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Protein

Neuronal acetylcholine receptor subunit alpha-3

Gene

CHRNA3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-3
Gene namesi
Name:CHRNA3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 230ExtracellularSequence analysisAdd BLAST209
Transmembranei231 – 255HelicalSequence analysisAdd BLAST25
Transmembranei263 – 281HelicalSequence analysisAdd BLAST19
Transmembranei296 – 318HelicalSequence analysisAdd BLAST23
Topological domaini319 – 467CytoplasmicBy similarityAdd BLAST149
Transmembranei468 – 487HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000034522 – 495Neuronal acetylcholine receptor subunit alpha-3Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi149 ↔ 163By similarity
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi213 ↔ 214Associated with receptor activationBy similarity
Modified residuei403PhosphoserineBy similarity1
Modified residuei406PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ07263.
PRIDEiQ07263.

Interactioni

Subunit structurei

Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004070.

Structurei

3D structure databases

ProteinModelPortaliQ07263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ07263.
KOiK04805.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRSRLRRL LLLLLLPVAS TSDAEHRLFE RLFEDYNEII RPVANVSDPV
60 70 80 90 100
IIQFEVSMSQ LVKVDEVNQI METNLWLKQI WNDYKLKWNP SDYDGAEFMR
110 120 130 140 150
VPAEKIWKPD IVLYNNAVGD FQVDDKTKAL LKYTGEVTWI PPAIFKSSCK
160 170 180 190 200
IDVTYFPFDY QNCTMKFGSW SYDKAKIDLV LIGSSMNLKD YWESGEWAII
210 220 230 240 250
KAPGYKHDIK YNCCEEIYPD ITYSLYIRRL PLFYTINLII PCLLISFLTV
260 270 280 290 300
LVFYLPSDCG EKVTLCISVL LSLTVFLLVI TETIPSTSLV IPLIGEYLLF
310 320 330 340 350
TMIFVTLSIV ITVFVLNVHY RTPTTHTMPA WVKTIFLNLL PRVMFMTRPA
360 370 380 390 400
SNEGNTQRPR PFYSAELSNL NCFSRIESKV CKEGYPCQDG LCGYCHHRRA
410 420 430 440 450
KISNFSANLT RSSSSESVDA VLSLSALSPE IKEAIQSVKY IAENMKAQNE
460 470 480 490
AKEIQDDWKY VAMVIDRIFL WVFILVCILG TAGLFLQPLM TRDDA
Length:495
Mass (Da):56,914
Last modified:October 1, 1994 - v1
Checksum:i322825629821EA07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57032 mRNA. Translation: CAA40348.1.
PIRiS60589.
RefSeqiNP_777144.1. NM_174719.2.
UniGeneiBt.63828.

Genome annotation databases

GeneIDi282702.
KEGGibta:282702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57032 mRNA. Translation: CAA40348.1.
PIRiS60589.
RefSeqiNP_777144.1. NM_174719.2.
UniGeneiBt.63828.

3D structure databases

ProteinModelPortaliQ07263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004070.

Chemistry databases

ChEMBLiCHEMBL5317.

Proteomic databases

PaxDbiQ07263.
PRIDEiQ07263.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282702.
KEGGibta:282702.

Organism-specific databases

CTDi1136.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ07263.
KOiK04805.

Miscellaneous databases

PROiQ07263.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACHA3_BOVIN
AccessioniPrimary (citable) accession number: Q07263
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 5, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.