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Q07243

- MTF1_MOUSE

UniProt

Q07243 - MTF1_MOUSE

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Protein

Metal regulatory transcription factor 1

Gene

Mtf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 16325C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19325C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22325C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25225C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28225C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31225C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. histone acetyltransferase binding Source: MGI
  3. metal ion binding Source: UniProtKB-KW
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  6. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  7. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: MGI
  2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  3. response to cadmium ion Source: MGI
  4. response to oxidative stress Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metal regulatory transcription factor 1
Alternative name(s):
MRE-binding transcription factor
Transcription factor MTF-1
Gene namesi
Name:Mtf1
Synonyms:Mtf-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:101786. Mtf1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 675674Metal regulatory transcription factor 1PRO_0000047221Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine1 Publication
Modified residuei5 – 51Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ07243.

PTM databases

PhosphoSiteiQ07243.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ07243.
ExpressionAtlasiQ07243. baseline and differential.
GenevestigatoriQ07243.

Interactioni

Protein-protein interaction databases

BioGridi201591. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ07243.
SMRiQ07243. Positions 137-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi132 – 1376Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi329 – 40577Asp-rich (acidic)Add
BLAST
Compositional biasi406 – 506101Pro-richAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 16325C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19325C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22325C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25225C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28225C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31225C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000059609.
HOVERGENiHBG006412.
InParanoidiQ07243.
OMAiEDTNHSL.
OrthoDBiEOG76T9QH.
TreeFamiTF106493.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07243-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEHSPDDNI IFFKGEEDDL TPHDKMLRFV DDNGLVPSSS GTVYDRTTVL
60 70 80 90 100
IEQDPGTLED DEDDGQCGEP LPFLVEGEEG FLIDQEAMSQ GYVQHIISPD
110 120 130 140 150
QIHLTINPGS TPMPRNIEGA TLTLQSECPE TKRKEVKRYQ CTFEGCPRTY
160 170 180 190 200
STAGNLRTHQ KTHRGEYTFV CNQEGCGKAF LTSYSLRIHV RVHTKEKPFE
210 220 230 240 250
CDVQGCEKAF NTLYRLKAHQ RLHTGKTFNC ESQGCSKYFT TLSDLRKHIR
260 270 280 290 300
THTGEKPFRC DHDGCGKAFA ASHHLKTHVR THTGERPFFC PSNGCEKTFS
310 320 330 340 350
TQYSLKSHMK GHDNKGTAYS ALPQHNGSED TNHSLYLSEL GLLSTDSELQ
360 370 380 390 400
ENSSSTQDQD LSTISPAIIF ESMFQNSDDP GIQDDPLQTA ALIDSFNGDA
410 420 430 440 450
ESVIDVPPPA GNSASLSLPL VLQSGISEPP QPLLPATAPS APPPAPSLGP
460 470 480 490 500
GSQPAAFGSP PALLQPPEVP VPHSTQFAAN HQEFLPHPQA PPQTIVPGLS
510 520 530 540 550
VVAGAPASAA TVASAVAAPA PPQSTTEPLP AMVQTLPLGA NSVLTNNPTI
560 570 580 590 600
TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEQVYF
610 620 630 640 650
ATAVPVASGT GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERAAGRR
660 670
KGCSSPPPPE PNPQPPDGPS LQLPP
Length:675
Mass (Da):72,603
Last modified:July 27, 2011 - v2
Checksum:i3FD37F1736D07FC6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti603 – 6031A → T in CAA50470. (PubMed:8467794)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71327 mRNA. Translation: CAA50470.1.
AJ251880 Genomic DNA. Translation: CAB71344.1.
AL606933 Genomic DNA. Translation: CAM16099.1.
CH466552 Genomic DNA. Translation: EDL30350.1.
BC017679 mRNA. Translation: AAH17679.1.
CCDSiCCDS18627.1.
PIRiS35335.
RefSeqiNP_032662.3. NM_008636.4.
XP_006502893.1. XM_006502830.1.
XP_006502894.1. XM_006502831.1.
UniGeneiMm.272397.

Genome annotation databases

EnsembliENSMUST00000030723; ENSMUSP00000030723; ENSMUSG00000028890.
ENSMUST00000106193; ENSMUSP00000101799; ENSMUSG00000028890.
GeneIDi17764.
KEGGimmu:17764.
UCSCiuc008urb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71327 mRNA. Translation: CAA50470.1 .
AJ251880 Genomic DNA. Translation: CAB71344.1 .
AL606933 Genomic DNA. Translation: CAM16099.1 .
CH466552 Genomic DNA. Translation: EDL30350.1 .
BC017679 mRNA. Translation: AAH17679.1 .
CCDSi CCDS18627.1.
PIRi S35335.
RefSeqi NP_032662.3. NM_008636.4.
XP_006502893.1. XM_006502830.1.
XP_006502894.1. XM_006502831.1.
UniGenei Mm.272397.

3D structure databases

ProteinModelPortali Q07243.
SMRi Q07243. Positions 137-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201591. 3 interactions.

PTM databases

PhosphoSitei Q07243.

Proteomic databases

PRIDEi Q07243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030723 ; ENSMUSP00000030723 ; ENSMUSG00000028890 .
ENSMUST00000106193 ; ENSMUSP00000101799 ; ENSMUSG00000028890 .
GeneIDi 17764.
KEGGi mmu:17764.
UCSCi uc008urb.2. mouse.

Organism-specific databases

CTDi 4520.
MGIi MGI:101786. Mtf1.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118771.
HOGENOMi HOG000059609.
HOVERGENi HBG006412.
InParanoidi Q07243.
OMAi EDTNHSL.
OrthoDBi EOG76T9QH.
TreeFami TF106493.

Miscellaneous databases

ChiTaRSi Mtf1. mouse.
NextBioi 292465.
PROi Q07243.
SOURCEi Search...

Gene expression databases

Bgeei Q07243.
ExpressionAtlasi Q07243. baseline and differential.
Genevestigatori Q07243.

Family and domain databases

Gene3Di 3.30.160.60. 6 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter."
    Radtke F., Heuchel R., Georgiev O., Hergersberg M., Gariglio M., Dembic Z., Schaffner W.
    EMBO J. 12:1355-1362(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Radtke F.
    Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Characterization of the mouse gene for the heavy metal-responsive transcription factor MTF-1."
    Auf der Maur A., Belser T., Wang Y., Gunes C., Lichtlen P., Georgiev O., Schaffner W.
    Cell Stress Chaperones 5:196-206(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMTF1_MOUSE
AccessioniPrimary (citable) accession number: Q07243
Secondary accession number(s): Q9JJW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3