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Protein

Sulfite oxidase, mitochondrial

Gene

Suox

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Sulfite + O2 + H2O = sulfate + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • heme b1 PublicationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.1 Publication
  • Mo-molybdopterin1 PublicationNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.1 Publication

Pathwayi: sulfur metabolism

This protein is involved in the pathway sulfur metabolism, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway sulfur metabolism and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi119Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi144Iron (heme axial ligand)PROSITE-ProRule annotation1
Binding sitei146Heme bBy similarity1
Binding sitei148Heme bBy similarity1
Metal bindingi265MolybdenumBy similarity1
Binding sitei323MolybdopterinBy similarity1
Binding sitei362MolybdopterinBy similarity1
Binding sitei367MolybdopterinBy similarity1

GO - Molecular functioni

  • heme binding Source: RGD
  • molybdenum ion binding Source: InterPro
  • molybdopterin cofactor binding Source: RGD
  • sulfite oxidase activity Source: RGD

GO - Biological processi

  • nitrate assimilation Source: InterPro
  • response to nutrient Source: RGD
  • sulfur compound metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, Molybdenum

Enzyme and pathway databases

UniPathwayiUPA00096.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfite oxidase, mitochondrial (EC:1.8.3.1)
Gene namesi
Name:Suox
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619994. Suox.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • mitochondrial intermembrane space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 80MitochondrionAdd BLAST80
ChainiPRO_000000648481 – 546Sulfite oxidase, mitochondrialAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ07116.
PRIDEiQ07116.

PTM databases

iPTMnetiQ07116.
PhosphoSitePlusiQ07116.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008018.

Structurei

3D structure databases

ProteinModelPortaliQ07116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 162Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 175HingeBy similarity10
Regioni176 – 402Moco domainBy similarityAdd BLAST227
Regioni216 – 220Molybdopterin-bindingBy similarity5
Regioni378 – 380Molybdopterin-bindingBy similarity3
Regioni403 – 539HomodimerizationBy similarityAdd BLAST137

Sequence similaritiesi

Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0535. Eukaryota.
KOG4576. Eukaryota.
COG2041. LUCA.
HOGENOMiHOG000252609.
HOVERGENiHBG017865.
InParanoidiQ07116.
KOiK00387.
PhylomeDBiQ07116.

Family and domain databases

Gene3Di2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PRINTSiPR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
SSF56524. SSF56524. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRLYRSVA VGLPRAIRAK STPLRLCIQA CSSSDSLKPQ HPSLTFSDDN
60 70 80 90 100
SRTRGWKVMG TLIGLGAVLA YHDHRCRASQ ESPRIYSKED VRSHNNLKTG
110 120 130 140 150
VWVTLGSEVF DVTKFVDLHP GGQSKLMLAA GGPLEPFWAL YAVHNQPHVR
160 170 180 190 200
ELLAEYKIGE LNPEDRMSPP LEASDPYSND PMRHPALRIN SQRPFNAEPP
210 220 230 240 250
PELLTESYIT PNPIFFTRNH LPVPNLDPDT YRLHVVGAPG GQSLSLSLDD
260 270 280 290 300
LHKFPKHEVT VTLQCAGNRR SEMNKVKEVK GLEWRTGAIS TARWAGARLC
310 320 330 340 350
DVLAQAGHRL RETEAHVCFE GLDSDPTGTA YGASIPLARA MDPQAEVLLA
360 370 380 390 400
YEMNGQPLPR DHGFPVRVVV PGVVGARHVK WLGRVSVESE ESYSHWQRRD
410 420 430 440 450
YKGFSPSVDW DTVDFDLAPS IQELPIQSAI TQPQDGTTVE SGEVIIKGYA
460 470 480 490 500
WSGGGRAVIR VDVSMDGGLT WQEAELEGEE QHPRKAWAWR IWQLKAHVPA
510 520 530 540
EQKELNIICK AVDDSYNVQP DTVAPIWNLR GVLSNAWHRV HVQVVP
Length:546
Mass (Da):60,806
Last modified:July 10, 2007 - v2
Checksum:iB4A4E46A8F15765D
GO

Sequence cautioni

The sequence AAA16618 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98K → Q in AAA16618 (PubMed:8276806).Curated1
Sequence conflicti178S → T AA sequence (PubMed:2249998).Curated1
Sequence conflicti294W → R AA sequence (PubMed:2249998).Curated1
Sequence conflicti318C → Q AA sequence (PubMed:2249998).Curated1
Sequence conflicti338A → G AA sequence (PubMed:2249998).Curated1
Sequence conflicti362H → S AA sequence (PubMed:2249998).Curated1
Sequence conflicti362H → S AA sequence (PubMed:3393528).Curated1
Sequence conflicti394 – 396SHW → HYL AA sequence (PubMed:2249998).Curated3
Sequence conflicti432Q → V AA sequence (PubMed:2249998).Curated1
Sequence conflicti514D → A AA sequence (PubMed:2249998).Curated1
Sequence conflicti527W → A AA sequence (PubMed:2249998).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061991 mRNA. Translation: AAH61991.2.
L05084 mRNA. Translation: AAA16618.1. Different initiation.
PIRiA53107.
RefSeqiNP_112389.3. NM_031127.3.
UniGeneiRn.25720.

Genome annotation databases

GeneIDi81805.
KEGGirno:81805.
UCSCiRGD:619994. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061991 mRNA. Translation: AAH61991.2.
L05084 mRNA. Translation: AAA16618.1. Different initiation.
PIRiA53107.
RefSeqiNP_112389.3. NM_031127.3.
UniGeneiRn.25720.

3D structure databases

ProteinModelPortaliQ07116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008018.

PTM databases

iPTMnetiQ07116.
PhosphoSitePlusiQ07116.

Proteomic databases

PaxDbiQ07116.
PRIDEiQ07116.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81805.
KEGGirno:81805.
UCSCiRGD:619994. rat.

Organism-specific databases

CTDi6821.
RGDi619994. Suox.

Phylogenomic databases

eggNOGiKOG0535. Eukaryota.
KOG4576. Eukaryota.
COG2041. LUCA.
HOGENOMiHOG000252609.
HOVERGENiHBG017865.
InParanoidiQ07116.
KOiK00387.
PhylomeDBiQ07116.

Enzyme and pathway databases

UniPathwayiUPA00096.

Miscellaneous databases

PROiQ07116.

Family and domain databases

Gene3Di2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PRINTSiPR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
SSF56524. SSF56524. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUOX_RAT
AccessioniPrimary (citable) accession number: Q07116
Secondary accession number(s): Q6P6W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.