ID   UGPA_BOVIN              Reviewed;         508 AA.
AC   Q07130; Q17QU0;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   16-JUN-2009, entry version 49.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE            EC=2.7.7.9;
DE   AltName: Full=UDP-glucose pyrophosphorylase;
DE            Short=UDPGP;
DE            Short=UGPase;
GN   Name=UGP2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=Danshaku-Imo; TISSUE=Liver;
RX   MEDLINE=94012583; PubMed=8407878;
RA   Konishi Y., Tanizawa K., Muroya S., Fukui T.;
RT   "Molecular cloning, nucleotide sequencing, and affinity labeling of
RT   bovine liver UDP-glucose pyrophosphorylase.";
RL   J. Biochem. 114:61-68(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a central role as a glucosyl donor in cellular
CC       metabolic pathways.
CC   -!- CATALYTIC ACTIVITY: UTP + alpha-D-glucose 1-phosphate =
CC       diphosphate + UDP-glucose.
CC   -!- SUBUNIT: Homooctamer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the UDPGP type 1 family.
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DR   EMBL; L14019; AAA30801.1; -; mRNA.
DR   EMBL; BC118181; AAI18182.1; -; mRNA.
DR   IPI; IPI00689863; -.
DR   PIR; JX0277; JX0277.
DR   RefSeq; NP_776637.1; -.
DR   UniGene; Bt.3567; -.
DR   Ensembl; ENSBTAG00000000111; Bos taurus.
DR   GeneID; 281565; -.
DR   KEGG; bta:281565; -.
DR   HOVERGEN; Q07130; -.
DR   OMA; Q07130; AEYIMEL.
DR   BRENDA; 2.7.7.9; 251.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase...; IEA:EC.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR002618; UDPGP_trans.
DR   InterPro; IPR016267; UDPGP_trans_sub.
DR   PANTHER; PTHR11952; UDPGP_trans; 1.
DR   Pfam; PF01704; UDPGP; 1.
DR   PIRSF; PIRSF000806; UDPGP; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Nucleotidyltransferase;
KW   Transferase.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    508       UTP--glucose-1-phosphate
FT                                uridylyltransferase.
FT                                /FTId=PRO_0000185751.
FT   MOD_RES       2      2       Blocked amino end (Ser).
SQ   SEQUENCE   508 AA;  56903 MW;  A264DD254E6ED934 CRC64;
     MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTAPSHEFEH TKKDLDGFRK
     LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN VSSVLNKLVV VKLNGGLGTS
     MGCKGPKSLI GVRNENTFLD LTVQQIEHLN KTYDTDVPLV LMNSFNTDED TKKILQKYNH
     CRVKIYTFNQ SRYPRINKES LLPVAKNVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI
     GEGKEYIFVS NIDNLGATVD LYILNHLMNP PNGKPCEFVM EVTNKTRADV KGGTLTQYEG
     KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM EIIVNPKTLD
     GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD LLLVMSNLYS LNAGSLTMSE
     KREFPTVPLV KLGSSFTKVQ DYLRRFESIP DMLELDHLTV SGDVTFGKNV SLKGTVIIIA
     NHGDRIDIPP GAVLENKIVS GNLRILDH
//