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Protein

Transforming growth factor beta-3

Gene

Tgfb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in embryogenesis and cell differentiation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation
R-RNO-2129379 Molecules associated with elastic fibres

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta-3
Short name:
TGF-beta-3
Cleaved into the following chain:
Gene namesi
Name:Tgfb3
Synonyms:Tgf-b3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3851 Tgfb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003380224 – 300Latency-associated peptideBy similarityAdd BLAST277
ChainiPRO_0000033803301 – 412Transforming growth factor beta-3Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi307 ↔ 316By similarity
Disulfide bondi315 ↔ 378By similarity
Disulfide bondi344 ↔ 409By similarity
Disulfide bondi348 ↔ 411By similarity
Disulfide bondi377InterchainBy similarity

Post-translational modificationi

The precursor is cleaved into mature TGF-beta-3 and LAP, which remains non-covalently linked to mature TGF-beta-3 rendering it inactive.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ07258

PTM databases

PhosphoSitePlusiQ07258

Expressioni

Gene expression databases

BgeeiENSRNOG00000009867
GenevisibleiQ07258 RN

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with ASPN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013516

Structurei

3D structure databases

ProteinModelPortaliQ07258
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi261 – 263Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000290198
HOVERGENiHBG074115
InParanoidiQ07258
KOiK13377
OMAiPEPSVMT
OrthoDBiEOG091G0BMM
PhylomeDBiQ07258
TreeFamiTF351793

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR016319 TGF-beta
IPR015615 TGF-beta-rel
IPR015618 TGFB3
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PIRSFiPIRSF001787 TGF-beta, 1 hit
PRINTSiPR01423 TGFBETA
PR01426 TGFBETA3
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMHLQRALV VLALLNLATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK
60 70 80 90 100
LRLTSPPEPS VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQETSESEY
110 120 130 140 150
YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVE KNGTNLFRAE
160 170 180 190 200
FRVLRVPNPS SKRTEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL
210 220 230 240 250
SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE NVHEVMEIKF
260 270 280 290 300
KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDS PGQGGQRKKR
310 320 330 340 350
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY
360 370 380 390 400
LRSSDTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ
410
LSNMVVKSCK CS
Length:412
Mass (Da):47,116
Last modified:February 1, 1996 - v2
Checksum:i24FD7D899090AA9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03491 mRNA Translation: AAA67915.1
BC092195 mRNA Translation: AAH92195.1
X71903 mRNA Translation: CAA50722.1
PIRiA55706
RefSeqiNP_037306.1, NM_013174.2
UniGeneiRn.7018

Genome annotation databases

EnsembliENSRNOT00000013516; ENSRNOP00000013516; ENSRNOG00000009867
GeneIDi25717
KEGGirno:25717
UCSCiRGD:3851 rat

Similar proteinsi

Entry informationi

Entry nameiTGFB3_RAT
AccessioniPrimary (citable) accession number: Q07258
Secondary accession number(s): Q56A31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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