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Protein

Neuronal acetylcholine receptor subunit alpha-3

Gene

CHRNA3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-3
Gene namesi
Name:CHRNA3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 230209ExtracellularSequence analysisAdd
BLAST
Transmembranei231 – 25525HelicalSequence analysisAdd
BLAST
Transmembranei263 – 28119HelicalSequence analysisAdd
BLAST
Transmembranei296 – 31823HelicalSequence analysisAdd
BLAST
Topological domaini319 – 467149CytoplasmicBy similarityAdd
BLAST
Transmembranei468 – 48720HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3350221.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 495474Neuronal acetylcholine receptor subunit alpha-3PRO_0000000345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence analysis
Disulfide bondi149 ↔ 163By similarity
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence analysis
Disulfide bondi213 ↔ 214Associated with receptor activationBy similarity
Modified residuei403 – 4031PhosphoserineBy similarity
Modified residuei406 – 4061PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ07263.
PRIDEiQ07263.

Interactioni

Subunit structurei

Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004070.

Structurei

3D structure databases

ProteinModelPortaliQ07263.
SMRiQ07263. Positions 231-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ07263.
KOiK04805.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRSRLRRL LLLLLLPVAS TSDAEHRLFE RLFEDYNEII RPVANVSDPV
60 70 80 90 100
IIQFEVSMSQ LVKVDEVNQI METNLWLKQI WNDYKLKWNP SDYDGAEFMR
110 120 130 140 150
VPAEKIWKPD IVLYNNAVGD FQVDDKTKAL LKYTGEVTWI PPAIFKSSCK
160 170 180 190 200
IDVTYFPFDY QNCTMKFGSW SYDKAKIDLV LIGSSMNLKD YWESGEWAII
210 220 230 240 250
KAPGYKHDIK YNCCEEIYPD ITYSLYIRRL PLFYTINLII PCLLISFLTV
260 270 280 290 300
LVFYLPSDCG EKVTLCISVL LSLTVFLLVI TETIPSTSLV IPLIGEYLLF
310 320 330 340 350
TMIFVTLSIV ITVFVLNVHY RTPTTHTMPA WVKTIFLNLL PRVMFMTRPA
360 370 380 390 400
SNEGNTQRPR PFYSAELSNL NCFSRIESKV CKEGYPCQDG LCGYCHHRRA
410 420 430 440 450
KISNFSANLT RSSSSESVDA VLSLSALSPE IKEAIQSVKY IAENMKAQNE
460 470 480 490
AKEIQDDWKY VAMVIDRIFL WVFILVCILG TAGLFLQPLM TRDDA
Length:495
Mass (Da):56,914
Last modified:October 1, 1994 - v1
Checksum:i322825629821EA07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57032 mRNA. Translation: CAA40348.1.
PIRiS60589.
RefSeqiNP_777144.1. NM_174719.2.
UniGeneiBt.63828.

Genome annotation databases

GeneIDi282702.
KEGGibta:282702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57032 mRNA. Translation: CAA40348.1.
PIRiS60589.
RefSeqiNP_777144.1. NM_174719.2.
UniGeneiBt.63828.

3D structure databases

ProteinModelPortaliQ07263.
SMRiQ07263. Positions 231-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004070.

Chemistry

ChEMBLiCHEMBL3350221.

Proteomic databases

PaxDbiQ07263.
PRIDEiQ07263.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282702.
KEGGibta:282702.

Organism-specific databases

CTDi1136.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ07263.
KOiK04805.

Miscellaneous databases

PROiQ07263.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structure of an agonist binding subunit of the nicotinic acetylcholine receptor from bovine adrenal chromaffin cells."
    Criado M., Alamo L., Navarro A.
    Neurochem. Res. 17:281-287(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiACHA3_BOVIN
AccessioniPrimary (citable) accession number: Q07263
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.