Reviewed, UniProtKB/Swiss-Prot Q07288 (ADH1_KLUMA)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1

Gene names

Name:

ADH1

Organism

Kluyveromyces marxianus (Yeast) (Candida kefyr)

Taxonomic identifier

4911 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Homotetramer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Alcohol dehydrogenase 1		PRO_0000160724
Sites
	Metal binding	44	1	Zinc 1; catalytic By similarity
	Metal binding	67	1	Zinc 1; catalytic By similarity
	Metal binding	98	1	Zinc 2 By similarity
	Metal binding	101	1	Zinc 2 By similarity
	Metal binding	104	1	Zinc 2 By similarity
	Metal binding	112	1	Zinc 2 By similarity
	Metal binding	154	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q07288-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: A75D2EBE82E355BD	FASTA	348	37,159
	10 20 30 40 50 60 MAIPETQKGV IFYEHGGELQ YKDIPVPKPK PNELLINVKY SGVCHTDLHA WQGDWPLDTK 70 80 90 100 110 120 LPLVGGHEGA GIVVAMGENV TGWEIGDYAG IKWLNGSCMS CEECELSNEP NCPKADLSGY 130 140 150 160 170 180 THDGSFQQYA TADAVQAARI PKNVDLAEVA PILCAGVTVY KALKSAHIKA GDWVAISGAC 190 200 210 220 230 240 GGLGSLAIQY AKAMGYRVLG IDAGDEKAKL FKELGGEYFI DFTKTKDMVA EVIEATNGVA 250 260 270 280 290 300 HAVINVSVSE AAISTSVLYT RSNGTVVLVG LPRDAQCKSD VFNQVVKSIS IVGSYVGNRA 310 320 330 340 DTREALDFFS RGLVKAPIKI LGLSELASVY DKMVKGQIVG RIVVDTSK

References

[1]

"Sequence of a gene coding for a cytoplasmic alcohol dehydrogenase from Kluyveromyces marxianus ATCC 12424." Ladriere J.-M., Delcour J., Vandenhaute J. Biochim. Biophys. Acta 1173:99-101(1993) [PubMed: 8485163] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 12424 / NRRL Y-610.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X60224 Genomic DNA. Translation: CAA42785.1.
PIR	S32521.
3D structure databases
HSSP	HSSP built from PDB template 1JVB based on UniProtKB P39462.
SMR	Q07288. Positions 2-348.
ModBase	Search...
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1_KLUMA

Accession

Primary (citable) accession number: Q07288

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 25, 2008
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)