Q07264 (ADH1_ZEALU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase 1
EC=1.1.1.1

Gene names

Name:

ADH1

Organism

Zea luxurians (Guatemalan teosinte) (Euchlaena luxurians)

Taxonomic identifier

15945 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogoneae › Zea

Protein attributes

Sequence length	293 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›293	›293	Alcohol dehydrogenase 1		PRO_0000160704
Regions
	Nucleotide binding	129 – 134	6	NAD By similarity
	Nucleotide binding	222 – 224	3	NAD By similarity
Sites
	Metal binding	26	1	Zinc 2 By similarity
	Metal binding	29	1	Zinc 2 By similarity
	Metal binding	32	1	Zinc 2 By similarity
	Metal binding	40	1	Zinc 2 By similarity
	Metal binding	104	1	Zinc 1; catalytic By similarity
	Binding site	153	1	NAD By similarity
	Binding site	158	1	NAD By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	293	1

Sequences

	Sequence		Length	Mass (Da)
	Q07264 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: E1B343AE6EF9CBD4	FASTA	293	31,490
	10 20 30 40 50 60 IIESVGEGVT DVAPGDHVLP VFTGECKECA HCKSAESNMC DLLRINTDRG VMIGDGKSRF 70 80 90 100 110 120 SINGKPIYHF VGTSTFSEYT VMHVGCVAKI NPQAPLDKVC VLSCGISTGL GASINVAKPP 130 140 150 160 170 180 KGSTVAVFGL GAVGLAAAEG ARIAGASRII GVDLNPSRFE EARKFGCTEF VNPKDHNKPV 190 200 210 220 230 240 QEVLAEMTNG GVDRSVECTG NINAMIQAFE CVHDGWGVAV LVGVPHKDAE FKTHPMNFLN 250 260 270 280 290 ERTLKGTFFG NYKPRTDLPN VVELYMKKEL EVEKFITHSV PFAEINKAFD LMA

References

[1]	"Molecular evolution of the Adh1 locus in the genus Zea." Gaut B.S., Clegg M.T. Proc. Natl. Acad. Sci. U.S.A. 90:5095-5099(1993) [PubMed: 8506356] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L08588 Genomic DNA. Translation: AAA74639.1. L08590 Genomic DNA. Translation: AAA74641.1.
UniGene	Zm.1540.
3D structure databases
ProteinModelPortal	Q07264.
SMR	Q07264. Positions 1-293.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Gramene	Q07264.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
PROSITE	PS00059. ADH_ZINC. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1_ZEALU

Accession

Primary (citable) accession number: Q07264

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1996
Last modified:	December 14, 2011
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program