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Q07217

- CP11A_ONCMY

UniProt

Q07217 - CP11A_ONCMY

Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene

cyp11a1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. Increased amounts during final oocyte maturation may be responsible for the rapid increase in the follicular production of maturation-inducing hormone 17-alpha,20-beta-DP.

    Catalytic activityi

    Cholesterol + 6 reduced adrenodoxin + 3 O2 = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi458 – 4581Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. cholesterol monooxygenase (side-chain-cleaving) activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. C21-steroid hormone metabolic process Source: UniProtKB-UniPathway
    2. cholesterol metabolic process Source: UniProtKB-KW
    3. steroid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Steroidogenesis, Sterol metabolism

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00229.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cholesterol side-chain cleavage enzyme, mitochondrial (EC:1.14.15.6)
    Alternative name(s):
    CYPXIA1
    Cholesterol desmolase
    Cytochrome P450 11A1
    Cytochrome P450(scc)
    Gene namesi
    Name:cyp11a1
    OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
    Taxonomic identifieri8022 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
    BLAST
    Chaini40 – 514475Cholesterol side-chain cleavage enzyme, mitochondrialPRO_0000003593Add
    BLAST

    Expressioni

    Tissue specificityi

    Not found in early vitellogenic follicles, barely detected in postvitellogenic follicles and abundant in post ovulatory follicles.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG051098.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07217-1 [UniParc]FASTAAdd to Basket

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    MMVSWSVCRS SLALPACGLP SARHNSSMPV VRQALSPDNS STVQNFSEIP    50
    GLWRNGLANL YSFWKLDGFR NIHRVMVHNF NTFGPIYREK IGYYDSVNII 100
    KPEMPAILFK AEGHYPKRLT VEAWTSYRDY RNRKYGVLLK NGEDWRSNRV 150
    ILNREVISPK VLGNFVPLLD EVGQDFVARV HKKIERSGQD KWTTDLSQEL 200
    FKYALESVGS VLYGERLGLM LDYINPEAQH FIDCISLMFK TTSPMLYIPP 250
    AMLRRVGAKI WRDHVEAWDG IFNQADRCIQ NIYRTMRQDT NTHGKYPGVL 300
    ASLLMLDKLS IEDIKASVTE LMAGGVDTTS ITLLWTLYEL ARHPDLQEEL 350
    RAEVAVARQS TQGDMLQMLK MIPLVKGALK ETLRLHPVAV SLQRYITEEI 400
    VIQNYHIPCG TLVQLGLYAM GRDPDVFPRP EKYLPSRWLR TENQYFRSLG 450
    FGFGPRQCLG RRIAETEMQL FLIHMLENFR VDKQRQVEVH STFELILLPE 500
    KPILLTLKPL KSGQ 514
    Length:514
    Mass (Da):59,137
    Last modified:October 1, 1994 - v1
    Checksum:i0C6F49ECE8FF38FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S57305 mRNA. Translation: AAB25804.1.
    PIRiS32197.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S57305 mRNA. Translation: AAB25804.1 .
    PIRi S32197.

    3D structure databases

    ProteinModelPortali Q07217.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG051098.

    Enzyme and pathway databases

    UniPathwayi UPA00229 .

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rainbow trout ovarian cholesterol side-chain cleavage cytochrome P450 (P450scc). cDNA cloning and mRNA expression during oogenesis."
      Takahashi M., Tanaka M., Sakai N., Adachi S., Miller W.L., Nagahama Y.
      FEBS Lett. 319:45-48(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiCP11A_ONCMY
    AccessioniPrimary (citable) accession number: Q07217
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3