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Protein

Kallikrein-1

Gene

KLK1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Charge relay systemBy similarity
Active sitei116 – 1161Charge relay systemBy similarity
Active sitei209 – 2091Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.35. 1793.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-1 (EC:3.4.21.35)
Alternative name(s):
Kidney/pancreas/salivary gland kallikrein
Tissue kallikrein
Gene namesi
Name:KLK1
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Propeptidei19 – 246Activation peptideCuratedPRO_0000027925
Chaini25 – 257233Kallikrein-1PRO_0000027926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 169PROSITE-ProRule annotation
Disulfide bondi47 ↔ 63PROSITE-ProRule annotation
Glycosylationi90 – 901O-linked (GalNAc...)By similarity
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi101 – 1011O-linked (GalNAc...)By similarity
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi148 ↔ 215PROSITE-ProRule annotation
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi162 – 1621O-linked (GalNAc...)By similarity
Disulfide bondi180 ↔ 194PROSITE-ProRule annotation
Disulfide bondi205 ↔ 230PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ07276.
SMRiQ07276. Positions 25-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 254230Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.
KOiK01325.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFLVLCLAL SLGGTGRAPP IQSRIVGGWE CSQPWQAALY HFSTFQCGGI
60 70 80 90 100
LVHPQWVLTA AHCISDNYQL WLGRHNLFDD EDTAQFVHVS ESFPHPGFNM
110 120 130 140 150
SLLKNHTRQA DDYSHDLMLL RLTQPAEITD AVQVVELPTQ EPEVGSTCLA
160 170 180 190 200
SGWGSIEPEN FSFPDDLQCV DLEILPNDEC AKAHTQKVTE FMLCAGHLEG
210 220 230 240 250
GKDTCVGDSG GPLTCDGVLQ GVTSWGYIPC GSPNKPAVFV KVLSYVKWIE

DTIAENS
Length:257
Mass (Da):28,237
Last modified:October 1, 1994 - v1
Checksum:i32774D4C069316A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10039 mRNA. Translation: AAA36853.1.
PIRiS33772.
RefSeqiNP_001272131.1. NM_001285202.1.
UniGeneiMfa.5390.

Genome annotation databases

GeneIDi102135781.
KEGGimcf:102135781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10039 mRNA. Translation: AAA36853.1.
PIRiS33772.
RefSeqiNP_001272131.1. NM_001285202.1.
UniGeneiMfa.5390.

3D structure databases

ProteinModelPortaliQ07276.
SMRiQ07276. Positions 25-257.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102135781.
KEGGimcf:102135781.

Organism-specific databases

CTDi3816.

Phylogenomic databases

HOVERGENiHBG013304.
KOiK01325.

Enzyme and pathway databases

BRENDAi3.4.21.35. 1793.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes."
    Lin F.K., Lin C.H., Chou C., Chen K., Lu H.S., Bacheller B., Herrera C., Jones T., Chao J., Chao L.
    Biochim. Biophys. Acta 1173:325-328(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKLK1_MACFA
AccessioniPrimary (citable) accession number: Q07276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 1, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.