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Q07159 (ALF1_STACT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase class 1

EC=4.1.2.13
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name=FBP aldolase
Gene names
Name:fda
Ordered Locus Names:Sca_2144
OrganismStaphylococcus carnosus (strain TM300) [Complete proteome] [HAMAP]
Taxonomic identifier396513 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP-Rule MF_00729

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. HAMAP-Rule MF_00729

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 296295Fructose-bisphosphate aldolase class 1 HAMAP-Rule MF_00729
PRO_0000216909

Sites

Active site1751Proton acceptor By similarity
Active site2121Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07159 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 13B5033BE67BF7E9

FASTA29632,851
        10         20         30         40         50         60 
MNQEQFDKIK NGKGFIAALD QSGGSTPKAL KDYGVEENEY SNDEEMFNLV HDMRTRIITS 

        70         80         90        100        110        120 
PAFNGEKILG AILFEQTMDR EVEGKYTGSY LADKGIVPFL KVDKGLAEEA DGVQLMKPIP 

       130        140        150        160        170        180 
DLDKLLDRAN ERGIFGTKMR SNILENNKEA IEKVVKQQFE VAKEIIAAGL VPIIEPEVNI 

       190        200        210        220        230        240 
NAKDKEAIEA NLAEAIKAEL DNLKKDQYVM LKLTIPTKVN AYSELIEHPQ VIRVVALSGG 

       250        260        270        280        290 
YSRDEANKIL KQNDGLIASF SRALVSDLNA QQSDAEFNEK LQEAIDTIFD ASVNKA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, sequencing, and characterization of the gene encoding the class I fructose-1,6-bisphosphate aldolase of Staphylococcus carnosus."
Witke C., Goetz F.
J. Bacteriol. 175:7495-7499(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-8.
[2]"Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300."
Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C., Goetz F.
Appl. Environ. Microbiol. 75:811-822(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TM300.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X71729 Genomic DNA. Translation: CAA50663.1.
AM295250 Genomic DNA. Translation: CAL29049.1.
PIRA49943.
RefSeqYP_002635234.1. NC_012121.1.

3D structure databases

ProteinModelPortalQ07159.
SMRQ07159. Positions 1-294.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING396513.Sca_2144.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7551079.
KEGGsca:Sca_2144.
PATRIC19605162. VBIStaCar105558_2143.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3588.
HOGENOMHOG000073502.
KOK01623.
OMAYTGDYLA.
OrthoDBEOG6M6JJT.

Enzyme and pathway databases

BioCycSCAR396513:GJ9G-2205-MONOMER.
UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00729. FBP_aldolase_1.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
IPR023014. FBP_aldolase_I_bac.
[Graphical view]
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF1_STACT
AccessionPrimary (citable) accession number: Q07159
Secondary accession number(s): B9DJW7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways