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Protein

1-aminocyclopropane-1-carboxylate synthase

Gene

ACS1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of 1-aminocyclopropane-1-carboxylate, a direct precursor of ethylene in higher plants.

Catalytic activityi

S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.

Cofactori

Pathwayi: ethylene biosynthesis via S-adenosyl-L-methionine

This protein is involved in step 1 of the subpathway that synthesizes ethylene from S-adenosyl-L-methionine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1-aminocyclopropane-1-carboxylate synthase (ACS1)
  2. 1-aminocyclopropane-1-carboxylate oxidase (ACO)
This subpathway is part of the pathway ethylene biosynthesis via S-adenosyl-L-methionine, which is itself part of Alkene biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ethylene from S-adenosyl-L-methionine, the pathway ethylene biosynthesis via S-adenosyl-L-methionine and in Alkene biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Ethylene biosynthesis, Fruit ripening

Keywords - Ligandi

Pyridoxal phosphate, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00384; UER00562.

Names & Taxonomyi

Protein namesi
Recommended name:
1-aminocyclopropane-1-carboxylate synthase (EC:4.4.1.14)
Short name:
ACC synthase
Alternative name(s):
S-adenosyl-L-methionine methylthioadenosine-lyase
Gene namesi
Name:ACS1
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239201 – 4911-aminocyclopropane-1-carboxylate synthaseAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei278N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ07262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07262-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFENEKNSS ILSKLATNEE LGENSPYFDG WKAYDNDPFH PLKNPNGVIQ
60 70 80 90 100
MGLAENQLCF DLIEEWIKRN PNASICTTEG IKSFRAIANF QDYHGLPEFR
110 120 130 140 150
SAIAKFMEKT RGGRVTFDPE RVVMAGGATG ANETIIFCLA DTGDAFLVPS
160 170 180 190 200
PYYPAFNRDL RWRTGVQLIP IPCDSSNNFQ ITTKAVREAY ENAQKSNIKV
210 220 230 240 250
KGLILTNPSN PLGTTLDRDT LKNLLTFTNQ HNIHLVCDEI YAATVFNTPQ
260 270 280 290 300
FVSIAEILDD ETSHCNKDLV HIVYSLSKDM GLPGFRVGIV YSFNDAVVNC
310 320 330 340 350
ARKMSSFGLV STQTQYLLAE MLSDERFVSN FLTESSKRLA KRHKHFTNGL
360 370 380 390 400
EEVGIKCLRS NAGLFCWMDL RPLLKESTFD SEMSLWRVII NDVKLNVSPG
410 420 430 440 450
SSFDCQEPGF FRVCFANMDD ETVDIALARI RSFVGVKKSG DESTPILMEK
460 470 480 490
KQQWKKNNLR LSFSKRMYDE SVNLSPLSSP IPHSPLVRAR T
Length:491
Mass (Da):55,291
Last modified:October 1, 1994 - v1
Checksum:i57B9FF4306686DFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65982 mRNA. Translation: CAA46797.1.
PIRiT03978.
RefSeqiNP_001313190.1. NM_001326261.1.
UniGeneiNta.4191.

Genome annotation databases

GeneIDi107831434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65982 mRNA. Translation: CAA46797.1.
PIRiT03978.
RefSeqiNP_001313190.1. NM_001326261.1.
UniGeneiNta.4191.

3D structure databases

ProteinModelPortaliQ07262.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107831434.

Enzyme and pathway databases

UniPathwayiUPA00384; UER00562.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1A1C_TOBAC
AccessioniPrimary (citable) accession number: Q07262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 5, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.