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Q07203

- CRP_XENLA

UniProt

Q07203 - CRP_XENLA

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Protein

C-reactive protein

Gene

crp

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through its calcium-dependent binding to phosphorylcholine.

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Calcium 1By similarity
Metal bindingi77 – 771Calcium 1By similarity
Metal bindingi154 – 1541Calcium 1By similarity
Metal bindingi154 – 1541Calcium 2By similarity
Metal bindingi155 – 1551Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi156 – 1561Calcium 1By similarity
Metal bindingi156 – 1561Calcium 2By similarity
Metal bindingi166 – 1661Calcium 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Acute phase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Short name:
CRP
Gene namesi
Name:crp
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6464307. crp.4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16161 PublicationAdd
BLAST
Chaini17 – 238222C-reactive proteinPRO_0000023536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171Pyrrolidone carboxylic acidBy similarity
Disulfide bondi52 ↔ 113By similarity

Post-translational modificationi

Cys-89 or Cys-223 or Cys-236 could be involved in interchain disulfide linkage.

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Developmental stagei

Is initially detected at the late tail bud stage when the liver appears.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked. It is not known if it assembles into a pentaxin (or pentraxin) structure. Pentaxins have a discoid arrangement of 5 non-covalently bound subunits.

Structurei

3D structure databases

ProteinModelPortaliQ07203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 238222PentaxinAdd
BLAST

Sequence similaritiesi

Belongs to the pentaxin family.Curated
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005405.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07203-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERFALWFIF LAGSLAQEDL VGNVFLFPKP SVTTYAILKP EVEKPLKNLT
60 70 80 90 100
VCLRSYTTLT RFHSLLSLAT SNPLQDNAFL LFSKPPNQCS IYINQEENVF
110 120 130 140 150
KVDPTAVEWK HTCVSWDSVS GVVELWIDGK LYPRTVSKKA SSIGFPSSII
160 170 180 190 200
QGQEQDSFGG GFNIDQSFVG EISDVHMWDY VLTPDHIQKV LFANMDFNGN
210 220 230
IISWRSLQYE LRGQATTQPK RQCKTLEHHY GLFAKCYK
Length:238
Mass (Da):27,085
Last modified:October 1, 1994 - v1
Checksum:i495875AA4E2986A6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401P → A.1 Publication
Natural varianti66 – 661L → F.1 Publication
Natural varianti151 – 1511Q → L.1 Publication
Natural varianti181 – 1811V → I.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08166 Genomic DNA. Translation: AAA49692.1.
PIRiA45487.
RefSeqiNP_001165686.1. NM_001172215.1.
UniGeneiXl.87595.

Genome annotation databases

GeneIDi100337615.
KEGGixla:100337615.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08166 Genomic DNA. Translation: AAA49692.1 .
PIRi A45487.
RefSeqi NP_001165686.1. NM_001172215.1.
UniGenei Xl.87595.

3D structure databases

ProteinModelPortali Q07203.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100337615.
KEGGi xla:100337615.

Organism-specific databases

CTDi 100337615.
Xenbasei XB-GENE-6464307. crp.4.

Phylogenomic databases

HOVERGENi HBG005405.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00895. PENTAXIN.
SMARTi SM00159. PTX. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00289. PENTAXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of C-reactive protein (CRP) cDNA and genomic DNA from Xenopus laevis. A species representing an intermediate stage in CRP evolution."
    Lin L., Liu T.-Y.
    J. Biol. Chem. 268:6809-6815(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 17-31 AND 152-160, DEVELOPMENTAL STAGE, VARIANTS ALA-40; PHE-66; LEU-151 AND ILE-181.
    Tissue: Liver.

Entry informationi

Entry nameiCRP_XENLA
AccessioniPrimary (citable) accession number: Q07203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3