Zinc finger protein 36, C3H1 type-like 1

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Q07352 (TISB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 123. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Zinc finger protein 36, C3H1 type-like 1

Alternative name(s):
Butyrate response factor 1
EGF-response factor 1
Short name=ERF-1
Protein TIS11B

Gene names

Name:	ZFP36L1
Synonyms:	BERG36, BRF1, ERF1, RNF162B, TIS11B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable regulatory protein involved in regulating the response to growth factors.
Subcellular location	Nucleus.
Sequence similarities	Contains 2 C3H1-type zinc fingers.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell differentiation in thymus Inferred from electronic annotation. Source: Compara gene expression Traceable author statement. Source: Reactome mRNA metabolic process Traceable author statement. Source: Reactome nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Inferred from electronic annotation. Source: Compara regulation of mRNA stability Inferred from direct assay PubMed 15467755. Source: MGI regulation of translation Inferred from electronic annotation. Source: Compara vasculogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Traceable author statement. Source: Reactome nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA binding Inferred from direct assay PubMed 15467755. Source: MGI sequence-specific DNA binding transcription factor activity Non-traceable author statement PubMed 8595910. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MAPK14	Q16539	2	EBI-721823,EBI-73946

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 338

338

Zinc finger protein 36, C3H1 type-like 1

PRO_0000089167

Regions

Zinc finger

114 – 142

C3H1-type 1

Zinc finger

152 – 180

C3H1-type 2

Compositional bias

307 – 316

Poly-Ser

Amino acid modifications

Modified residue

Phosphoserine Ref.6

Modified residue

Phosphoserine By similarity

Experimental info

Sequence conflict

H → R in CAA67781. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

Q07352 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 98236CD40C4531D2
Show »

FASTA

338

36,314

        10         20         30         40         50         60 
MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS 

        70         80         90        100        110        120 
KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP TQKQPGGGQV NSSRYKTELC 

       130        140        150        160        170        180 
RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE 

       190        200        210        220        230        240 
ERRALAGARD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS 

       250        260        270        280        290        300 
PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 

       310        320        330 
DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes." Barnard R.C., Pascall J.C., Brown K.D., McKay I.A., Williams N.S., Bustin S.A. Nucleic Acids Res. 21:3580-3580(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes." Bustin S.A., Nie X.F., Barnard R.C., Kumar V., Pascall J.C., Brown K.D., Leigh I.M., Williams N.S., McKay L.A. DNA Cell Biol. 13:449-459(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36." Ning Z.Q., Norton J.D., Li J., Murphy J.J. Eur. J. Immunol. 26:2356-2363(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[6]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X79066, X79067 mRNA. Translation: CAA55670.1.
X99404 mRNA. Translation: CAA67781.1.
BT019468 mRNA. Translation: AAV38275.1.
BC018340 mRNA. Translation: AAH18340.1.

IPI

IPI00016635.

PIR

S34854.

RefSeq

NP_001231627.1. NM_001244698.1.
NP_001231630.1. NM_001244701.1.
NP_004917.2. NM_004926.3.

UniGene

Hs.85155.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1W0V	X-ray	2.27	C	325-333	[»]
1W0W	X-ray	2.10	C	325-333	[»]

ProteinModelPortal

Q07352.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q07352. 4 interactions.

MINT

MINT-1375566.

STRING

9606.ENSP00000337386.

PTM databases

PhosphoSite

Q07352.

Polymorphism databases

DMDM

1351254.

Proteomic databases

PaxDb

Q07352.

PeptideAtlas

Q07352.

PRIDE

Q07352.

Protocols and materials databases

DNASU

677.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000336440; ENSP00000337386; ENSG00000185650.
ENST00000439696; ENSP00000388402; ENSG00000185650.

GeneID

677.

KEGG

hsa:677.

UCSC

uc001xkh.2. human.

Organism-specific databases

CTD

677.

GeneCards

GC14M069254.

HGNC

HGNC:1107. ZFP36L1.

HPA

HPA001301.

MIM

601064. gene.

neXtProt

NX_Q07352.

PharmGKB

PA35027.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5063.

HOGENOM

HOG000233479.

HOVERGEN

HBG008483.

InParanoid

Q07352.

OMA

HSYSFAG.

OrthoDB

EOG480HXD.

PhylomeDB

Q07352.

Enzyme and pathway databases

Reactome

REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpress

Q07352.

Bgee

Q07352.

CleanEx

HS_BRF1.
HS_ZFP36L1.

Genevestigator

Q07352.

GermOnline

ENSG00000185650. Homo sapiens.

Family and domain databases

InterPro

IPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]

Pfam

PF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]

SMART

SM00356. ZnF_C3H1. 2 hits.
[Graphical view]

PROSITE

PS50103. ZF_C3H1. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

ZFP36L1. human.

EvolutionaryTrace

Q07352.

GenomeRNAi

677.

NextBio

2790.

SOURCE

Search...

Entry information

Entry name

TISB_HUMAN

Accession

Primary (citable) accession number: Q07352
Secondary accession number(s): Q13851

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents