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Q07337 (OSPC_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Outer surface protein C

Short name=PC
Gene names
Name:ospC
Ordered Locus Names:BB_B19
Encoded onPlasmid lp54
OrganismBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]
Taxonomic identifier224326 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Not known; major immunodominant protein.

Subcellular location

Cell outer membrane; Lipid-anchor.

Ontologies

Keywords
   Cellular componentCell outer membrane
Membrane
   DomainSignal
   PTMLipoprotein
Palmitate
   Technical term3D-structure
Complete proteome
Plasmid
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcell outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Chain19 – 210192Outer surface protein C
PRO_0000018083

Amino acid modifications

Lipidation191N-palmitoyl cysteine By similarity
Lipidation191S-diacylglycerol cysteine By similarity

Secondary structure

..................... 210
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q07337 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7A4FC978F91777BF

FASTA21022,341
        10         20         30         40         50         60 
MKKNTLSAIL MTLFLFISCN NSGKDGNTSA NSADESVKGP NLTEISKKIT DSNAVLLAVK 

        70         80         90        100        110        120 
EVEALLSSID EIAAKAIGKK IHQNNGLDTE NNHNGSLLAG AYAISTLIKQ KLDGLKNEGL 

       130        140        150        160        170        180 
KEKIDAAKKC SETFTNKLKE KHTDLGKEGV TDADAKEAIL KTNGTKTKGA EELGKLFESV 

       190        200        210 
EVLSKAAKEM LANSVKELTS PVVAESPKKP 

« Hide

References

« Hide 'large scale' references
[1]"Genetic heterogenity of the genes coding for the outer surface protein C (OspC) and the flagellin of Borrelia burgdorferi."
Jauris-Heipke S., Fuchs R., Motz M., Preac-Mursic V., Schwab E., Will G., Wilske B.
Med. Microbiol. Immunol. 182:37-50(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[2]"Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi."
Wilske B., Preace-Mursic V., Jauris S., Pradel I., Soutschek E., Schwab E., Wanner G.
Infect. Immun. 61:2182-2191(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[3]"Molecular characterization and expression of p23 (OspC) from a North American strain of Borrelia burgdorferi."
Padula S.J., Sampieri A., Dias F., Szczepanski A., Ryan R.W.
Infect. Immun. 61:5097-5105(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[4]"Molecular analysis of genes encoding outer surface protein C (OspC) of Borrelia burgdorferi sensu lato: relationship to ospA genotype and evidence of lateral gene exchange of ospC."
Jauris-Heipke S., Liegl G., Preac-Mursic V., Roessler D., Schwab E., Soutschek E., Will G., Wilske B.
J. Clin. Microbiol. 33:1860-1866(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: PKa.
[5]"Outer surface protein C gene sequence analysis of Borrelia burgdorferi sensu lato isolates from Japan."
Fukunaga M., Hamase A.
J. Clin. Microbiol. 33:2415-2420(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[6]"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi."
Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. expand/collapse author list , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C.
Nature 390:580-586(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[7]"Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia."
Livey I., Gibbs C.P., Schuster R., Dorner F.
Mol. Microbiol. 18:257-269(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-210.
Strain: Ip2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69596 Genomic DNA. Translation: CAA49306.1.
U01894 Unassigned DNA. Translation: AAA16058.1.
X69589 Genomic DNA. No translation available.
D49497 Genomic DNA. Translation: BAA08457.1.
AE000792 Genomic DNA. Translation: AAC66329.1.
L42887 Genomic DNA. Translation: AAB36995.1.
PIRG70218.
S69927.
RefSeqNP_047005.1. NC_001903.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GGQX-ray2.51A/B/C/D38-210[»]
ProteinModelPortalQ07337.
SMRQ07337. Positions 40-201.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224326.BBB19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC66329; AAC66329; BB_B19.
GeneID1194415.
KEGGbbu:BB_B19.
PATRIC20559107. VBIBorBur75917_1608.

Phylogenomic databases

eggNOGNOG148362.
OMAEANRNES.
OrthoDBEOG6K4032.

Enzyme and pathway databases

BioCycBBUR224326:G9SO-1500-MONOMER.

Family and domain databases

Gene3D1.20.120.240. 1 hit.
InterProIPR001800. Lipoprotein_6.
[Graphical view]
PfamPF01441. Lipoprotein_6. 1 hit.
[Graphical view]
ProDomPD001149. Lipoprotein_6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF63515. SSF63515. 1 hit.
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ07337.

Entry information

Entry nameOSPC_BORBU
AccessionPrimary (citable) accession number: Q07337
Secondary accession number(s): Q9S3P3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references