Q07130 (UGPA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UTP--glucose-1-phosphate uridylyltransferase
EC=2.7.7.9

Alternative name(s):
UDP-glucose pyrophosphorylase
Short name=UDPGP
Short name=UGPase

Gene names

Name:

UGP2

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a central role as a glucosyl donor in cellular metabolic pathways.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Subunit structure	Homooctamer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the UDPGP type 1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Nucleotidyltransferase Transferase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000185751
Regions
	Region	457 – 508	52	Oligomerization By similarity
Sites
	Active site	396	1	By similarity
	Metal binding	127	1	Magnesium By similarity
	Metal binding	253	1	Magnesium By similarity
Amino acid modifications
	Modified residue	2	1	Blocked amino end (Ser)
	Modified residue	13	1	Phosphoserine By similarity
	Modified residue	438	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q07130 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: A264DD254E6ED934	FASTA	508	56,903
	10 20 30 40 50 60 MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTAPSHEFEH TKKDLDGFRK 70 80 90 100 110 120 LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN VSSVLNKLVV VKLNGGLGTS 130 140 150 160 170 180 MGCKGPKSLI GVRNENTFLD LTVQQIEHLN KTYDTDVPLV LMNSFNTDED TKKILQKYNH 190 200 210 220 230 240 CRVKIYTFNQ SRYPRINKES LLPVAKNVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI 250 260 270 280 290 300 GEGKEYIFVS NIDNLGATVD LYILNHLMNP PNGKPCEFVM EVTNKTRADV KGGTLTQYEG 310 320 330 340 350 360 KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM EIIVNPKTLD 370 380 390 400 410 420 GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD LLLVMSNLYS LNAGSLTMSE 430 440 450 460 470 480 KREFPTVPLV KLGSSFTKVQ DYLRRFESIP DMLELDHLTV SGDVTFGKNV SLKGTVIIIA 490 500 NHGDRIDIPP GAVLENKIVS GNLRILDH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, nucleotide sequencing, and affinity labeling of bovine liver UDP-glucose pyrophosphorylase." Konishi Y., Tanizawa K., Muroya S., Fukui T. J. Biochem. 114:61-68(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Strain: Danshaku-Imo. Tissue: Liver.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thalamus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L14019 mRNA. Translation: AAA30801.1. BC118181 mRNA. Translation: AAI18182.1.
IPI	IPI00689863.
PIR	JX0277.
RefSeq	NP_776637.1. NM_174212.2.
UniGene	Bt.3567.
3D structure databases
ProteinModelPortal	Q07130.
SMR	Q07130. Positions 51-508.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000042228.
Proteomic databases
PaxDb	Q07130.
PRIDE	Q07130.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000044762; ENSBTAP00000042228; ENSBTAG00000000111.
GeneID	281565.
KEGG	bta:281565.
Organism-specific databases
CTD	7360.
Phylogenomic databases
eggNOG	COG4284.
GeneTree	ENSGT00390000003174.
HOGENOM	HOG000113618.
HOVERGEN	HBG055396.
InParanoid	Q07130.
KO	K00963.
OMA	PPNGKRC.
OrthoDB	EOG4RFKSC.
Enzyme and pathway databases
SABIO-RK	Q07130.
Family and domain databases
InterPro	IPR002618. UDPGP_trans. IPR016267. UDPGP_trans_subgr. [Graphical view]
PANTHER	PTHR11952. PTHR11952. 1 hit. PTHR11952:SF1. PTHR11952:SF1. 1 hit.
Pfam	PF01704. UDPGP. 1 hit. [Graphical view]
PIRSF	PIRSF000806. UDPGP. 1 hit.
ProtoNet	Search...
Other
NextBio	20805515.

Entry information

Entry name

UGPA_BOVIN

Accession

Primary (citable) accession number: Q07130
Secondary accession number(s): Q17QU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program