ID   CRP_XENLA               Reviewed;         238 AA.
AC   Q07203;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   16-JUN-2009, entry version 67.
DE   RecName: Full=C-reactive protein;
DE            Short=CRP;
DE   Flags: Precursor;
GN   Name=crp;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 17-31 AND
RP   152-160.
RC   TISSUE=Liver;
RX   MEDLINE=93203287; PubMed=8454653;
RA   Lin L., Liu T.-Y.;
RT   "Isolation and characterization of C-reactive protein (CRP) cDNA and
RT   genomic DNA from Xenopus laevis. A species representing an
RT   intermediate stage in CRP evolution.";
RL   J. Biol. Chem. 268:6809-6815(1993).
CC   -!- FUNCTION: CRP displays several functions associated with host
CC       defense: it promotes agglutination, bacterial capsular swelling,
CC       phagocytosis, and complement fixation through its calcium-
CC       dependent binding to phosphorylcholine.
CC   -!- COFACTOR: Binds 2 calcium ions per subunit (By similarity).
CC   -!- SUBUNIT: Homodimer; disulfide-linked. It is not known if it
CC       assembles into a pentaxin (or pentraxin) structure. Pentaxins have
CC       a discoid arrangement of 5 non-covalently bound subunits.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: Is initially detected at the late tail bud
CC       stage when the liver appears.
CC   -!- PTM: Cys-89 or Cys-223 or Cys-236 could be involved in interchain
CC       disulfide linkage.
CC   -!- SIMILARITY: Belongs to the pentaxin family.
CC   -!- SIMILARITY: Contains 1 pentaxin domain.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=No more Christmas
CC       pudding? - Issue 30 of January 2003;
CC       URL="http://www.expasy.org/spotlight/back_issues/sptlt030.shtml";
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DR   EMBL; L08166; AAA49692.1; -; Genomic_DNA.
DR   PIR; A45487; A45487.
DR   HSSP; P02741; 1B09.
DR   HOVERGEN; Q07203; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR013320; ConA-like_subgrp.
DR   InterPro; IPR001759; Pentaxin.
DR   Gene3D; G3DSA:2.60.120.200; ConA_like_subgrp; 1.
DR   Pfam; PF00354; Pentaxin; 1.
DR   PRINTS; PR00895; PENTAXIN.
DR   ProDom; PD002153; Pentaxin; 1.
DR   SMART; SM00159; PTX; 1.
DR   PROSITE; PS00289; PENTAXIN; 1.
PE   1: Evidence at protein level;
KW   Acute phase; Calcium; Direct protein sequencing; Disulfide bond;
KW   Metal-binding; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL        1     16
FT   CHAIN        17    238       C-reactive protein.
FT                                /FTId=PRO_0000023536.
FT   DOMAIN       17    238       Pentaxin.
FT   METAL        76     76       Calcium 1 (By similarity).
FT   METAL        77     77       Calcium 1 (By similarity).
FT   METAL       154    154       Calcium 1 (By similarity).
FT   METAL       154    154       Calcium 2 (By similarity).
FT   METAL       155    155       Calcium 1; via carbonyl oxygen (By
FT                                similarity).
FT   METAL       156    156       Calcium 1 (By similarity).
FT   METAL       156    156       Calcium 2 (By similarity).
FT   METAL       166    166       Calcium 2 (By similarity).
FT   MOD_RES      17     17       Pyrrolidone carboxylic acid (By
FT                                similarity).
FT   DISULFID     52    113       By similarity.
FT   VARIANT      40     40       P -> A.
FT   VARIANT      66     66       L -> F.
FT   VARIANT     151    151       Q -> L.
FT   VARIANT     181    181       V -> I.
SQ   SEQUENCE   238 AA;  27085 MW;  495875AA4E2986A6 CRC64;
     MERFALWFIF LAGSLAQEDL VGNVFLFPKP SVTTYAILKP EVEKPLKNLT VCLRSYTTLT
     RFHSLLSLAT SNPLQDNAFL LFSKPPNQCS IYINQEENVF KVDPTAVEWK HTCVSWDSVS
     GVVELWIDGK LYPRTVSKKA SSIGFPSSII QGQEQDSFGG GFNIDQSFVG EISDVHMWDY
     VLTPDHIQKV LFANMDFNGN IISWRSLQYE LRGQATTQPK RQCKTLEHHY GLFAKCYK
//