Reviewed, UniProtKB/Swiss-Prot Q07130 (UGPA_BOVIN)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase
      Short name=UDPGP
      Short name=UGPase

Gene names

Name:

UGP2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays a central role as a glucosyl donor in cellular metabolic pathways.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Subunit structure	Homooctamer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the UDPGP type 1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 508	507	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000185751
Amino acid modifications
	Modified residue	2	1	Blocked amino end (Ser)

Sequences

	Sequence		Length	Mass (Da)
	Q07130-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: A264DD254E6ED934	FASTA	508	56,903
	10 20 30 40 50 60 MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTAPSHEFEH TKKDLDGFRK 70 80 90 100 110 120 LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN VSSVLNKLVV VKLNGGLGTS 130 140 150 160 170 180 MGCKGPKSLI GVRNENTFLD LTVQQIEHLN KTYDTDVPLV LMNSFNTDED TKKILQKYNH 190 200 210 220 230 240 CRVKIYTFNQ SRYPRINKES LLPVAKNVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI 250 260 270 280 290 300 GEGKEYIFVS NIDNLGATVD LYILNHLMNP PNGKPCEFVM EVTNKTRADV KGGTLTQYEG 310 320 330 340 350 360 KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM EIIVNPKTLD 370 380 390 400 410 420 GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD LLLVMSNLYS LNAGSLTMSE 430 440 450 460 470 480 KREFPTVPLV KLGSSFTKVQ DYLRRFESIP DMLELDHLTV SGDVTFGKNV SLKGTVIIIA 490 500 NHGDRIDIPP GAVLENKIVS GNLRILDH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, nucleotide sequencing, and affinity labeling of bovine liver UDP-glucose pyrophosphorylase." Konishi Y., Tanizawa K., Muroya S., Fukui T. J. Biochem. 114:61-68(1993) [PubMed: 8407878] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Strain: Danshaku-Imo. Tissue: Liver.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thalamus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L14019 mRNA. Translation: AAA30801.1. BC118181 mRNA. Translation: AAI18182.1.
IPI	IPI00689863.
PIR	JX0277.
RefSeq	NP_776637.1.
UniGene	Bt.3567
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000000111. Bos taurus. [Contig view]
GeneID	281565.
KEGG	bta:281565.
Phylogenomic databases
HOVERGEN	Q07130.
OMA	Q07130. AEYIMEL.
Enzyme and pathway databases
BRENDA	2.7.7.9. 251.
Family and domain databases
InterPro	IPR002618. UDPGP_trans. IPR016267. UDPGP_trans_sub. [Graphical view]
PANTHER	PTHR11952. UDPGP_trans. 1 hit.
Pfam	PF01704. UDPGP. 1 hit. [Graphical view]
PIRSF	PIRSF000806. UDPGP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UGPA_BOVIN

Accession

Primary (citable) accession number: Q07130
Secondary accession number(s): Q17QU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)