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Protein

1-aminocyclopropane-1-carboxylate synthase

Gene

ACS1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of 1-aminocyclopropane-1-carboxylate, a direct precursor of ethylene in higher plants.

Catalytic activityi

S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.

Cofactori

Pathwayi: ethylene biosynthesis via S-adenosyl-L-methionine

This protein is involved in step 1 of the subpathway that synthesizes ethylene from S-adenosyl-L-methionine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1-aminocyclopropane-1-carboxylate synthase (ACS1)
  2. 1-aminocyclopropane-1-carboxylate oxidase (ACO)
This subpathway is part of the pathway ethylene biosynthesis via S-adenosyl-L-methionine, which is itself part of Alkene biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ethylene from S-adenosyl-L-methionine, the pathway ethylene biosynthesis via S-adenosyl-L-methionine and in Alkene biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processEthylene biosynthesis, Fruit ripening
LigandPyridoxal phosphate, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00384; UER00562

Names & Taxonomyi

Protein namesi
Recommended name:
1-aminocyclopropane-1-carboxylate synthase (EC:4.4.1.14)
Short name:
ACC synthase
Alternative name(s):
S-adenosyl-L-methionine methylthioadenosine-lyase
Gene namesi
Name:ACS1
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi
  • UP000084051 Componenti: Genome assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239201 – 4911-aminocyclopropane-1-carboxylate synthaseAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei278N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiQ07262

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ07262
SMRiQ07262
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK20772

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q07262-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFENEKNSS ILSKLATNEE LGENSPYFDG WKAYDNDPFH PLKNPNGVIQ
60 70 80 90 100
MGLAENQLCF DLIEEWIKRN PNASICTTEG IKSFRAIANF QDYHGLPEFR
110 120 130 140 150
SAIAKFMEKT RGGRVTFDPE RVVMAGGATG ANETIIFCLA DTGDAFLVPS
160 170 180 190 200
PYYPAFNRDL RWRTGVQLIP IPCDSSNNFQ ITTKAVREAY ENAQKSNIKV
210 220 230 240 250
KGLILTNPSN PLGTTLDRDT LKNLLTFTNQ HNIHLVCDEI YAATVFNTPQ
260 270 280 290 300
FVSIAEILDD ETSHCNKDLV HIVYSLSKDM GLPGFRVGIV YSFNDAVVNC
310 320 330 340 350
ARKMSSFGLV STQTQYLLAE MLSDERFVSN FLTESSKRLA KRHKHFTNGL
360 370 380 390 400
EEVGIKCLRS NAGLFCWMDL RPLLKESTFD SEMSLWRVII NDVKLNVSPG
410 420 430 440 450
SSFDCQEPGF FRVCFANMDD ETVDIALARI RSFVGVKKSG DESTPILMEK
460 470 480 490
KQQWKKNNLR LSFSKRMYDE SVNLSPLSSP IPHSPLVRAR T
Length:491
Mass (Da):55,291
Last modified:October 1, 1994 - v1
Checksum:i57B9FF4306686DFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65982 mRNA Translation: CAA46797.1
PIRiT03978
RefSeqiNP_001313190.2, NM_001326261.2
UniGeneiNta.4191

Genome annotation databases

GeneIDi107831434
KEGGinta:107831434

Similar proteinsi

Entry informationi

Entry namei1A1C_TOBAC
AccessioniPrimary (citable) accession number: Q07262
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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