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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)
Alternative name(s):
SAICAR synthetase
Gene namesi
Name:purC
Ordered Locus Names:SP_0044
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001008821 – 235Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST235

Interactioni

Protein-protein interaction databases

STRINGi170187.SpneT_02000421.

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Beta strandi10 – 16Combined sources7
Beta strandi22 – 27Combined sources6
Beta strandi29 – 32Combined sources4
Beta strandi34 – 37Combined sources4
Beta strandi39 – 41Combined sources3
Helixi45 – 62Combined sources18
Beta strandi67 – 72Combined sources6
Beta strandi74 – 81Combined sources8
Beta strandi87 – 95Combined sources9
Helixi98 – 104Combined sources7
Beta strandi111 – 121Combined sources11
Helixi124 – 126Combined sources3
Helixi133 – 138Combined sources6
Helixi144 – 166Combined sources23
Turni167 – 169Combined sources3
Beta strandi171 – 181Combined sources11
Beta strandi187 – 191Combined sources5
Helixi195 – 197Combined sources3
Beta strandi198 – 201Combined sources4
Helixi211 – 214Combined sources4
Helixi220 – 231Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FE2X-ray2.29A/B1-235[»]
4FGRX-ray2.60A/B1-235[»]
4NYEX-ray2.69A/B1-235[»]
ProteinModelPortaliQ07296.
SMRiQ07296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.Curated

Phylogenomic databases

eggNOGiENOG4105C8V. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth. 1 hit.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQLIYSGK AKDIYTTEDE NLIISTYKDQ ATAFNGVKKE QIAGKGVLNN
60 70 80 90 100
QISSFIFEKL NVAGVATHFV EKLSDTEQLN KKVKIIPLEV VLRNYTAGSF
110 120 130 140 150
SKRFGVDEGI ALETPIVEFY YKNDDLDDPF INDEHVKFLQ IAGDQQIAYL
160 170 180 190 200
KEETRRINEL LKVWFAEIGL KLIDFKLEFG FDKDGKIILA DEFSPDNCRL
210 220 230
WDADGNHMDK DVFRRGLGEL TDVYEIVWEK LQELK
Length:235
Mass (Da):27,003
Last modified:September 26, 2001 - v2
Checksum:iC9B5601921400DD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62V → A in AAA69512 (PubMed:8407811).Curated1
Sequence conflicti62V → A in AAA03540 (PubMed:8407811).Curated1
Sequence conflicti143G → D in AAA69512 (PubMed:8407811).Curated1
Sequence conflicti143G → D in AAA03540 (PubMed:8407811).Curated1
Sequence conflicti154T → A in AAA69512 (PubMed:8407811).Curated1
Sequence conflicti154T → A in AAA03540 (PubMed:8407811).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36180 Genomic DNA. Translation: AAA69512.1.
L15190 Genomic DNA. Translation: AAA03540.1.
AE005672 Genomic DNA. Translation: AAK74233.1.
PIRiA36941.
H95004.
RefSeqiWP_000043309.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK74233; AAK74233; SP_0044.
KEGGispn:SP_0044.
PATRICi19704415. VBIStrPne105772_0052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36180 Genomic DNA. Translation: AAA69512.1.
L15190 Genomic DNA. Translation: AAA03540.1.
AE005672 Genomic DNA. Translation: AAK74233.1.
PIRiA36941.
H95004.
RefSeqiWP_000043309.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FE2X-ray2.29A/B1-235[»]
4FGRX-ray2.60A/B1-235[»]
4NYEX-ray2.69A/B1-235[»]
ProteinModelPortaliQ07296.
SMRiQ07296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02000421.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK74233; AAK74233; SP_0044.
KEGGispn:SP_0044.
PATRICi19704415. VBIStrPne105772_0052.

Phylogenomic databases

eggNOGiENOG4105C8V. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth. 1 hit.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPUR7_STRPN
AccessioniPrimary (citable) accession number: Q07296
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: September 26, 2001
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.