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Q07276

- KLK1_MACFA

UniProt

Q07276 - KLK1_MACFA

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Protein
Kallikrein-1
Gene
KLK1
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Charge relay system By similarity
Active sitei116 – 1161Charge relay system By similarity
Active sitei209 – 2091Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.35. 3121.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-1 (EC:3.4.21.35)
Alternative name(s):
Kidney/pancreas/salivary gland kallikrein
Tissue kallikrein
Gene namesi
Name:KLK1
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarity
Add
BLAST
Propeptidei19 – 246Activation peptide Inferred
PRO_0000027925
Chaini25 – 257233Kallikrein-1
PRO_0000027926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 169 By similarity
Disulfide bondi47 ↔ 63 By similarity
Glycosylationi90 – 901O-linked (GalNAc...) By similarity
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi101 – 1011O-linked (GalNAc...) By similarity
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi148 ↔ 215 By similarity
Glycosylationi160 – 1601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi162 – 1621O-linked (GalNAc...) By similarity
Disulfide bondi180 ↔ 194 By similarity
Disulfide bondi205 ↔ 230 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ07276.
SMRiQ07276. Positions 25-257.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 254230Peptidase S1
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.
KOiK01325.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07276-1 [UniParc]FASTAAdd to Basket

« Hide

MWFLVLCLAL SLGGTGRAPP IQSRIVGGWE CSQPWQAALY HFSTFQCGGI    50
LVHPQWVLTA AHCISDNYQL WLGRHNLFDD EDTAQFVHVS ESFPHPGFNM 100
SLLKNHTRQA DDYSHDLMLL RLTQPAEITD AVQVVELPTQ EPEVGSTCLA 150
SGWGSIEPEN FSFPDDLQCV DLEILPNDEC AKAHTQKVTE FMLCAGHLEG 200
GKDTCVGDSG GPLTCDGVLQ GVTSWGYIPC GSPNKPAVFV KVLSYVKWIE 250
DTIAENS 257
Length:257
Mass (Da):28,237
Last modified:October 1, 1994 - v1
Checksum:i32774D4C069316A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10039 mRNA. Translation: AAA36853.1.
PIRiS33772.
RefSeqiNP_001272131.1. NM_001285202.1.
UniGeneiMfa.5390.

Genome annotation databases

GeneIDi102135781.
KEGGimcf:102135781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10039 mRNA. Translation: AAA36853.1 .
PIRi S33772.
RefSeqi NP_001272131.1. NM_001285202.1.
UniGenei Mfa.5390.

3D structure databases

ProteinModelPortali Q07276.
SMRi Q07276. Positions 25-257.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 102135781.
KEGGi mcf:102135781.

Organism-specific databases

CTDi 3816.

Phylogenomic databases

HOVERGENi HBG013304.
KOi K01325.

Enzyme and pathway databases

BRENDAi 3.4.21.35. 3121.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes."
    Lin F.K., Lin C.H., Chou C., Chen K., Lu H.S., Bacheller B., Herrera C., Jones T., Chao J., Chao L.
    Biochim. Biophys. Acta 1173:325-328(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKLK1_MACFA
AccessioniPrimary (citable) accession number: Q07276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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