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Q07235

- GDN_MOUSE

UniProt

Q07235 - GDN_MOUSE

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Protein
Glia-derived nexin
Gene
Serpine2, Pi7, Pn1, Spi4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei364 – 3652Reactive bond By similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. receptor binding Source: MGI
  3. serine-type endopeptidase inhibitor activity Source: BHF-UCL

GO - Biological processi

  1. blood coagulation Source: MGI
  2. cerebellar granular layer morphogenesis Source: MGI
  3. detection of mechanical stimulus involved in sensory perception Source: MGI
  4. innervation Source: MGI
  5. long-term synaptic potentiation Source: MGI
  6. mating plug formation Source: MGI
  7. negative regulation of cell growth Source: MGI
  8. negative regulation of cell proliferation Source: MGI
  9. negative regulation of endopeptidase activity Source: GOC
  10. negative regulation of peptidase activity Source: MGI
  11. negative regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  12. negative regulation of plasminogen activation Source: BHF-UCL
  13. negative regulation of platelet activation Source: BHF-UCL
  14. negative regulation of platelet aggregation Source: BHF-UCL
  15. negative regulation of protein catabolic process Source: MGI
  16. negative regulation of protein processing Source: BHF-UCL
  17. negative regulation of proteolysis Source: Ensembl
  18. negative regulation of smoothened signaling pathway Source: MGI
  19. negative regulation of sodium ion transport Source: MGI
  20. positive regulation of astrocyte differentiation Source: Ensembl
  21. regulation of synaptic transmission, glutamatergic Source: MGI
  22. regulation of timing of cell differentiation Source: MGI
  23. response to wounding Source: MGI
  24. secretion by cell Source: MGI
  25. secretory granule organization Source: MGI
  26. seminal vesicle epithelium development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI04.021.

Names & Taxonomyi

Protein namesi
Recommended name:
Glia-derived nexin
Short name:
GDN
Alternative name(s):
Peptidase inhibitor 7
Short name:
PI-7
Protease nexin 1
Short name:
PN-1
Protease nexin I
Serine protease-inhibitor 4
Serpin E2
Gene namesi
Name:Serpine2
Synonyms:Pi7, Pn1, Spi4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:101780. Serpine2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extracellular matrix Source: Ensembl
  3. extracellular region Source: BHF-UCL
  4. extracellular space Source: RefGenome
  5. extrinsic component of external side of plasma membrane Source: Ensembl
  6. neuromuscular junction Source: BHF-UCL
  7. platelet alpha granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarity
Add
BLAST
Chaini20 – 397378Glia-derived nexin
PRO_0000032505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi159 – 1591N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ07235.
PaxDbiQ07235.
PRIDEiQ07235.

PTM databases

PhosphoSiteiQ07235.

Expressioni

Tissue specificityi

Most abundant in seminal vesicles.

Gene expression databases

ArrayExpressiQ07235.
BgeeiQ07235.
GenevestigatoriQ07235.

Structurei

3D structure databases

ProteinModelPortaliQ07235.
SMRiQ07235. Positions 21-397.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238519.
HOVERGENiHBG106493.
InParanoidiQ07235.
KOiK16643.
OMAiIQVFNQI.
OrthoDBiEOG7327PB.
PhylomeDBiQ07235.
TreeFamiTF352620.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07235-1 [UniParc]FASTAAdd to Basket

« Hide

MNWHFPFFIL TTVTLYSVHS QFNSLSLEEL GSNTGIQVFN QIIKSRPHEN    50
VVVSPHGIAS ILGMLQLGAD GKTKKQLSTV MRYNVNGVGK VLKKINKAIV 100
SKKNKDIVTV ANAVFLRNGF KMEVPFAVRN KDVFQCEVQN VNFQDPASAS 150
ESINFWVKNE TRGMIDNLLS PNLIDGALTR LVLVNAVYFK GLWKSRFQPE 200
STKKRTFVAG DGKSYQVPML AQLSVFRSGS TRTPNGLWYN FIELPYHGES 250
ISMLIALPTE SSTPLSAIIP HITTKTIDSW MNTMVPKRMQ LVLPKFTAVA 300
QTDLKEPLKA LGITEMFEPS KANFTKITRS ESLHVSHILQ KAKIEVSEDG 350
TKASAATTAI LIARSSPPWF IVDRPFLFSI RHNPTGAILF LGQVNKP 397
Length:397
Mass (Da):44,207
Last modified:February 1, 1996 - v2
Checksum:iB8EBAE3CA899D4A5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti313 – 3131I → V in AAH10675. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70296 mRNA. Translation: CAA49777.1.
BC010675 mRNA. Translation: AAH10675.1.
X70946 Genomic DNA. Translation: CAA50285.1.
CCDSiCCDS15092.1.
PIRiI48717.
RefSeqiNP_033281.1. NM_009255.4.
XP_006496522.1. XM_006496459.1.
XP_006496523.1. XM_006496460.1.
UniGeneiMm.3093.

Genome annotation databases

EnsembliENSMUST00000027467; ENSMUSP00000027467; ENSMUSG00000026249.
GeneIDi20720.
KEGGimmu:20720.
UCSCiuc007bqz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70296 mRNA. Translation: CAA49777.1 .
BC010675 mRNA. Translation: AAH10675.1 .
X70946 Genomic DNA. Translation: CAA50285.1 .
CCDSi CCDS15092.1.
PIRi I48717.
RefSeqi NP_033281.1. NM_009255.4.
XP_006496522.1. XM_006496459.1.
XP_006496523.1. XM_006496460.1.
UniGenei Mm.3093.

3D structure databases

ProteinModelPortali Q07235.
SMRi Q07235. Positions 21-397.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I04.021.

PTM databases

PhosphoSitei Q07235.

Proteomic databases

MaxQBi Q07235.
PaxDbi Q07235.
PRIDEi Q07235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027467 ; ENSMUSP00000027467 ; ENSMUSG00000026249 .
GeneIDi 20720.
KEGGi mmu:20720.
UCSCi uc007bqz.2. mouse.

Organism-specific databases

CTDi 5270.
MGIi MGI:101780. Serpine2.

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238519.
HOVERGENi HBG106493.
InParanoidi Q07235.
KOi K16643.
OMAi IQVFNQI.
OrthoDBi EOG7327PB.
PhylomeDBi Q07235.
TreeFami TF352620.

Miscellaneous databases

ChiTaRSi SERPINE2. mouse.
NextBioi 299317.
PROi Q07235.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q07235.
Bgeei Q07235.
Genevestigatori Q07235.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Belin D.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Protease-nexin I as an androgen-dependent secretory product of the murine seminal vesicle."
    Vassalli J.-D., Huarte J., Bosco D., Sappino A.P., Sappino N., Velardi A., Wohlwend A., Erno H., Monard D., Belin D.
    EMBO J. 12:1871-1878(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-366.
    Strain: BALB/c.

Entry informationi

Entry nameiGDN_MOUSE
AccessioniPrimary (citable) accession number: Q07235
Secondary accession number(s): Q921T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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