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Q07235 (GDN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glia-derived nexin

Short name=GDN
Alternative name(s):
Peptidase inhibitor 7
Short name=PI-7
Protease nexin 1
Short name=PN-1
Protease nexin I
Serine protease-inhibitor 4
Serpin E2
Gene names
Name:Serpine2
Synonyms:Pi7, Pn1, Spi4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Subcellular location

Secretedextracellular space.

Tissue specificity

Most abundant in seminal vesicles.

Sequence similarities

Belongs to the serpin family.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentSecreted
   DomainSignal
   LigandHeparin-binding
   Molecular functionDevelopmental protein
Protease inhibitor
Serine protease inhibitor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood coagulation

Inferred from mutant phenotype PubMed 19855083. Source: MGI

cerebellar granular layer morphogenesis

Inferred from mutant phenotype PubMed 17409116. Source: MGI

detection of mechanical stimulus involved in sensory perception

Inferred from mutant phenotype PubMed 15509762. Source: MGI

innervation

Inferred from mutant phenotype PubMed 17409231. Source: MGI

long-term synaptic potentiation

Inferred from mutant phenotype PubMed 9169529. Source: MGI

mating plug formation

Inferred from mutant phenotype PubMed 11248026. Source: MGI

negative regulation of cell growth

Inferred from genetic interaction PubMed 18398001. Source: MGI

negative regulation of cell proliferation

Inferred from genetic interaction PubMed 18398001. Source: MGI

negative regulation of endopeptidase activity

Inferred from mutant phenotype PubMed 11248026PubMed 19855083. Source: GOC

negative regulation of peptidase activity

Inferred from mutant phenotype PubMed 15509762PubMed 18398001. Source: MGI

negative regulation of phosphatidylinositol 3-kinase signaling

Inferred from genetic interaction PubMed 18398001. Source: MGI

negative regulation of plasminogen activation

Inferred from mutant phenotype PubMed 19855083. Source: BHF-UCL

negative regulation of platelet activation

Inferred from mutant phenotype PubMed 19855083. Source: BHF-UCL

negative regulation of platelet aggregation

Inferred from mutant phenotype PubMed 19855083. Source: BHF-UCL

negative regulation of protein catabolic process

Inferred from mutant phenotype PubMed 15509762PubMed 16319172. Source: MGI

negative regulation of protein processing

Inferred by curator PubMed 19855083. Source: BHF-UCL

negative regulation of proteolysis

Inferred from electronic annotation. Source: Ensembl

negative regulation of smoothened signaling pathway

Inferred from genetic interaction PubMed 17409116. Source: MGI

negative regulation of sodium ion transport

Inferred from mutant phenotype PubMed 16941024. Source: MGI

positive regulation of astrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of synaptic transmission, glutamatergic

Inferred from mutant phenotype PubMed 15509762. Source: MGI

regulation of timing of cell differentiation

Inferred from mutant phenotype PubMed 17409116. Source: MGI

response to wounding

Inferred from mutant phenotype PubMed 17409231. Source: MGI

secretion by cell

Inferred from mutant phenotype PubMed 16319172. Source: MGI

secretory granule organization

Inferred from mutant phenotype PubMed 16319172. Source: MGI

seminal vesicle epithelium development

Inferred from mutant phenotype PubMed 11248026. Source: MGI

   Cellular_componentcytosol

Inferred from electronic annotation. Source: Ensembl

extracellular matrix

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from direct assay PubMed 2037625. Source: BHF-UCL

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

extrinsic component of external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

neuromuscular junction

Inferred from direct assay PubMed 2037625. Source: BHF-UCL

platelet alpha granule

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

receptor binding

Inferred from genetic interaction PubMed 17409116. Source: MGI

serine-type endopeptidase inhibitor activity

Inferred from mutant phenotype PubMed 19855083. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 397378Glia-derived nexin
PRO_0000032505

Sites

Site364 – 3652Reactive bond By similarity

Amino acid modifications

Glycosylation1591N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3131I → V in AAH10675. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q07235 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: B8EBAE3CA899D4A5

FASTA39744,207
        10         20         30         40         50         60 
MNWHFPFFIL TTVTLYSVHS QFNSLSLEEL GSNTGIQVFN QIIKSRPHEN VVVSPHGIAS 

        70         80         90        100        110        120 
ILGMLQLGAD GKTKKQLSTV MRYNVNGVGK VLKKINKAIV SKKNKDIVTV ANAVFLRNGF 

       130        140        150        160        170        180 
KMEVPFAVRN KDVFQCEVQN VNFQDPASAS ESINFWVKNE TRGMIDNLLS PNLIDGALTR 

       190        200        210        220        230        240 
LVLVNAVYFK GLWKSRFQPE STKKRTFVAG DGKSYQVPML AQLSVFRSGS TRTPNGLWYN 

       250        260        270        280        290        300 
FIELPYHGES ISMLIALPTE SSTPLSAIIP HITTKTIDSW MNTMVPKRMQ LVLPKFTAVA 

       310        320        330        340        350        360 
QTDLKEPLKA LGITEMFEPS KANFTKITRS ESLHVSHILQ KAKIEVSEDG TKASAATTAI 

       370        380        390 
LIARSSPPWF IVDRPFLFSI RHNPTGAILF LGQVNKP 

« Hide

References

« Hide 'large scale' references
[1]Belin D.
Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Protease-nexin I as an androgen-dependent secretory product of the murine seminal vesicle."
Vassalli J.-D., Huarte J., Bosco D., Sappino A.P., Sappino N., Velardi A., Wohlwend A., Erno H., Monard D., Belin D.
EMBO J. 12:1871-1878(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-366.
Strain: BALB/c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X70296 mRNA. Translation: CAA49777.1.
BC010675 mRNA. Translation: AAH10675.1.
X70946 Genomic DNA. Translation: CAA50285.1.
CCDSCCDS15092.1.
PIRI48717.
RefSeqNP_033281.1. NM_009255.4.
XP_006496522.1. XM_006496459.1.
XP_006496523.1. XM_006496460.1.
UniGeneMm.3093.

3D structure databases

ProteinModelPortalQ07235.
SMRQ07235. Positions 21-397.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI04.021.

PTM databases

PhosphoSiteQ07235.

Proteomic databases

MaxQBQ07235.
PaxDbQ07235.
PRIDEQ07235.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027467; ENSMUSP00000027467; ENSMUSG00000026249.
GeneID20720.
KEGGmmu:20720.
UCSCuc007bqz.2. mouse.

Organism-specific databases

CTD5270.
MGIMGI:101780. Serpine2.

Phylogenomic databases

eggNOGCOG4826.
HOGENOMHOG000238519.
HOVERGENHBG106493.
InParanoidQ07235.
KOK16643.
OMAIQVFNQI.
OrthoDBEOG7327PB.
PhylomeDBQ07235.
TreeFamTF352620.

Gene expression databases

ArrayExpressQ07235.
BgeeQ07235.
GenevestigatorQ07235.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSERPINE2. mouse.
NextBio299317.
PROQ07235.
SOURCESearch...

Entry information

Entry nameGDN_MOUSE
AccessionPrimary (citable) accession number: Q07235
Secondary accession number(s): Q921T7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot