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Q07337

- OSPC_BORBU

UniProt

Q07337 - OSPC_BORBU

Protein

Outer surface protein C

Gene

ospC

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Not known; major immunodominant protein.

    GO - Biological processi

    1. defense response Source: InterPro

    Enzyme and pathway databases

    BioCyciBBUR224326:G9SO-1500-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Outer surface protein C
    Short name:
    PC
    Gene namesi
    Name:ospC
    Ordered Locus Names:BB_B19
    Encoded oniPlasmid lp540 Publication
    OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    Taxonomic identifieri224326 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001807: Plasmid cp26

    Subcellular locationi

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell outer membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818PROSITE-ProRule annotationAdd
    BLAST
    Chaini19 – 210192Outer surface protein CPRO_0000018083Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi19 – 191N-palmitoyl cysteinePROSITE-ProRule annotation
    Lipidationi19 – 191S-diacylglycerol cysteinePROSITE-ProRule annotation

    Keywords - PTMi

    Lipoprotein, Palmitate

    Interactioni

    Protein-protein interaction databases

    STRINGi224326.BBB19.

    Structurei

    Secondary structure

    1
    210
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi42 – 7534
    Turni76 – 783
    Beta strandi79 – 824
    Turni83 – 853
    Beta strandi86 – 894
    Helixi95 – 11319
    Turni118 – 1203
    Helixi121 – 14020
    Helixi142 – 1454
    Beta strandi146 – 1483
    Helixi152 – 1598
    Turni167 – 1693
    Helixi170 – 19526
    Helixi196 – 1994

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1GGQX-ray2.51A/B/C/D38-210[»]
    ProteinModelPortaliQ07337.
    SMRiQ07337. Positions 40-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ07337.

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG148362.
    OMAiEANRNES.
    OrthoDBiEOG6K4032.

    Family and domain databases

    Gene3Di1.20.120.240. 1 hit.
    InterProiIPR001800. Lipoprotein_6.
    [Graphical view]
    PfamiPF01441. Lipoprotein_6. 1 hit.
    [Graphical view]
    ProDomiPD001149. Lipoprotein_6. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF63515. SSF63515. 1 hit.
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07337-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKNTLSAIL MTLFLFISCN NSGKDGNTSA NSADESVKGP NLTEISKKIT    50
    DSNAVLLAVK EVEALLSSID EIAAKAIGKK IHQNNGLDTE NNHNGSLLAG 100
    AYAISTLIKQ KLDGLKNEGL KEKIDAAKKC SETFTNKLKE KHTDLGKEGV 150
    TDADAKEAIL KTNGTKTKGA EELGKLFESV EVLSKAAKEM LANSVKELTS 200
    PVVAESPKKP 210
    Length:210
    Mass (Da):22,341
    Last modified:November 1, 1996 - v1
    Checksum:i7A4FC978F91777BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69596 Genomic DNA. Translation: CAA49306.1.
    U01894 Unassigned DNA. Translation: AAA16058.1.
    X69589 Genomic DNA. No translation available.
    D49497 Genomic DNA. Translation: BAA08457.1.
    AE000792 Genomic DNA. Translation: AAC66329.1.
    L42887 Genomic DNA. Translation: AAB36995.1.
    PIRiG70218.
    S69927.
    RefSeqiNP_047005.1. NC_001903.1.
    WP_010890595.1. NC_001903.1.

    Genome annotation databases

    EnsemblBacteriaiAAC66329; AAC66329; BB_B19.
    GeneIDi1194415.
    KEGGibbu:BB_B19.
    PATRICi20559107. VBIBorBur75917_1608.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69596 Genomic DNA. Translation: CAA49306.1 .
    U01894 Unassigned DNA. Translation: AAA16058.1 .
    X69589 Genomic DNA. No translation available.
    D49497 Genomic DNA. Translation: BAA08457.1 .
    AE000792 Genomic DNA. Translation: AAC66329.1 .
    L42887 Genomic DNA. Translation: AAB36995.1 .
    PIRi G70218.
    S69927.
    RefSeqi NP_047005.1. NC_001903.1.
    WP_010890595.1. NC_001903.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1GGQ X-ray 2.51 A/B/C/D 38-210 [» ]
    ProteinModelPortali Q07337.
    SMRi Q07337. Positions 40-201.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224326.BBB19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC66329 ; AAC66329 ; BB_B19 .
    GeneIDi 1194415.
    KEGGi bbu:BB_B19.
    PATRICi 20559107. VBIBorBur75917_1608.

    Phylogenomic databases

    eggNOGi NOG148362.
    OMAi EANRNES.
    OrthoDBi EOG6K4032.

    Enzyme and pathway databases

    BioCyci BBUR224326:G9SO-1500-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q07337.

    Family and domain databases

    Gene3Di 1.20.120.240. 1 hit.
    InterProi IPR001800. Lipoprotein_6.
    [Graphical view ]
    Pfami PF01441. Lipoprotein_6. 1 hit.
    [Graphical view ]
    ProDomi PD001149. Lipoprotein_6. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF63515. SSF63515. 1 hit.
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic heterogenity of the genes coding for the outer surface protein C (OspC) and the flagellin of Borrelia burgdorferi."
      Jauris-Heipke S., Fuchs R., Motz M., Preac-Mursic V., Schwab E., Will G., Wilske B.
      Med. Microbiol. Immunol. 182:37-50(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
    2. "Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi."
      Wilske B., Preace-Mursic V., Jauris S., Pradel I., Soutschek E., Schwab E., Wanner G.
      Infect. Immun. 61:2182-2191(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
    3. "Molecular characterization and expression of p23 (OspC) from a North American strain of Borrelia burgdorferi."
      Padula S.J., Sampieri A., Dias F., Szczepanski A., Ryan R.W.
      Infect. Immun. 61:5097-5105(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
    4. "Molecular analysis of genes encoding outer surface protein C (OspC) of Borrelia burgdorferi sensu lato: relationship to ospA genotype and evidence of lateral gene exchange of ospC."
      Jauris-Heipke S., Liegl G., Preac-Mursic V., Roessler D., Schwab E., Soutschek E., Will G., Wilske B.
      J. Clin. Microbiol. 33:1860-1866(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: PKa.
    5. "Outer surface protein C gene sequence analysis of Borrelia burgdorferi sensu lato isolates from Japan."
      Fukunaga M., Hamase A.
      J. Clin. Microbiol. 33:2415-2420(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
    7. "Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia."
      Livey I., Gibbs C.P., Schuster R., Dorner F.
      Mol. Microbiol. 18:257-269(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-210.
      Strain: Ip2.

    Entry informationi

    Entry nameiOSPC_BORBU
    AccessioniPrimary (citable) accession number: Q07337
    Secondary accession number(s): Q9S3P3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Plasmid, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3