Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and SCAN domain-containing protein 21

Gene

Zscan21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Strong transcriptional activator. Associated with meiosis in both male and female gametogenesis. May have different functions in somatic cells.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri359 – 38123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 40923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri415 – 43622C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri526 – 54823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Oogenesis, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 21
Alternative name(s):
CtFIN51
Transcription factor RU49
Zinc finger protein 38
Short name:
Zfp-38
Gene namesi
Name:Zscan21
Synonyms:Zfp-38, Zfp38, Zipro1, Znf38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:99182. Zscan21.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Zinc finger and SCAN domain-containing protein 21PRO_0000047296Add
BLAST

Proteomic databases

EPDiQ07231.
MaxQBiQ07231.
PaxDbiQ07231.
PeptideAtlasiQ07231.
PRIDEiQ07231.

PTM databases

iPTMnetiQ07231.
PhosphoSiteiQ07231.

Expressioni

Tissue specificityi

Expressed predominantly in the spermatocytes and spermatids of adult testes. It is also present at lower levels in the ovary, brain, spleen, embryo and fetus.

Developmental stagei

First detected between 2 and 3 weeks after birth, in parallel with the onset and progression of meiosis. It is expressed during oogenesis from the pachytene stage of meiotic prophase through to postmeiotic cells.

Gene expression databases

BgeeiQ07231.
CleanExiMM_ZSCAN21.
ExpressionAtlasiQ07231. baseline and differential.
GenevisibleiQ07231. MM.

Interactioni

Protein-protein interaction databases

BioGridi204660. 1 interaction.
STRINGi10090.ENSMUSP00000053430.

Structurei

3D structure databases

ProteinModelPortaliQ07231.
SMRiQ07231. Positions 114-205, 351-551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 56391-1Add
BLAST
Repeati57 – 95391-2Add
BLAST
Repeati96 – 134391-3Add
BLAST
Domaini122 – 20483SCAN boxPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni18 – 1341173 X 39 AA approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri359 – 38123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 40923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri415 – 43622C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri526 – 54823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ07231.
KOiK09230.
OMAiRLERQWV.
OrthoDBiEOG7QRQTP.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVVGMATV LGPRPPQESM GPSPIKVEED EEKDKCCPTL ELSHKHFRQS
60 70 80 90 100
GNQDTLEPMG PSTIKAEEDE SKDKCRPNLE ISRKSFKQFG YQDTLEQLGP
110 120 130 140 150
STIKAEEDDE KDKGHPSPEI SRQRFRQFGY HDTPGPREAL SQLRVLCCEW
160 170 180 190 200
LQPEIHTKEQ ILELLVLEQF LTILPRELQT WVQQHCPESA EEAVTLLEDL
210 220 230 240 250
EQELDEPGLQ VSSPPNEQKQ SWEKMSTSGT AMESLSSTET QHVDASPKYE
260 270 280 290 300
FWGPLYIQET GEEEVFTQDP RKRQGFKSNP QKEDSADEHR SSEEESHADG
310 320 330 340 350
LKRTVIPMIP ANKYGSRSER QWANNLERER GTKASLQDTG SRKGAEPAST
360 370 380 390 400
RPAPGEKRYI CAECGKAFSN SSNLTKHRRT HTGEKPYVCT KCGKAFSHSS
410 420 430 440 450
NLTLHYRTHL VDRPYDCKCG KAFGQSSDLL KHQRMHTEEA PYQCKDCGKA
460 470 480 490 500
FSGKGSLIRH YRIHTGEKPY QCNECGKSFS QHAGLSSHQR LHTGEKPYKC
510 520 530 540 550
KECGKAFNHS SNFNKHHRIH TGEKPYWCSH CGKTFCSKSN LSKHQRVHTG

EGEVQ
Length:555
Mass (Da):63,012
Last modified:July 27, 2011 - v2
Checksum:i39321721BBE3687D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti193 – 1931A → T in BAA01480 (PubMed:1397691).Curated
Sequence conflicti216 – 2161N → S in AAB03786 (PubMed:8625807).Curated
Sequence conflicti234 – 2341S → P in AAB03786 (PubMed:8625807).Curated
Sequence conflicti334 – 34714ASLQD…KGAEP → PLFKTQVPGRGRA in AAB03786 (PubMed:8625807).CuratedAdd
BLAST
Sequence conflicti401 – 4022NL → KV in AAB03786 (PubMed:8625807).Curated
Sequence conflicti478 – 4781S → E in AAB03786 (PubMed:8625807).Curated
Sequence conflicti495 – 4951E → K in CAA45280 (PubMed:1284028).Curated
Sequence conflicti507 – 5071F → L in CAA45280 (PubMed:1284028).Curated
Sequence conflicti510 – 5101S → N in CAA45280 (PubMed:1284028).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10630 mRNA. Translation: BAA01480.1.
X63747 mRNA. Translation: CAA45280.1.
U41671 mRNA. Translation: AAB03786.1.
AK146875 mRNA. Translation: BAE27498.1.
CH466529 Genomic DNA. Translation: EDL19218.1.
BC010591 mRNA. Translation: AAH10591.1.
CCDSiCCDS19790.1.
PIRiA56560.
RefSeqiNP_001038168.1. NM_001044703.2.
NP_001038169.1. NM_001044704.2.
NP_001038170.1. NM_001044705.2.
NP_035887.2. NM_011757.3.
XP_011239244.1. XM_011240942.1.
UniGeneiMm.2760.

Genome annotation databases

EnsembliENSMUST00000062350; ENSMUSP00000053430; ENSMUSG00000037017.
ENSMUST00000080732; ENSMUSP00000079557; ENSMUSG00000037017.
ENSMUST00000110959; ENSMUSP00000106584; ENSMUSG00000037017.
ENSMUST00000110960; ENSMUSP00000106585; ENSMUSG00000037017.
ENSMUST00000110961; ENSMUSP00000106586; ENSMUSG00000037017.
GeneIDi22697.
KEGGimmu:22697.
UCSCiuc009aem.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10630 mRNA. Translation: BAA01480.1.
X63747 mRNA. Translation: CAA45280.1.
U41671 mRNA. Translation: AAB03786.1.
AK146875 mRNA. Translation: BAE27498.1.
CH466529 Genomic DNA. Translation: EDL19218.1.
BC010591 mRNA. Translation: AAH10591.1.
CCDSiCCDS19790.1.
PIRiA56560.
RefSeqiNP_001038168.1. NM_001044703.2.
NP_001038169.1. NM_001044704.2.
NP_001038170.1. NM_001044705.2.
NP_035887.2. NM_011757.3.
XP_011239244.1. XM_011240942.1.
UniGeneiMm.2760.

3D structure databases

ProteinModelPortaliQ07231.
SMRiQ07231. Positions 114-205, 351-551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204660. 1 interaction.
STRINGi10090.ENSMUSP00000053430.

PTM databases

iPTMnetiQ07231.
PhosphoSiteiQ07231.

Proteomic databases

EPDiQ07231.
MaxQBiQ07231.
PaxDbiQ07231.
PeptideAtlasiQ07231.
PRIDEiQ07231.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062350; ENSMUSP00000053430; ENSMUSG00000037017.
ENSMUST00000080732; ENSMUSP00000079557; ENSMUSG00000037017.
ENSMUST00000110959; ENSMUSP00000106584; ENSMUSG00000037017.
ENSMUST00000110960; ENSMUSP00000106585; ENSMUSG00000037017.
ENSMUST00000110961; ENSMUSP00000106586; ENSMUSG00000037017.
GeneIDi22697.
KEGGimmu:22697.
UCSCiuc009aem.2. mouse.

Organism-specific databases

CTDi7589.
MGIiMGI:99182. Zscan21.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ07231.
KOiK09230.
OMAiRLERQWV.
OrthoDBiEOG7QRQTP.
TreeFamiTF338304.

Miscellaneous databases

PROiQ07231.
SOURCEiSearch...

Gene expression databases

BgeeiQ07231.
CleanExiMM_ZSCAN21.
ExpressionAtlasiQ07231. baseline and differential.
GenevisibleiQ07231. MM.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a mouse zinc finger protein gene in both spermatocytes and oocytes during meiosis."
    Noce T., Fujiwara Y., Sezaki M., Fujimoto H., Higashinakagawa T.
    Dev. Biol. 153:356-367(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BTBRTF.
    Tissue: Spermatocyte.
  2. "The ubiquitous transactivator Zfp-38 is upregulated during spermatogenesis with differential transcription."
    Chowdhury K.
    Mech. Dev. 39:129-142(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor RU49."
    Yang X.W., Zhong R., Heintz N.
    Development 122:555-566(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiZSC21_MOUSE
AccessioniPrimary (citable) accession number: Q07231
Secondary accession number(s): Q921V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.