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Protein

Gelsolin

Gene

Gel

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi599 – 5991Calcium 1By similarity
Metal bindingi623 – 6231Calcium 1By similarity
Metal bindingi705 – 7051Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi706 – 7061Calcium 2By similarity
Metal bindingi728 – 7281Calcium 2By similarity

GO - Molecular functioni

  • actin binding Source: FlyBase
  • calcium ion binding Source: InterPro

GO - Biological processi

  • actin filament polymerization Source: UniProtKB
  • actin filament severing Source: InterPro
  • actin nucleation Source: InterPro
  • barbed-end actin filament capping Source: InterPro
  • phagocytosis Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-264870. Caspase-mediated cleavage of cytoskeletal proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Gelsolin
Gene namesi
Name:Gel
ORF Names:CG1106
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0010225. Gel.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: FlyBase
  • cytosol Source: UniProtKB
  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 798770GelsolinPRO_0000036393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901Phosphotyrosine; by SRCCurated
Modified residuei612 – 6121Phosphotyrosine; by SRCCurated
Modified residuei662 – 6621Phosphotyrosine; by SRCCurated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ07171.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are ubiquitously expressed in early embryo. Isoform 1 is expressed in the fat body, and is abundant in hemolymph. Isoform 2 is expressed in parts of the gut.1 Publication

Gene expression databases

BgeeiFBgn0010225.
GenevisibleiQ07171. DM.

Interactioni

Subunit structurei

Binds to actin and to fibronectin.1 Publication

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

BioGridi70060. 4 interactions.
IntActiQ07171. 4 interactions.
MINTiMINT-4080740.
STRINGi7227.FBpp0078607.

Structurei

3D structure databases

ProteinModelPortaliQ07171.
SMRiQ07171. Positions 58-784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati78 – 13154Gelsolin-like 1Add
BLAST
Repeati203 – 24341Gelsolin-like 2Add
BLAST
Repeati322 – 36544Gelsolin-like 3Add
BLAST
Repeati474 – 52451Gelsolin-like 4Add
BLAST
Repeati583 – 62543Gelsolin-like 5Add
BLAST
Repeati689 – 73042Gelsolin-like 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 181125Actin-severingSequence analysisAdd
BLAST
Regioni128 – 1314Actin-actin interfilament contact pointBy similarity
Regioni167 – 1748Polyphosphoinositide bindingBy similarity
Regioni193 – 2019Polyphosphoinositide bindingBy similarity
Regioni451 – 792342Actin-binding, Ca-sensitiveSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated
Contains 6 gelsolin-like repeats.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG0443. Eukaryota.
ENOG410XR0A. LUCA.
GeneTreeiENSGT00760000119111.
InParanoidiQ07171.
KOiK05768.
OMAiWDDNYWQ.
OrthoDBiEOG091G05SC.
PhylomeDBiQ07171.

Family and domain databases

Gene3Di3.40.20.10. 6 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR030004. Gelsolin.
IPR007123. Gelsolin-like_dom.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF39. PTHR11977:SF39. 1 hit.
PfamiPF00626. Gelsolin. 5 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1Curated1 Publication (identifier: Q07171-1) [UniParc]FASTAAdd to basket
Also known as: BCurated1 Publication, DImported, FImported, SecretedCurated1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDASGAATMA VLSSLLVFLA LSSSLCSAGT LNARPAFPVQ SGEIQPSGQN
60 70 80 90 100
SKQAARRVMH PSFANAGRTP GLEIWRIENF EPVIYPKTNY GKFYTGDSFI
110 120 130 140 150
VLNTIENKKD KKLSWDVHFW LGLETSTDEA GAAAILTVQL DDLLNGGPVQ
160 170 180 190 200
HREVQDHESQ LFLSYFKNGI RYEQGGVGTG FKHVETNAQG ETRLFQVKGK
210 220 230 240 250
RNVRVRQVNL SVSSMNTGDC FILDAGSDIY VYVGSQAKRV EKLKAISAAN
260 270 280 290 300
QIRDQDHNGR ARVQIVDDFS TDADKQHFFD VLGSGSADQV PDESTADEDS
310 320 330 340 350
AFERTDAAAV SLYKVSDASG KLKVDIIGQK PLTQAMLDTR ECFILDTGSG
360 370 380 390 400
IFVWVGKGAT QKEKTDAMAK AQEFLRTKKY PAWTQIHRIV EGSESAPFKQ
410 420 430 440 450
YFDTWRDAGM SHSRLIRSAL GIGSDELLND DEIDSVVTQL KKSGGRAFGF
460 470 480 490 500
MPDHGQNVIE TITQYVAKPG SDEIVVSTVP FDEKLPLLGF ASYVLTYNYE
510 520 530 540 550
ANNGDTGSLT YVWHGVKASA AARKRAFEEG LVGSKDGLLV QTNQGHEPRH
560 570 580 590 600
FYKIFKGKLL TSFTALPVTA QLFRIRGTVE SDVHASEVAA DSSSLASSDA
610 620 630 640 650
FVLHSGKSHK IYIWNGLGAS AFEKQAAVDR FSDYWDDVEL EQVEEGAEPD
660 670 680 690 700
EFWEELNGEG QYDRSLGDDG APLLESRLFH CHLSSGGFLK VEEVAQYEQE
710 720 730 740 750
DLDSDDIMLL DAGDEIYLWV GYGVSEEENG KLLDTAKLYF NLEPTARSFD
760 770 780 790
TVSIIRVPQG KEPRVFKRMF PNWDDNYWQN QPSYEDMKQL VIDANNEV
Length:798
Mass (Da):88,375
Last modified:June 1, 2000 - v2
Checksum:i79828666DC0965CC
GO
Isoform 2Curated1 Publication (identifier: Q07171-2) [UniParc]FASTAAdd to basket
Also known as: ACurated1 Publication, CytoplasmicCurated1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:740
Mass (Da):82,528
Checksum:i7B7B6F466F979632
GO
Isoform KImported (identifier: Q07171-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MDASGAATMAVLSS → MF

Note: No experimental confirmation available.
Show »
Length:786
Mass (Da):87,359
Checksum:i399CAFEE4734F7F9
GO

Sequence cautioni

The sequence AAA28568 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAM50316 differs from that shown.Intron retention.Curated
The sequence AAM50316 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence AAM50316 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence ABY20529 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA53295 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti498 – 4981N → S in CAA53294 (PubMed:8175883).Curated
Sequence conflicti498 – 4981N → S in CAA53295 (PubMed:8175883).Curated
Sequence conflicti646 – 6461G → S in CAA53294 (PubMed:8175883).Curated
Sequence conflicti646 – 6461G → S in CAA53295 (PubMed:8175883).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5858Missing in isoform 2. 1 PublicationVSP_007010Add
BLAST
Alternative sequencei1 – 1414MDASG…AVLSS → MF in isoform K. VSP_058364Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08794 mRNA. Translation: AAA28568.1. Different initiation.
X75629 mRNA. Translation: CAA53294.1.
X75630 mRNA. Translation: CAA53295.1. Different initiation.
AE014297 Genomic DNA. Translation: AAF52162.2.
AE014297 Genomic DNA. Translation: AAF52163.1.
AE014297 Genomic DNA. Translation: AAF52164.3.
AE014297 Genomic DNA. Translation: AAN13333.3.
AE014297 Genomic DNA. Translation: AAO41510.1.
AY119662 mRNA. Translation: AAM50316.1. Sequence problems.
BT031288 mRNA. Translation: ABY20529.1. Different initiation.
PIRiA53909.
RefSeqiNP_001036657.2. NM_001043192.3. [Q07171-2]
NP_524865.2. NM_080126.4. [Q07171-1]
NP_730788.1. NM_164319.4. [Q07171-2]
NP_730790.2. NM_164321.5. [Q07171-1]
NP_788571.1. NM_176394.3. [Q07171-1]
NP_996148.2. NM_206426.4. [Q07171-6]
NP_996149.3. NM_206427.4.

Genome annotation databases

EnsemblMetazoaiFBtr0078968; FBpp0078607; FBgn0010225. [Q07171-1]
FBtr0078969; FBpp0078608; FBgn0010225. [Q07171-1]
FBtr0078973; FBpp0078612; FBgn0010225. [Q07171-1]
FBtr0309256; FBpp0301195; FBgn0010225. [Q07171-1]
GeneIDi46008.
KEGGidme:Dmel_CG1106.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08794 mRNA. Translation: AAA28568.1. Different initiation.
X75629 mRNA. Translation: CAA53294.1.
X75630 mRNA. Translation: CAA53295.1. Different initiation.
AE014297 Genomic DNA. Translation: AAF52162.2.
AE014297 Genomic DNA. Translation: AAF52163.1.
AE014297 Genomic DNA. Translation: AAF52164.3.
AE014297 Genomic DNA. Translation: AAN13333.3.
AE014297 Genomic DNA. Translation: AAO41510.1.
AY119662 mRNA. Translation: AAM50316.1. Sequence problems.
BT031288 mRNA. Translation: ABY20529.1. Different initiation.
PIRiA53909.
RefSeqiNP_001036657.2. NM_001043192.3. [Q07171-2]
NP_524865.2. NM_080126.4. [Q07171-1]
NP_730788.1. NM_164319.4. [Q07171-2]
NP_730790.2. NM_164321.5. [Q07171-1]
NP_788571.1. NM_176394.3. [Q07171-1]
NP_996148.2. NM_206426.4. [Q07171-6]
NP_996149.3. NM_206427.4.

3D structure databases

ProteinModelPortaliQ07171.
SMRiQ07171. Positions 58-784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi70060. 4 interactions.
IntActiQ07171. 4 interactions.
MINTiMINT-4080740.
STRINGi7227.FBpp0078607.

Proteomic databases

PaxDbiQ07171.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078968; FBpp0078607; FBgn0010225. [Q07171-1]
FBtr0078969; FBpp0078608; FBgn0010225. [Q07171-1]
FBtr0078973; FBpp0078612; FBgn0010225. [Q07171-1]
FBtr0309256; FBpp0301195; FBgn0010225. [Q07171-1]
GeneIDi46008.
KEGGidme:Dmel_CG1106.

Organism-specific databases

CTDi46008.
FlyBaseiFBgn0010225. Gel.

Phylogenomic databases

eggNOGiKOG0443. Eukaryota.
ENOG410XR0A. LUCA.
GeneTreeiENSGT00760000119111.
InParanoidiQ07171.
KOiK05768.
OMAiWDDNYWQ.
OrthoDBiEOG091G05SC.
PhylomeDBiQ07171.

Enzyme and pathway databases

ReactomeiR-DME-264870. Caspase-mediated cleavage of cytoskeletal proteins.

Miscellaneous databases

ChiTaRSiBsg. fly.
GenomeRNAii46008.
PROiQ07171.

Gene expression databases

BgeeiFBgn0010225.
GenevisibleiQ07171. DM.

Family and domain databases

Gene3Di3.40.20.10. 6 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR030004. Gelsolin.
IPR007123. Gelsolin-like_dom.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF39. PTHR11977:SF39. 1 hit.
PfamiPF00626. Gelsolin. 5 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGELS_DROME
AccessioniPrimary (citable) accession number: Q07171
Secondary accession number(s): A4V2C8
, A9UNC4, Q0KIE3, Q0KIE4, Q8MRF9, Q9VMZ1, Q9VMZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: June 1, 2000
Last modified: September 7, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

Lacks one of the cysteines to make the disulfide bridge in isoform 1. It is replaced by Val-233.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.