Reviewed,
UniProtKB/Swiss-Prot Q07310 (NRX3A_RAT)
Last modified
November 4, 2008.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Neurexin-3-alpha Alternative name(s): Neurexin III-alpha | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 1578 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. |
| Subunit structure | The laminin G-like domain 2 binds to NXPH1. Isoforms alpha 4B bind to alpha-dystroglycan. The cytoplasmic C-terminal region binds to CASK. |
| Subcellular location | Cell membrane; Single-pass type I membrane proteinPotential. Secreted. Note= Some isoforms seems to be secreted. |
| Tissue specificity | Brain. |
| Sequence similarities | Belongs to the neurexin family. Contains 3 EGF-like domains. Contains 6 laminin G-like domains. |
Ontologies
Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Cell membrane Membrane Secreted |
| Coding sequence diversity | Alternative splicing |
| Domain | EGF-like domain Repeat Signal Transmembrane |
| Ligand | Calcium Metal-binding |
| PTM | Glycoprotein |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-KW integral to membraneInferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 19 isoforms produced by alternative splicing. [Align] [Select] Notes: There are five major alternatively spliced sites, each of which may be spliced in up to twelve different ways. Combinatorial splicing at each of these five sites may lead to the generation of at least 288 isoforms but for simplicity only individual splice events are explicitly described below. Isoforms Alpha 5A to isoform Alpha 5H lack the transmembrane domain. Experimental confirmation may be lacking for some isoforms. | ||||||
| Isoform 1 (identifier: Q07310-1) Also known as: Alpha-5I; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q07310-2) Also known as: Alpha-1B; The sequence of this isoform differs from the canonical sequence as follows: 253-256: Missing. | ||||||
| Isoform 3 (identifier: Q07310-3) Also known as: Alpha-1C; The sequence of this isoform differs from the canonical sequence as follows: 237-242: Missing. | ||||||
| Isoform 4 (identifier: Q07310-4) Also known as: Alpha-1D; The sequence of this isoform differs from the canonical sequence as follows: 237-242: Missing. 253-256: Missing. | ||||||
| Isoform 5 (identifier: Q07310-5) Also known as: Alpha-1E; The sequence of this isoform differs from the canonical sequence as follows: 243-256: Missing. | ||||||
| Isoform 6 (identifier: Q07310-6) Also known as: Alpha-1F; The sequence of this isoform differs from the canonical sequence as follows: 237-256: Missing. | ||||||
| Isoform 7 (identifier: Q07310-7) Also known as: Alpha-3B; The sequence of this isoform differs from the canonical sequence as follows: 754-763: DCIRINCNSS → G | ||||||
| Isoform 8 (identifier: Q07310-8) Also known as: Alpha-4B; The sequence of this isoform differs from the canonical sequence as follows: 1210-1239: Missing. | ||||||
| Isoform 9 (identifier: Q07310-9) Also known as: Alpha-5A; The sequence of this isoform differs from the canonical sequence as follows: 1372-1478: Missing. 1479-1578: ANPTEPGIRR...QKNKDKEYYV → ARSSNAARIT...LKFMCCHPPP | ||||||
| Isoform 10 (identifier: Q07310-10) Also known as: Alpha-5B; The sequence of this isoform differs from the canonical sequence as follows: 1369-1371: Missing. 1372-1478: Missing. 1479-1578: ANPTEPGIRR...QKNKDKEYYV → ARSSNAARIT...LKFMCCHPPP | ||||||
| Isoform 11 (identifier: Q07310-11) Also known as: Alpha-5C; The sequence of this isoform differs from the canonical sequence as follows: 1372-1478: Missing. 1479-1578: ANPTEPGIRR...QKNKDKEYYV → VLERRIILNLKTNAHPKSLQSKTC | ||||||
| Isoform 12 (identifier: Q07310-12) Also known as: Alpha-5D; The sequence of this isoform differs from the canonical sequence as follows: 1369-1371: Missing. 1372-1478: Missing. 1479-1578: ANPTEPGIRR...QKNKDKEYYV → VLERRIILNLKTNAHPKSLQSKTC | ||||||
| Isoform 13 (identifier: Q07310-13) Also known as: Alpha-5E; The sequence of this isoform differs from the canonical sequence as follows: 1372-1478: Missing. 1479-1578: ANPTEPGIRR...QKNKDKEYYV → DILLKSF | ||||||
| Isoform 14 (identifier: Q07310-14) Also known as: Alpha-5F; The sequence of this isoform differs from the canonical sequence as follows: 1369-1371: Missing. 1372-1478: Missing. 1479-1578: ANPTEPGIRR...QKNKDKEYYV → DILLKSF | ||||||
| Isoform 15 (identifier: Q07310-15) Also known as: Alpha-5G; The sequence of this isoform differs from the canonical sequence as follows: 1372-1478: Missing. 1479-1578: ANPTEPGIRR...QKNKDKEYYV → ATTTTKKSNFQECGNSICPRAFLHNFLL | ||||||
| Isoform 16 (identifier: Q07310-16) Also known as: Alpha-5H; The sequence of this isoform differs from the canonical sequence as follows: 1369-1371: Missing. 1372-1478: Missing. 1479-1578: ANPTEPGIRR...QKNKDKEYYV → ATTTTKKSNFQECGNSICPRAFLHNFLL | ||||||
| Isoform 17 (identifier: Q07310-17) Also known as: Alpha-5J; The sequence of this isoform differs from the canonical sequence as follows: 1369-1371: Missing. | ||||||
| Isoform 18 (identifier: Q07310-18) Also known as: Alpha-5K; The sequence of this isoform differs from the canonical sequence as follows: 1372-1478: Missing. | ||||||
| Isoform 19 (identifier: Q07310-19) Also known as: Alpha-5L; The sequence of this isoform differs from the canonical sequence as follows: 1369-1371: Missing. 1372-1478: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 27 | 27 | |||||||||
| Chain | 28 – 1578 | 1551 | Neurexin-3-alpha | PRO_0000019500 | |||||||
Regions | |||||||||||
| Topological domain | 28 – 1503 | 1476 | Extracellular Potential | ||||||||
| Transmembrane | 1504 – 1524 | 21 | Potential | ||||||||
| Topological domain | 1525 – 1578 | 54 | Cytoplasmic Potential | ||||||||
| Domain | 28 – 202 | 175 | Laminin G-like 1 | ||||||||
| Domain | 198 – 235 | 38 | EGF-like 1 | ||||||||
| Domain | 260 – 444 | 185 | Laminin G-like 2 | ||||||||
| Domain | 451 – 643 | 193 | Laminin G-like 3 | ||||||||
| Domain | 647 – 684 | 38 | EGF-like 2 | ||||||||
| Domain | 689 – 861 | 173 | Laminin G-like 4 | ||||||||
| Domain | 875 – 1050 | 176 | Laminin G-like 5 | ||||||||
| Domain | 1053 – 1090 | 38 | EGF-like 3 | ||||||||
| Domain | 1094 – 1294 | 201 | Laminin G-like 6 | ||||||||
| Compositional bias | 282 – 285 | 4 | Poly-Ser | ||||||||
| Compositional bias | 1323 – 1326 | 4 | Poly-Thr | ||||||||
| Compositional bias | 1329 – 1332 | 4 | Poly-Thr | ||||||||
| Compositional bias | 1407 – 1410 | 4 | Poly-Thr | ||||||||
| Compositional bias | 1422 – 1425 | 4 | Poly-Ser | ||||||||
| Compositional bias | 1511 – 1514 | 4 | Poly-Ala | ||||||||
Sites | |||||||||||
| Metal binding | 308 | 1 | Calcium By similarity | ||||||||
| Metal binding | 325 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 378 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 58 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 105 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 761 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1193 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1291 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1335 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1500 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 202 ↔ 213 | By similarity | |||||||||
| Disulfide bond | 207 ↔ 222 | By similarity | |||||||||
| Disulfide bond | 224 ↔ 234 | By similarity | |||||||||
| Disulfide bond | 408 ↔ 444 | By similarity | |||||||||
| Disulfide bond | 614 ↔ 643 | By similarity | |||||||||
| Disulfide bond | 651 ↔ 662 | By similarity | |||||||||
| Disulfide bond | 656 ↔ 671 | By similarity | |||||||||
| Disulfide bond | 673 ↔ 683 | By similarity | |||||||||
| Disulfide bond | 1022 ↔ 1050 | By similarity | |||||||||
| Disulfide bond | 1057 ↔ 1068 | By similarity | |||||||||
| Disulfide bond | 1062 ↔ 1077 | By similarity | |||||||||
| Disulfide bond | 1079 ↔ 1089 | By similarity | |||||||||
Natural variations | |||||||||||
| Alternative sequence | 237 – 256 | 20 | Missing in isoform 6. | VSP_003522 | |||||||
| Alternative sequence | 237 – 242 | 6 | Missing in isoform 3 and isoform 4. | VSP_003521 | |||||||
| Alternative sequence | 243 – 256 | 14 | Missing in isoform 5. | VSP_003523 | |||||||
| Alternative sequence | 253 – 256 | 4 | Missing in isoform 2 and isoform 4. | VSP_003524 | |||||||
| Alternative sequence | 754 – 763 | 10 | DCIRINCNSS → G in isoform 7. | VSP_003525 | |||||||
| Alternative sequence | 1210 – 1239 | 30 | Missing in isoform 8. | VSP_003526 | |||||||
| Alternative sequence | 1369 – 1371 | 3 | Missing in isoform 10, isoform 12, isoform 14, isoform 16, isoform 17 and isoform 19. | VSP_003527 | |||||||
| Alternative sequence | 1372 – 1478 | 107 | Missing in isoform 9, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14, isoform 15, isoform 16, isoform 18 and isoform 19. | VSP_003528 | |||||||
| Alternative sequence | 1479 – 1578 | 100 | ANPTE…KEYYV → VLERRIILNLKTNAHPKSLQ SKTC in isoform 11 and isoform 12. | VSP_003530 | |||||||
| Alternative sequence | 1479 – 1578 | 100 | ANPTE…KEYYV → DILLKSF in isoform 13 and isoform 14. | VSP_003531 | |||||||
| Alternative sequence | 1479 – 1578 | 100 | ANPTE…KEYYV → ATTTTKKSNFQECGNSICPR AFLHNFLL in isoform 15 and isoform 16. | VSP_003532 | |||||||
| Alternative sequence | 1479 – 1578 | 100 | ANPTE…KEYYV → ARSSNAARITPCRPYMDMAT HLHIYPSHLHLLCSTLIDTP LPFPHPFFPMLPPSLALLKF MCCHPPP in isoform 9 and isoform 10. | VSP_003529 | |||||||
Sequences
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Clusters with