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Protein

Histone H1t

Gene

Hist1h1t

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei54Important for nucleosome binding propertiesBy similarity1

GO - Molecular functioni

  • DNA binding Source: MGI
  • double-stranded DNA binding Source: CAFA

GO - Biological processi

  • binding of sperm to zona pellucida Source: MGI
  • cell differentiation Source: UniProtKB-KW
  • flagellated sperm motility Source: MGI
  • multicellular organism development Source: UniProtKB-KW
  • nucleosome assembly Source: InterPro
  • spermatogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1t
Alternative name(s):
Testicular H1 histone
Gene namesi
Name:Hist1h1t
Synonyms:H1ft, H1t
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1888530. Hist1h1t.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001959192 – 208Histone H1tAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9Phosphoserine1 Publication1
Modified residuei56CitrullineBy similarity1
Modified residuei141Phosphoserine2 Publications1
Modified residuei156Phosphothreonine2 Publications1
Modified residuei163Phosphoserine1 Publication1
Modified residuei178Phosphoserine2 Publications1

Post-translational modificationi

Phosphorylated in early spermatids.1 Publication
Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

MaxQBiQ07133.
PaxDbiQ07133.
PRIDEiQ07133.

PTM databases

iPTMnetiQ07133.
PhosphoSitePlusiQ07133.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Developmental stagei

This histone is a testis-specific H1 variant that appears during meiosis in spermatogenesis.1 Publication

Gene expression databases

CleanExiMM_HIST1H1T.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037304.

Structurei

3D structure databases

ProteinModelPortaliQ07133.
SMRiQ07133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 111H15PROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
HOGENOMiHOG000251627.
HOVERGENiHBG009035.
InParanoidiQ07133.
KOiK11275.
PhylomeDBiQ07133.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00538. Linker_histone. 1 hit.
PRINTSiPR00624. HISTONEH5.
SMARTiView protein in SMART
SM00526. H15. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS51504. H15. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETAPAASS TLVPAPVEKP SSKRRGKKPG LAPARKPRGF SVSKLIPEAL
60 70 80 90 100
STSQERAGMS LAALKKALAA AGYDVEKNNS RIKLALKRLV NKGVLVQTKG
110 120 130 140 150
TGASGSFKLS KKAASGNDKG KGKKSASAKA KKMGLPRASR SPKSSKTKAV
160 170 180 190 200
KKPKATPTKA SGSGRKTKGA KGVQQRKSPA KARAANPNSG KAKMVMQKTD

LRKAAGRK
Length:208
Mass (Da):21,540
Last modified:January 23, 2007 - v4
Checksum:i25E35B84008B22C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18E → EE in AAO06219 (PubMed:12408966).Curated1
Sequence conflicti164G → R in AAB38417 (Ref. 2) Curated1
Sequence conflicti164G → R in AAA18359 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28753 Genomic DNA. Translation: AAB38417.1.
X72805 Genomic DNA. Translation: CAA51325.1.
U06232 Unassigned DNA. Translation: AAA18359.1.
AY158908 Genomic DNA. Translation: AAO06219.1.
BC119305 mRNA. Translation: AAI19306.1.
BC119307 mRNA. Translation: AAI19308.1.
PIRiS43434.
RefSeqiNP_034507.2. NM_010377.3.
UniGeneiMm.8048.

Genome annotation databases

GeneIDi107970.
KEGGimmu:107970.

Similar proteinsi

Entry informationi

Entry nameiH1T_MOUSE
AccessioniPrimary (citable) accession number: Q07133
Secondary accession number(s): Q0VEA3, Q8CGP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 130 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families