Reviewed, UniProtKB/Swiss-Prot Q07211 (SCRK_STRMU)

Names and origin

Protein names

Recommended name:
    Fructokinase
    EC=2.7.1.4

Gene names

Name:	scrK
Ordered Locus Names:	SMU_1840

Organism

Streptococcus mutans [Complete proteome] [HAMAP]

Taxonomic identifier

1309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + D-fructose = ADP + D-fructose 6-phosphate.
Cofactor	Magnesium By similarity.
Enzyme regulation	Inhibition by zinc ions Potential.
Sequence similarities	Belongs to the ROK (nagC/xylR) family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW fructokinase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Fructokinase		PRO_0000095686
Regions
	Nucleotide binding	236 – 240	5	ATP By similarity
Sites
	Metal binding	156	1	Zinc By similarity
	Metal binding	174	1	Zinc By similarity
	Metal binding	177	1	Zinc By similarity
	Metal binding	180	1	Zinc By similarity
	Binding site	133	1	ATP By similarity
	Binding site	188	1	ATP; via imide nitrogen By similarity
Experimental info
	Sequence conflict	139	1	T → A in BAA02467. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q07211-1 [UniParc]. Last modified November 28, 2002. Version 2. Checksum: 1089AF37B2C5B807	FASTA	293	31,712
	10 20 30 40 50 60 MSKLYGSIEA GGTKFVCAVG DENFQILEKV QFPTTTPYET IEKTVAFFKK FEADLASVAI 70 80 90 100 110 120 GSFGPIDIDQ NSDTYGYITS TPKPNWANVD FVGLISKDFK IPFYFTTDVN SSAYGETIAR 130 140 150 160 170 180 SNVKSLVYYT IGTGIGAGTI QNGEFIGGMG HTEAGHVYMA PHPNDVHHGF VGTCPFHKGC 190 200 210 220 230 240 LEGLAAGPSL EARTGIRGEL IEQNSEVWDI QAYYIAQAAI QATVLYRPQV IVFGGGVMAQ 250 260 270 280 290 EHMLNRVREK FTSLLNDYLP VPDVKDYIVT PAVAENGSAT LGNLALAKKI AAR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, characterization and sequence analysis of the scrK gene encoding fructokinase of Streptococcus mutans." Sato Y., Yamamoto Y., Kizaki H., Kuramitsu H.K. J. Gen. Microbiol. 139:921-927(1993) [PubMed: 8336109] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GS-5.
[2]	"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D13175 Genomic DNA. Translation: BAA02467.1. AE014133 Genomic DNA. Translation: AAN59463.1.
RefSeq	NP_722157.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1029053.
GenomeReviews	Gene locus SMU_1840 in contig AE014133_GR.
KEGG	smu:SMU.1840.
NMPDR	fig|210007.1.peg.1670.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q07211.
OMA	Q07211. GMAAGPS.
Enzyme and pathway databases
BioCyc	SMUT210007:SMU_1840-MON.
BRENDA	2.7.1.4. 20716.
Family and domain databases
InterPro	IPR000600. ROK. [Graphical view]
Pfam	PF00480. ROK. 1 hit. [Graphical view]
PROSITE	PS01125. ROK. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SCRK_STRMU

Accession

Primary (citable) accession number: Q07211

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	November 28, 2002
Last modified:	June 16, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)