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Q07337

- OSPC_BORBU

UniProt

Q07337 - OSPC_BORBU

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Protein

Outer surface protein C

Gene

ospC

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Not known; major immunodominant protein.

GO - Biological processi

  1. defense response Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-1500-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer surface protein C
Short name:
PC
Gene namesi
Name:ospC
Ordered Locus Names:BB_B19
Encoded oniPlasmid lp540 Publication
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Plasmid cp26

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818PROSITE-ProRule annotationAdd
BLAST
Chaini19 – 210192Outer surface protein CPRO_0000018083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi19 – 191N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi19 – 191S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi224326.BBB19.

Structurei

Secondary structure

1
210
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi42 – 7534Combined sources
Turni76 – 783Combined sources
Beta strandi79 – 824Combined sources
Turni83 – 853Combined sources
Beta strandi86 – 894Combined sources
Helixi95 – 11319Combined sources
Turni118 – 1203Combined sources
Helixi121 – 14020Combined sources
Helixi142 – 1454Combined sources
Beta strandi146 – 1483Combined sources
Helixi152 – 1598Combined sources
Turni167 – 1693Combined sources
Helixi170 – 19526Combined sources
Helixi196 – 1994Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GGQX-ray2.51A/B/C/D38-210[»]
ProteinModelPortaliQ07337.
SMRiQ07337. Positions 40-201.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07337.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG148362.
OMAiEANRNES.
OrthoDBiEOG6K4032.

Family and domain databases

Gene3Di1.20.120.240. 1 hit.
InterProiIPR001800. Lipoprotein_6.
[Graphical view]
PfamiPF01441. Lipoprotein_6. 1 hit.
[Graphical view]
ProDomiPD001149. Lipoprotein_6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63515. SSF63515. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07337-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKNTLSAIL MTLFLFISCN NSGKDGNTSA NSADESVKGP NLTEISKKIT
60 70 80 90 100
DSNAVLLAVK EVEALLSSID EIAAKAIGKK IHQNNGLDTE NNHNGSLLAG
110 120 130 140 150
AYAISTLIKQ KLDGLKNEGL KEKIDAAKKC SETFTNKLKE KHTDLGKEGV
160 170 180 190 200
TDADAKEAIL KTNGTKTKGA EELGKLFESV EVLSKAAKEM LANSVKELTS
210
PVVAESPKKP
Length:210
Mass (Da):22,341
Last modified:November 1, 1996 - v1
Checksum:i7A4FC978F91777BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69596 Genomic DNA. Translation: CAA49306.1.
U01894 Unassigned DNA. Translation: AAA16058.1.
X69589 Genomic DNA. No translation available.
D49497 Genomic DNA. Translation: BAA08457.1.
AE000792 Genomic DNA. Translation: AAC66329.1.
L42887 Genomic DNA. Translation: AAB36995.1.
PIRiG70218.
S69927.
RefSeqiNP_047005.1. NC_001903.1.
WP_010890595.1. NC_001903.1.

Genome annotation databases

EnsemblBacteriaiAAC66329; AAC66329; BB_B19.
GeneIDi1194415.
KEGGibbu:BB_B19.
PATRICi20559107. VBIBorBur75917_1608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69596 Genomic DNA. Translation: CAA49306.1 .
U01894 Unassigned DNA. Translation: AAA16058.1 .
X69589 Genomic DNA. No translation available.
D49497 Genomic DNA. Translation: BAA08457.1 .
AE000792 Genomic DNA. Translation: AAC66329.1 .
L42887 Genomic DNA. Translation: AAB36995.1 .
PIRi G70218.
S69927.
RefSeqi NP_047005.1. NC_001903.1.
WP_010890595.1. NC_001903.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GGQ X-ray 2.51 A/B/C/D 38-210 [» ]
ProteinModelPortali Q07337.
SMRi Q07337. Positions 40-201.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224326.BBB19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC66329 ; AAC66329 ; BB_B19 .
GeneIDi 1194415.
KEGGi bbu:BB_B19.
PATRICi 20559107. VBIBorBur75917_1608.

Phylogenomic databases

eggNOGi NOG148362.
OMAi EANRNES.
OrthoDBi EOG6K4032.

Enzyme and pathway databases

BioCyci BBUR224326:G9SO-1500-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q07337.

Family and domain databases

Gene3Di 1.20.120.240. 1 hit.
InterProi IPR001800. Lipoprotein_6.
[Graphical view ]
Pfami PF01441. Lipoprotein_6. 1 hit.
[Graphical view ]
ProDomi PD001149. Lipoprotein_6. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63515. SSF63515. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic heterogenity of the genes coding for the outer surface protein C (OspC) and the flagellin of Borrelia burgdorferi."
    Jauris-Heipke S., Fuchs R., Motz M., Preac-Mursic V., Schwab E., Will G., Wilske B.
    Med. Microbiol. Immunol. 182:37-50(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  2. "Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi."
    Wilske B., Preace-Mursic V., Jauris S., Pradel I., Soutschek E., Schwab E., Wanner G.
    Infect. Immun. 61:2182-2191(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  3. "Molecular characterization and expression of p23 (OspC) from a North American strain of Borrelia burgdorferi."
    Padula S.J., Sampieri A., Dias F., Szczepanski A., Ryan R.W.
    Infect. Immun. 61:5097-5105(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  4. "Molecular analysis of genes encoding outer surface protein C (OspC) of Borrelia burgdorferi sensu lato: relationship to ospA genotype and evidence of lateral gene exchange of ospC."
    Jauris-Heipke S., Liegl G., Preac-Mursic V., Roessler D., Schwab E., Soutschek E., Will G., Wilske B.
    J. Clin. Microbiol. 33:1860-1866(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PKa.
  5. "Outer surface protein C gene sequence analysis of Borrelia burgdorferi sensu lato isolates from Japan."
    Fukunaga M., Hamase A.
    J. Clin. Microbiol. 33:2415-2420(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  7. "Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia."
    Livey I., Gibbs C.P., Schuster R., Dorner F.
    Mol. Microbiol. 18:257-269(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-210.
    Strain: Ip2.

Entry informationi

Entry nameiOSPC_BORBU
AccessioniPrimary (citable) accession number: Q07337
Secondary accession number(s): Q9S3P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3