Q07337 (OSPC_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Outer surface protein C
Short name=PC

Gene names

Name:	ospC
Ordered Locus Names:	BB_B19

Encoded on

Plasmid lp54

Organism

Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]

Taxonomic identifier

224326 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group › Borrelia burgdorferi

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Not known; major immunodominant protein.
Subcellular location	Cell outer membrane; Lipid-anchor.

Ontologies

Keywords
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal
PTM	Lipoprotein Palmitate
Technical term	3D-structure Complete proteome Plasmid Reference proteome
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: InterPro
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 18

18

By similarity

Chain

19 – 210

192

Outer surface protein C

PRO_0000018083

Amino acid modifications

Lipidation

19

1

N-palmitoyl cysteine By similarity

Lipidation

19

1

S-diacylglycerol cysteine By similarity

Secondary structure

1

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210

Helix Strand Turn

Details...

Helix

42 – 75

34

Turn

76 – 78

3

Beta strand

79 – 82

4

Turn

83 – 85

3

Beta strand

86 – 89

4

Helix

95 – 113

19

Turn

118 – 120

3

Helix

121 – 140

20

Helix

142 – 145

4

Beta strand

146 – 148

3

Helix

152 – 159

8

Turn

167 – 169

3

Helix

170 – 195

26

Helix

196 – 199

4

Sequences

	Sequence		Length	Mass (Da)
	Q07337 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7A4FC978F91777BF	FASTA	210	22,341
	10 20 30 40 50 60 MKKNTLSAIL MTLFLFISCN NSGKDGNTSA NSADESVKGP NLTEISKKIT DSNAVLLAVK 70 80 90 100 110 120 EVEALLSSID EIAAKAIGKK IHQNNGLDTE NNHNGSLLAG AYAISTLIKQ KLDGLKNEGL 130 140 150 160 170 180 KEKIDAAKKC SETFTNKLKE KHTDLGKEGV TDADAKEAIL KTNGTKTKGA EELGKLFESV 190 200 210 EVLSKAAKEM LANSVKELTS PVVAESPKKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic heterogenity of the genes coding for the outer surface protein C (OspC) and the flagellin of Borrelia burgdorferi." Jauris-Heipke S., Fuchs R., Motz M., Preac-Mursic V., Schwab E., Will G., Wilske B. Med. Microbiol. Immunol. 182:37-50(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[2]	"Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi." Wilske B., Preace-Mursic V., Jauris S., Pradel I., Soutschek E., Schwab E., Wanner G. Infect. Immun. 61:2182-2191(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[3]	"Molecular characterization and expression of p23 (OspC) from a North American strain of Borrelia burgdorferi." Padula S.J., Sampieri A., Dias F., Szczepanski A., Ryan R.W. Infect. Immun. 61:5097-5105(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[4]	"Molecular analysis of genes encoding outer surface protein C (OspC) of Borrelia burgdorferi sensu lato: relationship to ospA genotype and evidence of lateral gene exchange of ospC." Jauris-Heipke S., Liegl G., Preac-Mursic V., Roessler D., Schwab E., Soutschek E., Will G., Wilske B. J. Clin. Microbiol. 33:1860-1866(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: PKa.
[5]	"Outer surface protein C gene sequence analysis of Borrelia burgdorferi sensu lato isolates from Japan." Fukunaga M., Hamase A. J. Clin. Microbiol. 33:2415-2420(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[6]	"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[7]	"Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia." Livey I., Gibbs C.P., Schuster R., Dorner F. Mol. Microbiol. 18:257-269(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-210. Strain: Ip2.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X69596 Genomic DNA. Translation: CAA49306.1.
U01894 Unassigned DNA. Translation: AAA16058.1.
X69589 Genomic DNA. No translation available.
D49497 Genomic DNA. Translation: BAA08457.1.
AE000792 Genomic DNA. Translation: AAC66329.1.
L42887 Genomic DNA. Translation: AAB36995.1.

PIR

G70218.
S69927.

RefSeq

NP_047005.1. NC_001903.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1GGQ	X-ray	2.51	A/B/C/D	38-210	[»]

ProteinModelPortal

Q07337.

SMR

Q07337. Positions 40-201.

ModBase

Search...

Protein-protein interaction databases

STRING

224326.BBB19.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAC66329; AAC66329; BB_B19.

GeneID

1194415.

KEGG

bbu:BB_B19.

PATRIC

20559107. VBIBorBur75917_1608.

Phylogenomic databases

eggNOG

NOG148362.

OMA

YAISTLI.

ProtClustDB

CLSK541241.

Enzyme and pathway databases

BioCyc

BBUR224326:G9SO-1500-MONOMER.

Family and domain databases

Gene3D

1.20.120.240. 1 hit.

InterPro

IPR001800. Lipoprotein_6.
[Graphical view]

Pfam

PF01441. Lipoprotein_6. 1 hit.
[Graphical view]

ProDom

PD001149. Lipoprotein_6. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF63515. Lipoprotein_6. 1 hit.

PROSITE

PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q07337.

Entry information

Entry name

OSPC_BORBU

Accession

Primary (citable) accession number: Q07337
Secondary accession number(s): Q9S3P3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program