEiQ07352.

Protocols and materials databases

DNASUi677.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336440; ENSP00000337386; ENSG00000185650.
ENST00000439696; ENSP00000388402; ENSG00000185650.
GeneIDi677.
KEGGihsa:677.
UCSCiuc001xkh.3. human.

Organism-specific databases

CTDi677.
DisGeNETi677.
GeneCardsiZFP36L1.
HGNCiHGNC:1107. ZFP36L1.
HPAiHPA001301.
MIMi601064. gene.
neXtProtiNX_Q07352.
OpenTargetsiENSG00000185650.
PharmGKBiPA35027.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1677. Eukaryota.
COG5063. LUCA.
GeneTreeiENSGT00530000063262.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiQ07352.
KOiK18753.
OMAiLQHSYSF.
OrthoDBiEOG091G0957.
PhylomeDBiQ07352.
TreeFamiTF315463.

Enzyme and pathway databases

ReactomeiR-HSA-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
SIGNORiQ07352.

Miscellaneous databases

ChiTaRSiZFP36L1. human.
EvolutionaryTraceiQ07352.
GeneWikiiZFP36L1.
GenomeRNAii677.
PROiQ07352.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185650.
CleanExiHS_BRF1.
HS_ZFP36L1.
ExpressionAtlasiQ07352. baseline and differential.
GenevisibleiQ07352. HS.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTISB_HUMAN
AccessioniPrimary (citable) accession number: Q07352
Secondary accession number(s): Q13851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.