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Q07258

- TGFB3_RAT

UniProt

Q07258 - TGFB3_RAT

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Protein

Transforming growth factor beta-3

Gene

Tgfb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in embryogenesis and cell differentiation.

GO - Molecular functioni

  1. protein heterodimerization activity Source: RGD
  2. transforming growth factor beta receptor binding Source: RGD

GO - Biological processi

  1. activation of MAPK activity Source: RGD
  2. aging Source: RGD
  3. cell-cell junction organization Source: Ensembl
  4. cell growth Source: InterPro
  5. detection of hypoxia Source: Ensembl
  6. digestive tract development Source: RGD
  7. embryonic neurocranium morphogenesis Source: RGD
  8. female pregnancy Source: RGD
  9. frontal suture morphogenesis Source: RGD
  10. inner ear development Source: RGD
  11. in utero embryonic development Source: Ensembl
  12. lung alveolus development Source: Ensembl
  13. lung development Source: RGD
  14. mammary gland development Source: Ensembl
  15. menstrual cycle phase Source: Ensembl
  16. negative regulation of cell proliferation Source: RGD
  17. negative regulation of DNA replication Source: Ensembl
  18. negative regulation of macrophage cytokine production Source: Ensembl
  19. negative regulation of neuron apoptotic process Source: Ensembl
  20. negative regulation of transforming growth factor beta receptor signaling pathway Source: RGD
  21. ossification involved in bone remodeling Source: Ensembl
  22. palate development Source: Ensembl
  23. positive regulation of apoptotic process Source: RGD
  24. positive regulation of bone mineralization Source: Ensembl
  25. positive regulation of cell division Source: UniProtKB-KW
  26. positive regulation of collagen biosynthetic process Source: Ensembl
  27. positive regulation of DNA replication Source: Ensembl
  28. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  29. positive regulation of filopodium assembly Source: Ensembl
  30. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  31. positive regulation of protein secretion Source: Ensembl
  32. positive regulation of SMAD protein import into nucleus Source: Ensembl
  33. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  34. regulation of endothelial cell differentiation Source: RGD
  35. regulation of epithelial cell differentiation Source: RGD
  36. regulation of epithelial cell proliferation Source: RGD
  37. response to estrogen Source: RGD
  38. response to hypoxia Source: RGD
  39. response to laminar fluid shear stress Source: RGD
  40. response to progesterone Source: Ensembl
  41. salivary gland morphogenesis Source: Ensembl
  42. SMAD protein import into nucleus Source: RGD
  43. transforming growth factor beta receptor signaling pathway Source: Ensembl
  44. wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Enzyme and pathway databases

ReactomeiREACT_198592. Molecules associated with elastic fibres.
REACT_198757. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta-3
Short name:
TGF-beta-3
Cleaved into the following chain:
Gene namesi
Name:Tgfb3
Synonyms:Tgf-b3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi3851. Tgfb3.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: RGD
  2. cytoplasm Source: RGD
  3. extracellular matrix Source: Ensembl
  4. extracellular space Source: RGD
  5. neuronal cell body Source: RGD
  6. nucleus Source: RGD
  7. secretory granule Source: RGD
  8. T-tubule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 300277Latency-associated peptideBy similarityPRO_0000033802Add
BLAST
Chaini301 – 412112Transforming growth factor beta-3PRO_0000033803Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi307 ↔ 316By similarity
Disulfide bondi315 ↔ 378By similarity
Disulfide bondi344 ↔ 409By similarity
Disulfide bondi348 ↔ 411By similarity
Disulfide bondi377 – 377InterchainBy similarity

Post-translational modificationi

The precursor is cleaved into mature TGF-beta-3 and LAP, which remains non-covalently linked to mature TGF-beta-3 rendering it inactive.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ07258.
PRIDEiQ07258.

Expressioni

Gene expression databases

GenevestigatoriQ07258.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with ASPN (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013516.

Structurei

3D structure databases

ProteinModelPortaliQ07258.
SMRiQ07258. Positions 301-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi261 – 2633Cell attachment siteSequence Analysis

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG269146.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000290198.
HOVERGENiHBG074115.
InParanoidiQ07258.
KOiK13377.
OMAiPEPSVMT.
OrthoDBiEOG70GMFT.
PhylomeDBiQ07258.
TreeFamiTF351793.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
IPR015618. Transform_grow_fac_b3.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF001787. TGF-beta. 1 hit.
PRINTSiPR01423. TGFBETA.
PR01426. TGFBETA3.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07258-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKMHLQRALV VLALLNLATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK
60 70 80 90 100
LRLTSPPEPS VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQETSESEY
110 120 130 140 150
YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVE KNGTNLFRAE
160 170 180 190 200
FRVLRVPNPS SKRTEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL
210 220 230 240 250
SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE NVHEVMEIKF
260 270 280 290 300
KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDS PGQGGQRKKR
310 320 330 340 350
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY
360 370 380 390 400
LRSSDTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ
410
LSNMVVKSCK CS
Length:412
Mass (Da):47,116
Last modified:February 1, 1996 - v2
Checksum:i24FD7D899090AA9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03491 mRNA. Translation: AAA67915.1.
BC092195 mRNA. Translation: AAH92195.1.
X71903 mRNA. Translation: CAA50722.1.
PIRiA55706.
RefSeqiNP_037306.1. NM_013174.2.
UniGeneiRn.7018.

Genome annotation databases

EnsembliENSRNOT00000013516; ENSRNOP00000013516; ENSRNOG00000009867.
GeneIDi25717.
KEGGirno:25717.
UCSCiRGD:3851. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03491 mRNA. Translation: AAA67915.1 .
BC092195 mRNA. Translation: AAH92195.1 .
X71903 mRNA. Translation: CAA50722.1 .
PIRi A55706.
RefSeqi NP_037306.1. NM_013174.2.
UniGenei Rn.7018.

3D structure databases

ProteinModelPortali Q07258.
SMRi Q07258. Positions 301-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000013516.

Proteomic databases

PaxDbi Q07258.
PRIDEi Q07258.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000013516 ; ENSRNOP00000013516 ; ENSRNOG00000009867 .
GeneIDi 25717.
KEGGi rno:25717.
UCSCi RGD:3851. rat.

Organism-specific databases

CTDi 7043.
RGDi 3851. Tgfb3.

Phylogenomic databases

eggNOGi NOG269146.
GeneTreei ENSGT00760000119112.
HOGENOMi HOG000290198.
HOVERGENi HBG074115.
InParanoidi Q07258.
KOi K13377.
OMAi PEPSVMT.
OrthoDBi EOG70GMFT.
PhylomeDBi Q07258.
TreeFami TF351793.

Enzyme and pathway databases

Reactomei REACT_198592. Molecules associated with elastic fibres.
REACT_198757. ECM proteoglycans.

Miscellaneous databases

NextBioi 607801.
PROi Q07258.

Gene expression databases

Genevestigatori Q07258.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
IPR015618. Transform_grow_fac_b3.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PIRSFi PIRSF001787. TGF-beta. 1 hit.
PRINTSi PR01423. TGFBETA.
PR01426. TGFBETA3.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3."
    Wang J., Kuliszewski M., Yee W., Sedlackova L., Xu J., Tseu I., Post M.
    J. Biol. Chem. 270:2722-2728(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "A role for TGF-beta in oligodendrocyte differentiation."
    McKinnon R.D., Piras G., Ida J., Dubois-Dalq M.
    J. Cell Biol. 121:1397-1407(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 159-213.

Entry informationi

Entry nameiTGFB3_RAT
AccessioniPrimary (citable) accession number: Q07258
Secondary accession number(s): Q56A31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3