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Protein

Glia-derived nexin

Gene

Serpine2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei364 – 3652Reactive bondBy similarity

GO - Molecular functioni

  • glycosaminoglycan binding Source: MGI
  • heparin binding Source: MGI
  • receptor binding Source: MGI
  • serine-type endopeptidase inhibitor activity Source: BHF-UCL

GO - Biological processi

  • blood coagulation Source: MGI
  • cerebellar granular layer morphogenesis Source: MGI
  • dense core granule biogenesis Source: Ensembl
  • detection of mechanical stimulus involved in sensory perception Source: MGI
  • embryo implantation Source: Ensembl
  • innervation Source: MGI
  • long-term synaptic potentiation Source: MGI
  • mating plug formation Source: MGI
  • negative regulation of blood coagulation Source: MGI
  • negative regulation of cell growth Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of endopeptidase activity Source: GOC
  • negative regulation of peptidase activity Source: MGI
  • negative regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  • negative regulation of plasminogen activation Source: BHF-UCL
  • negative regulation of platelet activation Source: BHF-UCL
  • negative regulation of platelet aggregation Source: BHF-UCL
  • negative regulation of protein catabolic process Source: MGI
  • negative regulation of protein processing Source: BHF-UCL
  • negative regulation of proteolysis Source: MGI
  • negative regulation of smoothened signaling pathway Source: MGI
  • negative regulation of sodium ion transport Source: MGI
  • positive regulation of astrocyte differentiation Source: MGI
  • positive regulation of neuron projection development Source: Ensembl
  • regulation of synaptic transmission, glutamatergic Source: MGI
  • regulation of timing of cell differentiation Source: MGI
  • response to radiation Source: Ensembl
  • response to wounding Source: MGI
  • secretion by cell Source: MGI
  • secretory granule organization Source: MGI
  • seminal vesicle epithelium development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_286713. Common Pathway of Fibrin Clot Formation.
REACT_340184. Intrinsic Pathway of Fibrin Clot Formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glia-derived nexin
Short name:
GDN
Alternative name(s):
Peptidase inhibitor 7
Short name:
PI-7
Protease nexin 1
Short name:
PN-1
Protease nexin I
Serine protease-inhibitor 4
Serpin E2
Gene namesi
Name:Serpine2
Synonyms:Pi7, Pn1, Spi4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:101780. Serpine2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 397378Glia-derived nexinPRO_0000032505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ07235.
PaxDbiQ07235.
PRIDEiQ07235.

PTM databases

PhosphoSiteiQ07235.

Expressioni

Tissue specificityi

Most abundant in seminal vesicles.

Gene expression databases

BgeeiQ07235.
ExpressionAtlasiQ07235. baseline and differential.
GenevisibleiQ07235. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027467.

Structurei

3D structure databases

ProteinModelPortaliQ07235.
SMRiQ07235. Positions 21-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG106493.
InParanoidiQ07235.
KOiK16643.
OMAiTGIQVFN.
OrthoDBiEOG7327PB.
PhylomeDBiQ07235.
TreeFamiTF352620.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWHFPFFIL TTVTLYSVHS QFNSLSLEEL GSNTGIQVFN QIIKSRPHEN
60 70 80 90 100
VVVSPHGIAS ILGMLQLGAD GKTKKQLSTV MRYNVNGVGK VLKKINKAIV
110 120 130 140 150
SKKNKDIVTV ANAVFLRNGF KMEVPFAVRN KDVFQCEVQN VNFQDPASAS
160 170 180 190 200
ESINFWVKNE TRGMIDNLLS PNLIDGALTR LVLVNAVYFK GLWKSRFQPE
210 220 230 240 250
STKKRTFVAG DGKSYQVPML AQLSVFRSGS TRTPNGLWYN FIELPYHGES
260 270 280 290 300
ISMLIALPTE SSTPLSAIIP HITTKTIDSW MNTMVPKRMQ LVLPKFTAVA
310 320 330 340 350
QTDLKEPLKA LGITEMFEPS KANFTKITRS ESLHVSHILQ KAKIEVSEDG
360 370 380 390
TKASAATTAI LIARSSPPWF IVDRPFLFSI RHNPTGAILF LGQVNKP
Length:397
Mass (Da):44,207
Last modified:February 1, 1996 - v2
Checksum:iB8EBAE3CA899D4A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti313 – 3131I → V in AAH10675 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70296 mRNA. Translation: CAA49777.1.
BC010675 mRNA. Translation: AAH10675.1.
X70946 Genomic DNA. Translation: CAA50285.1.
CCDSiCCDS15092.1.
PIRiI48717.
RefSeqiNP_033281.1. NM_009255.4.
XP_006496522.1. XM_006496459.2.
XP_006496523.1. XM_006496460.2.
UniGeneiMm.3093.

Genome annotation databases

EnsembliENSMUST00000027467; ENSMUSP00000027467; ENSMUSG00000026249.
GeneIDi20720.
KEGGimmu:20720.
UCSCiuc007bqz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70296 mRNA. Translation: CAA49777.1.
BC010675 mRNA. Translation: AAH10675.1.
X70946 Genomic DNA. Translation: CAA50285.1.
CCDSiCCDS15092.1.
PIRiI48717.
RefSeqiNP_033281.1. NM_009255.4.
XP_006496522.1. XM_006496459.2.
XP_006496523.1. XM_006496460.2.
UniGeneiMm.3093.

3D structure databases

ProteinModelPortaliQ07235.
SMRiQ07235. Positions 21-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027467.

PTM databases

PhosphoSiteiQ07235.

Proteomic databases

MaxQBiQ07235.
PaxDbiQ07235.
PRIDEiQ07235.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027467; ENSMUSP00000027467; ENSMUSG00000026249.
GeneIDi20720.
KEGGimmu:20720.
UCSCiuc007bqz.2. mouse.

Organism-specific databases

CTDi5270.
MGIiMGI:101780. Serpine2.

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG106493.
InParanoidiQ07235.
KOiK16643.
OMAiTGIQVFN.
OrthoDBiEOG7327PB.
PhylomeDBiQ07235.
TreeFamiTF352620.

Enzyme and pathway databases

ReactomeiREACT_286713. Common Pathway of Fibrin Clot Formation.
REACT_340184. Intrinsic Pathway of Fibrin Clot Formation.

Miscellaneous databases

ChiTaRSiSerpine2. mouse.
NextBioi299317.
PROiQ07235.
SOURCEiSearch...

Gene expression databases

BgeeiQ07235.
ExpressionAtlasiQ07235. baseline and differential.
GenevisibleiQ07235. MM.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Belin D.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Protease-nexin I as an androgen-dependent secretory product of the murine seminal vesicle."
    Vassalli J.-D., Huarte J., Bosco D., Sappino A.P., Sappino N., Velardi A., Wohlwend A., Erno H., Monard D., Belin D.
    EMBO J. 12:1871-1878(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-366.
    Strain: BALB/c.

Entry informationi

Entry nameiGDN_MOUSE
AccessioniPrimary (citable) accession number: Q07235
Secondary accession number(s): Q921T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 1, 1996
Last modified: July 22, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.