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Q07352 (TISB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 36, C3H1 type-like 1
Alternative name(s):
Butyrate response factor 1
EGF-response factor 1
Short name=ERF-1
Protein TIS11B
Gene names
Name:ZFP36L1
Synonyms:BERG36, BRF1, ERF1, RNF162B, TIS11B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable regulatory protein involved in regulating the response to growth factors.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Shuttles between the nucleus and the cytoplasm By similarity.

Sequence similarities

Contains 2 C3H1-type zinc fingers.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA metabolic process

Traceable author statement. Source: Reactome

T cell differentiation in thymus

Inferred from electronic annotation. Source: Ensembl

gene expression

Traceable author statement. Source: Reactome

mRNA metabolic process

Traceable author statement. Source: Reactome

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Inferred from electronic annotation. Source: Ensembl

regulation of mRNA stability

Inferred from direct assay PubMed 15467755. Source: MGI

regulation of transcription, DNA-templated

Non-traceable author statement PubMed 8595910. Source: GOC

regulation of translation

Inferred from electronic annotation. Source: Ensembl

vasculogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

mRNA binding

Inferred from direct assay PubMed 15467755. Source: MGI

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

poly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 16189514. Source: IntAct

sequence-specific DNA binding transcription factor activity

Non-traceable author statement PubMed 8595910. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MAPK14Q165392EBI-721823,EBI-73946

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Zinc finger protein 36, C3H1 type-like 1
PRO_0000089167

Regions

Zinc finger114 – 14229C3H1-type 1
Zinc finger152 – 18029C3H1-type 2
Compositional bias307 – 31610Poly-Ser

Amino acid modifications

Modified residue541Phosphoserine Ref.6

Experimental info

Sequence conflict631H → R in CAA67781. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q07352 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 98236CD40C4531D2

FASTA33836,314
        10         20         30         40         50         60 
MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS 

        70         80         90        100        110        120 
KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP TQKQPGGGQV NSSRYKTELC 

       130        140        150        160        170        180 
RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE 

       190        200        210        220        230        240 
ERRALAGARD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS 

       250        260        270        280        290        300 
PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 

       310        320        330 
DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD 

« Hide

References

« Hide 'large scale' references
[1]"Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes."
Barnard R.C., Pascall J.C., Brown K.D., McKay I.A., Williams N.S., Bustin S.A.
Nucleic Acids Res. 21:3580-3580(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes."
Bustin S.A., Nie X.F., Barnard R.C., Kumar V., Pascall J.C., Brown K.D., Leigh I.M., Williams N.S., McKay L.A.
DNA Cell Biol. 13:449-459(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36."
Ning Z.Q., Norton J.D., Li J., Murphy J.J.
Eur. J. Immunol. 26:2356-2363(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[6]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Thermodynamic and structural equivalence of two HLA-B27 subtypes complexed with a self-peptide."
Hulsmeyer M., Welfle K., Pohlmann T., Misselwitz R., Alexiev U., Welfle H., Saenger W., Uchanska-Ziegler B., Ziegler A.
J. Mol. Biol. 346:1367-1379(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 325-333 IN COMPLEX WITH MAJOR HISTOCOMPATIBILITY COMPLEX HLA.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X79066, X79067 mRNA. Translation: CAA55670.1.
X99404 mRNA. Translation: CAA67781.1.
BT019468 mRNA. Translation: AAV38275.1.
BC018340 mRNA. Translation: AAH18340.1.
CCDSCCDS9791.1.
PIRS34854.
RefSeqNP_001231627.1. NM_001244698.1.
NP_001231630.1. NM_001244701.1.
NP_004917.2. NM_004926.3.
UniGeneHs.707091.
Hs.85155.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1W0VX-ray2.27C325-333[»]
1W0WX-ray2.10C325-333[»]
ProteinModelPortalQ07352.
SMRQ07352. Positions 112-181.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107144. 12 interactions.
IntActQ07352. 4 interactions.
MINTMINT-1375566.
STRING9606.ENSP00000337386.

PTM databases

PhosphoSiteQ07352.

Polymorphism databases

DMDM1351254.

Proteomic databases

MaxQBQ07352.
PaxDbQ07352.
PeptideAtlasQ07352.
PRIDEQ07352.

Protocols and materials databases

DNASU677.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000336440; ENSP00000337386; ENSG00000185650.
ENST00000439696; ENSP00000388402; ENSG00000185650.
GeneID677.
KEGGhsa:677.
UCSCuc001xkh.2. human.

Organism-specific databases

CTD677.
GeneCardsGC14M069254.
HGNCHGNC:1107. ZFP36L1.
HPAHPA001301.
MIM601064. gene.
neXtProtNX_Q07352.
PharmGKBPA35027.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5063.
HOGENOMHOG000233479.
HOVERGENHBG008483.
InParanoidQ07352.
OMAWPSSNPF.
PhylomeDBQ07352.
TreeFamTF315463.

Enzyme and pathway databases

ReactomeREACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ07352.
BgeeQ07352.
CleanExHS_BRF1.
HS_ZFP36L1.
GenevestigatorQ07352.

Family and domain databases

Gene3D4.10.1000.10. 2 hits.
InterProIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
PROSITEPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZFP36L1. human.
EvolutionaryTraceQ07352.
GeneWikiZFP36L1.
GenomeRNAi677.
NextBio2790.
PROQ07352.
SOURCESearch...

Entry information

Entry nameTISB_HUMAN
AccessionPrimary (citable) accession number: Q07352
Secondary accession number(s): Q13851
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM