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Q07130

- UGPA_BOVIN

UniProt

Q07130 - UGPA_BOVIN

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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene
UGP2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi127 – 1271Magnesium By similarity
Metal bindingi253 – 2531Magnesium By similarity
Active sitei396 – 3961 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_213093. Glycogen synthesis.
REACT_214113. Formation of the active cofactor, UDP-glucuronate.
SABIO-RKQ07130.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:UGP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508UTP--glucose-1-phosphate uridylyltransferasePRO_0000185751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Blocked amino end (Ser)
Modified residuei13 – 131Phosphoserine By similarity
Modified residuei438 – 4381N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ07130.
PRIDEiQ07130.

Interactioni

Subunit structurei

Homooctamer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042228.

Structurei

3D structure databases

ProteinModelPortaliQ07130.
SMRiQ07130. Positions 51-508.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni457 – 50852Oligomerization By similarityAdd
BLAST
Regioni502 – 5032Critical for end-to-end subunit interaction By similarity

Sequence similaritiesi

Belongs to the UDPGP type 1 family.

Phylogenomic databases

eggNOGiCOG4284.
GeneTreeiENSGT00390000003174.
HOGENOMiHOG000113618.
HOVERGENiHBG055396.
InParanoidiQ07130.
KOiK00963.
OMAiPPNGKRC.
OrthoDBiEOG7ZPNK4.
TreeFamiTF300567.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07130-1 [UniParc]FASTAAdd to Basket

« Hide

MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTAPSHEFEH    50
TKKDLDGFRK LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN 100
VSSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN 150
KTYDTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES 200
LLPVAKNVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI GEGKEYIFVS 250
NIDNLGATVD LYILNHLMNP PNGKPCEFVM EVTNKTRADV KGGTLTQYEG 300
KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM 350
EIIVNPKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD 400
LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP 450
DMLELDHLTV SGDVTFGKNV SLKGTVIIIA NHGDRIDIPP GAVLENKIVS 500
GNLRILDH 508
Length:508
Mass (Da):56,903
Last modified:January 23, 2007 - v2
Checksum:iA264DD254E6ED934
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14019 mRNA. Translation: AAA30801.1.
BC118181 mRNA. Translation: AAI18182.1.
PIRiJX0277.
RefSeqiNP_776637.1. NM_174212.2.
UniGeneiBt.3567.

Genome annotation databases

EnsembliENSBTAT00000044762; ENSBTAP00000042228; ENSBTAG00000000111.
GeneIDi281565.
KEGGibta:281565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14019 mRNA. Translation: AAA30801.1 .
BC118181 mRNA. Translation: AAI18182.1 .
PIRi JX0277.
RefSeqi NP_776637.1. NM_174212.2.
UniGenei Bt.3567.

3D structure databases

ProteinModelPortali Q07130.
SMRi Q07130. Positions 51-508.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000042228.

Proteomic databases

PaxDbi Q07130.
PRIDEi Q07130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000044762 ; ENSBTAP00000042228 ; ENSBTAG00000000111 .
GeneIDi 281565.
KEGGi bta:281565.

Organism-specific databases

CTDi 7360.

Phylogenomic databases

eggNOGi COG4284.
GeneTreei ENSGT00390000003174.
HOGENOMi HOG000113618.
HOVERGENi HBG055396.
InParanoidi Q07130.
KOi K00963.
OMAi PPNGKRC.
OrthoDBi EOG7ZPNK4.
TreeFami TF300567.

Enzyme and pathway databases

Reactomei REACT_213093. Glycogen synthesis.
REACT_214113. Formation of the active cofactor, UDP-glucuronate.
SABIO-RK Q07130.

Miscellaneous databases

NextBioi 20805515.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view ]
PANTHERi PTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
Pfami PF01704. UDPGP. 1 hit.
[Graphical view ]
PIRSFi PIRSF000806. UDPGP. 1 hit.
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, nucleotide sequencing, and affinity labeling of bovine liver UDP-glucose pyrophosphorylase."
    Konishi Y., Tanizawa K., Muroya S., Fukui T.
    J. Biochem. 114:61-68(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: Danshaku-Imo.
    Tissue: Liver.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thalamus.

Entry informationi

Entry nameiUGPA_BOVIN
AccessioniPrimary (citable) accession number: Q07130
Secondary accession number(s): Q17QU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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