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Q07337

- OSPC_BORBU

UniProt

Q07337 - OSPC_BORBU

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Protein

Outer surface protein C

Gene
ospC, BB_B19
Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Not known; major immunodominant protein.

GO - Biological processi

  1. defense response Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-1500-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer surface protein C
Short name:
PC
Gene namesi
Name:ospC
Ordered Locus Names:BB_B19
Encoded oniPlasmid lp540 Publication
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Plasmid cp26

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarityAdd
BLAST
Chaini19 – 210192Outer surface protein CPRO_0000018083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi19 – 191N-palmitoyl cysteine By similarity
Lipidationi19 – 191S-diacylglycerol cysteine By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi224326.BBB19.

Structurei

Secondary structure

1
210
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi42 – 7534
Turni76 – 783
Beta strandi79 – 824
Turni83 – 853
Beta strandi86 – 894
Helixi95 – 11319
Turni118 – 1203
Helixi121 – 14020
Helixi142 – 1454
Beta strandi146 – 1483
Helixi152 – 1598
Turni167 – 1693
Helixi170 – 19526
Helixi196 – 1994

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GGQX-ray2.51A/B/C/D38-210[»]
ProteinModelPortaliQ07337.
SMRiQ07337. Positions 40-201.

Miscellaneous databases

EvolutionaryTraceiQ07337.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG148362.
OMAiEANRNES.
OrthoDBiEOG6K4032.

Family and domain databases

Gene3Di1.20.120.240. 1 hit.
InterProiIPR001800. Lipoprotein_6.
[Graphical view]
PfamiPF01441. Lipoprotein_6. 1 hit.
[Graphical view]
ProDomiPD001149. Lipoprotein_6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63515. SSF63515. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07337-1 [UniParc]FASTAAdd to Basket

« Hide

MKKNTLSAIL MTLFLFISCN NSGKDGNTSA NSADESVKGP NLTEISKKIT    50
DSNAVLLAVK EVEALLSSID EIAAKAIGKK IHQNNGLDTE NNHNGSLLAG 100
AYAISTLIKQ KLDGLKNEGL KEKIDAAKKC SETFTNKLKE KHTDLGKEGV 150
TDADAKEAIL KTNGTKTKGA EELGKLFESV EVLSKAAKEM LANSVKELTS 200
PVVAESPKKP 210
Length:210
Mass (Da):22,341
Last modified:November 1, 1996 - v1
Checksum:i7A4FC978F91777BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69596 Genomic DNA. Translation: CAA49306.1.
U01894 Unassigned DNA. Translation: AAA16058.1.
X69589 Genomic DNA. No translation available.
D49497 Genomic DNA. Translation: BAA08457.1.
AE000792 Genomic DNA. Translation: AAC66329.1.
L42887 Genomic DNA. Translation: AAB36995.1.
PIRiG70218.
S69927.
RefSeqiNP_047005.1. NC_001903.1.
WP_010890595.1. NC_001903.1.

Genome annotation databases

EnsemblBacteriaiAAC66329; AAC66329; BB_B19.
GeneIDi1194415.
KEGGibbu:BB_B19.
PATRICi20559107. VBIBorBur75917_1608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69596 Genomic DNA. Translation: CAA49306.1 .
U01894 Unassigned DNA. Translation: AAA16058.1 .
X69589 Genomic DNA. No translation available.
D49497 Genomic DNA. Translation: BAA08457.1 .
AE000792 Genomic DNA. Translation: AAC66329.1 .
L42887 Genomic DNA. Translation: AAB36995.1 .
PIRi G70218.
S69927.
RefSeqi NP_047005.1. NC_001903.1.
WP_010890595.1. NC_001903.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GGQ X-ray 2.51 A/B/C/D 38-210 [» ]
ProteinModelPortali Q07337.
SMRi Q07337. Positions 40-201.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224326.BBB19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC66329 ; AAC66329 ; BB_B19 .
GeneIDi 1194415.
KEGGi bbu:BB_B19.
PATRICi 20559107. VBIBorBur75917_1608.

Phylogenomic databases

eggNOGi NOG148362.
OMAi EANRNES.
OrthoDBi EOG6K4032.

Enzyme and pathway databases

BioCyci BBUR224326:G9SO-1500-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q07337.

Family and domain databases

Gene3Di 1.20.120.240. 1 hit.
InterProi IPR001800. Lipoprotein_6.
[Graphical view ]
Pfami PF01441. Lipoprotein_6. 1 hit.
[Graphical view ]
ProDomi PD001149. Lipoprotein_6. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63515. SSF63515. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic heterogenity of the genes coding for the outer surface protein C (OspC) and the flagellin of Borrelia burgdorferi."
    Jauris-Heipke S., Fuchs R., Motz M., Preac-Mursic V., Schwab E., Will G., Wilske B.
    Med. Microbiol. Immunol. 182:37-50(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  2. "Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi."
    Wilske B., Preace-Mursic V., Jauris S., Pradel I., Soutschek E., Schwab E., Wanner G.
    Infect. Immun. 61:2182-2191(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  3. "Molecular characterization and expression of p23 (OspC) from a North American strain of Borrelia burgdorferi."
    Padula S.J., Sampieri A., Dias F., Szczepanski A., Ryan R.W.
    Infect. Immun. 61:5097-5105(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  4. "Molecular analysis of genes encoding outer surface protein C (OspC) of Borrelia burgdorferi sensu lato: relationship to ospA genotype and evidence of lateral gene exchange of ospC."
    Jauris-Heipke S., Liegl G., Preac-Mursic V., Roessler D., Schwab E., Soutschek E., Will G., Wilske B.
    J. Clin. Microbiol. 33:1860-1866(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PKa.
  5. "Outer surface protein C gene sequence analysis of Borrelia burgdorferi sensu lato isolates from Japan."
    Fukunaga M., Hamase A.
    J. Clin. Microbiol. 33:2415-2420(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  7. "Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia."
    Livey I., Gibbs C.P., Schuster R., Dorner F.
    Mol. Microbiol. 18:257-269(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-210.
    Strain: Ip2.

Entry informationi

Entry nameiOSPC_BORBU
AccessioniPrimary (citable) accession number: Q07337
Secondary accession number(s): Q9S3P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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