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Q07235

- GDN_MOUSE

UniProt

Q07235 - GDN_MOUSE

Protein

Glia-derived nexin

Gene

Serpine2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei364 – 3652Reactive bondBy similarity

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. receptor binding Source: MGI
    3. serine-type endopeptidase inhibitor activity Source: BHF-UCL

    GO - Biological processi

    1. blood coagulation Source: MGI
    2. cerebellar granular layer morphogenesis Source: MGI
    3. detection of mechanical stimulus involved in sensory perception Source: MGI
    4. innervation Source: MGI
    5. long-term synaptic potentiation Source: MGI
    6. mating plug formation Source: MGI
    7. negative regulation of cell growth Source: MGI
    8. negative regulation of cell proliferation Source: MGI
    9. negative regulation of endopeptidase activity Source: GOC
    10. negative regulation of peptidase activity Source: MGI
    11. negative regulation of phosphatidylinositol 3-kinase signaling Source: MGI
    12. negative regulation of plasminogen activation Source: BHF-UCL
    13. negative regulation of platelet activation Source: BHF-UCL
    14. negative regulation of platelet aggregation Source: BHF-UCL
    15. negative regulation of protein catabolic process Source: MGI
    16. negative regulation of protein processing Source: BHF-UCL
    17. negative regulation of proteolysis Source: Ensembl
    18. negative regulation of smoothened signaling pathway Source: MGI
    19. negative regulation of sodium ion transport Source: MGI
    20. positive regulation of astrocyte differentiation Source: Ensembl
    21. regulation of synaptic transmission, glutamatergic Source: MGI
    22. regulation of timing of cell differentiation Source: MGI
    23. response to wounding Source: MGI
    24. secretion by cell Source: MGI
    25. secretory granule organization Source: MGI
    26. seminal vesicle epithelium development Source: MGI

    Keywords - Molecular functioni

    Developmental protein, Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Keywords - Ligandi

    Heparin-binding

    Protein family/group databases

    MEROPSiI04.021.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glia-derived nexin
    Short name:
    GDN
    Alternative name(s):
    Peptidase inhibitor 7
    Short name:
    PI-7
    Protease nexin 1
    Short name:
    PN-1
    Protease nexin I
    Serine protease-inhibitor 4
    Serpin E2
    Gene namesi
    Name:Serpine2
    Synonyms:Pi7, Pn1, Spi4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:101780. Serpine2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. extracellular matrix Source: Ensembl
    3. extracellular region Source: BHF-UCL
    4. extracellular space Source: RefGenome
    5. extrinsic component of external side of plasma membrane Source: Ensembl
    6. neuromuscular junction Source: BHF-UCL
    7. platelet alpha granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 397378Glia-derived nexinPRO_0000032505Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ07235.
    PaxDbiQ07235.
    PRIDEiQ07235.

    PTM databases

    PhosphoSiteiQ07235.

    Expressioni

    Tissue specificityi

    Most abundant in seminal vesicles.

    Gene expression databases

    ArrayExpressiQ07235.
    BgeeiQ07235.
    GenevestigatoriQ07235.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07235.
    SMRiQ07235. Positions 21-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG106493.
    InParanoidiQ07235.
    KOiK16643.
    OMAiIQVFNQI.
    OrthoDBiEOG7327PB.
    PhylomeDBiQ07235.
    TreeFamiTF352620.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07235-1 [UniParc]FASTAAdd to Basket

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    MNWHFPFFIL TTVTLYSVHS QFNSLSLEEL GSNTGIQVFN QIIKSRPHEN    50
    VVVSPHGIAS ILGMLQLGAD GKTKKQLSTV MRYNVNGVGK VLKKINKAIV 100
    SKKNKDIVTV ANAVFLRNGF KMEVPFAVRN KDVFQCEVQN VNFQDPASAS 150
    ESINFWVKNE TRGMIDNLLS PNLIDGALTR LVLVNAVYFK GLWKSRFQPE 200
    STKKRTFVAG DGKSYQVPML AQLSVFRSGS TRTPNGLWYN FIELPYHGES 250
    ISMLIALPTE SSTPLSAIIP HITTKTIDSW MNTMVPKRMQ LVLPKFTAVA 300
    QTDLKEPLKA LGITEMFEPS KANFTKITRS ESLHVSHILQ KAKIEVSEDG 350
    TKASAATTAI LIARSSPPWF IVDRPFLFSI RHNPTGAILF LGQVNKP 397
    Length:397
    Mass (Da):44,207
    Last modified:February 1, 1996 - v2
    Checksum:iB8EBAE3CA899D4A5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti313 – 3131I → V in AAH10675. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70296 mRNA. Translation: CAA49777.1.
    BC010675 mRNA. Translation: AAH10675.1.
    X70946 Genomic DNA. Translation: CAA50285.1.
    CCDSiCCDS15092.1.
    PIRiI48717.
    RefSeqiNP_033281.1. NM_009255.4.
    XP_006496522.1. XM_006496459.1.
    XP_006496523.1. XM_006496460.1.
    UniGeneiMm.3093.

    Genome annotation databases

    EnsembliENSMUST00000027467; ENSMUSP00000027467; ENSMUSG00000026249.
    GeneIDi20720.
    KEGGimmu:20720.
    UCSCiuc007bqz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70296 mRNA. Translation: CAA49777.1 .
    BC010675 mRNA. Translation: AAH10675.1 .
    X70946 Genomic DNA. Translation: CAA50285.1 .
    CCDSi CCDS15092.1.
    PIRi I48717.
    RefSeqi NP_033281.1. NM_009255.4.
    XP_006496522.1. XM_006496459.1.
    XP_006496523.1. XM_006496460.1.
    UniGenei Mm.3093.

    3D structure databases

    ProteinModelPortali Q07235.
    SMRi Q07235. Positions 21-397.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.021.

    PTM databases

    PhosphoSitei Q07235.

    Proteomic databases

    MaxQBi Q07235.
    PaxDbi Q07235.
    PRIDEi Q07235.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027467 ; ENSMUSP00000027467 ; ENSMUSG00000026249 .
    GeneIDi 20720.
    KEGGi mmu:20720.
    UCSCi uc007bqz.2. mouse.

    Organism-specific databases

    CTDi 5270.
    MGIi MGI:101780. Serpine2.

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG106493.
    InParanoidi Q07235.
    KOi K16643.
    OMAi IQVFNQI.
    OrthoDBi EOG7327PB.
    PhylomeDBi Q07235.
    TreeFami TF352620.

    Miscellaneous databases

    ChiTaRSi SERPINE2. mouse.
    NextBioi 299317.
    PROi Q07235.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q07235.
    Bgeei Q07235.
    Genevestigatori Q07235.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Belin D.
      Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Protease-nexin I as an androgen-dependent secretory product of the murine seminal vesicle."
      Vassalli J.-D., Huarte J., Bosco D., Sappino A.P., Sappino N., Velardi A., Wohlwend A., Erno H., Monard D., Belin D.
      EMBO J. 12:1871-1878(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-366.
      Strain: BALB/c.

    Entry informationi

    Entry nameiGDN_MOUSE
    AccessioniPrimary (citable) accession number: Q07235
    Secondary accession number(s): Q921T7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3