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Protein

C-X-C motif chemokine 9

Gene

CXCL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • CXCR3 chemokine receptor binding Source: UniProtKB
  • cytokine activity Source: ProtInc

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • cell-cell signaling Source: ProtInc
  • cellular defense response Source: ProtInc
  • chemokine-mediated signaling pathway Source: GO_Central
  • chemotaxis Source: UniProtKB
  • defense response Source: ProtInc
  • defense response to virus Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: Reactome
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • killing of cells of other organism Source: UniProtKB
  • positive regulation of cAMP-mediated signaling Source: UniProtKB
  • positive regulation of cAMP metabolic process Source: UniProtKB
  • positive regulation of leukocyte chemotaxis Source: GO_Central
  • positive regulation of myoblast differentiation Source: Ensembl
  • positive regulation of myoblast fusion Source: Ensembl
  • positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  • regulation of cell proliferation Source: UniProtKB
  • response to lipopolysaccharide Source: GO_Central
  • signal transduction Source: ProtInc
  • T cell chemotaxis Source: GO_Central

Keywordsi

Molecular functionCytokine
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 9
Alternative name(s):
Gamma-interferon-induced monokine
Monokine induced by interferon-gamma
Short name:
HuMIG
Short name:
MIG
Small-inducible cytokine B9
Gene namesi
Name:CXCL9
Synonyms:CMK, MIG, SCYB9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138755.5
HGNCiHGNC:7098 CXCL9
MIMi601704 gene
neXtProtiNX_Q07325

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4283
OpenTargetsiENSG00000138755
PharmGKBiPA35495

Polymorphism and mutation databases

BioMutaiCXCL9
DMDMi585487

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000000509923 – 125C-X-C motif chemokine 9Add BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 58By similarity
Disulfide bondi33 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ07325
PaxDbiQ07325
PeptideAtlasiQ07325
PRIDEiQ07325

PTM databases

iPTMnetiQ07325
PhosphoSitePlusiQ07325

Miscellaneous databases

PMAP-CutDBiQ07325

Expressioni

Inductioni

By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells.

Gene expression databases

BgeeiENSG00000138755
CleanExiHS_CXCL9
GenevisibleiQ07325 HS

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • CXCR3 chemokine receptor binding Source: UniProtKB
  • cytokine activity Source: ProtInc

Protein-protein interaction databases

BioGridi110429, 7 interactors
DIPiDIP-5892N
IntActiQ07325, 24 interactors
MINTiQ07325
STRINGi9606.ENSP00000354901

Structurei

3D structure databases

ProteinModelPortaliQ07325
SMRiQ07325
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1Z5 Eukaryota
ENOG410Z394 LUCA
GeneTreeiENSGT00530000063958
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiQ07325
KOiK05416
OMAiNGRCSCI
OrthoDBiEOG091G0YSL
PhylomeDBiQ07325
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR027225 CXCL9
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF44 PTHR10179:SF44, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSGVLFLL GIILLVLIGV QGTPVVRKGR CSCISTNQGT IHLQSLKDLK
60 70 80 90 100
QFAPSPSCEK IEIIATLKNG VQTCLNPDSA DVKELIKKWE KQVSQKKKQK
110 120
NGKKHQKKKV LKVRKSQRSR QKKTT
Length:125
Mass (Da):14,019
Last modified:October 1, 1994 - v1
Checksum:i630F8FCFCE125709
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72755 mRNA Translation: CAA51284.1
BC063122 mRNA Translation: AAH63122.1
BC095396 mRNA Translation: AAH95396.1
CCDSiCCDS34014.1
PIRiJN0470
RefSeqiNP_002407.1, NM_002416.2
UniGeneiHs.77367

Genome annotation databases

EnsembliENST00000264888; ENSP00000354901; ENSG00000138755
GeneIDi4283
KEGGihsa:4283
UCSCiuc003hjh.2 human

Similar proteinsi

Entry informationi

Entry nameiCXCL9_HUMAN
AccessioniPrimary (citable) accession number: Q07325
Secondary accession number(s): Q503B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 28, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health