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Q07276

- KLK1_MACFA

UniProt

Q07276 - KLK1_MACFA

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Protein

Kallikrein-1

Gene

KLK1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Charge relay systemBy similarity
Active sitei116 – 1161Charge relay systemBy similarity
Active sitei209 – 2091Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.35. 3121.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-1 (EC:3.4.21.35)
Alternative name(s):
Kidney/pancreas/salivary gland kallikrein
Tissue kallikrein
Gene namesi
Name:KLK1
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Propeptidei19 – 246Activation peptideCuratedPRO_0000027925
Chaini25 – 257233Kallikrein-1PRO_0000027926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 169PROSITE-ProRule annotation
Disulfide bondi47 ↔ 63PROSITE-ProRule annotation
Glycosylationi90 – 901O-linked (GalNAc...)By similarity
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi101 – 1011O-linked (GalNAc...)By similarity
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi148 ↔ 215PROSITE-ProRule annotation
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi162 – 1621O-linked (GalNAc...)By similarity
Disulfide bondi180 ↔ 194PROSITE-ProRule annotation
Disulfide bondi205 ↔ 230PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ07276.
SMRiQ07276. Positions 25-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 254230Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.
KOiK01325.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07276 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWFLVLCLAL SLGGTGRAPP IQSRIVGGWE CSQPWQAALY HFSTFQCGGI
60 70 80 90 100
LVHPQWVLTA AHCISDNYQL WLGRHNLFDD EDTAQFVHVS ESFPHPGFNM
110 120 130 140 150
SLLKNHTRQA DDYSHDLMLL RLTQPAEITD AVQVVELPTQ EPEVGSTCLA
160 170 180 190 200
SGWGSIEPEN FSFPDDLQCV DLEILPNDEC AKAHTQKVTE FMLCAGHLEG
210 220 230 240 250
GKDTCVGDSG GPLTCDGVLQ GVTSWGYIPC GSPNKPAVFV KVLSYVKWIE

DTIAENS
Length:257
Mass (Da):28,237
Last modified:October 1, 1994 - v1
Checksum:i32774D4C069316A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10039 mRNA. Translation: AAA36853.1.
PIRiS33772.
RefSeqiNP_001272131.1. NM_001285202.1.
UniGeneiMfa.5390.

Genome annotation databases

GeneIDi102135781.
KEGGimcf:102135781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10039 mRNA. Translation: AAA36853.1 .
PIRi S33772.
RefSeqi NP_001272131.1. NM_001285202.1.
UniGenei Mfa.5390.

3D structure databases

ProteinModelPortali Q07276.
SMRi Q07276. Positions 25-257.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 102135781.
KEGGi mcf:102135781.

Organism-specific databases

CTDi 3816.

Phylogenomic databases

HOVERGENi HBG013304.
KOi K01325.

Enzyme and pathway databases

BRENDAi 3.4.21.35. 3121.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes."
    Lin F.K., Lin C.H., Chou C., Chen K., Lu H.S., Bacheller B., Herrera C., Jones T., Chao J., Chao L.
    Biochim. Biophys. Acta 1173:325-328(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKLK1_MACFA
AccessioniPrimary (citable) accession number: Q07276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 1, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3