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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

UGP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi127 – 1271MagnesiumBy similarity
Metal bindingi253 – 2531MagnesiumBy similarity
Active sitei396 – 3961By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_305023. Formation of the active cofactor, UDP-glucuronate.
REACT_336380. Glycogen synthesis.
SABIO-RKQ07130.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:UGP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508UTP--glucose-1-phosphate uridylyltransferasePRO_0000185751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Blocked amino end (Ser)
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei426 – 4261PhosphothreonineBy similarity
Modified residuei434 – 4341PhosphoserineBy similarity
Modified residuei438 – 4381N6-acetyllysineBy similarity
Modified residuei448 – 4481PhosphoserineBy similarity
Modified residuei461 – 4611PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ07130.
PRIDEiQ07130.

Interactioni

Subunit structurei

Homooctamer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042228.

Structurei

3D structure databases

ProteinModelPortaliQ07130.
SMRiQ07130. Positions 51-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni457 – 50852OligomerizationBy similarityAdd
BLAST
Regioni502 – 5032Critical for end-to-end subunit interactionBy similarity

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiCOG4284.
GeneTreeiENSGT00390000003174.
HOGENOMiHOG000113618.
HOVERGENiHBG055396.
InParanoidiQ07130.
KOiK00963.
OMAiIAKDVSY.
OrthoDBiEOG7ZPNK4.
TreeFamiTF300567.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07130-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTAPSHEFEH
60 70 80 90 100
TKKDLDGFRK LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN
110 120 130 140 150
VSSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN
160 170 180 190 200
KTYDTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES
210 220 230 240 250
LLPVAKNVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI GEGKEYIFVS
260 270 280 290 300
NIDNLGATVD LYILNHLMNP PNGKPCEFVM EVTNKTRADV KGGTLTQYEG
310 320 330 340 350
KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM
360 370 380 390 400
EIIVNPKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD
410 420 430 440 450
LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP
460 470 480 490 500
DMLELDHLTV SGDVTFGKNV SLKGTVIIIA NHGDRIDIPP GAVLENKIVS

GNLRILDH
Length:508
Mass (Da):56,903
Last modified:January 23, 2007 - v2
Checksum:iA264DD254E6ED934
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14019 mRNA. Translation: AAA30801.1.
BC118181 mRNA. Translation: AAI18182.1.
PIRiJX0277.
RefSeqiNP_776637.1. NM_174212.2.
UniGeneiBt.3567.

Genome annotation databases

EnsembliENSBTAT00000044762; ENSBTAP00000042228; ENSBTAG00000000111.
GeneIDi281565.
KEGGibta:281565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14019 mRNA. Translation: AAA30801.1.
BC118181 mRNA. Translation: AAI18182.1.
PIRiJX0277.
RefSeqiNP_776637.1. NM_174212.2.
UniGeneiBt.3567.

3D structure databases

ProteinModelPortaliQ07130.
SMRiQ07130. Positions 51-508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042228.

Proteomic databases

PaxDbiQ07130.
PRIDEiQ07130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000044762; ENSBTAP00000042228; ENSBTAG00000000111.
GeneIDi281565.
KEGGibta:281565.

Organism-specific databases

CTDi7360.

Phylogenomic databases

eggNOGiCOG4284.
GeneTreeiENSGT00390000003174.
HOGENOMiHOG000113618.
HOVERGENiHBG055396.
InParanoidiQ07130.
KOiK00963.
OMAiIAKDVSY.
OrthoDBiEOG7ZPNK4.
TreeFamiTF300567.

Enzyme and pathway databases

ReactomeiREACT_305023. Formation of the active cofactor, UDP-glucuronate.
REACT_336380. Glycogen synthesis.
SABIO-RKQ07130.

Miscellaneous databases

NextBioi20805515.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, nucleotide sequencing, and affinity labeling of bovine liver UDP-glucose pyrophosphorylase."
    Konishi Y., Tanizawa K., Muroya S., Fukui T.
    J. Biochem. 114:61-68(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: Danshaku-Imo.
    Tissue: Liver.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thalamus.

Entry informationi

Entry nameiUGPA_BOVIN
AccessioniPrimary (citable) accession number: Q07130
Secondary accession number(s): Q17QU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.