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Reviewed, UniProtKB/Swiss-Prot Q07288 (ADH1_KLUMA)

Last modified June 16, 2009. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1
Gene names
Name: ADH1
OrganismKluyveromyces marxianus (Yeast) (Candida kefyr)
Taxonomic identifier4911 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

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Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homotetramer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalcohol dehydrogenase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Alcohol dehydrogenase 1
PRO_0000160724

Regions

Nucleotide binding178 – 1847NAD By similarity
Nucleotide binding269 – 2713NAD By similarity

Sites

Metal binding441Zinc 1; catalytic By similarity
Metal binding671Zinc 1; catalytic By similarity
Metal binding981Zinc 2 By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1121Zinc 2 By similarity
Metal binding1541Zinc 1; catalytic By similarity
Binding site2021NAD By similarity
Binding site2071NAD By similarity
Binding site3411NAD By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q07288-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: A75D2EBE82E355BD

FASTA34837,159
        10         20         30         40         50         60 
MAIPETQKGV IFYEHGGELQ YKDIPVPKPK PNELLINVKY SGVCHTDLHA WQGDWPLDTK 

        70         80         90        100        110        120 
LPLVGGHEGA GIVVAMGENV TGWEIGDYAG IKWLNGSCMS CEECELSNEP NCPKADLSGY 

       130        140        150        160        170        180 
THDGSFQQYA TADAVQAARI PKNVDLAEVA PILCAGVTVY KALKSAHIKA GDWVAISGAC 

       190        200        210        220        230        240 
GGLGSLAIQY AKAMGYRVLG IDAGDEKAKL FKELGGEYFI DFTKTKDMVA EVIEATNGVA 

       250        260        270        280        290        300 
HAVINVSVSE AAISTSVLYT RSNGTVVLVG LPRDAQCKSD VFNQVVKSIS IVGSYVGNRA 

       310        320        330        340 
DTREALDFFS RGLVKAPIKI LGLSELASVY DKMVKGQIVG RIVVDTSK

« Hide

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References

[1]"Sequence of a gene coding for a cytoplasmic alcohol dehydrogenase from Kluyveromyces marxianus ATCC 12424."
Ladriere J.-M., Delcour J., Vandenhaute J.
Biochim. Biophys. Acta 1173:99-101(1993) [PubMed: 8485163] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 12424 / NRRL Y-610.

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Cross-references

Sequence databases

X60224 Genomic DNA. Translation: CAA42785.1.
PIRS32521.

3D structure databases

HSSPHSSP built from PDB template 1JVB based on UniProtKB P39462.
SMRQ07288. Positions 2-348.
ModBaseSearch...

Enzyme and pathway databases

BRENDA1.1.1.1. 97088.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADH1_KLUMA
AccessionPrimary (citable) accession number: Q07288
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents