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Q07176 (MMK1_MEDSA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase homolog MMK1

EC=2.7.11.24
Alternative name(s):
MAP kinase ERK1
MAP kinase MSK7
Gene names
Name:MMK1
Synonyms:ERK1, MSK7
OrganismMedicago sativa (Alfalfa)
Taxonomic identifier3879 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the mitogenic induction of symbiotic root nodules on Alfalfa by Rhizobium signal molecules.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Tissue specificity

Roots and stems.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-213 and Tyr-215, which activates the enzyme By similarity. Autophosphorylated. Ref.2

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Mitogen-activated protein kinase homolog MMK1
PRO_0000186317

Regions

Domain55 – 340286Protein kinase
Nucleotide binding61 – 699ATP By similarity
Motif213 – 2153TXY

Sites

Active site1811Proton acceptor By similarity
Binding site841ATP By similarity

Amino acid modifications

Modified residue2131Phosphothreonine By similarity
Modified residue2151Phosphotyrosine Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q07176 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 8672871A3D34EAD2

FASTA38744,402
        10         20         30         40         50         60 
MEGGGAPPAD TVMSDAAPAP PQMGIENIPA VLSHGGRFIQ YNIFGNIFEV TAKYKPPIMP 

        70         80         90        100        110        120 
IGKGAYGIVC SAHNSETNEH VAVKKIANAF DNKIDAKRTL REIKLLRHMD HENVVAIRDI 

       130        140        150        160        170        180 
VPPPQREVFN DVYIAYELMD TDLHQIIRSN QALSEEHCQY FLYQILRGLK YIHSANVLHR 

       190        200        210        220        230        240 
DLKPSNLLLN ANCDLKICDF GLARVTSETD FMTEYVVTRW YRAPELLLNS SDYTAAIDVW 

       250        260        270        280        290        300 
SVGCIFMELM DRKPLFPGRD HVHQLRLLME LIGTPSEDDL GFLNENAKRY IRQLPPYRRQ 

       310        320        330        340        350        360 
SFQEKFPHVH PEAIDLVEKM LTFDPRKRIT VEDALAHPYL TSLHDISDEP VCMTPFSFDF 

       370        380 
EQHALTEEQM KELIYREALA FNPEYQQ 

« Hide

References

[1]"The plant homologue of MAP kinase is expressed in a cell cycle-dependent and organ-specific manner."
Jonak C., Pay A., Boegre L., Hirt H., Heberle-Bors E.
Plant J. 3:611-617(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"MsERK1: a mitogen-activated protein kinase from a flowering plant."
Duerr B., Gawienowski M., Ropp T., Jacobs T.
Plant Cell 5:87-96(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION AT TYR-215.
Strain: cv. Iroquois.
Tissue: Seedling root.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X66469 mRNA. Translation: CAA47099.1.
L07042 mRNA. Translation: AAB41548.1.
PIRS48123.

3D structure databases

ProteinModelPortalQ07176.
SMRQ07176. Positions 44-387.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.11.24. 3078.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMMK1_MEDSA
AccessionPrimary (citable) accession number: Q07176
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families