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Protein

Transforming growth factor beta-2

Gene

Tgfb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.
R-RNO-2129379. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta-2
Short name:
TGF-beta-2
Cleaved into the following chain:
Gene namesi
Name:Tgfb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi70491. Tgfb2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003379021 – 330Latency-associated peptideAdd BLAST310
ChainiPRO_0000033791331 – 442Transforming growth factor beta-2Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi337 ↔ 346By similarity
Disulfide bondi345 ↔ 408By similarity
Disulfide bondi374 ↔ 439By similarity
Disulfide bondi378 ↔ 441By similarity
Disulfide bondi407InterchainBy similarity

Post-translational modificationi

The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ07257.
PRIDEiQ07257.

PTM databases

PhosphoSitePlusiQ07257.

Expressioni

Tissue specificityi

Isoform TGF-beta2B expressed in the aorta, primary bronchus, uterus, heart, skeletal muscle, sciatic nerve and spinal cord but not in the intestine.1 Publication

Developmental stagei

High expression at E14. Sharp decline in expression between E16 and E18. Absent in adulthood.1 Publication

Inductioni

Both isoforms down-regulated during muscle development. Up-regulated after denervation.1 Publication

Gene expression databases

BgeeiENSRNOG00000002418.
ExpressionAtlasiQ07257. baseline and differential.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with ASPN and the serine proteases, HTRA1 and HTRA3. Latency-associated peptide interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction. Interacts with MFAP5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003313.

Structurei

3D structure databases

ProteinModelPortaliQ07257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOVERGENiHBG074115.
InParanoidiQ07257.
KOiK13376.
PhylomeDBiQ07257.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_propeptide.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR003940. TGFb2.
IPR017948. TGFb_CS.
PANTHERiPTHR11848. PTHR11848. 1 hit.
PTHR11848:SF141. PTHR11848:SF141. 1 hit.
PfamiView protein in Pfam
PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
PIRSFiPIRSF001787. TGF-beta. 1 hit.
PRINTSiPR01423. TGFBETA.
PR01425. TGFBETA2.
SMARTiView protein in SMART
SM00204. TGFB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform TGF-beta2B (identifier: Q07257-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHYCVLRTFL LLHLVPVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL
60 70 80 90 100
TSPPEDYPEP DEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA
110 120 130 140 150
KEVYKIDMPS HFPSETVCPV VTTSSGSVGS FCSIQSQVLC GYLDAIPPTF
160 170 180 190 200
YRPYFRIVRF DVSTMEKNAS NLVKAEFRVF RLQNPKARVA EQRIELYQIL
210 220 230 240 250
KSKDLTSPTQ RYIDSKVVKT RAEGEWLSFD VTDAVHEWLH HKDRNLGFKI
260 270 280 290 300
SLHCPCCTFI PSNNYIIPNK SQELEARFAG IDGTSTYASG DQKTIKSTRK
310 320 330 340 350
KSSGKTPHLL LMLLPSYRLE SQQSSRRRKR ALDAAYCFRN VQDNCCLRPL
360 370 380 390 400
YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHTK VLSLYNTINP
410 420 430 440
EASASPCCVS QDLEPLTILY YIGNTPKIEQ LSNMIVKSCK CS
Length:442
Mass (Da):50,534
Last modified:May 15, 2002 - v2
Checksum:i69C81A19CE06C253
GO
Isoform TGF-beta2A (identifier: Q07257-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-143: Missing.
     144-144: D → N

Show »
Length:414
Mass (Da):47,728
Checksum:i485DFC04EC0CA291
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99Y → C in CAB42003 (PubMed:11014222).Curated1
Sequence conflicti310L → P in AAD24484 (Ref. 3) Curated1
Sequence conflicti343D → H in CAB42003 (PubMed:11014222).Curated1
Sequence conflicti343D → H in CAA50723 (PubMed:8509457).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006418116 – 143Missing in isoform TGF-beta2A. 3 PublicationsAdd BLAST28
Alternative sequenceiVSP_006419144D → N in isoform TGF-beta2A. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153012 mRNA. Translation: AAD34159.1.
AF153013 mRNA. Translation: AAD34160.1.
AJ132718 mRNA. Translation: CAB42003.1.
AF135598 mRNA. Translation: AAD24484.1.
X71904 mRNA. Translation: CAA50723.1.
M96643 mRNA. Translation: AAA88514.1. Sequence problems.
PIRiA40699.
RefSeqiNP_112393.1. NM_031131.1. [Q07257-1]
XP_006250510.1. XM_006250448.3. [Q07257-2]
UniGeneiRn.24539.

Genome annotation databases

EnsembliENSRNOT00000087023; ENSRNOP00000074059; ENSRNOG00000002418. [Q07257-2]
GeneIDi81809.
KEGGirno:81809.
UCSCiRGD:70491. rat. [Q07257-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTGFB2_RAT
AccessioniPrimary (citable) accession number: Q07257
Secondary accession number(s): Q63574
, Q9QW26, Q9R281, Q9R298, Q9R2B8, Q9WUQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: May 15, 2002
Last modified: November 22, 2017
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families