Zinc finger and SCAN domain-containing protein 2

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Q07230 (ZSCA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 116. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Zinc finger and SCAN domain-containing protein 2

Alternative name(s):
Zinc finger protein 29
Short name=Zfp-29

Gene names

Name:	Zscan2
Synonyms:	Zfp-29, Zfp29

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	614 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. Ref.1
Subcellular location	Nucleus Ref.1.
Tissue specificity	In the adult, predominantly found in spermatids. Also present in the embryo. Ref.1
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 14 C2H2-type zinc fingers. Contains 1 SCAN box domain.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 614

614

Zinc finger and SCAN domain-containing protein 2

PRO_0000047750

Regions

Domain

69 – 127

SCAN box

Zinc finger

222 – 244

C2H2-type 1

Zinc finger

250 – 272

C2H2-type 2

Zinc finger

278 – 300

C2H2-type 3

Zinc finger

306 – 328

C2H2-type 4

Zinc finger

334 – 356

C2H2-type 5

Zinc finger

362 – 384

C2H2-type 6

Zinc finger

390 – 412

C2H2-type 7

Zinc finger

418 – 440

C2H2-type 8

Zinc finger

446 – 468

C2H2-type 9

Zinc finger

474 – 496

C2H2-type 10

Zinc finger

502 – 524

C2H2-type 11

Zinc finger

530 – 552

C2H2-type 12

Zinc finger

558 – 580

C2H2-type 13

Zinc finger

586 – 608

C2H2-type 14

Secondary structure

614

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q07230 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 738156A0A9413DF7
Show »

FASTA

614

68,714

        10         20         30         40         50         60 
MAAEVPAVST PLSPLVQVPQ EEDEQAEVTT MILEDDAWVQ EAVLQEDGPE SEPFPQSAGK 

        70         80         90        100        110        120 
GSPQEEDAAE GPQGALVRFR ELCRRWLRPE VHTKEQMLTV LPREIQAWLQ EHRPESSEEA 

       130        140        150        160        170        180 
VALVEDLTQT FRHSDFEIQS ENGENSNEDM FEGVESHGMF LNISGGEGGQ QSDGDSDFER 

       190        200        210        220        230        240 
DCGSGGAQGH APGEDPRVVP SEGREVGQLI GLQGTYLGEK PYECPQCGKT FSRKSHLITH 

       250        260        270        280        290        300 
ERTHTGEKYY KCDECGKSFS DGSNFSRHQT THTGEKPYKC RDCGKSFSRS ANLITHQRIH 

       310        320        330        340        350        360 
TGEKPFQCAE CGKSFSRSPN LIAHQRTHTG EKPYSCPECG KSFGNRSSLN THQGIHTGEK 

       370        380        390        400        410        420 
PYACKECGES FSYNSNLIRH QRIHTGEKPY KCTECGQKFS QSSALITHRR THTGEKPYQC 

       430        440        450        460        470        480 
GECGKNFSRS SNLATHRRTH LVEKPYKCGL CGKSFSQSSS LIAHQGTHTG EKPYECLTCG 

       490        500        510        520        530        540 
ESFSWSSNLI KHQRTHTGEK PYRCGDCGKG FSQRSQLVVH QRTHTGEKPY KCLMCGKSFS 

       550        560        570        580        590        600 
RGSILVMHQR AHLGDKPYRC PECGKGFSWN SVLIIHQRIH TGEKPYRCPE CGKGFSNSSN 

       610 
FITHQRTHLK EKLY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A zinc finger protein-encoding gene expressed in the post-meiotic phase of spermatogenesis." Denny P., Ashworth A. Gene 106:221-227(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X55126 mRNA. Translation: CAA38920.1.
BC046961 mRNA. Translation: AAH46961.1.

IPI

IPI00115057.

PIR

JH0500.

RefSeq

NP_033579.1. NM_009553.2.

UniGene

Mm.358645.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2I13	X-ray	1.96	A/B	218-372	[»]

ProteinModelPortal

Q07230.

SMR

Q07230. Positions 67-127, 218-614.

ModBase

Search...

Protein-protein interaction databases

STRING

10090.ENSMUSP00000042321.

PTM databases

PhosphoSite

Q07230.

Proteomic databases

PRIDE

Q07230.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000044115; ENSMUSP00000042321; ENSMUSG00000038797.

GeneID

22691.

KEGG

mmu:22691.

UCSC

uc009ibh.1. mouse.

Organism-specific databases

CTD

54993.

MGI

MGI:99176. Zscan2.

Phylogenomic databases

eggNOG

COG5048.

GeneTree

ENSGT00670000097537.

HOGENOM

HOG000234619.

HOVERGEN

HBG018163.

InParanoid

Q07230.

K09230.

OMA

HRRTHLV.

OrthoDB

EOG4BCDMD.

Gene expression databases

ArrayExpress

Q07230.

Bgee

Q07230.

CleanEx

MM_ZSCAN2.

Genevestigator

Q07230.

GermOnline

ENSMUSG00000038797. Mus musculus.

Family and domain databases

Gene3D

3.30.160.60. 14 hits.

InterPro

IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

Pfam

PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]

SMART

SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]

SUPFAM

SSF47353. Retrov_capsid_C. 1 hit.

PROSITE

PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q07230.

NextBio

303139.

SOURCE

Search...

Entry information

Entry name

ZSCA2_MOUSE

Accession

Primary (citable) accession number: Q07230

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents