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Protein

Gamma-hemolysin component C

Gene

hlgC

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis

Protein family/group databases

TCDBi1.C.3.4.3. the Alpha-hemolysin channel-forming toxin (Alphahl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-hemolysin component C
Alternative name(s):
H-gamma-1
H-gamma-I
Gene namesi
Name:hlgC
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001842630 – 315Gamma-hemolysin component CAdd BLAST286

Interactioni

Subunit structurei

Toxicity requires sequential binding and synergistic association of a class S and a class F component which form heterooligomeric complexes. HlgC (class S) associates with HlgB (class F) thus forming an CB toxin.

Protein-protein interaction databases

STRINGi93062.SACOL2421.

Structurei

3D structure databases

ProteinModelPortaliQ07227.
SMRiQ07227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aerolysin family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR003963. Bi-component_toxin_staph.
IPR016183. Leukocidin/porin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
[Graphical view]
PRINTSiPR01468. BICOMPNTOXIN.
SUPFAMiSSF56959. SSF56959. 1 hit.
TIGRFAMsiTIGR01002. hlyII. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKNKILTTT LSVSLLAPLA NPLLENAKAA NDTEDIGKGS DIEIIKRTED
60 70 80 90 100
KTSNKWGVTQ NIQFDFVKDK KYNKDALILK MQGFISSRTT YYNYKKTNHV
110 120 130 140 150
KAMRWPFQYN IGLKTNDKYV SLINYLPKNK IESTNVSQTL GYNIGGNFQS
160 170 180 190 200
APSLGGNGSF NYSKSISYTQ QNYVSEVEQQ NSKSVLWGVK ANSFATESGQ
210 220 230 240 250
KSAFDSDLFV GYKPHSKDPR DYFVPDSELP PLVQSGFNPS FIATVSHEKG
260 270 280 290 300
SSDTSEFEIT YGRNMDVTHA IKRSTHYGNS YLDGHRVHNA FVNRNYTVKY
310
EVNWKTHEIK VKGQN
Length:315
Mass (Da):35,614
Last modified:November 1, 1996 - v1
Checksum:i77359819736620BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01055 Genomic DNA. Translation: AAA26638.1.
PIRiC49238.
RefSeqiWP_000916713.1. NZ_MAQP01000007.1.

Genome annotation databases

GeneIDi28379963.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01055 Genomic DNA. Translation: AAA26638.1.
PIRiC49238.
RefSeqiWP_000916713.1. NZ_MAQP01000007.1.

3D structure databases

ProteinModelPortaliQ07227.
SMRiQ07227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL2421.

Protein family/group databases

TCDBi1.C.3.4.3. the Alpha-hemolysin channel-forming toxin (Alphahl) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi28379963.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR003963. Bi-component_toxin_staph.
IPR016183. Leukocidin/porin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
[Graphical view]
PRINTSiPR01468. BICOMPNTOXIN.
SUPFAMiSSF56959. SSF56959. 1 hit.
TIGRFAMsiTIGR01002. hlyII. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHLGC_STAAU
AccessioniPrimary (citable) accession number: Q07227
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.