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Q07130 (UGPA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UTP--glucose-1-phosphate uridylyltransferase

EC=2.7.7.9
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name=UDPGP
Short name=UGPase
Gene names
Name:UGP2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a central role as a glucosyl donor in cellular metabolic pathways.

Catalytic activity

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Subunit structure

Homooctamer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the UDPGP type 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508UTP--glucose-1-phosphate uridylyltransferase
PRO_0000185751

Regions

Region457 – 50852Oligomerization By similarity
Region502 – 5032Critical for end-to-end subunit interaction By similarity

Sites

Active site3961 By similarity
Metal binding1271Magnesium By similarity
Metal binding2531Magnesium By similarity

Amino acid modifications

Modified residue21Blocked amino end (Ser)
Modified residue131Phosphoserine By similarity
Modified residue4381N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07130 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: A264DD254E6ED934

FASTA50856,903
        10         20         30         40         50         60 
MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTAPSHEFEH TKKDLDGFRK 

        70         80         90        100        110        120 
LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN VSSVLNKLVV VKLNGGLGTS 

       130        140        150        160        170        180 
MGCKGPKSLI GVRNENTFLD LTVQQIEHLN KTYDTDVPLV LMNSFNTDED TKKILQKYNH 

       190        200        210        220        230        240 
CRVKIYTFNQ SRYPRINKES LLPVAKNVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI 

       250        260        270        280        290        300 
GEGKEYIFVS NIDNLGATVD LYILNHLMNP PNGKPCEFVM EVTNKTRADV KGGTLTQYEG 

       310        320        330        340        350        360 
KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM EIIVNPKTLD 

       370        380        390        400        410        420 
GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD LLLVMSNLYS LNAGSLTMSE 

       430        440        450        460        470        480 
KREFPTVPLV KLGSSFTKVQ DYLRRFESIP DMLELDHLTV SGDVTFGKNV SLKGTVIIIA 

       490        500 
NHGDRIDIPP GAVLENKIVS GNLRILDH 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, nucleotide sequencing, and affinity labeling of bovine liver UDP-glucose pyrophosphorylase."
Konishi Y., Tanizawa K., Muroya S., Fukui T.
J. Biochem. 114:61-68(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Strain: Danshaku-Imo.
Tissue: Liver.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L14019 mRNA. Translation: AAA30801.1.
BC118181 mRNA. Translation: AAI18182.1.
PIRJX0277.
RefSeqNP_776637.1. NM_174212.2.
UniGeneBt.3567.

3D structure databases

ProteinModelPortalQ07130.
SMRQ07130. Positions 51-508.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000042228.

Proteomic databases

PaxDbQ07130.
PRIDEQ07130.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000044762; ENSBTAP00000042228; ENSBTAG00000000111.
GeneID281565.
KEGGbta:281565.

Organism-specific databases

CTD7360.

Phylogenomic databases

eggNOGCOG4284.
GeneTreeENSGT00390000003174.
HOGENOMHOG000113618.
HOVERGENHBG055396.
InParanoidQ07130.
KOK00963.
OMAPPNGKRC.
OrthoDBEOG7ZPNK4.
TreeFamTF300567.

Enzyme and pathway databases

SABIO-RKQ07130.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
InterProIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_trans.
IPR016267. UDPGP_trans_subgr.
[Graphical view]
PANTHERPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFPIRSF000806. UDPGP. 1 hit.
SUPFAMSSF53448. SSF53448. 1 hit.
ProtoNetSearch...

Other

NextBio20805515.

Entry information

Entry nameUGPA_BOVIN
AccessionPrimary (citable) accession number: Q07130
Secondary accession number(s): Q17QU0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families