Reviewed, UniProtKB/Swiss-Prot Q07262 (1A1C_TOBAC)

Names and origin

Protein names

Recommended name:
    1-aminocyclopropane-1-carboxylate synthase
      Short name=ACC synthase
    EC=4.4.1.14
Alternative name(s):
    S-adenosyl-L-methionine methylthioadenosine-lyase

Gene names

Name:

ACS1

Organism

Nicotiana tabacum (Common tobacco)

Taxonomic identifier

4097 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of 1-aminocyclopropane-1-carboxylate, a direct precursor of ethylene in higher plants.
Catalytic activity	S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.
Cofactor	Pyridoxal phosphate.
Pathway	Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 1/2.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Biological process	Ethylene biosynthesis Fruit ripening
Ligand	Pyridoxal phosphate S-adenosyl-L-methionine
Molecular function	Lyase
Gene Ontology (GO)
Biological process	ethylene biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW ripening Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring nitrogenous groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	1-aminocyclopropane-1-carboxylate synthase		PRO_0000123920
Amino acid modifications
	Modified residue	278	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q07262-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 57B9FF4306686DFD	FASTA	491	55,291
	10 20 30 40 50 60 MGFENEKNSS ILSKLATNEE LGENSPYFDG WKAYDNDPFH PLKNPNGVIQ MGLAENQLCF 70 80 90 100 110 120 DLIEEWIKRN PNASICTTEG IKSFRAIANF QDYHGLPEFR SAIAKFMEKT RGGRVTFDPE 130 140 150 160 170 180 RVVMAGGATG ANETIIFCLA DTGDAFLVPS PYYPAFNRDL RWRTGVQLIP IPCDSSNNFQ 190 200 210 220 230 240 ITTKAVREAY ENAQKSNIKV KGLILTNPSN PLGTTLDRDT LKNLLTFTNQ HNIHLVCDEI 250 260 270 280 290 300 YAATVFNTPQ FVSIAEILDD ETSHCNKDLV HIVYSLSKDM GLPGFRVGIV YSFNDAVVNC 310 320 330 340 350 360 ARKMSSFGLV STQTQYLLAE MLSDERFVSN FLTESSKRLA KRHKHFTNGL EEVGIKCLRS 370 380 390 400 410 420 NAGLFCWMDL RPLLKESTFD SEMSLWRVII NDVKLNVSPG SSFDCQEPGF FRVCFANMDD 430 440 450 460 470 480 ETVDIALARI RSFVGVKKSG DESTPILMEK KQQWKKNNLR LSFSKRMYDE SVNLSPLSSP 490 IPHSPLVRAR T

References

[1]	"Nucleotide sequence of the Nicotiana tabacum cv Xanthi gene encoding 1-aminocyclopropane-1-carboxylate synthase." Bailey B.A., Avni A., Li N., Matoo A.K., Anderson J.D. Plant Physiol. 100:1615-1616(1992) [PubMed: 16653174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Xanthi.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X65982 mRNA. Translation: CAA46797.1.
PIR	T03978.
3D structure databases
HSSP	HSSP built from PDB template 1IAX based on UniProtKB P18485.
SMR	Q07262. Positions 16-438.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.4.1.14. 298.
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotransferase_I/II. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

1A1C_TOBAC

Accession

Primary (citable) accession number: Q07262

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	September 22, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)