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Q07243

- MTF1_MOUSE

UniProt

Q07243 - MTF1_MOUSE

Protein

Metal regulatory transcription factor 1

Gene

Mtf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri139 – 16325C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri169 – 19325C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri199 – 22325C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25225C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri258 – 28225C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri288 – 31225C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. histone acetyltransferase binding Source: MGI
    3. metal ion binding Source: UniProtKB-KW
    4. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: MGI
    2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    3. response to cadmium ion Source: MGI
    4. response to oxidative stress Source: MGI
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metal regulatory transcription factor 1
    Alternative name(s):
    MRE-binding transcription factor
    Transcription factor MTF-1
    Gene namesi
    Name:Mtf1
    Synonyms:Mtf-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:101786. Mtf1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 675674Metal regulatory transcription factor 1PRO_0000047221Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycine1 Publication
    Modified residuei5 – 51Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ07243.

    PTM databases

    PhosphoSiteiQ07243.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ07243.
    BgeeiQ07243.
    GenevestigatoriQ07243.

    Interactioni

    Protein-protein interaction databases

    BioGridi201591. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07243.
    SMRiQ07243. Positions 112-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi132 – 1376Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi329 – 40577Asp-rich (acidic)Add
    BLAST
    Compositional biasi406 – 506101Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri139 – 16325C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri169 – 19325C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri199 – 22325C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25225C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri258 – 28225C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri288 – 31225C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00740000114893.
    HOGENOMiHOG000059609.
    HOVERGENiHBG006412.
    InParanoidiQ9JJW8.
    OMAiEDTNHSL.
    OrthoDBiEOG76T9QH.
    TreeFamiTF106493.

    Family and domain databases

    Gene3Di3.30.160.60. 6 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 6 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07243-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEHSPDDNI IFFKGEEDDL TPHDKMLRFV DDNGLVPSSS GTVYDRTTVL    50
    IEQDPGTLED DEDDGQCGEP LPFLVEGEEG FLIDQEAMSQ GYVQHIISPD 100
    QIHLTINPGS TPMPRNIEGA TLTLQSECPE TKRKEVKRYQ CTFEGCPRTY 150
    STAGNLRTHQ KTHRGEYTFV CNQEGCGKAF LTSYSLRIHV RVHTKEKPFE 200
    CDVQGCEKAF NTLYRLKAHQ RLHTGKTFNC ESQGCSKYFT TLSDLRKHIR 250
    THTGEKPFRC DHDGCGKAFA ASHHLKTHVR THTGERPFFC PSNGCEKTFS 300
    TQYSLKSHMK GHDNKGTAYS ALPQHNGSED TNHSLYLSEL GLLSTDSELQ 350
    ENSSSTQDQD LSTISPAIIF ESMFQNSDDP GIQDDPLQTA ALIDSFNGDA 400
    ESVIDVPPPA GNSASLSLPL VLQSGISEPP QPLLPATAPS APPPAPSLGP 450
    GSQPAAFGSP PALLQPPEVP VPHSTQFAAN HQEFLPHPQA PPQTIVPGLS 500
    VVAGAPASAA TVASAVAAPA PPQSTTEPLP AMVQTLPLGA NSVLTNNPTI 550
    TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEQVYF 600
    ATAVPVASGT GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERAAGRR 650
    KGCSSPPPPE PNPQPPDGPS LQLPP 675
    Length:675
    Mass (Da):72,603
    Last modified:July 27, 2011 - v2
    Checksum:i3FD37F1736D07FC6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti603 – 6031A → T in CAA50470. (PubMed:8467794)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71327 mRNA. Translation: CAA50470.1.
    AJ251880 Genomic DNA. Translation: CAB71344.1.
    AL606933 Genomic DNA. Translation: CAM16099.1.
    CH466552 Genomic DNA. Translation: EDL30350.1.
    BC017679 mRNA. Translation: AAH17679.1.
    CCDSiCCDS18627.1.
    PIRiS35335.
    RefSeqiNP_032662.3. NM_008636.4.
    XP_006502893.1. XM_006502830.1.
    XP_006502894.1. XM_006502831.1.
    UniGeneiMm.272397.

    Genome annotation databases

    EnsembliENSMUST00000030723; ENSMUSP00000030723; ENSMUSG00000028890.
    ENSMUST00000106193; ENSMUSP00000101799; ENSMUSG00000028890.
    GeneIDi17764.
    KEGGimmu:17764.
    UCSCiuc008urb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71327 mRNA. Translation: CAA50470.1 .
    AJ251880 Genomic DNA. Translation: CAB71344.1 .
    AL606933 Genomic DNA. Translation: CAM16099.1 .
    CH466552 Genomic DNA. Translation: EDL30350.1 .
    BC017679 mRNA. Translation: AAH17679.1 .
    CCDSi CCDS18627.1.
    PIRi S35335.
    RefSeqi NP_032662.3. NM_008636.4.
    XP_006502893.1. XM_006502830.1.
    XP_006502894.1. XM_006502831.1.
    UniGenei Mm.272397.

    3D structure databases

    ProteinModelPortali Q07243.
    SMRi Q07243. Positions 112-315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201591. 3 interactions.

    PTM databases

    PhosphoSitei Q07243.

    Proteomic databases

    PRIDEi Q07243.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030723 ; ENSMUSP00000030723 ; ENSMUSG00000028890 .
    ENSMUST00000106193 ; ENSMUSP00000101799 ; ENSMUSG00000028890 .
    GeneIDi 17764.
    KEGGi mmu:17764.
    UCSCi uc008urb.2. mouse.

    Organism-specific databases

    CTDi 4520.
    MGIi MGI:101786. Mtf1.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00740000114893.
    HOGENOMi HOG000059609.
    HOVERGENi HBG006412.
    InParanoidi Q9JJW8.
    OMAi EDTNHSL.
    OrthoDBi EOG76T9QH.
    TreeFami TF106493.

    Miscellaneous databases

    ChiTaRSi MTF1. mouse.
    NextBioi 292465.
    PROi Q07243.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q07243.
    Bgeei Q07243.
    Genevestigatori Q07243.

    Family and domain databases

    Gene3Di 3.30.160.60. 6 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 6 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter."
      Radtke F., Heuchel R., Georgiev O., Hergersberg M., Gariglio M., Dembic Z., Schaffner W.
      EMBO J. 12:1355-1362(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Radtke F.
      Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Characterization of the mouse gene for the heavy metal-responsive transcription factor MTF-1."
      Auf der Maur A., Belser T., Wang Y., Gunes C., Lichtlen P., Georgiev O., Schaffner W.
      Cell Stress Chaperones 5:196-206(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiMTF1_MOUSE
    AccessioniPrimary (citable) accession number: Q07243
    Secondary accession number(s): Q9JJW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3