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Protein

Histone H1t

Gene

Hist1h1t

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei54 – 541Important for nucleosome binding propertiesBy similarity

GO - Molecular functioni

  • DNA binding Source: MGI

GO - Biological processi

  • binding of sperm to zona pellucida Source: MGI
  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • nucleosome assembly Source: InterPro
  • spermatogenesis Source: MGI
  • sperm motility Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1t
Alternative name(s):
Testicular H1 histone
Gene namesi
Name:Hist1h1t
Synonyms:H1ft, H1t
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1888530. Hist1h1t.

Subcellular locationi

GO - Cellular componenti

  • condensed nuclear chromosome Source: MGI
  • intracellular Source: MGI
  • nucleosome Source: InterPro
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 208207Histone H1tPRO_0000195919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Phosphoserine1 Publication
Modified residuei56 – 561CitrullineBy similarity
Modified residuei141 – 1411Phosphoserine2 Publications
Modified residuei156 – 1561Phosphothreonine2 Publications
Modified residuei163 – 1631Phosphoserine1 Publication
Modified residuei178 – 1781Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated in early spermatids.1 Publication
Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

MaxQBiQ07133.
PaxDbiQ07133.
PRIDEiQ07133.

PTM databases

iPTMnetiQ07133.
PhosphoSiteiQ07133.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Developmental stagei

This histone is a testis-specific H1 variant that appears during meiosis in spermatogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000036211.
CleanExiMM_HIST1H1T.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037304.

Structurei

3D structure databases

ProteinModelPortaliQ07133.
SMRiQ07133. Positions 39-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 11174H15PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
HOGENOMiHOG000251627.
HOVERGENiHBG009035.
InParanoidiQ07133.
KOiK11275.
PhylomeDBiQ07133.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETAPAASS TLVPAPVEKP SSKRRGKKPG LAPARKPRGF SVSKLIPEAL
60 70 80 90 100
STSQERAGMS LAALKKALAA AGYDVEKNNS RIKLALKRLV NKGVLVQTKG
110 120 130 140 150
TGASGSFKLS KKAASGNDKG KGKKSASAKA KKMGLPRASR SPKSSKTKAV
160 170 180 190 200
KKPKATPTKA SGSGRKTKGA KGVQQRKSPA KARAANPNSG KAKMVMQKTD

LRKAAGRK
Length:208
Mass (Da):21,540
Last modified:January 23, 2007 - v4
Checksum:i25E35B84008B22C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181E → EE in AAO06219 (PubMed:12408966).Curated
Sequence conflicti164 – 1641G → R in AAB38417 (Ref. 2) Curated
Sequence conflicti164 – 1641G → R in AAA18359 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28753 Genomic DNA. Translation: AAB38417.1.
X72805 Genomic DNA. Translation: CAA51325.1.
U06232 Unassigned DNA. Translation: AAA18359.1.
AY158908 Genomic DNA. Translation: AAO06219.1.
BC119305 mRNA. Translation: AAI19306.1.
BC119307 mRNA. Translation: AAI19308.1.
PIRiS43434.
RefSeqiNP_034507.2. NM_010377.3.
UniGeneiMm.8048.

Genome annotation databases

GeneIDi107970.
KEGGimmu:107970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28753 Genomic DNA. Translation: AAB38417.1.
X72805 Genomic DNA. Translation: CAA51325.1.
U06232 Unassigned DNA. Translation: AAA18359.1.
AY158908 Genomic DNA. Translation: AAO06219.1.
BC119305 mRNA. Translation: AAI19306.1.
BC119307 mRNA. Translation: AAI19308.1.
PIRiS43434.
RefSeqiNP_034507.2. NM_010377.3.
UniGeneiMm.8048.

3D structure databases

ProteinModelPortaliQ07133.
SMRiQ07133. Positions 39-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037304.

PTM databases

iPTMnetiQ07133.
PhosphoSiteiQ07133.

Proteomic databases

MaxQBiQ07133.
PaxDbiQ07133.
PRIDEiQ07133.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107970.
KEGGimmu:107970.

Organism-specific databases

CTDi3010.
MGIiMGI:1888530. Hist1h1t.

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
HOGENOMiHOG000251627.
HOVERGENiHBG009035.
InParanoidiQ07133.
KOiK11275.
PhylomeDBiQ07133.

Miscellaneous databases

PROiQ07133.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036211.
CleanExiMM_HIST1H1T.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH1T_MOUSE
AccessioniPrimary (citable) accession number: Q07133
Secondary accession number(s): Q0VEA3, Q8CGP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 123 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.