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Q07176

- MMK1_MEDSA

UniProt

Q07176 - MMK1_MEDSA

Protein

Mitogen-activated protein kinase homolog MMK1

Gene

MMK1

Organism
Medicago sativa (Alfalfa)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    May play a role in the mitogenic induction of symbiotic root nodules on Alfalfa by Rhizobium signal molecules.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by tyrosine and threonine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei84 – 841ATPPROSITE-ProRule annotation
    Active sitei181 – 1811Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 699ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. conjugation Source: UniProtKB-KW
    2. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Conjugation, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.24. 3078.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase homolog MMK1 (EC:2.7.11.24)
    Alternative name(s):
    MAP kinase ERK1
    MAP kinase MSK7
    Gene namesi
    Name:MMK1
    Synonyms:ERK1, MSK7
    OrganismiMedicago sativa (Alfalfa)
    Taxonomic identifieri3879 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 387387Mitogen-activated protein kinase homolog MMK1PRO_0000186317Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei213 – 2131PhosphothreonineBy similarity
    Modified residuei215 – 2151Phosphotyrosine1 Publication

    Post-translational modificationi

    Dually phosphorylated on Thr-213 and Tyr-215, which activates the enzyme By similarity. Autophosphorylated.By similarity1 Publication

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Tissue specificityi

    Roots and stems.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07176.
    SMRiQ07176. Positions 44-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 340286Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi213 – 2153TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q07176-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGGGAPPAD TVMSDAAPAP PQMGIENIPA VLSHGGRFIQ YNIFGNIFEV    50
    TAKYKPPIMP IGKGAYGIVC SAHNSETNEH VAVKKIANAF DNKIDAKRTL 100
    REIKLLRHMD HENVVAIRDI VPPPQREVFN DVYIAYELMD TDLHQIIRSN 150
    QALSEEHCQY FLYQILRGLK YIHSANVLHR DLKPSNLLLN ANCDLKICDF 200
    GLARVTSETD FMTEYVVTRW YRAPELLLNS SDYTAAIDVW SVGCIFMELM 250
    DRKPLFPGRD HVHQLRLLME LIGTPSEDDL GFLNENAKRY IRQLPPYRRQ 300
    SFQEKFPHVH PEAIDLVEKM LTFDPRKRIT VEDALAHPYL TSLHDISDEP 350
    VCMTPFSFDF EQHALTEEQM KELIYREALA FNPEYQQ 387
    Length:387
    Mass (Da):44,402
    Last modified:October 1, 1994 - v1
    Checksum:i8672871A3D34EAD2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66469 mRNA. Translation: CAA47099.1.
    L07042 mRNA. Translation: AAB41548.1.
    PIRiS48123.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66469 mRNA. Translation: CAA47099.1 .
    L07042 mRNA. Translation: AAB41548.1 .
    PIRi S48123.

    3D structure databases

    ProteinModelPortali Q07176.
    SMRi Q07176. Positions 44-387.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.11.24. 3078.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The plant homologue of MAP kinase is expressed in a cell cycle-dependent and organ-specific manner."
      Jonak C., Pay A., Boegre L., Hirt H., Heberle-Bors E.
      Plant J. 3:611-617(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. "MsERK1: a mitogen-activated protein kinase from a flowering plant."
      Duerr B., Gawienowski M., Ropp T., Jacobs T.
      Plant Cell 5:87-96(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION AT TYR-215.
      Strain: cv. Iroquois.
      Tissue: Seedling root.

    Entry informationi

    Entry nameiMMK1_MEDSA
    AccessioniPrimary (citable) accession number: Q07176
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3