Q07325 (CXCL9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-X-C motif chemokine 9

Alternative name(s):
Gamma-interferon-induced monokine
Monokine induced by interferon-gamma
Short name=HuMIG
Short name=MIG
Small-inducible cytokine B9

Gene names

Name:	CXCL9
Synonyms:	CMK, MIG, SCYB9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
Subcellular location	Secreted.
Induction	By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells.
Sequence similarities	Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
Biological process	Inflammatory response
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Traceable author statement PubMed 10903763. Source: ProtInc cell-cell signaling Traceable author statement Ref.1. Source: ProtInc cellular defense response Traceable author statement PubMed 10570316. Source: ProtInc chemotaxis Traceable author statement PubMed 10903763. Source: ProtInc defense response to virus Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: InterPro inflammatory response Traceable author statement PubMed 10903763. Source: ProtInc
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara extracellular space Traceable author statement Ref.1. Source: ProtInc
Molecular_function	chemokine activity Traceable author statement PubMed 10903763. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Ref.3
	Chain	23 – 125	103	C-X-C motif chemokine 9		PRO_0000005099
Amino acid modifications
	Disulfide bond	31 ↔ 58		By similarity
	Disulfide bond	33 ↔ 74		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q07325 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 630F8FCFCE125709	FASTA	125	14,019
	10 20 30 40 50 60 MKKSGVLFLL GIILLVLIGV QGTPVVRKGR CSCISTNQGT IHLQSLKDLK QFAPSPSCEK 70 80 90 100 110 120 IEIIATLKNG VQTCLNPDSA DVKELIKKWE KQVSQKKKQK NGKKHQKKKV LKVRKSQRSR QKKTT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"HuMig: a new human member of the chemokine family of cytokines." Farber J.M. Biochem. Biophys. Res. Commun. 192:223-230(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Monocyte.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Skin.
[3]	"Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)." Tensen C.P., Flier J., van der Raaij-Helmer E.M.H., Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R. J. Invest. Dermatol. 112:716-722(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-28. Tissue: Keratinocyte.
+	Additional computationally mapped references.

Web resources

Wikipedia

CXCL9 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	X72755 mRNA. Translation: CAA51284.1. BC063122 mRNA. Translation: AAH63122.1. BC095396 mRNA. Translation: AAH95396.1.
IPI	IPI00016534.
PIR	JN0470.
RefSeq	NP_002407.1. NM_002416.1.
UniGene	Hs.77367.
3D structure databases
ProteinModelPortal	Q07325.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5892N.
IntAct	Q07325. 2 interactions.
MINT	MINT-153157.
STRING	9606.ENSP00000354901.
PTM databases
PhosphoSite	Q07325.
Polymorphism databases
DMDM	585487.
Proteomic databases
PaxDb	Q07325.
PRIDE	Q07325.
Protocols and materials databases
DNASU	4283.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264888; ENSP00000354901; ENSG00000138755.
GeneID	4283.
KEGG	hsa:4283.
UCSC	uc003hjh.1. human.
Organism-specific databases
CTD	4283.
GeneCards	GC04M076922.
HGNC	HGNC:7098. CXCL9.
MIM	601704. gene.
neXtProt	NX_Q07325.
PharmGKB	PA35495.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG38935.
HOGENOM	HOG000220915.
HOVERGEN	HBG107789.
InParanoid	Q07325.
KO	K05416.
OMA	DQTCLNP.
OrthoDB	EOG42Z4RW.
PhylomeDB	Q07325.
Enzyme and pathway databases
Pathway_Interaction_DB	il23pathway. IL23-mediated signaling events.
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q07325.
CleanEx	HS_CXCL9.
Genevestigator	Q07325.
GermOnline	ENSG00000138755. Homo sapiens.
Family and domain databases
InterPro	IPR001089. Chemokine_CXC. IPR018048. Chemokine_CXC_CS. IPR001811. Chemokine_IL8-like_dom. IPR027225. CXCL9. [Graphical view]
PANTHER	PTHR10179. PTHR10179. 1 hit. PTHR10179:SF6. PTHR10179:SF6. 1 hit.
Pfam	PF00048. IL8. 1 hit. [Graphical view]
PRINTS	PR00437. SMALLCYTKCXC.
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00471. SMALL_CYTOKINES_CXC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CXCL9. human.
GenomeRNAi	4283.
NextBio	16849.
PMAP-CutDB	Q07325.
SOURCE	Search...

Entry information

Entry name

CXCL9_HUMAN

Accession

Primary (citable) accession number: Q07325
Secondary accession number(s): Q503B4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	May 1, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.