Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q07325

- CXCL9_HUMAN

UniProt

Q07325 - CXCL9_HUMAN

Protein

C-X-C motif chemokine 9

Gene

CXCL9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.

    GO - Molecular functioni

    1. chemokine activity Source: UniProtKB
    2. CXCR3 chemokine receptor binding Source: UniProtKB
    3. cytokine activity Source: ProtInc
    4. protein binding Source: IntAct

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell chemotaxis Source: GOC
    3. cellular defense response Source: ProtInc
    4. chemotaxis Source: UniProtKB
    5. defense response Source: ProtInc
    6. defense response to virus Source: Ensembl
    7. G-protein coupled receptor signaling pathway Source: ProtInc
    8. immune response Source: InterPro
    9. inflammatory response Source: ProtInc
    10. positive regulation of cAMP-mediated signaling Source: UniProtKB
    11. positive regulation of cAMP metabolic process Source: UniProtKB
    12. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
    13. regulation of cell proliferation Source: UniProtKB
    14. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C motif chemokine 9
    Alternative name(s):
    Gamma-interferon-induced monokine
    Monokine induced by interferon-gamma
    Short name:
    HuMIG
    Short name:
    MIG
    Small-inducible cytokine B9
    Gene namesi
    Name:CXCL9
    Synonyms:CMK, MIG, SCYB9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:7098. CXCL9.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular region Source: Reactome
    3. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35495.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 125103C-X-C motif chemokine 9PRO_0000005099Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 58By similarity
    Disulfide bondi33 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ07325.
    PRIDEiQ07325.

    PTM databases

    PhosphoSiteiQ07325.

    Miscellaneous databases

    PMAP-CutDBQ07325.

    Expressioni

    Inductioni

    By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells.

    Gene expression databases

    BgeeiQ07325.
    CleanExiHS_CXCL9.
    GenevestigatoriQ07325.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DPP4P274872EBI-3911467,EBI-2871277

    Protein-protein interaction databases

    BioGridi110429. 3 interactions.
    DIPiDIP-5892N.
    IntActiQ07325. 3 interactions.
    MINTiMINT-153157.
    STRINGi9606.ENSP00000354901.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07325.
    SMRiQ07325. Positions 30-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38935.
    HOGENOMiHOG000220915.
    HOVERGENiHBG107789.
    InParanoidiQ07325.
    KOiK05416.
    OMAiGDQTCLN.
    OrthoDBiEOG7HHWVH.
    PhylomeDBiQ07325.
    TreeFamiTF333433.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    IPR027225. CXCL9.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF28. PTHR10179:SF28. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07325-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKSGVLFLL GIILLVLIGV QGTPVVRKGR CSCISTNQGT IHLQSLKDLK    50
    QFAPSPSCEK IEIIATLKNG VQTCLNPDSA DVKELIKKWE KQVSQKKKQK 100
    NGKKHQKKKV LKVRKSQRSR QKKTT 125
    Length:125
    Mass (Da):14,019
    Last modified:October 1, 1994 - v1
    Checksum:i630F8FCFCE125709
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72755 mRNA. Translation: CAA51284.1.
    BC063122 mRNA. Translation: AAH63122.1.
    BC095396 mRNA. Translation: AAH95396.1.
    CCDSiCCDS34014.1.
    PIRiJN0470.
    RefSeqiNP_002407.1. NM_002416.1.
    UniGeneiHs.77367.

    Genome annotation databases

    EnsembliENST00000264888; ENSP00000354901; ENSG00000138755.
    GeneIDi4283.
    KEGGihsa:4283.
    UCSCiuc003hjh.1. human.

    Polymorphism databases

    DMDMi585487.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXCL9 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72755 mRNA. Translation: CAA51284.1 .
    BC063122 mRNA. Translation: AAH63122.1 .
    BC095396 mRNA. Translation: AAH95396.1 .
    CCDSi CCDS34014.1.
    PIRi JN0470.
    RefSeqi NP_002407.1. NM_002416.1.
    UniGenei Hs.77367.

    3D structure databases

    ProteinModelPortali Q07325.
    SMRi Q07325. Positions 30-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110429. 3 interactions.
    DIPi DIP-5892N.
    IntActi Q07325. 3 interactions.
    MINTi MINT-153157.
    STRINGi 9606.ENSP00000354901.

    PTM databases

    PhosphoSitei Q07325.

    Polymorphism databases

    DMDMi 585487.

    Proteomic databases

    PaxDbi Q07325.
    PRIDEi Q07325.

    Protocols and materials databases

    DNASUi 4283.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264888 ; ENSP00000354901 ; ENSG00000138755 .
    GeneIDi 4283.
    KEGGi hsa:4283.
    UCSCi uc003hjh.1. human.

    Organism-specific databases

    CTDi 4283.
    GeneCardsi GC04M076922.
    HGNCi HGNC:7098. CXCL9.
    MIMi 601704. gene.
    neXtProti NX_Q07325.
    PharmGKBi PA35495.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG38935.
    HOGENOMi HOG000220915.
    HOVERGENi HBG107789.
    InParanoidi Q07325.
    KOi K05416.
    OMAi GDQTCLN.
    OrthoDBi EOG7HHWVH.
    PhylomeDBi Q07325.
    TreeFami TF333433.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    ChiTaRSi CXCL9. human.
    GeneWikii CXCL9.
    GenomeRNAii 4283.
    NextBioi 16849.
    PMAP-CutDB Q07325.
    PROi Q07325.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q07325.
    CleanExi HS_CXCL9.
    Genevestigatori Q07325.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    IPR027225. CXCL9.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF28. PTHR10179:SF28. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HuMig: a new human member of the chemokine family of cytokines."
      Farber J.M.
      Biochem. Biophys. Res. Commun. 192:223-230(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Monocyte.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta and Skin.
    3. "Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)."
      Tensen C.P., Flier J., van der Raaij-Helmer E.M.H., Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R.
      J. Invest. Dermatol. 112:716-722(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-28.
      Tissue: Keratinocyte.

    Entry informationi

    Entry nameiCXCL9_HUMAN
    AccessioniPrimary (citable) accession number: Q07325
    Secondary accession number(s): Q503B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3