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Q07158

- TPS1_KLULA

UniProt

Q07158 - TPS1_KLULA

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Protein
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit
Gene
TPS1, GGS1, KLLA0B08822g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Appears to play a role in controlling and restricting the influx of sugar into glycolysis, probably at the level of hexokinase. Necessary for trehalose-6-phosphate synthase and phosphatase activities.

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:TPS1
Synonyms:GGS1
Ordered Locus Names:KLLA0B08822g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome B

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit
PRO_0000122498Add
BLAST

Interactioni

Subunit structurei

Trehalose synthase/phosphatase complex contains three or four polypeptides of 56 kDa (TPS1), 102 kDa (TPS2), 115 kDa (TPS3) and 123 kDa (TSL1).

Protein-protein interaction databases

STRINGi28985.Q07158.

Structurei

3D structure databases

ProteinModelPortaliQ07158.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0380.
HOGENOMiHOG000191477.
KOiK00697.
OMAiWGESFVK.
OrthoDBiEOG76QFS6.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07158-1 [UniParc]FASTAAdd to Basket

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MVNQDISKLS LNECPGSVIV ISNRLPVTIK KDEKTGEYEY SMSSGGLVTA    50
LQGLKKSTTF QWYGWPGLEV PDEDKAKVKR ELLEKFNAIP IFLSDEVADL 100
HYNGFSNSIL WPLFHYHPGE ITFDDTAWLA YNEANMAFAD EIEGNINDND 150
VVWVHDYHLM LLPEMIRQRV IAKKLKNIKI GWFLHTPFPS SEIYRILPVR 200
QEILKGVLSC DLIGFHTYDY ARHFLSAVQR ILNVNTLPNG VEFDGRFVNV 250
GAFPIGIDVE TFTEGLKQDA VIKRIKELKE SFKGCKIIIG VDRLDYIKGV 300
PQKLHALEVF LGAHPEWIGK VVLVQVAVPS RGDVEEYQYL RSVVNELVGR 350
INGQFGTAEF VPIHFMHRSI PFQELISLYA VSDVCLVSST RDGMNLVSYE 400
YISCQEEKKG TLILSEFTGA AQSLNGALIV NPWNTDDLAE SINEALTVPE 450
EKRAANWEKL YKYISKYTSA FWGENFVHEL YRLGSSNN 488
Length:488
Mass (Da):55,356
Last modified:October 1, 1994 - v1
Checksum:iD616654C166B3C17
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X72499 Genomic DNA. Translation: CAA51164.1.
CR382122 Genomic DNA. Translation: CAH02314.1.
PIRiS38987.
RefSeqiXP_451921.1. XM_451921.1.

Genome annotation databases

GeneIDi2896906.
KEGGikla:KLLA0B08822g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X72499 Genomic DNA. Translation: CAA51164.1 .
CR382122 Genomic DNA. Translation: CAH02314.1 .
PIRi S38987.
RefSeqi XP_451921.1. XM_451921.1.

3D structure databases

ProteinModelPortali Q07158.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q07158.

Protein family/group databases

CAZyi GT20. Glycosyltransferase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2896906.
KEGGi kla:KLLA0B08822g.

Phylogenomic databases

eggNOGi COG0380.
HOGENOMi HOG000191477.
KOi K00697.
OMAi WGESFVK.
OrthoDBi EOG76QFS6.

Family and domain databases

InterProi IPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02400. trehalose_OtsA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Disruption of the Kluyveromyces lactis GGS1 gene causes inability to grow on glucose and fructose and is suppressed by mutations that reduce sugar uptake."
    Luyten K., de Koning W., Tesseur I., Ruiz M.C., Ramos J., Cobbaert P., Thevelein J.M., Hohmann S.
    Eur. J. Biochem. 217:701-713(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Entry informationi

Entry nameiTPS1_KLULA
AccessioniPrimary (citable) accession number: Q07158
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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