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Q07275

- DUT_EBVA8

UniProt

Q07275 - DUT_EBVA8

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into DNA. Induces immune dysregulation that contributes to the pathophysiology of the virus infection (By similarity).By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761Substrate; via amide nitrogenBy similarity
Binding sitei84 – 841Substrate; via amide nitrogen and carbonyl oxygenBy similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:DUT
ORF Names:BLLF3
OrganismiEpstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri82830 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007639: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi4 ↔ 246By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ07275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni171 – 1733Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 3 hits.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

Q07275-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEACPHIRYA FQNDKLLLQQ ASVGRLTLVN KTTILLRPMK TTTVDLGLYA
60 70 80 90 100
RPPEGHGLML WGSTSRPVTS HVGIIDPGYT GELRLILQNQ RRYNSTLRPS
110 120 130 140 150
ELKIHLAAFR YATPQMEEDK GPINHPQYPG DVGLDVSLPK DLALFPHQTV
160 170 180 190 200
SVTLTVPPPS IPHHRPTIFG RSGLAMQGIL VKPCRWRRGG VDVSLTNFSD
210 220 230 240 250
QTVFLNKYRR FCQLVYLHKH HLTSFYSPHS DAGVLGPRSL FRWASCAFEE
260 270
VPGLAMGDSG LSEALEGRQG RGFGSSGQ
Length:278
Mass (Da):30,892
Last modified:May 26, 2009 - v2
Checksum:i05073FAB4B863531
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti245 – 2451S → T in AAA02786. (PubMed:8393237)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07923 Genomic DNA. Translation: AAA02786.1. Sequence problems.
DQ279927 Genomic DNA. Translation: ABB89239.1.
RefSeqiYP_001129459.1. NC_009334.1.

Genome annotation databases

GeneIDi5176172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07923 Genomic DNA. Translation: AAA02786.1 . Sequence problems.
DQ279927 Genomic DNA. Translation: ABB89239.1 .
RefSeqi YP_001129459.1. NC_009334.1.

3D structure databases

ProteinModelPortali Q07275.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5176172.

Family and domain databases

Gene3Di 2.70.40.10. 3 hits.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Epstein-Barr virus candidate vaccine antigen gp340/220 is highly conserved between virus types A and B."
    Lees J.F., Arrand J.E., Pepper S.V., Stewart J.P., Mackett M., Arrand J.R.
    Virology 195:578-586(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome of Epstein-Barr virus type 2 strain AG876."
    Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.
    Virology 350:164-170(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_EBVA8
AccessioniPrimary (citable) accession number: Q07275
Secondary accession number(s): Q1HVG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3