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Protein

Zinc finger and SCAN domain-containing protein 2

Gene

Zscan2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 24423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri530 – 55223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri558 – 58023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri586 – 60823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 2
Alternative name(s):
Zinc finger protein 29
Short name:
Zfp-29
Gene namesi
Name:Zscan2
Synonyms:Zfp-29, Zfp29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99176. Zscan2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614Zinc finger and SCAN domain-containing protein 2PRO_0000047750Add
BLAST

Proteomic databases

PaxDbiQ07230.
PRIDEiQ07230.

PTM databases

iPTMnetiQ07230.
PhosphoSiteiQ07230.

Expressioni

Tissue specificityi

In the adult, predominantly found in spermatids. Also present in the embryo.1 Publication

Gene expression databases

BgeeiQ07230.
CleanExiMM_ZSCAN2.
ExpressionAtlasiQ07230. baseline and differential.
GenevisibleiQ07230. MM.

Interactioni

Protein-protein interaction databases

BioGridi204655. 4 interactions.
STRINGi10090.ENSMUSP00000042321.

Structurei

Secondary structure

1
614
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni225 – 2273Combined sources
Helixi235 – 2395Combined sources
Helixi240 – 2423Combined sources
Turni253 – 2553Combined sources
Beta strandi258 – 2614Combined sources
Helixi262 – 27312Combined sources
Turni281 – 2833Combined sources
Beta strandi286 – 2883Combined sources
Helixi290 – 30112Combined sources
Turni309 – 3113Combined sources
Beta strandi314 – 3174Combined sources
Helixi318 – 32912Combined sources
Turni337 – 3393Combined sources
Beta strandi342 – 3443Combined sources
Helixi346 – 35712Combined sources
Turni365 – 3673Combined sources
Beta strandi370 – 3723Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I13X-ray1.96A/B218-388[»]
ProteinModelPortaliQ07230.
SMRiQ07230. Positions 67-127, 220-614.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07230.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 12759SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 24423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri530 – 55223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri558 – 58023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri586 – 60823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ07230.
KOiK09230.
OMAiHRRTHLV.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ07230.
TreeFamiTF337913.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 9 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEVPAVST PLSPLVQVPQ EEDEQAEVTT MILEDDAWVQ EAVLQEDGPE
60 70 80 90 100
SEPFPQSAGK GSPQEEDAAE GPQGALVRFR ELCRRWLRPE VHTKEQMLTV
110 120 130 140 150
LPREIQAWLQ EHRPESSEEA VALVEDLTQT FRHSDFEIQS ENGENSNEDM
160 170 180 190 200
FEGVESHGMF LNISGGEGGQ QSDGDSDFER DCGSGGAQGH APGEDPRVVP
210 220 230 240 250
SEGREVGQLI GLQGTYLGEK PYECPQCGKT FSRKSHLITH ERTHTGEKYY
260 270 280 290 300
KCDECGKSFS DGSNFSRHQT THTGEKPYKC RDCGKSFSRS ANLITHQRIH
310 320 330 340 350
TGEKPFQCAE CGKSFSRSPN LIAHQRTHTG EKPYSCPECG KSFGNRSSLN
360 370 380 390 400
THQGIHTGEK PYACKECGES FSYNSNLIRH QRIHTGEKPY KCTECGQKFS
410 420 430 440 450
QSSALITHRR THTGEKPYQC GECGKNFSRS SNLATHRRTH LVEKPYKCGL
460 470 480 490 500
CGKSFSQSSS LIAHQGTHTG EKPYECLTCG ESFSWSSNLI KHQRTHTGEK
510 520 530 540 550
PYRCGDCGKG FSQRSQLVVH QRTHTGEKPY KCLMCGKSFS RGSILVMHQR
560 570 580 590 600
AHLGDKPYRC PECGKGFSWN SVLIIHQRIH TGEKPYRCPE CGKGFSNSSN
610
FITHQRTHLK EKLY
Length:614
Mass (Da):68,714
Last modified:November 1, 1996 - v1
Checksum:i738156A0A9413DF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55126 mRNA. Translation: CAA38920.1.
BC046961 mRNA. Translation: AAH46961.1.
CCDSiCCDS21399.1.
PIRiJH0500.
RefSeqiNP_033579.1. NM_009553.2.
XP_006540868.1. XM_006540805.2.
XP_006540869.1. XM_006540806.2.
XP_006540870.1. XM_006540807.2.
XP_006540871.1. XM_006540808.2.
XP_006540872.1. XM_006540809.2.
XP_006540873.1. XM_006540810.2.
XP_006540874.1. XM_006540811.2.
XP_006540875.1. XM_006540812.2.
UniGeneiMm.358645.

Genome annotation databases

EnsembliENSMUST00000044115; ENSMUSP00000042321; ENSMUSG00000038797.
GeneIDi22691.
KEGGimmu:22691.
UCSCiuc009ibh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55126 mRNA. Translation: CAA38920.1.
BC046961 mRNA. Translation: AAH46961.1.
CCDSiCCDS21399.1.
PIRiJH0500.
RefSeqiNP_033579.1. NM_009553.2.
XP_006540868.1. XM_006540805.2.
XP_006540869.1. XM_006540806.2.
XP_006540870.1. XM_006540807.2.
XP_006540871.1. XM_006540808.2.
XP_006540872.1. XM_006540809.2.
XP_006540873.1. XM_006540810.2.
XP_006540874.1. XM_006540811.2.
XP_006540875.1. XM_006540812.2.
UniGeneiMm.358645.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I13X-ray1.96A/B218-388[»]
ProteinModelPortaliQ07230.
SMRiQ07230. Positions 67-127, 220-614.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204655. 4 interactions.
STRINGi10090.ENSMUSP00000042321.

PTM databases

iPTMnetiQ07230.
PhosphoSiteiQ07230.

Proteomic databases

PaxDbiQ07230.
PRIDEiQ07230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044115; ENSMUSP00000042321; ENSMUSG00000038797.
GeneIDi22691.
KEGGimmu:22691.
UCSCiuc009ibh.1. mouse.

Organism-specific databases

CTDi54993.
MGIiMGI:99176. Zscan2.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ07230.
KOiK09230.
OMAiHRRTHLV.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ07230.
TreeFamiTF337913.

Miscellaneous databases

EvolutionaryTraceiQ07230.
NextBioi303139.
PROiQ07230.
SOURCEiSearch...

Gene expression databases

BgeeiQ07230.
CleanExiMM_ZSCAN2.
ExpressionAtlasiQ07230. baseline and differential.
GenevisibleiQ07230. MM.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 9 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A zinc finger protein-encoding gene expressed in the post-meiotic phase of spermatogenesis."
    Denny P., Ashworth A.
    Gene 106:221-227(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiZSCA2_MOUSE
AccessioniPrimary (citable) accession number: Q07230
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.