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Q07243 (MTF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metal regulatory transcription factor 1
Alternative name(s):
MRE-binding transcription factor
Transcription factor MTF-1
Gene names
Name:Mtf1
Synonyms:Mtf-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length675 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).

Subcellular location

Nucleus Potential.

Tissue specificity

Ubiquitously expressed. Ref.3

Sequence similarities

Contains 6 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7
Chain2 – 675674Metal regulatory transcription factor 1
PRO_0000047221

Regions

Zinc finger139 – 16325C2H2-type 1
Zinc finger169 – 19325C2H2-type 2
Zinc finger199 – 22325C2H2-type 3
Zinc finger228 – 25225C2H2-type 4
Zinc finger258 – 28225C2H2-type 5
Zinc finger288 – 31225C2H2-type 6
Motif132 – 1376Nuclear localization signal Potential
Compositional bias329 – 40577Asp-rich (acidic)
Compositional bias406 – 506101Pro-rich

Amino acid modifications

Modified residue21N-acetylglycine Ref.7
Modified residue51Phosphoserine Ref.7

Experimental info

Sequence conflict6031A → T in CAA50470. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q07243 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 3FD37F1736D07FC6

FASTA67572,603
        10         20         30         40         50         60 
MGEHSPDDNI IFFKGEEDDL TPHDKMLRFV DDNGLVPSSS GTVYDRTTVL IEQDPGTLED 

        70         80         90        100        110        120 
DEDDGQCGEP LPFLVEGEEG FLIDQEAMSQ GYVQHIISPD QIHLTINPGS TPMPRNIEGA 

       130        140        150        160        170        180 
TLTLQSECPE TKRKEVKRYQ CTFEGCPRTY STAGNLRTHQ KTHRGEYTFV CNQEGCGKAF 

       190        200        210        220        230        240 
LTSYSLRIHV RVHTKEKPFE CDVQGCEKAF NTLYRLKAHQ RLHTGKTFNC ESQGCSKYFT 

       250        260        270        280        290        300 
TLSDLRKHIR THTGEKPFRC DHDGCGKAFA ASHHLKTHVR THTGERPFFC PSNGCEKTFS 

       310        320        330        340        350        360 
TQYSLKSHMK GHDNKGTAYS ALPQHNGSED TNHSLYLSEL GLLSTDSELQ ENSSSTQDQD 

       370        380        390        400        410        420 
LSTISPAIIF ESMFQNSDDP GIQDDPLQTA ALIDSFNGDA ESVIDVPPPA GNSASLSLPL 

       430        440        450        460        470        480 
VLQSGISEPP QPLLPATAPS APPPAPSLGP GSQPAAFGSP PALLQPPEVP VPHSTQFAAN 

       490        500        510        520        530        540 
HQEFLPHPQA PPQTIVPGLS VVAGAPASAA TVASAVAAPA PPQSTTEPLP AMVQTLPLGA 

       550        560        570        580        590        600 
NSVLTNNPTI TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEQVYF 

       610        620        630        640        650        660 
ATAVPVASGT GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERAAGRR KGCSSPPPPE 

       670 
PNPQPPDGPS LQLPP 

« Hide

References

« Hide 'large scale' references
[1]"Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter."
Radtke F., Heuchel R., Georgiev O., Hergersberg M., Gariglio M., Dembic Z., Schaffner W.
EMBO J. 12:1355-1362(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Radtke F.
Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Characterization of the mouse gene for the heavy metal-responsive transcription factor MTF-1."
Auf der Maur A., Belser T., Wang Y., Gunes C., Lichtlen P., Georgiev O., Schaffner W.
Cell Stress Chaperones 5:196-206(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
[7]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X71327 mRNA. Translation: CAA50470.1.
AJ251880 Genomic DNA. Translation: CAB71344.1.
AL606933 Genomic DNA. Translation: CAM16099.1.
CH466552 Genomic DNA. Translation: EDL30350.1.
BC017679 mRNA. Translation: AAH17679.1.
CCDSCCDS18627.1.
PIRS35335.
RefSeqNP_032662.3. NM_008636.4.
XP_006502893.1. XM_006502830.1.
XP_006502894.1. XM_006502831.1.
UniGeneMm.272397.

3D structure databases

ProteinModelPortalQ07243.
SMRQ07243. Positions 112-315.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201591. 3 interactions.

PTM databases

PhosphoSiteQ07243.

Proteomic databases

PRIDEQ07243.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030723; ENSMUSP00000030723; ENSMUSG00000028890.
ENSMUST00000106193; ENSMUSP00000101799; ENSMUSG00000028890.
GeneID17764.
KEGGmmu:17764.
UCSCuc008urb.2. mouse.

Organism-specific databases

CTD4520.
MGIMGI:101786. Mtf1.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00740000114893.
HOGENOMHOG000059609.
HOVERGENHBG006412.
InParanoidQ9JJW8.
OMAEDTNHSL.
OrthoDBEOG76T9QH.
TreeFamTF106493.

Gene expression databases

ArrayExpressQ07243.
BgeeQ07243.
GenevestigatorQ07243.

Family and domain databases

Gene3D3.30.160.60. 6 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMTF1. mouse.
NextBio292465.
PROQ07243.
SOURCESearch...

Entry information

Entry nameMTF1_MOUSE
AccessionPrimary (citable) accession number: Q07243
Secondary accession number(s): Q9JJW8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot