Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q07158

- TPS1_KLULA

UniProt

Q07158 - TPS1_KLULA

Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

Gene

TPS1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Appears to play a role in controlling and restricting the influx of sugar into glycolysis, probably at the level of hexokinase. Necessary for trehalose-6-phosphate synthase and phosphatase activities.

    Catalytic activityi

    UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

    GO - Molecular functioni

    1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. trehalose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT20. Glycosyltransferase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit (EC:2.4.1.15)
    Alternative name(s):
    Trehalose-6-phosphate synthase
    UDP-glucose-glucosephosphate glucosyltransferase
    Gene namesi
    Name:TPS1
    Synonyms:GGS1
    Ordered Locus Names:KLLA0B08822g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome B

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunitPRO_0000122498Add
    BLAST

    Interactioni

    Subunit structurei

    Trehalose synthase/phosphatase complex contains three or four polypeptides of 56 kDa (TPS1), 102 kDa (TPS2), 115 kDa (TPS3) and 123 kDa (TSL1).

    Protein-protein interaction databases

    STRINGi28985.Q07158.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 20 family.Curated

    Phylogenomic databases

    eggNOGiCOG0380.
    HOGENOMiHOG000191477.
    KOiK00697.
    OMAiWGESFVK.
    OrthoDBiEOG76QFS6.

    Family and domain databases

    InterProiIPR001830. Glyco_trans_20.
    IPR012766. Trehalose_OtsA.
    [Graphical view]
    PfamiPF00982. Glyco_transf_20. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q07158-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNQDISKLS LNECPGSVIV ISNRLPVTIK KDEKTGEYEY SMSSGGLVTA    50
    LQGLKKSTTF QWYGWPGLEV PDEDKAKVKR ELLEKFNAIP IFLSDEVADL 100
    HYNGFSNSIL WPLFHYHPGE ITFDDTAWLA YNEANMAFAD EIEGNINDND 150
    VVWVHDYHLM LLPEMIRQRV IAKKLKNIKI GWFLHTPFPS SEIYRILPVR 200
    QEILKGVLSC DLIGFHTYDY ARHFLSAVQR ILNVNTLPNG VEFDGRFVNV 250
    GAFPIGIDVE TFTEGLKQDA VIKRIKELKE SFKGCKIIIG VDRLDYIKGV 300
    PQKLHALEVF LGAHPEWIGK VVLVQVAVPS RGDVEEYQYL RSVVNELVGR 350
    INGQFGTAEF VPIHFMHRSI PFQELISLYA VSDVCLVSST RDGMNLVSYE 400
    YISCQEEKKG TLILSEFTGA AQSLNGALIV NPWNTDDLAE SINEALTVPE 450
    EKRAANWEKL YKYISKYTSA FWGENFVHEL YRLGSSNN 488
    Length:488
    Mass (Da):55,356
    Last modified:October 1, 1994 - v1
    Checksum:iD616654C166B3C17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72499 Genomic DNA. Translation: CAA51164.1.
    CR382122 Genomic DNA. Translation: CAH02314.1.
    PIRiS38987.
    RefSeqiXP_451921.1. XM_451921.1.

    Genome annotation databases

    GeneIDi2896906.
    KEGGikla:KLLA0B08822g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72499 Genomic DNA. Translation: CAA51164.1 .
    CR382122 Genomic DNA. Translation: CAH02314.1 .
    PIRi S38987.
    RefSeqi XP_451921.1. XM_451921.1.

    3D structure databases

    ProteinModelPortali Q07158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q07158.

    Protein family/group databases

    CAZyi GT20. Glycosyltransferase Family 20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2896906.
    KEGGi kla:KLLA0B08822g.

    Phylogenomic databases

    eggNOGi COG0380.
    HOGENOMi HOG000191477.
    KOi K00697.
    OMAi WGESFVK.
    OrthoDBi EOG76QFS6.

    Family and domain databases

    InterProi IPR001830. Glyco_trans_20.
    IPR012766. Trehalose_OtsA.
    [Graphical view ]
    Pfami PF00982. Glyco_transf_20. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02400. trehalose_OtsA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Disruption of the Kluyveromyces lactis GGS1 gene causes inability to grow on glucose and fructose and is suppressed by mutations that reduce sugar uptake."
      Luyten K., de Koning W., Tesseur I., Ruiz M.C., Ramos J., Cobbaert P., Thevelein J.M., Hohmann S.
      Eur. J. Biochem. 217:701-713(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

    Entry informationi

    Entry nameiTPS1_KLULA
    AccessioniPrimary (citable) accession number: Q07158
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3