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Protein

Sulfite oxidase, mitochondrial

Gene

Suox

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Sulfite + O2 + H2O = sulfate + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • heme b1 PublicationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.1 Publication
  • Mo-molybdopterin1 PublicationNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.1 Publication

Pathwayi: sulfur metabolism

This protein is involved in the pathway sulfur metabolism, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway sulfur metabolism and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi119Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi144Iron (heme axial ligand)PROSITE-ProRule annotation1
Binding sitei146Heme bBy similarity1
Binding sitei148Heme bBy similarity1
Metal bindingi265MolybdenumBy similarity1
Binding sitei323MolybdopterinBy similarity1
Binding sitei362MolybdopterinBy similarity1
Binding sitei367MolybdopterinBy similarity1

GO - Molecular functioni

  • heme binding Source: RGD
  • molybdenum ion binding Source: InterPro
  • molybdopterin cofactor binding Source: RGD
  • sulfite oxidase activity Source: RGD

GO - Biological processi

  • nitrate assimilation Source: InterPro
  • response to nutrient Source: RGD
  • sulfur compound metabolic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionOxidoreductase
LigandHeme, Iron, Metal-binding, Molybdenum

Enzyme and pathway databases

UniPathwayiUPA00096

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfite oxidase, mitochondrial (EC:1.8.3.1)
Gene namesi
Name:Suox
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619994 Suox

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 80MitochondrionAdd BLAST80
ChainiPRO_000000648481 – 546Sulfite oxidase, mitochondrialAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ07116
PRIDEiQ07116

PTM databases

CarbonylDBiQ07116
iPTMnetiQ07116
PhosphoSitePlusiQ07116

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008018

Structurei

3D structure databases

ProteinModelPortaliQ07116
SMRiQ07116
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 162Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 175HingeBy similarity10
Regioni176 – 402Moco domainBy similarityAdd BLAST227
Regioni216 – 220Molybdopterin-bindingBy similarity5
Regioni378 – 380Molybdopterin-bindingBy similarity3
Regioni403 – 539HomodimerizationBy similarityAdd BLAST137

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0535 Eukaryota
KOG4576 Eukaryota
COG2041 LUCA
HOGENOMiHOG000252609
HOVERGENiHBG017865
InParanoidiQ07116
KOiK00387
PhylomeDBiQ07116

Family and domain databases

Gene3Di3.10.120.10, 1 hit
3.90.420.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
IPR014756 Ig_E-set
IPR005066 MoCF_OxRdtse_dimer
IPR008335 Mopterin_OxRdtase_euk
IPR000572 OxRdtase_Mopterin-bd_dom
IPR036374 OxRdtase_Mopterin-bd_sf
IPR022407 OxRdtase_Mopterin_BS
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF03404 Mo-co_dimer, 1 hit
PF00174 Oxidored_molyb, 1 hit
PRINTSiPR00363 CYTOCHROMEB5
PR00407 EUMOPTERIN
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
SSF56524 SSF56524, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit
PS00559 MOLYBDOPTERIN_EUK, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRLYRSVA VGLPRAIRAK STPLRLCIQA CSSSDSLKPQ HPSLTFSDDN
60 70 80 90 100
SRTRGWKVMG TLIGLGAVLA YHDHRCRASQ ESPRIYSKED VRSHNNLKTG
110 120 130 140 150
VWVTLGSEVF DVTKFVDLHP GGQSKLMLAA GGPLEPFWAL YAVHNQPHVR
160 170 180 190 200
ELLAEYKIGE LNPEDRMSPP LEASDPYSND PMRHPALRIN SQRPFNAEPP
210 220 230 240 250
PELLTESYIT PNPIFFTRNH LPVPNLDPDT YRLHVVGAPG GQSLSLSLDD
260 270 280 290 300
LHKFPKHEVT VTLQCAGNRR SEMNKVKEVK GLEWRTGAIS TARWAGARLC
310 320 330 340 350
DVLAQAGHRL RETEAHVCFE GLDSDPTGTA YGASIPLARA MDPQAEVLLA
360 370 380 390 400
YEMNGQPLPR DHGFPVRVVV PGVVGARHVK WLGRVSVESE ESYSHWQRRD
410 420 430 440 450
YKGFSPSVDW DTVDFDLAPS IQELPIQSAI TQPQDGTTVE SGEVIIKGYA
460 470 480 490 500
WSGGGRAVIR VDVSMDGGLT WQEAELEGEE QHPRKAWAWR IWQLKAHVPA
510 520 530 540
EQKELNIICK AVDDSYNVQP DTVAPIWNLR GVLSNAWHRV HVQVVP
Length:546
Mass (Da):60,806
Last modified:July 10, 2007 - v2
Checksum:iB4A4E46A8F15765D
GO

Sequence cautioni

The sequence AAA16618 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98K → Q in AAA16618 (PubMed:8276806).Curated1
Sequence conflicti178S → T AA sequence (PubMed:2249998).Curated1
Sequence conflicti294W → R AA sequence (PubMed:2249998).Curated1
Sequence conflicti318C → Q AA sequence (PubMed:2249998).Curated1
Sequence conflicti338A → G AA sequence (PubMed:2249998).Curated1
Sequence conflicti362H → S AA sequence (PubMed:2249998).Curated1
Sequence conflicti362H → S AA sequence (PubMed:3393528).Curated1
Sequence conflicti394 – 396SHW → HYL AA sequence (PubMed:2249998).Curated3
Sequence conflicti432Q → V AA sequence (PubMed:2249998).Curated1
Sequence conflicti514D → A AA sequence (PubMed:2249998).Curated1
Sequence conflicti527W → A AA sequence (PubMed:2249998).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061991 mRNA Translation: AAH61991.2
L05084 mRNA Translation: AAA16618.1 Different initiation.
PIRiA53107
RefSeqiNP_112389.3, NM_031127.3
UniGeneiRn.25720

Genome annotation databases

GeneIDi81805
KEGGirno:81805
UCSCiRGD:619994 rat

Similar proteinsi

Entry informationi

Entry nameiSUOX_RAT
AccessioniPrimary (citable) accession number: Q07116
Secondary accession number(s): Q6P6W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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