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Q07217

- CP11A_ONCMY

UniProt

Q07217 - CP11A_ONCMY

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Protein
Cholesterol side-chain cleavage enzyme, mitochondrial
Gene
cyp11a1
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. Increased amounts during final oocyte maturation may be responsible for the rapid increase in the follicular production of maturation-inducing hormone 17-alpha,20-beta-DP.

Catalytic activityi

Cholesterol + 6 reduced adrenodoxin + 3 O2 = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.

Cofactori

Heme group By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi458 – 4581Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. cholesterol monooxygenase (side-chain-cleaving) activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. C21-steroid hormone metabolic process Source: UniProtKB-UniPathway
  2. cholesterol metabolic process Source: UniProtKB-KW
  3. steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Steroidogenesis, Sterol metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00229.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholesterol side-chain cleavage enzyme, mitochondrial (EC:1.14.15.6)
Alternative name(s):
CYPXIA1
Cholesterol desmolase
Cytochrome P450 11A1
Cytochrome P450(scc)
Gene namesi
Name:cyp11a1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939Mitochondrion Reviewed prediction
Add
BLAST
Chaini40 – 514475Cholesterol side-chain cleavage enzyme, mitochondrial
PRO_0000003593Add
BLAST

Expressioni

Tissue specificityi

Not found in early vitellogenic follicles, barely detected in postvitellogenic follicles and abundant in post ovulatory follicles.

Structurei

3D structure databases

ProteinModelPortaliQ07217.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051098.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07217-1 [UniParc]FASTAAdd to Basket

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MMVSWSVCRS SLALPACGLP SARHNSSMPV VRQALSPDNS STVQNFSEIP    50
GLWRNGLANL YSFWKLDGFR NIHRVMVHNF NTFGPIYREK IGYYDSVNII 100
KPEMPAILFK AEGHYPKRLT VEAWTSYRDY RNRKYGVLLK NGEDWRSNRV 150
ILNREVISPK VLGNFVPLLD EVGQDFVARV HKKIERSGQD KWTTDLSQEL 200
FKYALESVGS VLYGERLGLM LDYINPEAQH FIDCISLMFK TTSPMLYIPP 250
AMLRRVGAKI WRDHVEAWDG IFNQADRCIQ NIYRTMRQDT NTHGKYPGVL 300
ASLLMLDKLS IEDIKASVTE LMAGGVDTTS ITLLWTLYEL ARHPDLQEEL 350
RAEVAVARQS TQGDMLQMLK MIPLVKGALK ETLRLHPVAV SLQRYITEEI 400
VIQNYHIPCG TLVQLGLYAM GRDPDVFPRP EKYLPSRWLR TENQYFRSLG 450
FGFGPRQCLG RRIAETEMQL FLIHMLENFR VDKQRQVEVH STFELILLPE 500
KPILLTLKPL KSGQ 514
Length:514
Mass (Da):59,137
Last modified:October 1, 1994 - v1
Checksum:i0C6F49ECE8FF38FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S57305 mRNA. Translation: AAB25804.1.
PIRiS32197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S57305 mRNA. Translation: AAB25804.1 .
PIRi S32197.

3D structure databases

ProteinModelPortali Q07217.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG051098.

Enzyme and pathway databases

UniPathwayi UPA00229 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rainbow trout ovarian cholesterol side-chain cleavage cytochrome P450 (P450scc). cDNA cloning and mRNA expression during oogenesis."
    Takahashi M., Tanaka M., Sakai N., Adachi S., Miller W.L., Nagahama Y.
    FEBS Lett. 319:45-48(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCP11A_ONCMY
AccessioniPrimary (citable) accession number: Q07217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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