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Q07276 (KLK1_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kallikrein-1

EC=3.4.21.35
Alternative name(s):
Kidney/pancreas/salivary gland kallikrein
Tissue kallikrein
Gene names
Name:KLK1
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activity

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
Zymogen
Gene Ontology (GO)
   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Propeptide19 – 246Activation peptide Probable
PRO_0000027925
Chain25 – 257233Kallikrein-1
PRO_0000027926

Regions

Domain25 – 254230Peptidase S1

Sites

Active site621Charge relay system By similarity
Active site1161Charge relay system By similarity
Active site2091Charge relay system By similarity

Amino acid modifications

Glycosylation901O-linked (GalNAc...) By similarity
Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation1011O-linked (GalNAc...) By similarity
Glycosylation1051N-linked (GlcNAc...) Potential
Glycosylation1601N-linked (GlcNAc...) Potential
Glycosylation1621O-linked (GalNAc...) By similarity
Disulfide bond31 ↔ 169 By similarity
Disulfide bond47 ↔ 63 By similarity
Disulfide bond148 ↔ 215 By similarity
Disulfide bond180 ↔ 194 By similarity
Disulfide bond205 ↔ 230 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07276 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 32774D4C069316A7

FASTA25728,237
        10         20         30         40         50         60 
MWFLVLCLAL SLGGTGRAPP IQSRIVGGWE CSQPWQAALY HFSTFQCGGI LVHPQWVLTA 

        70         80         90        100        110        120 
AHCISDNYQL WLGRHNLFDD EDTAQFVHVS ESFPHPGFNM SLLKNHTRQA DDYSHDLMLL 

       130        140        150        160        170        180 
RLTQPAEITD AVQVVELPTQ EPEVGSTCLA SGWGSIEPEN FSFPDDLQCV DLEILPNDEC 

       190        200        210        220        230        240 
AKAHTQKVTE FMLCAGHLEG GKDTCVGDSG GPLTCDGVLQ GVTSWGYIPC GSPNKPAVFV 

       250 
KVLSYVKWIE DTIAENS 

« Hide

References

[1]"Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes."
Lin F.K., Lin C.H., Chou C., Chen K., Lu H.S., Bacheller B., Herrera C., Jones T., Chao J., Chao L.
Biochim. Biophys. Acta 1173:325-328(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L10039 mRNA. Translation: AAA36853.1.
PIRS33772.
RefSeqNP_001272131.1. NM_001285202.1.
UniGeneMfa.5390.

3D structure databases

ProteinModelPortalQ07276.
SMRQ07276. Positions 25-257.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102135781.
KEGGmcf:102135781.

Organism-specific databases

CTD3816.

Phylogenomic databases

HOVERGENHBG013304.
KOK01325.

Enzyme and pathway databases

BRENDA3.4.21.35. 3121.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKLK1_MACFA
AccessionPrimary (citable) accession number: Q07276
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries