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Q07203

- CRP_XENLA

UniProt

Q07203 - CRP_XENLA

Protein

C-reactive protein

Gene

crp

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through its calcium-dependent binding to phosphorylcholine.

    Cofactori

    Binds 2 calcium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi76 – 761Calcium 1By similarity
    Metal bindingi77 – 771Calcium 1By similarity
    Metal bindingi154 – 1541Calcium 1By similarity
    Metal bindingi154 – 1541Calcium 2By similarity
    Metal bindingi155 – 1551Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi156 – 1561Calcium 1By similarity
    Metal bindingi156 – 1561Calcium 2By similarity
    Metal bindingi166 – 1661Calcium 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. acute-phase response Source: UniProtKB-KW

    Keywords - Biological processi

    Acute phase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-reactive protein
    Short name:
    CRP
    Gene namesi
    Name:crp
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6464307. crp.4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 16161 PublicationAdd
    BLAST
    Chaini17 – 238222C-reactive proteinPRO_0000023536Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei17 – 171Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi52 ↔ 113By similarity

    Post-translational modificationi

    Cys-89 or Cys-223 or Cys-236 could be involved in interchain disulfide linkage.

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Expressioni

    Developmental stagei

    Is initially detected at the late tail bud stage when the liver appears.1 Publication

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. It is not known if it assembles into a pentaxin (or pentraxin) structure. Pentaxins have a discoid arrangement of 5 non-covalently bound subunits.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07203.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 238222PentaxinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pentaxin family.Curated
    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG005405.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00895. PENTAXIN.
    SMARTiSM00159. PTX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS00289. PENTAXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07203-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERFALWFIF LAGSLAQEDL VGNVFLFPKP SVTTYAILKP EVEKPLKNLT    50
    VCLRSYTTLT RFHSLLSLAT SNPLQDNAFL LFSKPPNQCS IYINQEENVF 100
    KVDPTAVEWK HTCVSWDSVS GVVELWIDGK LYPRTVSKKA SSIGFPSSII 150
    QGQEQDSFGG GFNIDQSFVG EISDVHMWDY VLTPDHIQKV LFANMDFNGN 200
    IISWRSLQYE LRGQATTQPK RQCKTLEHHY GLFAKCYK 238
    Length:238
    Mass (Da):27,085
    Last modified:October 1, 1994 - v1
    Checksum:i495875AA4E2986A6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti40 – 401P → A.1 Publication
    Natural varianti66 – 661L → F.1 Publication
    Natural varianti151 – 1511Q → L.1 Publication
    Natural varianti181 – 1811V → I.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08166 Genomic DNA. Translation: AAA49692.1.
    PIRiA45487.
    RefSeqiNP_001165686.1. NM_001172215.1.
    UniGeneiXl.87595.

    Genome annotation databases

    GeneIDi100337615.
    KEGGixla:100337615.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    No more Christmas pudding? - Issue 30 of January 2003

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08166 Genomic DNA. Translation: AAA49692.1 .
    PIRi A45487.
    RefSeqi NP_001165686.1. NM_001172215.1.
    UniGenei Xl.87595.

    3D structure databases

    ProteinModelPortali Q07203.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100337615.
    KEGGi xla:100337615.

    Organism-specific databases

    CTDi 100337615.
    Xenbasei XB-GENE-6464307. crp.4.

    Phylogenomic databases

    HOVERGENi HBG005405.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00895. PENTAXIN.
    SMARTi SM00159. PTX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS00289. PENTAXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of C-reactive protein (CRP) cDNA and genomic DNA from Xenopus laevis. A species representing an intermediate stage in CRP evolution."
      Lin L., Liu T.-Y.
      J. Biol. Chem. 268:6809-6815(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 17-31 AND 152-160, DEVELOPMENTAL STAGE, VARIANTS ALA-40; PHE-66; LEU-151 AND ILE-181.
      Tissue: Liver.

    Entry informationi

    Entry nameiCRP_XENLA
    AccessioniPrimary (citable) accession number: Q07203
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3