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Protein

C-X-C motif chemokine 9

Gene

CXCL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.

GO - Molecular functioni

  1. chemokine activity Source: UniProtKB
  2. CXCR3 chemokine receptor binding Source: UniProtKB
  3. cytokine activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cellular defense response Source: ProtInc
  3. chemokine-mediated signaling pathway Source: GO_Central
  4. chemotaxis Source: UniProtKB
  5. defense response Source: ProtInc
  6. defense response to virus Source: Ensembl
  7. G-protein coupled receptor signaling pathway Source: ProtInc
  8. immune response Source: GO_Central
  9. inflammatory response Source: ProtInc
  10. positive regulation of cAMP-mediated signaling Source: UniProtKB
  11. positive regulation of cAMP metabolic process Source: UniProtKB
  12. positive regulation of leukocyte chemotaxis Source: GO_Central
  13. positive regulation of myoblast differentiation Source: Ensembl
  14. positive regulation of myoblast fusion Source: Ensembl
  15. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  16. regulation of cell proliferation Source: UniProtKB
  17. response to lipopolysaccharide Source: GO_Central
  18. signal transduction Source: ProtInc
  19. T cell chemotaxis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 9
Alternative name(s):
Gamma-interferon-induced monokine
Monokine induced by interferon-gamma
Short name:
HuMIG
Short name:
MIG
Small-inducible cytokine B9
Gene namesi
Name:CXCL9
Synonyms:CMK, MIG, SCYB9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:7098. CXCL9.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular region Source: Reactome
  3. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35495.

Polymorphism and mutation databases

BioMutaiCXCL9.
DMDMi585487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 125103C-X-C motif chemokine 9PRO_0000005099Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 58By similarity
Disulfide bondi33 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ07325.
PRIDEiQ07325.

PTM databases

PhosphoSiteiQ07325.

Miscellaneous databases

PMAP-CutDBQ07325.

Expressioni

Inductioni

By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells.

Gene expression databases

BgeeiQ07325.
CleanExiHS_CXCL9.
GenevestigatoriQ07325.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-3911467,EBI-749265
DPP4P274872EBI-3911467,EBI-2871277
PTPN5P548293EBI-3911467,EBI-1220572
SFTPCP116863EBI-3911467,EBI-10197617
SYNE4Q8N2053EBI-3911467,EBI-7131783

Protein-protein interaction databases

BioGridi110429. 7 interactions.
DIPiDIP-5892N.
IntActiQ07325. 7 interactions.
MINTiMINT-153157.
STRINGi9606.ENSP00000354901.

Structurei

3D structure databases

ProteinModelPortaliQ07325.
SMRiQ07325. Positions 30-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38935.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ07325.
KOiK05416.
OMAiNGDQTCL.
OrthoDBiEOG7HHWVH.
PhylomeDBiQ07325.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027225. CXCL9.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF28. PTHR10179:SF28. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSGVLFLL GIILLVLIGV QGTPVVRKGR CSCISTNQGT IHLQSLKDLK
60 70 80 90 100
QFAPSPSCEK IEIIATLKNG VQTCLNPDSA DVKELIKKWE KQVSQKKKQK
110 120
NGKKHQKKKV LKVRKSQRSR QKKTT
Length:125
Mass (Da):14,019
Last modified:October 1, 1994 - v1
Checksum:i630F8FCFCE125709
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72755 mRNA. Translation: CAA51284.1.
BC063122 mRNA. Translation: AAH63122.1.
BC095396 mRNA. Translation: AAH95396.1.
CCDSiCCDS34014.1.
PIRiJN0470.
RefSeqiNP_002407.1. NM_002416.2.
UniGeneiHs.77367.

Genome annotation databases

EnsembliENST00000264888; ENSP00000354901; ENSG00000138755.
GeneIDi4283.
KEGGihsa:4283.
UCSCiuc003hjh.1. human.

Polymorphism and mutation databases

BioMutaiCXCL9.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL9 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72755 mRNA. Translation: CAA51284.1.
BC063122 mRNA. Translation: AAH63122.1.
BC095396 mRNA. Translation: AAH95396.1.
CCDSiCCDS34014.1.
PIRiJN0470.
RefSeqiNP_002407.1. NM_002416.2.
UniGeneiHs.77367.

3D structure databases

ProteinModelPortaliQ07325.
SMRiQ07325. Positions 30-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110429. 7 interactions.
DIPiDIP-5892N.
IntActiQ07325. 7 interactions.
MINTiMINT-153157.
STRINGi9606.ENSP00000354901.

PTM databases

PhosphoSiteiQ07325.

Polymorphism and mutation databases

BioMutaiCXCL9.
DMDMi585487.

Proteomic databases

PaxDbiQ07325.
PRIDEiQ07325.

Protocols and materials databases

DNASUi4283.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264888; ENSP00000354901; ENSG00000138755.
GeneIDi4283.
KEGGihsa:4283.
UCSCiuc003hjh.1. human.

Organism-specific databases

CTDi4283.
GeneCardsiGC04M076922.
HGNCiHGNC:7098. CXCL9.
MIMi601704. gene.
neXtProtiNX_Q07325.
PharmGKBiPA35495.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG38935.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ07325.
KOiK05416.
OMAiNGDQTCL.
OrthoDBiEOG7HHWVH.
PhylomeDBiQ07325.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiCXCL9. human.
GeneWikiiCXCL9.
GenomeRNAii4283.
NextBioi16849.
PMAP-CutDBQ07325.
PROiQ07325.
SOURCEiSearch...

Gene expression databases

BgeeiQ07325.
CleanExiHS_CXCL9.
GenevestigatoriQ07325.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027225. CXCL9.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF28. PTHR10179:SF28. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "HuMig: a new human member of the chemokine family of cytokines."
    Farber J.M.
    Biochem. Biophys. Res. Commun. 192:223-230(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Monocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Skin.
  3. "Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)."
    Tensen C.P., Flier J., van der Raaij-Helmer E.M.H., Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R.
    J. Invest. Dermatol. 112:716-722(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-28.
    Tissue: Keratinocyte.

Entry informationi

Entry nameiCXCL9_HUMAN
AccessioniPrimary (citable) accession number: Q07325
Secondary accession number(s): Q503B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 29, 2015
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.