Reviewed, UniProtKB/Swiss-Prot Q07352 (TISB_HUMAN)

Names and origin

Protein names

Recommended name:
    Butyrate response factor 1
Alternative name(s):
    Protein TIS11B
    EGF-response factor 1
      Short name=ERF-1

Gene names

Name:	ZFP36L1
Synonyms:	BERG36, BRF1, ERF1, RNF162B, TIS11B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probable regulatory protein involved in regulating the response to growth factors.
Subcellular location	Nucleus.
Sequence similarities	Contains 2 C3H1-type zinc fingers.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	regulation of mRNA stability Inferred from direct assay. Source: MGI
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	mRNA binding Inferred from direct assay. Source: MGI protein binding Inferred from physical interaction. Source: IntAct transcription factor activity Non-traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MAPK14	Q16539	1	EBI-721823,EBI-73946

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Butyrate response factor 1		PRO_0000089167
Regions
	Zinc finger	114 – 142	29	C3H1-type 1
	Zinc finger	152 – 180	29	C3H1-type 2
	Compositional bias	307 – 316	10	Poly-Ser
Amino acid modifications
	Modified residue	54	1	Phosphoserine By similarity
	Modified residue	92	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	63	1	H → R in CAA67781. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q07352-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 98236CD40C4531D2	FASTA	338	36,314
	10 20 30 40 50 60 MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS 70 80 90 100 110 120 KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP TQKQPGGGQV NSSRYKTELC 130 140 150 160 170 180 RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE 190 200 210 220 230 240 ERRALAGARD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS 250 260 270 280 290 300 PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 310 320 330 DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes." Barnard R.C., Pascall J.C., Brown K.D., McKay I.A., Williams N.S., Bustin S.A. Nucleic Acids Res. 21:3580-3580(1993) [PubMed: 8346037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes." Bustin S.A., Nie X.F., Barnard R.C., Kumar V., Pascall J.C., Brown K.D., Leigh I.M., Williams N.S., McKay L.A. DNA Cell Biol. 13:449-459(1994) [PubMed: 8024689] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36." Ning Z.Q., Norton J.D., Li J., Murphy J.J. Eur. J. Immunol. 26:2356-2363(1996) [PubMed: 8898945] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

X79066, X79067 mRNA. Translation: CAA55670.1.
X99404 mRNA. Translation: CAA67781.1.
BT019468 mRNA. Translation: AAV38275.1.
BC018340 mRNA. Translation: AAH18340.1.

PIR

S34854.

RefSeq

NP_004917.2.

UniGene

Hs.699794
Hs.85155

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1W0V	X-ray	2.27	C	325-333	[»]
1W0W	X-ray	2.11	C	325-333	[»]

SMR

Q07352. Positions 112-181.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q07352.

PTM databases

PhosphoSite

Q07352.

Proteomic databases

PeptideAtlas

Q07352.

Genome annotation databases

Ensembl

ENSG00000185650. Homo sapiens. [Contig view]

GeneID

677.

KEGG

hsa:677.

Organism-specific databases

H-InvDB

HIX0011759.

HGNC

HGNC:1107. ZFP36L1.

HPA

HPA001301.

MIM

601064. gene.

PharmGKB

PA35027.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

Q07352.

HOVERGEN

Q07352.

Gene expression databases

ArrayExpress

Q07352.

CleanEx

HS_BRF1.
HS_ZFP36L1.

GermOnline

ENSG00000185650. Homo sapiens.

Family and domain databases

InterPro

IPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]

Pfam

PF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]

SMART

SM00356. ZnF_C3H1. 2 hits.
[Graphical view]

PROSITE

PS50103. ZF_C3H1. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

2790.

SOURCE

Search...

Entry information

Entry name

TISB_HUMAN

Accession

Primary (citable) accession number: Q07352
Secondary accession number(s): Q13851

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 25, 2008
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)