Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Kluyveromyces marxianus (Yeast) (Candida kefyr)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi154Zinc 1; catalyticBy similarity1
Binding sitei202NADBy similarity1
Binding sitei207NADBy similarity1
Binding sitei341NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 184NADBy similarity7
Nucleotide bindingi269 – 271NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Gene namesi
Name:ADH1
OrganismiKluyveromyces marxianus (Yeast) (Candida kefyr)
Taxonomic identifieri4911 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607241 – 348Alcohol dehydrogenase 1Add BLAST348

Proteomic databases

PRIDEiQ07288

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliQ07288
SMRiQ07288
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q07288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIPETQKGV IFYEHGGELQ YKDIPVPKPK PNELLINVKY SGVCHTDLHA
60 70 80 90 100
WQGDWPLDTK LPLVGGHEGA GIVVAMGENV TGWEIGDYAG IKWLNGSCMS
110 120 130 140 150
CEECELSNEP NCPKADLSGY THDGSFQQYA TADAVQAARI PKNVDLAEVA
160 170 180 190 200
PILCAGVTVY KALKSAHIKA GDWVAISGAC GGLGSLAIQY AKAMGYRVLG
210 220 230 240 250
IDAGDEKAKL FKELGGEYFI DFTKTKDMVA EVIEATNGVA HAVINVSVSE
260 270 280 290 300
AAISTSVLYT RSNGTVVLVG LPRDAQCKSD VFNQVVKSIS IVGSYVGNRA
310 320 330 340
DTREALDFFS RGLVKAPIKI LGLSELASVY DKMVKGQIVG RIVVDTSK
Length:348
Mass (Da):37,159
Last modified:February 1, 1995 - v1
Checksum:iA75D2EBE82E355BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60224 Genomic DNA Translation: CAA42785.1
PIRiS32521

Similar proteinsi

Entry informationi

Entry nameiADH1_KLUMA
AccessioniPrimary (citable) accession number: Q07288
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health