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Q07343

- PDE4B_HUMAN

UniProt

Q07343 - PDE4B_HUMAN

Protein

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Gene

PDE4B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.2 Publications

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.2 Publications

    Enzyme regulationi

    Inhibited by rolipram.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei406 – 4061Proton donor
    Metal bindingi410 – 4101Divalent metal cation 1
    Metal bindingi446 – 4461Divalent metal cation 1
    Metal bindingi447 – 4471Divalent metal cation 1
    Metal bindingi447 – 4471Divalent metal cation 2
    Binding sitei447 – 4471cAMP
    Metal bindingi564 – 5641Divalent metal cation 1
    Binding sitei564 – 5641cAMP
    Sitei567 – 5671Binds AMP, but not cAMPBy similarity
    Binding sitei615 – 6151cAMP

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi406 – 4105cAMP

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: BHF-UCL
    2. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: BHF-UCL
    3. cAMP binding Source: BHF-UCL
    4. ion channel binding Source: BHF-UCL
    5. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cAMP catabolic process Source: BHF-UCL
    2. cellular response to drug Source: BHF-UCL
    3. cellular response to epinephrine stimulus Source: BHF-UCL
    4. cellular response to lipopolysaccharide Source: BHF-UCL
    5. leukocyte migration Source: BHF-UCL
    6. negative regulation of relaxation of cardiac muscle Source: BHF-UCL
    7. neutrophil chemotaxis Source: BHF-UCL
    8. neutrophil homeostasis Source: BHF-UCL
    9. positive regulation of interferon-gamma production Source: BHF-UCL
    10. positive regulation of interleukin-2 production Source: BHF-UCL
    11. regulation of cardiac muscle cell contraction Source: BHF-UCL
    12. regulation of high voltage-gated calcium channel activity Source: BHF-UCL
    13. T cell receptor signaling pathway Source: BHF-UCL

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_15334. DARPP-32 events.
    REACT_19327. G alpha (s) signalling events.
    UniPathwayiUPA00762; UER00747.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC:3.1.4.53)
    Alternative name(s):
    DPDE4
    PDE32
    Gene namesi
    Name:PDE4B
    Synonyms:DPDE4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8781. PDE4B.

    Subcellular locationi

    GO - Cellular componenti

    1. cell periphery Source: Ensembl
    2. cytosol Source: Reactome
    3. nucleus Source: Ensembl
    4. perinuclear region of cytoplasm Source: Ensembl
    5. Z disc Source: BHF-UCL

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33129.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 736736cAMP-specific 3',5'-cyclic phosphodiesterase 4BPRO_0000198809Add
    BLAST

    Proteomic databases

    MaxQBiQ07343.
    PaxDbiQ07343.
    PRIDEiQ07343.

    PTM databases

    PhosphoSiteiQ07343.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, lung and skeletal muscle.

    Gene expression databases

    ArrayExpressiQ07343.
    BgeeiQ07343.
    CleanExiHS_PDE4B.
    GenevestigatoriQ07343.

    Organism-specific databases

    HPAiHPA003005.

    Interactioni

    Protein-protein interaction databases

    BioGridi111168. 5 interactions.
    IntActiQ07343. 3 interactions.
    STRINGi9606.ENSP00000332116.

    Structurei

    Secondary structure

    1
    736
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi248 – 26417
    Helixi266 – 27813
    Helixi324 – 3274
    Beta strandi328 – 3303
    Turni332 – 3343
    Helixi335 – 3428
    Turni343 – 3464
    Helixi352 – 3587
    Turni359 – 3613
    Helixi363 – 37412
    Helixi377 – 3804
    Helixi385 – 39713
    Beta strandi403 – 4075
    Helixi408 – 42215
    Helixi425 – 4273
    Turni428 – 4303
    Helixi433 – 44513
    Turni446 – 4494
    Helixi455 – 4606
    Helixi464 – 4685
    Turni469 – 4713
    Helixi474 – 48613
    Helixi490 – 4923
    Turni494 – 4974
    Helixi500 – 51516
    Helixi519 – 5213
    Helixi522 – 53413
    Beta strandi540 – 5423
    Helixi549 – 56416
    Helixi567 – 5693
    Helixi572 – 59524
    Helixi602 – 6043
    Turni606 – 6083
    Helixi611 – 62111
    Helixi623 – 63311
    Turni634 – 6385
    Helixi639 – 65416
    Beta strandi656 – 6583
    Beta strandi659 – 6624
    Helixi664 – 6663
    Helixi671 – 6777

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1F0JX-ray1.77A/B324-700[»]
    1JP1model-A324-700[»]
    1JP2model-A324-700[»]
    1RO6X-ray2.00A/B324-700[»]
    1RO9X-ray2.13A/B324-700[»]
    1RORX-ray2.00A/B324-700[»]
    1TB5X-ray2.15A/B324-700[»]
    1XLXX-ray2.19A/B324-700[»]
    1XLZX-ray2.06A/B324-700[»]
    1XM4X-ray2.31A/B324-700[»]
    1XM6X-ray1.92A/B324-700[»]
    1XMUX-ray2.30A/B324-700[»]
    1XMYX-ray2.40A/B324-700[»]
    1XN0X-ray2.31A/B324-700[»]
    1XOSX-ray2.28A324-700[»]
    1XOTX-ray2.34A/B324-700[»]
    1Y2HX-ray2.40A/B324-700[»]
    1Y2JX-ray2.55A/B324-700[»]
    2CHMX-ray1.60A450-475[»]
    2QYLX-ray1.95A324-659[»]
    3D3PX-ray1.75A324-675[»]
    3FRGX-ray1.70A324-675[»]
    3G45X-ray2.63A/B241-289[»]
    A/B305-659[»]
    3GWTX-ray1.75A324-675[»]
    3HC8X-ray1.79A440-653[»]
    3HDZX-ray1.80A451-475[»]
    A524-557[»]
    3HMVX-ray2.23A/B324-700[»]
    3KKTX-ray2.48A/B324-700[»]
    3LY2X-ray2.60A/B/C/D/E/F/G/H324-659[»]
    3O0JX-ray1.95A334-656[»]
    3O56X-ray2.42A324-675[»]
    3O57X-ray2.00A324-675[»]
    3W5EX-ray2.30A/B324-700[»]
    3WD9X-ray2.50A/B324-700[»]
    4KP6X-ray1.50A324-659[»]
    4MYQX-ray1.90A324-691[»]
    ProteinModelPortaliQ07343.
    SMRiQ07343. Positions 335-681.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ07343.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG122287.
    HOGENOMiHOG000236297.
    HOVERGENiHBG108239.
    InParanoidiQ07343.
    KOiK01120.
    OMAiLIWITAN.
    OrthoDBiEOG7HQNBC.
    PhylomeDBiQ07343.
    TreeFamiTF314638.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    InterProiIPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform PDE4B1 (identifier: Q07343-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKKSRSVMTV MADDNVKDYF ECSLSKSYSS SSNTLGIDLW RGRRCCSGNL    50
    QLPPLSQRQS ERARTPEGDG ISRPTTLPLT TLPSIAITTV SQECFDVENG 100
    PSPGRSPLDP QASSSAGLVL HATFPGHSQR RESFLYRSDS DYDLSPKAMS 150
    RNSSLPSEQH GDDLIVTPFA QVLASLRSVR NNFTILTNLH GTSNKRSPAA 200
    SQPPVSRVNP QEESYQKLAM ETLEELDWCL DQLETIQTYR SVSEMASNKF 250
    KRMLNRELTH LSEMSRSGNQ VSEYISNTFL DKQNDVEIPS PTQKDREKKK 300
    KQQLMTQISG VKKLMHSSSL NNTSISRFGV NTENEDHLAK ELEDLNKWGL 350
    NIFNVAGYSH NRPLTCIMYA IFQERDLLKT FRISSDTFIT YMMTLEDHYH 400
    SDVAYHNSLH AADVAQSTHV LLSTPALDAV FTDLEILAAI FAAAIHDVDH 450
    PGVSNQFLIN TNSELALMYN DESVLENHHL AVGFKLLQEE HCDIFMNLTK 500
    KQRQTLRKMV IDMVLATDMS KHMSLLADLK TMVETKKVTS SGVLLLDNYT 550
    DRIQVLRNMV HCADLSNPTK SLELYRQWTD RIMEEFFQQG DKERERGMEI 600
    SPMCDKHTAS VEKSQVGFID YIVHPLWETW ADLVQPDAQD ILDTLEDNRN 650
    WYQSMIPQSP SPPLDEQNRD CQGLMEKFQF ELTLDEEDSE GPEKEGEGHS 700
    YFSSTKTLCV IDPENRDSLG ETDIDIATED KSPVDT 736
    Length:736
    Mass (Da):83,343
    Last modified:February 1, 1995 - v1
    Checksum:i208FCE9CD40EF5EB
    GO
    Isoform PDE4B2 (identifier: Q07343-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-211: MKKSRSVMTV...QPPVSRVNPQ → MKEHGGTFSS...PNYMPVCLFA

    Show »
    Length:564
    Mass (Da):64,352
    Checksum:iA4F9FA0C5DB43380
    GO
    Isoform PDE4B3 (identifier: Q07343-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-93: MKKSRSVMTV...SIAITTVSQE → MTAKDSSKEL...QRRRFTVAHT

    Show »
    Length:721
    Mass (Da):82,096
    Checksum:i49618FFEAFF33D30
    GO
    Isoform PDE4B5 (identifier: Q07343-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-15: MKKSRSVMTVMADDN → MPEANYLLSVSWGYI
         16-248: Missing.

    Note: Brain-specific isoform.

    Show »
    Length:503
    Mass (Da):57,709
    Checksum:i23AF122BAF338C42
    GO

    Sequence cautioni

    The sequence AAA35643.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti703 – 7031S → C.
    Corresponds to variant rs2227297 [ dbSNP | Ensembl ].
    VAR_034373

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 211211MKKSR…RVNPQ → MKEHGGTFSSTGISGGSGDS AMDSLQPLQPNYMPVCLFA in isoform PDE4B2. 3 PublicationsVSP_004572Add
    BLAST
    Alternative sequencei1 – 9393MKKSR…TVSQE → MTAKDSSKELTASEPEVCIK TFKEQMHLELELPRLPGNRP TSPKISPRSSPRNSPCFFRK LLVNKSIRQRRRFTVAHT in isoform PDE4B3. 2 PublicationsVSP_004571Add
    BLAST
    Alternative sequencei1 – 1515MKKSR…MADDN → MPEANYLLSVSWGYI in isoform PDE4B5. 2 PublicationsVSP_047723Add
    BLAST
    Alternative sequencei16 – 248233Missing in isoform PDE4B5. 2 PublicationsVSP_047724Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12686 mRNA. Translation: AAA35643.1. Different initiation.
    L20966 mRNA. Translation: AAA03589.1.
    L20971 mRNA. Translation: AAA03593.1.
    U85048 mRNA. Translation: AAB96381.1.
    M97515 mRNA. Translation: AAA36426.1.
    EF595686 mRNA. Translation: ABQ85407.1.
    AK289969 mRNA. Translation: BAF82658.1.
    AK290006 mRNA. Translation: BAF82695.1.
    AK290206 mRNA. Translation: BAF82895.1.
    AL592285
    , AL109926, AL357273, AL359701 Genomic DNA. Translation: CAH70626.1.
    AL592285
    , AL109926, AL357273, AL359701 Genomic DNA. Translation: CAH70628.1.
    AL357273
    , AL109926, AL359701, AL592285 Genomic DNA. Translation: CAH73002.1.
    AL357273
    , AL109926, AL359701, AL592285 Genomic DNA. Translation: CAH73004.1.
    AL109926
    , AL357273, AL359701, AL592285 Genomic DNA. Translation: CAI21749.1.
    AL109926, AL359701 Genomic DNA. Translation: CAI21750.1.
    AL109926
    , AL357273, AL359701, AL592285 Genomic DNA. Translation: CAI21751.1.
    AL359701
    , AL109926, AL357273, AL592285 Genomic DNA. Translation: CAI23099.1.
    AL359701, AL109926 Genomic DNA. Translation: CAI23100.1.
    AL359701
    , AL109926, AL357273, AL592285 Genomic DNA. Translation: CAI23101.1.
    AL513493 Genomic DNA. No translation available.
    AL590783 Genomic DNA. No translation available.
    AL591487 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX06524.1.
    BC101480 mRNA. Translation: AAI01481.1.
    BC105040 mRNA. Translation: AAI05041.1.
    CCDSiCCDS30742.1. [Q07343-3]
    CCDS30743.1. [Q07343-2]
    CCDS632.1. [Q07343-1]
    PIRiI61354.
    RefSeqiNP_001032416.1. NM_001037339.1. [Q07343-2]
    NP_001032417.1. NM_001037340.1. [Q07343-3]
    NP_001032418.1. NM_001037341.1. [Q07343-1]
    NP_002591.2. NM_002600.3. [Q07343-1]
    XP_005270983.1. XM_005270926.1. [Q07343-4]
    UniGeneiHs.198072.

    Genome annotation databases

    EnsembliENST00000329654; ENSP00000332116; ENSG00000184588. [Q07343-1]
    ENST00000341517; ENSP00000342637; ENSG00000184588. [Q07343-1]
    ENST00000371045; ENSP00000360084; ENSG00000184588. [Q07343-2]
    ENST00000423207; ENSP00000392947; ENSG00000184588. [Q07343-3]
    ENST00000480109; ENSP00000432592; ENSG00000184588. [Q07343-4]
    GeneIDi5142.
    KEGGihsa:5142.
    UCSCiuc001dcn.3. human. [Q07343-1]
    uc001dcp.3. human. [Q07343-3]
    uc001dcq.3. human.

    Polymorphism databases

    DMDMi729163.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12686 mRNA. Translation: AAA35643.1 . Different initiation.
    L20966 mRNA. Translation: AAA03589.1 .
    L20971 mRNA. Translation: AAA03593.1 .
    U85048 mRNA. Translation: AAB96381.1 .
    M97515 mRNA. Translation: AAA36426.1 .
    EF595686 mRNA. Translation: ABQ85407.1 .
    AK289969 mRNA. Translation: BAF82658.1 .
    AK290006 mRNA. Translation: BAF82695.1 .
    AK290206 mRNA. Translation: BAF82895.1 .
    AL592285
    , AL109926 , AL357273 , AL359701 Genomic DNA. Translation: CAH70626.1 .
    AL592285
    , AL109926 , AL357273 , AL359701 Genomic DNA. Translation: CAH70628.1 .
    AL357273
    , AL109926 , AL359701 , AL592285 Genomic DNA. Translation: CAH73002.1 .
    AL357273
    , AL109926 , AL359701 , AL592285 Genomic DNA. Translation: CAH73004.1 .
    AL109926
    , AL357273 , AL359701 , AL592285 Genomic DNA. Translation: CAI21749.1 .
    AL109926 , AL359701 Genomic DNA. Translation: CAI21750.1 .
    AL109926
    , AL357273 , AL359701 , AL592285 Genomic DNA. Translation: CAI21751.1 .
    AL359701
    , AL109926 , AL357273 , AL592285 Genomic DNA. Translation: CAI23099.1 .
    AL359701 , AL109926 Genomic DNA. Translation: CAI23100.1 .
    AL359701
    , AL109926 , AL357273 , AL592285 Genomic DNA. Translation: CAI23101.1 .
    AL513493 Genomic DNA. No translation available.
    AL590783 Genomic DNA. No translation available.
    AL591487 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX06524.1 .
    BC101480 mRNA. Translation: AAI01481.1 .
    BC105040 mRNA. Translation: AAI05041.1 .
    CCDSi CCDS30742.1. [Q07343-3 ]
    CCDS30743.1. [Q07343-2 ]
    CCDS632.1. [Q07343-1 ]
    PIRi I61354.
    RefSeqi NP_001032416.1. NM_001037339.1. [Q07343-2 ]
    NP_001032417.1. NM_001037340.1. [Q07343-3 ]
    NP_001032418.1. NM_001037341.1. [Q07343-1 ]
    NP_002591.2. NM_002600.3. [Q07343-1 ]
    XP_005270983.1. XM_005270926.1. [Q07343-4 ]
    UniGenei Hs.198072.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1F0J X-ray 1.77 A/B 324-700 [» ]
    1JP1 model - A 324-700 [» ]
    1JP2 model - A 324-700 [» ]
    1RO6 X-ray 2.00 A/B 324-700 [» ]
    1RO9 X-ray 2.13 A/B 324-700 [» ]
    1ROR X-ray 2.00 A/B 324-700 [» ]
    1TB5 X-ray 2.15 A/B 324-700 [» ]
    1XLX X-ray 2.19 A/B 324-700 [» ]
    1XLZ X-ray 2.06 A/B 324-700 [» ]
    1XM4 X-ray 2.31 A/B 324-700 [» ]
    1XM6 X-ray 1.92 A/B 324-700 [» ]
    1XMU X-ray 2.30 A/B 324-700 [» ]
    1XMY X-ray 2.40 A/B 324-700 [» ]
    1XN0 X-ray 2.31 A/B 324-700 [» ]
    1XOS X-ray 2.28 A 324-700 [» ]
    1XOT X-ray 2.34 A/B 324-700 [» ]
    1Y2H X-ray 2.40 A/B 324-700 [» ]
    1Y2J X-ray 2.55 A/B 324-700 [» ]
    2CHM X-ray 1.60 A 450-475 [» ]
    2QYL X-ray 1.95 A 324-659 [» ]
    3D3P X-ray 1.75 A 324-675 [» ]
    3FRG X-ray 1.70 A 324-675 [» ]
    3G45 X-ray 2.63 A/B 241-289 [» ]
    A/B 305-659 [» ]
    3GWT X-ray 1.75 A 324-675 [» ]
    3HC8 X-ray 1.79 A 440-653 [» ]
    3HDZ X-ray 1.80 A 451-475 [» ]
    A 524-557 [» ]
    3HMV X-ray 2.23 A/B 324-700 [» ]
    3KKT X-ray 2.48 A/B 324-700 [» ]
    3LY2 X-ray 2.60 A/B/C/D/E/F/G/H 324-659 [» ]
    3O0J X-ray 1.95 A 334-656 [» ]
    3O56 X-ray 2.42 A 324-675 [» ]
    3O57 X-ray 2.00 A 324-675 [» ]
    3W5E X-ray 2.30 A/B 324-700 [» ]
    3WD9 X-ray 2.50 A/B 324-700 [» ]
    4KP6 X-ray 1.50 A 324-659 [» ]
    4MYQ X-ray 1.90 A 324-691 [» ]
    ProteinModelPortali Q07343.
    SMRi Q07343. Positions 335-681.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111168. 5 interactions.
    IntActi Q07343. 3 interactions.
    STRINGi 9606.ENSP00000332116.

    Chemistry

    BindingDBi Q07343.
    ChEMBLi CHEMBL2363066.
    DrugBanki DB00131. Adenosine monophosphate.
    DB01427. Amrinone.
    DB00201. Caffeine.
    DB01166. Cilostazol.
    DB00651. Dyphylline.
    DB00824. Enprofylline.
    DB01113. Papaverine.
    DB00806. Pentoxifylline.
    DB00277. Theophylline.
    GuidetoPHARMACOLOGYi 1301.

    PTM databases

    PhosphoSitei Q07343.

    Polymorphism databases

    DMDMi 729163.

    Proteomic databases

    MaxQBi Q07343.
    PaxDbi Q07343.
    PRIDEi Q07343.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329654 ; ENSP00000332116 ; ENSG00000184588 . [Q07343-1 ]
    ENST00000341517 ; ENSP00000342637 ; ENSG00000184588 . [Q07343-1 ]
    ENST00000371045 ; ENSP00000360084 ; ENSG00000184588 . [Q07343-2 ]
    ENST00000423207 ; ENSP00000392947 ; ENSG00000184588 . [Q07343-3 ]
    ENST00000480109 ; ENSP00000432592 ; ENSG00000184588 . [Q07343-4 ]
    GeneIDi 5142.
    KEGGi hsa:5142.
    UCSCi uc001dcn.3. human. [Q07343-1 ]
    uc001dcp.3. human. [Q07343-3 ]
    uc001dcq.3. human.

    Organism-specific databases

    CTDi 5142.
    GeneCardsi GC01P066339.
    HGNCi HGNC:8781. PDE4B.
    HPAi HPA003005.
    MIMi 600127. gene.
    neXtProti NX_Q07343.
    PharmGKBi PA33129.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG122287.
    HOGENOMi HOG000236297.
    HOVERGENi HBG108239.
    InParanoidi Q07343.
    KOi K01120.
    OMAi LIWITAN.
    OrthoDBi EOG7HQNBC.
    PhylomeDBi Q07343.
    TreeFami TF314638.

    Enzyme and pathway databases

    UniPathwayi UPA00762 ; UER00747 .
    Reactomei REACT_15334. DARPP-32 events.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    ChiTaRSi PDE4B. human.
    EvolutionaryTracei Q07343.
    GeneWikii PDE4B.
    GenomeRNAii 5142.
    NextBioi 19828.
    PROi Q07343.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q07343.
    Bgeei Q07343.
    CleanExi HS_PDE4B.
    Genevestigatori Q07343.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    InterProi IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family."
      Obernolte R., Bhakta S., Alvarez R., Bach C., Mulkins M., Jarnagin K., Shelton E.R.
      Gene 129:239-247(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE4B2).
    2. "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs."
      Bolger G., Michaeli T., Martins T., St John T., Steiner B., Rodgers L., Riggs M., Wigler M., Ferguson K.
      Mol. Cell. Biol. 13:6558-6571(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PDE4B1 AND PDE4B2).
      Tissue: Brain.
    3. "Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3."
      Huston E., Lumb S., Russell A., Catterall C., Ross A.H., Steele M.R., Bolger G.B., Perry M.J., Owens R.J., Houslay M.D.
      Biochem. J. 328:549-558(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE4B3).
    4. "A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA."
      McLaughlin M.M., Cieslinski L.B., Burman M., Torphy T.J., Livi G.P.
      J. Biol. Chem. 268:6470-6476(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE4B2).
      Tissue: Brain.
    5. "PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6)."
      Cheung Y.F., Kan Z., Garrett-Engele P., Gall I., Murdoch H., Baillie G.S., Camargo L.M., Johnson J.M., Houslay M.D., Castle J.C.
      J. Pharmacol. Exp. Ther. 322:600-609(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE4B5).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS PDE4B1; PDE4B3 AND PDE4B5).
      Tissue: Hippocampus and Thalamus.
    7. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PDE4B1).
      Tissue: Brain.
    10. "Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity."
      Xu R.X., Hassell A.M., Vanderwall D., Lambert M.H., Holmes W.D., Luther M.A., Rocque W.J., Milburn M.V., Zhao Y., Ke H., Nolte R.T.
      Science 288:1822-1825(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) OF 324-700 IN COMPLEX WITH METAL IONS, FUNCTION, COFACTOR.
    11. "Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram."
      Xu R.X., Rocque W.J., Lambert M.H., Vanderwall D.E., Luther M.A., Nolte R.T.
      J. Mol. Biol. 337:355-365(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 324-700 IN COMPLEX WITH AMP; METAL IONS AND THE INHIBITOR ROLIPRAM, FUNCTION, COFACTOR.
    12. Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 324-700 IN COMPLEX WITH AMP AND METAL IONS.
    13. Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 324-700 IN COMPLEX WITH METAL IONS AND INHIBITORS.
    14. "A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design."
      Card G.L., Blasdel L., England B.P., Zhang C., Suzuki Y., Gillette S., Fong D., Ibrahim P.N., Artis D.R., Bollag G., Milburn M.V., Kim S.-H., Schlessinger J., Zhang K.Y.J.
      Nat. Biotechnol. 23:201-207(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 324-700 IN COMPLEX WITH METAL IONS AND INHIBITORS.
    15. "Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors."
      Wang H., Peng M.-S., Chen Y., Geng J., Robinson H., Houslay M.D., Cai J., Ke H.
      Biochem. J. 408:193-201(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 324-659 IN COMPLEX WITH METAL IONS AND THE INHIBITOR NVP.
    16. Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 324-675 IN COMPLEX WITH METAL IONS AND INHIBITOR.

    Entry informationi

    Entry nameiPDE4B_HUMAN
    AccessioniPrimary (citable) accession number: Q07343
    Secondary accession number(s): A5YW33
    , O15443, Q13945, Q5TEK4, Q5TEK5, Q5TEK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3