Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q07130

- UGPA_BOVIN

UniProt

Q07130 - UGPA_BOVIN

Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

UGP2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays a central role as a glucosyl donor in cellular metabolic pathways.

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi127 – 1271MagnesiumBy similarity
    Metal bindingi253 – 2531MagnesiumBy similarity
    Active sitei396 – 3961By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_213093. Glycogen synthesis.
    REACT_214113. Formation of the active cofactor, UDP-glucuronate.
    SABIO-RKQ07130.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
    Alternative name(s):
    UDP-glucose pyrophosphorylase
    Short name:
    UDPGP
    Short name:
    UGPase
    Gene namesi
    Name:UGP2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 11

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508UTP--glucose-1-phosphate uridylyltransferasePRO_0000185751Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21Blocked amino end (Ser)
    Modified residuei13 – 131PhosphoserineBy similarity
    Modified residuei438 – 4381N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ07130.
    PRIDEiQ07130.

    Interactioni

    Subunit structurei

    Homooctamer.

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000042228.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07130.
    SMRiQ07130. Positions 51-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni457 – 50852OligomerizationBy similarityAdd
    BLAST
    Regioni502 – 5032Critical for end-to-end subunit interactionBy similarity

    Sequence similaritiesi

    Belongs to the UDPGP type 1 family.Curated

    Phylogenomic databases

    eggNOGiCOG4284.
    GeneTreeiENSGT00390000003174.
    HOGENOMiHOG000113618.
    HOVERGENiHBG055396.
    InParanoidiQ07130.
    KOiK00963.
    OMAiPPNGKRC.
    OrthoDBiEOG7ZPNK4.
    TreeFamiTF300567.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR029044. Nucleotide-diphossugar_trans.
    IPR016267. UDPGP_trans.
    IPR002618. UDPGP_trans_fam.
    [Graphical view]
    PANTHERiPTHR11952. PTHR11952. 1 hit.
    PTHR11952:SF1. PTHR11952:SF1. 1 hit.
    PfamiPF01704. UDPGP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000806. UDPGP. 1 hit.
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q07130-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTAPSHEFEH    50
    TKKDLDGFRK LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN 100
    VSSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN 150
    KTYDTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES 200
    LLPVAKNVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI GEGKEYIFVS 250
    NIDNLGATVD LYILNHLMNP PNGKPCEFVM EVTNKTRADV KGGTLTQYEG 300
    KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM 350
    EIIVNPKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD 400
    LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP 450
    DMLELDHLTV SGDVTFGKNV SLKGTVIIIA NHGDRIDIPP GAVLENKIVS 500
    GNLRILDH 508
    Length:508
    Mass (Da):56,903
    Last modified:January 23, 2007 - v2
    Checksum:iA264DD254E6ED934
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14019 mRNA. Translation: AAA30801.1.
    BC118181 mRNA. Translation: AAI18182.1.
    PIRiJX0277.
    RefSeqiNP_776637.1. NM_174212.2.
    UniGeneiBt.3567.

    Genome annotation databases

    EnsembliENSBTAT00000044762; ENSBTAP00000042228; ENSBTAG00000000111.
    GeneIDi281565.
    KEGGibta:281565.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14019 mRNA. Translation: AAA30801.1 .
    BC118181 mRNA. Translation: AAI18182.1 .
    PIRi JX0277.
    RefSeqi NP_776637.1. NM_174212.2.
    UniGenei Bt.3567.

    3D structure databases

    ProteinModelPortali Q07130.
    SMRi Q07130. Positions 51-508.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000042228.

    Proteomic databases

    PaxDbi Q07130.
    PRIDEi Q07130.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000044762 ; ENSBTAP00000042228 ; ENSBTAG00000000111 .
    GeneIDi 281565.
    KEGGi bta:281565.

    Organism-specific databases

    CTDi 7360.

    Phylogenomic databases

    eggNOGi COG4284.
    GeneTreei ENSGT00390000003174.
    HOGENOMi HOG000113618.
    HOVERGENi HBG055396.
    InParanoidi Q07130.
    KOi K00963.
    OMAi PPNGKRC.
    OrthoDBi EOG7ZPNK4.
    TreeFami TF300567.

    Enzyme and pathway databases

    Reactomei REACT_213093. Glycogen synthesis.
    REACT_214113. Formation of the active cofactor, UDP-glucuronate.
    SABIO-RK Q07130.

    Miscellaneous databases

    NextBioi 20805515.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR029044. Nucleotide-diphossugar_trans.
    IPR016267. UDPGP_trans.
    IPR002618. UDPGP_trans_fam.
    [Graphical view ]
    PANTHERi PTHR11952. PTHR11952. 1 hit.
    PTHR11952:SF1. PTHR11952:SF1. 1 hit.
    Pfami PF01704. UDPGP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000806. UDPGP. 1 hit.
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, nucleotide sequencing, and affinity labeling of bovine liver UDP-glucose pyrophosphorylase."
      Konishi Y., Tanizawa K., Muroya S., Fukui T.
      J. Biochem. 114:61-68(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: Danshaku-Imo.
      Tissue: Liver.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thalamus.

    Entry informationi

    Entry nameiUGPA_BOVIN
    AccessioniPrimary (citable) accession number: Q07130
    Secondary accession number(s): Q17QU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3