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Q07325 (CXCL9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C motif chemokine 9
Alternative name(s):
Gamma-interferon-induced monokine
Monokine induced by interferon-gamma
Short name=HuMIG
Short name=MIG
Small-inducible cytokine B9
Gene names
Name:CXCL9
Synonyms:CMK, MIG, SCYB9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length125 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.

Subcellular location

Secreted.

Induction

By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
   Biological processInflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 10903763. Source: ProtInc

cell chemotaxis

Inferred from direct assay PubMed 12782716. Source: GOC

cell-cell signaling

Traceable author statement Ref.1. Source: ProtInc

cellular defense response

Traceable author statement PubMed 10570316. Source: ProtInc

chemotaxis

Inferred from direct assay PubMed 12782716. Source: UniProtKB

defense response

Traceable author statement PubMed 2115167. Source: ProtInc

defense response to virus

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Traceable author statement PubMed 10903763. Source: ProtInc

positive regulation of cAMP metabolic process

Inferred from direct assay PubMed 12782716. Source: UniProtKB

positive regulation of cAMP-mediated signaling

Inferred from direct assay PubMed 12782716. Source: UniProtKB

positive regulation of release of sequestered calcium ion into cytosol

Inferred from direct assay PubMed 12782716. Source: UniProtKB

regulation of cell proliferation

Inferred from direct assay PubMed 12782716. Source: UniProtKB

signal transduction

Traceable author statement PubMed 10201891PubMed 10201901. Source: ProtInc

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionCXCR3 chemokine receptor binding

Inferred from direct assay PubMed 12782716. Source: UniProtKB

chemokine activity

Inferred from direct assay PubMed 12782716. Source: UniProtKB

cytokine activity

Traceable author statement PubMed 2115167. Source: ProtInc

protein binding

Inferred from physical interaction PubMed 18275857PubMed 21314817. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DPP4P274872EBI-3911467,EBI-2871277

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.3
Chain23 – 125103C-X-C motif chemokine 9
PRO_0000005099

Amino acid modifications

Disulfide bond31 ↔ 58 By similarity
Disulfide bond33 ↔ 74 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07325 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 630F8FCFCE125709

FASTA12514,019
        10         20         30         40         50         60 
MKKSGVLFLL GIILLVLIGV QGTPVVRKGR CSCISTNQGT IHLQSLKDLK QFAPSPSCEK 

        70         80         90        100        110        120 
IEIIATLKNG VQTCLNPDSA DVKELIKKWE KQVSQKKKQK NGKKHQKKKV LKVRKSQRSR 


QKKTT 

« Hide

References

« Hide 'large scale' references
[1]"HuMig: a new human member of the chemokine family of cytokines."
Farber J.M.
Biochem. Biophys. Res. Commun. 192:223-230(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Monocyte.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta and Skin.
[3]"Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)."
Tensen C.P., Flier J., van der Raaij-Helmer E.M.H., Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R.
J. Invest. Dermatol. 112:716-722(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-28.
Tissue: Keratinocyte.
+Additional computationally mapped references.

Web resources

Wikipedia

CXCL9 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X72755 mRNA. Translation: CAA51284.1.
BC063122 mRNA. Translation: AAH63122.1.
BC095396 mRNA. Translation: AAH95396.1.
CCDSCCDS34014.1.
PIRJN0470.
RefSeqNP_002407.1. NM_002416.1.
UniGeneHs.77367.

3D structure databases

ProteinModelPortalQ07325.
SMRQ07325. Positions 30-91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110429. 3 interactions.
DIPDIP-5892N.
IntActQ07325. 3 interactions.
MINTMINT-153157.
STRING9606.ENSP00000354901.

PTM databases

PhosphoSiteQ07325.

Polymorphism databases

DMDM585487.

Proteomic databases

PaxDbQ07325.
PRIDEQ07325.

Protocols and materials databases

DNASU4283.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264888; ENSP00000354901; ENSG00000138755.
GeneID4283.
KEGGhsa:4283.
UCSCuc003hjh.1. human.

Organism-specific databases

CTD4283.
GeneCardsGC04M076922.
HGNCHGNC:7098. CXCL9.
MIM601704. gene.
neXtProtNX_Q07325.
PharmGKBPA35495.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG38935.
HOGENOMHOG000220915.
HOVERGENHBG107789.
InParanoidQ07325.
KOK05416.
OMAGDQTCLN.
OrthoDBEOG7HHWVH.
PhylomeDBQ07325.
TreeFamTF333433.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ07325.
CleanExHS_CXCL9.
GenevestigatorQ07325.

Family and domain databases

InterProIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027225. CXCL9.
[Graphical view]
PANTHERPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF28. PTHR10179:SF28. 1 hit.
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR00437. SMALLCYTKCXC.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCXCL9. human.
GeneWikiCXCL9.
GenomeRNAi4283.
NextBio16849.
PMAP-CutDBQ07325.
PROQ07325.
SOURCESearch...

Entry information

Entry nameCXCL9_HUMAN
AccessionPrimary (citable) accession number: Q07325
Secondary accession number(s): Q503B4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM