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Protein

Somatotropin

Gene

gh

Organism
Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381ZincBy similarity
Metal bindingi192 – 1921ZincBy similarity

GO - Molecular functioni

  • growth hormone receptor binding Source: AgBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Somatotropin
Alternative name(s):
Growth hormone
Gene namesi
Name:gh
OrganismiOncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha)
Taxonomic identifieri74940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 210188SomatotropinPRO_0000033040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 183By similarity
Disulfide bondi200 ↔ 208By similarity

Keywords - PTMi

Disulfide bond

Interactioni

GO - Molecular functioni

  • growth hormone receptor binding Source: AgBase

Structurei

3D structure databases

ProteinModelPortaliQ07221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG011318.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQVFLLMPV LLVSCFLSQG AAIENQRLFN IAVSRVQHLH LLAQKMFNDF
60 70 80 90 100
DGTLLPDERR QLNKIFLLDF CNSDSIVSPV DKHETQKSSV LKLLHISFRL
110 120 130 140 150
IESWEYPSQT LIISNSLMVR NANQISEKLS DLKVGINLLI TGSQDAYMSL
160 170 180 190 200
DDNDSQQLPP YGNYYQNLGG DGNVRRNYEL LACFKKDMHK VETYLTVAKC
210
RKSLEANCTL
Length:210
Mass (Da):23,892
Last modified:November 1, 1996 - v1
Checksum:i65E4FD50E42C541B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S50867 mRNA. Translation: AAB24612.2.
PIRiI51186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S50867 mRNA. Translation: AAB24612.2.
PIRiI51186.

3D structure databases

ProteinModelPortaliQ07221.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG011318.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of salmon growth hormone cDNA."
    Song S., Trinh K.T., Hew C.-L.
    Yi Chuan Xue Bao 19:308-315(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Erratum
    Song S., Trinh K.T., Hew C.-L.
    Yi Chuan Xue Bao 20:380-380(1993)

Entry informationi

Entry nameiSOMA_ONCTS
AccessioniPrimary (citable) accession number: Q07221
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.