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Protein

Zinc finger and SCAN domain-containing protein 21

Gene

Zscan21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Strong transcriptional activator. Associated with meiosis in both male and female gametogenesis. May have different functions in somatic cells.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri359 – 381C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri387 – 409C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 436C2H2-type 3PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri442 – 464C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Oogenesis, Spermatogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 21
Alternative name(s):
CtFIN51
Transcription factor RU49
Zinc finger protein 38
Short name:
Zfp-38
Gene namesi
Name:Zscan21
Synonyms:Zfp-38, Zfp38, Zipro1, Znf38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:99182 Zscan21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472961 – 555Zinc finger and SCAN domain-containing protein 21Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki302Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki313Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki431Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ07231
PaxDbiQ07231
PeptideAtlasiQ07231
PRIDEiQ07231

PTM databases

iPTMnetiQ07231
PhosphoSitePlusiQ07231

Expressioni

Tissue specificityi

Expressed predominantly in the spermatocytes and spermatids of adult testes. It is also present at lower levels in the ovary, brain, spleen, embryo and fetus.

Developmental stagei

First detected between 2 and 3 weeks after birth, in parallel with the onset and progression of meiosis. It is expressed during oogenesis from the pachytene stage of meiotic prophase through to postmeiotic cells.

Gene expression databases

BgeeiENSMUSG00000037017
CleanExiMM_ZSCAN21
ExpressionAtlasiQ07231 baseline and differential
GenevisibleiQ07231 MM

Interactioni

Protein-protein interaction databases

BioGridi2046601 interactor.
STRINGi10090.ENSMUSP00000053430

Structurei

3D structure databases

ProteinModelPortaliQ07231
SMRiQ07231
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 561-1Add BLAST39
Repeati57 – 951-2Add BLAST39
Repeati96 – 1341-3Add BLAST39
Domaini122 – 204SCAN boxPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 1343 X 39 AA approximate tandem repeatsAdd BLAST117

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri359 – 381C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri387 – 409C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 436C2H2-type 3PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri442 – 464C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ07231
KOiK09230
OMAiKPYWCNH
OrthoDBiEOG091G02KC
TreeFamiTF338304

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.101 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequencei

Sequence statusi: Complete.

Q07231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVVGMATV LGPRPPQESM GPSPIKVEED EEKDKCCPTL ELSHKHFRQS
60 70 80 90 100
GNQDTLEPMG PSTIKAEEDE SKDKCRPNLE ISRKSFKQFG YQDTLEQLGP
110 120 130 140 150
STIKAEEDDE KDKGHPSPEI SRQRFRQFGY HDTPGPREAL SQLRVLCCEW
160 170 180 190 200
LQPEIHTKEQ ILELLVLEQF LTILPRELQT WVQQHCPESA EEAVTLLEDL
210 220 230 240 250
EQELDEPGLQ VSSPPNEQKQ SWEKMSTSGT AMESLSSTET QHVDASPKYE
260 270 280 290 300
FWGPLYIQET GEEEVFTQDP RKRQGFKSNP QKEDSADEHR SSEEESHADG
310 320 330 340 350
LKRTVIPMIP ANKYGSRSER QWANNLERER GTKASLQDTG SRKGAEPAST
360 370 380 390 400
RPAPGEKRYI CAECGKAFSN SSNLTKHRRT HTGEKPYVCT KCGKAFSHSS
410 420 430 440 450
NLTLHYRTHL VDRPYDCKCG KAFGQSSDLL KHQRMHTEEA PYQCKDCGKA
460 470 480 490 500
FSGKGSLIRH YRIHTGEKPY QCNECGKSFS QHAGLSSHQR LHTGEKPYKC
510 520 530 540 550
KECGKAFNHS SNFNKHHRIH TGEKPYWCSH CGKTFCSKSN LSKHQRVHTG

EGEVQ
Length:555
Mass (Da):63,012
Last modified:July 27, 2011 - v2
Checksum:i39321721BBE3687D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193A → T in BAA01480 (PubMed:1397691).Curated1
Sequence conflicti216N → S in AAB03786 (PubMed:8625807).Curated1
Sequence conflicti234S → P in AAB03786 (PubMed:8625807).Curated1
Sequence conflicti334 – 347ASLQD…KGAEP → PLFKTQVPGRGRA in AAB03786 (PubMed:8625807).CuratedAdd BLAST14
Sequence conflicti401 – 402NL → KV in AAB03786 (PubMed:8625807).Curated2
Sequence conflicti478S → E in AAB03786 (PubMed:8625807).Curated1
Sequence conflicti495E → K in CAA45280 (PubMed:1284028).Curated1
Sequence conflicti507F → L in CAA45280 (PubMed:1284028).Curated1
Sequence conflicti510S → N in CAA45280 (PubMed:1284028).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10630 mRNA Translation: BAA01480.1
X63747 mRNA Translation: CAA45280.1
U41671 mRNA Translation: AAB03786.1
AK146875 mRNA Translation: BAE27498.1
CH466529 Genomic DNA Translation: EDL19218.1
BC010591 mRNA Translation: AAH10591.1
CCDSiCCDS19790.1
PIRiA56560
RefSeqiNP_001038168.1, NM_001044703.2
NP_001038169.1, NM_001044704.2
NP_001038170.1, NM_001044705.2
NP_035887.2, NM_011757.3
XP_011239244.1, XM_011240942.1
UniGeneiMm.2760

Genome annotation databases

EnsembliENSMUST00000062350; ENSMUSP00000053430; ENSMUSG00000037017
ENSMUST00000080732; ENSMUSP00000079557; ENSMUSG00000037017
ENSMUST00000110959; ENSMUSP00000106584; ENSMUSG00000037017
ENSMUST00000110960; ENSMUSP00000106585; ENSMUSG00000037017
ENSMUST00000110961; ENSMUSP00000106586; ENSMUSG00000037017
GeneIDi22697
KEGGimmu:22697
UCSCiuc009aem.2 mouse

Similar proteinsi

Entry informationi

Entry nameiZSC21_MOUSE
AccessioniPrimary (citable) accession number: Q07231
Secondary accession number(s): Q921V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome