Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q07176

- MMK1_MEDSA

UniProt

Q07176 - MMK1_MEDSA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mitogen-activated protein kinase homolog MMK1

Gene

MMK1

Organism
Medicago sativa (Alfalfa)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the mitogenic induction of symbiotic root nodules on Alfalfa by Rhizobium signal molecules.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium.By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841ATPPROSITE-ProRule annotation
Active sitei181 – 1811Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 699ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. conjugation Source: UniProtKB-KW
  2. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Conjugation, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.24. 3078.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase homolog MMK1 (EC:2.7.11.24)
Alternative name(s):
MAP kinase ERK1
MAP kinase MSK7
Gene namesi
Name:MMK1
Synonyms:ERK1, MSK7
OrganismiMedicago sativa (Alfalfa)
Taxonomic identifieri3879 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Mitogen-activated protein kinase homolog MMK1PRO_0000186317Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei213 – 2131PhosphothreonineBy similarity
Modified residuei215 – 2151Phosphotyrosine1 Publication

Post-translational modificationi

Dually phosphorylated on Thr-213 and Tyr-215, which activates the enzyme (By similarity). Autophosphorylated.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Roots and stems.

Structurei

3D structure databases

ProteinModelPortaliQ07176.
SMRiQ07176. Positions 44-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 340286Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi213 – 2153TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07176-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGGGAPPAD TVMSDAAPAP PQMGIENIPA VLSHGGRFIQ YNIFGNIFEV
60 70 80 90 100
TAKYKPPIMP IGKGAYGIVC SAHNSETNEH VAVKKIANAF DNKIDAKRTL
110 120 130 140 150
REIKLLRHMD HENVVAIRDI VPPPQREVFN DVYIAYELMD TDLHQIIRSN
160 170 180 190 200
QALSEEHCQY FLYQILRGLK YIHSANVLHR DLKPSNLLLN ANCDLKICDF
210 220 230 240 250
GLARVTSETD FMTEYVVTRW YRAPELLLNS SDYTAAIDVW SVGCIFMELM
260 270 280 290 300
DRKPLFPGRD HVHQLRLLME LIGTPSEDDL GFLNENAKRY IRQLPPYRRQ
310 320 330 340 350
SFQEKFPHVH PEAIDLVEKM LTFDPRKRIT VEDALAHPYL TSLHDISDEP
360 370 380
VCMTPFSFDF EQHALTEEQM KELIYREALA FNPEYQQ
Length:387
Mass (Da):44,402
Last modified:October 1, 1994 - v1
Checksum:i8672871A3D34EAD2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66469 mRNA. Translation: CAA47099.1.
L07042 mRNA. Translation: AAB41548.1.
PIRiS48123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66469 mRNA. Translation: CAA47099.1 .
L07042 mRNA. Translation: AAB41548.1 .
PIRi S48123.

3D structure databases

ProteinModelPortali Q07176.
SMRi Q07176. Positions 44-387.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.11.24. 3078.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The plant homologue of MAP kinase is expressed in a cell cycle-dependent and organ-specific manner."
    Jonak C., Pay A., Boegre L., Hirt H., Heberle-Bors E.
    Plant J. 3:611-617(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "MsERK1: a mitogen-activated protein kinase from a flowering plant."
    Duerr B., Gawienowski M., Ropp T., Jacobs T.
    Plant Cell 5:87-96(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION AT TYR-215.
    Strain: cv. Iroquois.
    Tissue: Seedling root.

Entry informationi

Entry nameiMMK1_MEDSA
AccessioniPrimary (citable) accession number: Q07176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3