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Q07243

- MTF1_MOUSE

UniProt

Q07243 - MTF1_MOUSE

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Protein

Metal regulatory transcription factor 1

Gene
Mtf1, Mtf-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 16325C2H2-type 1Add
BLAST
Zinc fingeri169 – 19325C2H2-type 2Add
BLAST
Zinc fingeri199 – 22325C2H2-type 3Add
BLAST
Zinc fingeri228 – 25225C2H2-type 4Add
BLAST
Zinc fingeri258 – 28225C2H2-type 5Add
BLAST
Zinc fingeri288 – 31225C2H2-type 6Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. histone acetyltransferase binding Source: MGI
  3. metal ion binding Source: UniProtKB-KW
  4. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: MGI
  2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  3. response to cadmium ion Source: MGI
  4. response to oxidative stress Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metal regulatory transcription factor 1
Alternative name(s):
MRE-binding transcription factor
Transcription factor MTF-1
Gene namesi
Name:Mtf1
Synonyms:Mtf-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:101786. Mtf1.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 675674Metal regulatory transcription factor 1PRO_0000047221Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine1 Publication
Modified residuei5 – 51Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ07243.

PTM databases

PhosphoSiteiQ07243.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

ArrayExpressiQ07243.
BgeeiQ07243.
GenevestigatoriQ07243.

Interactioni

Protein-protein interaction databases

BioGridi201591. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ07243.
SMRiQ07243. Positions 112-315.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi132 – 1376Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi329 – 40577Asp-rich (acidic)Add
BLAST
Compositional biasi406 – 506101Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00740000114893.
HOGENOMiHOG000059609.
HOVERGENiHBG006412.
InParanoidiQ9JJW8.
OMAiEDTNHSL.
OrthoDBiEOG76T9QH.
TreeFamiTF106493.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07243-1 [UniParc]FASTAAdd to Basket

« Hide

MGEHSPDDNI IFFKGEEDDL TPHDKMLRFV DDNGLVPSSS GTVYDRTTVL    50
IEQDPGTLED DEDDGQCGEP LPFLVEGEEG FLIDQEAMSQ GYVQHIISPD 100
QIHLTINPGS TPMPRNIEGA TLTLQSECPE TKRKEVKRYQ CTFEGCPRTY 150
STAGNLRTHQ KTHRGEYTFV CNQEGCGKAF LTSYSLRIHV RVHTKEKPFE 200
CDVQGCEKAF NTLYRLKAHQ RLHTGKTFNC ESQGCSKYFT TLSDLRKHIR 250
THTGEKPFRC DHDGCGKAFA ASHHLKTHVR THTGERPFFC PSNGCEKTFS 300
TQYSLKSHMK GHDNKGTAYS ALPQHNGSED TNHSLYLSEL GLLSTDSELQ 350
ENSSSTQDQD LSTISPAIIF ESMFQNSDDP GIQDDPLQTA ALIDSFNGDA 400
ESVIDVPPPA GNSASLSLPL VLQSGISEPP QPLLPATAPS APPPAPSLGP 450
GSQPAAFGSP PALLQPPEVP VPHSTQFAAN HQEFLPHPQA PPQTIVPGLS 500
VVAGAPASAA TVASAVAAPA PPQSTTEPLP AMVQTLPLGA NSVLTNNPTI 550
TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEQVYF 600
ATAVPVASGT GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERAAGRR 650
KGCSSPPPPE PNPQPPDGPS LQLPP 675
Length:675
Mass (Da):72,603
Last modified:July 27, 2011 - v2
Checksum:i3FD37F1736D07FC6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti603 – 6031A → T in CAA50470. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71327 mRNA. Translation: CAA50470.1.
AJ251880 Genomic DNA. Translation: CAB71344.1.
AL606933 Genomic DNA. Translation: CAM16099.1.
CH466552 Genomic DNA. Translation: EDL30350.1.
BC017679 mRNA. Translation: AAH17679.1.
CCDSiCCDS18627.1.
PIRiS35335.
RefSeqiNP_032662.3. NM_008636.4.
XP_006502893.1. XM_006502830.1.
XP_006502894.1. XM_006502831.1.
UniGeneiMm.272397.

Genome annotation databases

EnsembliENSMUST00000030723; ENSMUSP00000030723; ENSMUSG00000028890.
ENSMUST00000106193; ENSMUSP00000101799; ENSMUSG00000028890.
GeneIDi17764.
KEGGimmu:17764.
UCSCiuc008urb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71327 mRNA. Translation: CAA50470.1 .
AJ251880 Genomic DNA. Translation: CAB71344.1 .
AL606933 Genomic DNA. Translation: CAM16099.1 .
CH466552 Genomic DNA. Translation: EDL30350.1 .
BC017679 mRNA. Translation: AAH17679.1 .
CCDSi CCDS18627.1.
PIRi S35335.
RefSeqi NP_032662.3. NM_008636.4.
XP_006502893.1. XM_006502830.1.
XP_006502894.1. XM_006502831.1.
UniGenei Mm.272397.

3D structure databases

ProteinModelPortali Q07243.
SMRi Q07243. Positions 112-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201591. 3 interactions.

PTM databases

PhosphoSitei Q07243.

Proteomic databases

PRIDEi Q07243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030723 ; ENSMUSP00000030723 ; ENSMUSG00000028890 .
ENSMUST00000106193 ; ENSMUSP00000101799 ; ENSMUSG00000028890 .
GeneIDi 17764.
KEGGi mmu:17764.
UCSCi uc008urb.2. mouse.

Organism-specific databases

CTDi 4520.
MGIi MGI:101786. Mtf1.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00740000114893.
HOGENOMi HOG000059609.
HOVERGENi HBG006412.
InParanoidi Q9JJW8.
OMAi EDTNHSL.
OrthoDBi EOG76T9QH.
TreeFami TF106493.

Miscellaneous databases

ChiTaRSi MTF1. mouse.
NextBioi 292465.
PROi Q07243.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q07243.
Bgeei Q07243.
Genevestigatori Q07243.

Family and domain databases

Gene3Di 3.30.160.60. 6 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter."
    Radtke F., Heuchel R., Georgiev O., Hergersberg M., Gariglio M., Dembic Z., Schaffner W.
    EMBO J. 12:1355-1362(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Radtke F.
    Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Characterization of the mouse gene for the heavy metal-responsive transcription factor MTF-1."
    Auf der Maur A., Belser T., Wang Y., Gunes C., Lichtlen P., Georgiev O., Schaffner W.
    Cell Stress Chaperones 5:196-206(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMTF1_MOUSE
AccessioniPrimary (citable) accession number: Q07243
Secondary accession number(s): Q9JJW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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