Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q07113

- MPRI_MOUSE

UniProt

Q07113 - MPRI_MOUSE

Protein

Cation-independent mannose-6-phosphate receptor

Gene

Igf2r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts as a positive regulator of T-cell coactivation, by binding DPP4 By similarity. Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.By similarity

    GO - Molecular functioni

    1. glycoprotein binding Source: UniProtKB
    2. G-protein coupled receptor activity Source: Ensembl
    3. insulin-like growth factor binding Source: MGI
    4. mannose binding Source: MGI
    5. phosphoprotein binding Source: UniProtKB
    6. retinoic acid binding Source: Ensembl
    7. transporter activity Source: InterPro

    GO - Biological processi

    1. liver development Source: Ensembl
    2. organ regeneration Source: Ensembl
    3. positive regulation of apoptotic process Source: Ensembl
    4. post-embryonic development Source: Ensembl
    5. response to retinoic acid Source: Ensembl
    6. spermatogenesis Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cation-independent mannose-6-phosphate receptor
    Short name:
    CI Man-6-P receptor
    Short name:
    CI-MPR
    Short name:
    M6PR
    Alternative name(s):
    300 kDa mannose 6-phosphate receptor
    Short name:
    MPR 300
    Insulin-like growth factor 2 receptor
    Insulin-like growth factor II receptor
    Short name:
    IGF-II receptor
    M6P/IGF2 receptor
    Short name:
    M6P/IGF2R
    CD_antigen: CD222
    Gene namesi
    Name:Igf2r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:96435. Igf2r.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. clathrin coat Source: Ensembl
    3. endocytic vesicle Source: UniProtKB
    4. endosome Source: MGI
    5. extracellular space Source: Ensembl
    6. integral component of membrane Source: UniProtKB-KW
    7. late endosome Source: Ensembl
    8. lysosomal membrane Source: UniProtKB-SubCell
    9. membrane Source: MGI
    10. nuclear envelope lumen Source: MGI
    11. nucleus Source: MGI
    12. perinuclear region of cytoplasm Source: Ensembl
    13. plasma membrane Source: Ensembl
    14. trans-Golgi network transport vesicle Source: MGI

    Keywords - Cellular componenti

    Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 24832448Cation-independent mannose-6-phosphate receptorPRO_0000019230Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi44 ↔ 64PROSITE-ProRule annotation
    Disulfide bondi72 ↔ 79PROSITE-ProRule annotation
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi112 ↔ 144PROSITE-ProRule annotation
    Disulfide bondi129 ↔ 156PROSITE-ProRule annotation
    Disulfide bondi169 ↔ 207PROSITE-ProRule annotation
    Disulfide bondi223 ↔ 230PROSITE-ProRule annotation
    Disulfide bondi270 ↔ 301PROSITE-ProRule annotation
    Disulfide bondi283 ↔ 313PROSITE-ProRule annotation
    Disulfide bondi323 ↔ 361PROSITE-ProRule annotation
    Disulfide bondi369 ↔ 377PROSITE-ProRule annotation
    Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi415 ↔ 449PROSITE-ProRule annotation
    Disulfide bondi429 ↔ 461PROSITE-ProRule annotation
    Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi537 – 5371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi575 – 5751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi621 ↔ 658PROSITE-ProRule annotation
    Disulfide bondi666 ↔ 673PROSITE-ProRule annotation
    Disulfide bondi724 ↔ 753PROSITE-ProRule annotation
    Glycosylationi740 – 7401N-linked (GlcNAc...)1 Publication
    Glycosylationi864 – 8641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi944 – 9441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1157 – 11571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1239 – 12391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1305 – 13051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1358 – 13581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1423 – 14231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1509 ↔ 1546PROSITE-ProRule annotation
    Glycosylationi1532 – 15321N-linked (GlcNAc...)2 Publications
    Disulfide bondi1552 ↔ 1559PROSITE-ProRule annotation
    Disulfide bondi1591 ↔ 1627PROSITE-ProRule annotation
    Disulfide bondi1607 ↔ 1639PROSITE-ProRule annotation
    Disulfide bondi1645 ↔ 1688PROSITE-ProRule annotation
    Glycosylationi1649 – 16491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1699 ↔ 1706PROSITE-ProRule annotation
    Disulfide bondi1743 ↔ 1776PROSITE-ProRule annotation
    Glycosylationi1750 – 17501N-linked (GlcNAc...)1 Publication
    Disulfide bondi1759 ↔ 1788PROSITE-ProRule annotation
    Disulfide bondi1797 ↔ 1832PROSITE-ProRule annotation
    Glycosylationi1809 – 18091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1843 ↔ 1849PROSITE-ProRule annotation
    Disulfide bondi1886 ↔ 1968PROSITE-ProRule annotation
    Disulfide bondi1896 ↔ 1920PROSITE-ProRule annotation
    Disulfide bondi1910 ↔ 1935PROSITE-ProRule annotation
    Disulfide bondi1950 ↔ 1980PROSITE-ProRule annotation
    Disulfide bondi1987 ↔ 2022PROSITE-ProRule annotation
    Disulfide bondi2032 ↔ 2039PROSITE-ProRule annotation
    Disulfide bondi2075 ↔ 2106PROSITE-ProRule annotation
    Glycosylationi2078 – 20781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2089 ↔ 2118PROSITE-ProRule annotation
    Glycosylationi2129 – 21291N-linked (GlcNAc...)Sequence Analysis
    Modified residuei2342 – 23421N6-acetyllysineBy similarity
    Modified residuei2401 – 24011Phosphoserine2 Publications
    Modified residuei2471 – 24711Phosphoserine1 Publication
    Modified residuei2476 – 24761Phosphoserine4 Publications

    Keywords - PTMi

    Acetylation, Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ07113.
    PaxDbiQ07113.
    PRIDEiQ07113.

    PTM databases

    PhosphoSiteiQ07113.

    Expressioni

    Gene expression databases

    ArrayExpressiQ07113.
    BgeeiQ07113.
    CleanExiMM_IGF2R.
    GenevestigatoriQ07113.

    Interactioni

    Subunit structurei

    Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3. Binds HA-I and HA-II plasma membrane adapters By similarity.By similarity

    Protein-protein interaction databases

    BioGridi200550. 1 interaction.
    IntActiQ07113. 4 interactions.
    MINTiMINT-200350.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07113.
    SMRiQ07113. Positions 43-2159.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini36 – 22952260LumenalSequence AnalysisAdd
    BLAST
    Topological domaini2317 – 2483167CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2296 – 231621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati35 – 1841501Add
    BLAST
    Repeati185 – 3391552Add
    BLAST
    Repeati340 – 4841453Add
    BLAST
    Repeati485 – 6371534Add
    BLAST
    Repeati638 – 7761395Add
    BLAST
    Repeati777 – 9431676Add
    BLAST
    Repeati945 – 10921487Add
    BLAST
    Repeati1093 – 12361448Add
    BLAST
    Repeati1237 – 13771419Add
    BLAST
    Repeati1378 – 152514810Add
    BLAST
    Repeati1526 – 165913411Add
    BLAST
    Repeati1660 – 181315412Add
    BLAST
    Repeati1814 – 200118813Add
    BLAST
    Domaini1891 – 193747Fibronectin type-IIPROSITE-ProRule annotationAdd
    BLAST
    Repeati2002 – 213012914Add
    BLAST
    Repeati2158 – 228212515Add
    BLAST

    Domaini

    Sequence similaritiesi

    Belongs to the MRL1/IGF2R family.Curated
    Contains 1 fibronectin type-II domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260109.
    GeneTreeiENSGT00390000013943.
    HOGENOMiHOG000113638.
    HOVERGENiHBG000334.
    InParanoidiQ07113.
    KOiK06564.
    OMAiVDCQVTD.
    OrthoDBiEOG74BJRG.
    PhylomeDBiQ07113.
    TreeFamiTF328963.

    Family and domain databases

    Gene3Di2.10.10.10. 1 hit.
    2.70.130.10. 16 hits.
    InterProiIPR000479. CIMR.
    IPR000562. FN_type2_col-bd.
    IPR013806. Kringle-like.
    IPR009011. Man6P_isomerase_rcpt-bd_dom.
    [Graphical view]
    PfamiPF00878. CIMR. 14 hits.
    PF00040. fn2. 1 hit.
    [Graphical view]
    SMARTiSM00059. FN2. 1 hit.
    [Graphical view]
    SUPFAMiSSF50911. SSF50911. 16 hits.
    SSF57440. SSF57440. 1 hit.
    PROSITEiPS00023. FN2_1. 1 hit.
    PS51092. FN2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07113-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAVQLGPVP SGPRVALLPP LLLLLLLAAA GSAQAQAVDL DALCSYTWEA     50
    VDSKNNAVYK INVCGNVGIS SCGPTSAICM CDLKTENCRS VGDSLLRSSA 100
    RSLLEFNTTM GCQPSDSQHR IQTSITFLCG KTLGTPEFVT ATDCVHYFEW 150
    RTTAACKKDI FKADKEVPCY AFDDKLQKHD LNPLIKLNGG YLVDDSDPDT 200
    SLFINVCRDI DSLRDPSTQL RVCPAGTAAC LLKGNQAFDV GRPKEGLKLL 250
    SKDRLVLTYV KEEGEKPDFC NGHSPAVTVT FVCPSERREG TIPKLTAKSN 300
    CRYEVEWITE YACHRDYLQS ESCSLSSEQH DITIDLSPLA QYGGSPYVSD 350
    GREYTFFINV CGDTKVSLCN NKEAAVCQEK KADSTQVKIA GRHQNQTLRY 400
    SDGDLTLIYS GGDECSSGFQ RMSVINFECN KTAGKDGRGE PVFTGEVDCT 450
    YFFTWDTKYA CIKEKEDLLC GAINGKKRYD LSVLARHSES EQNWEAVDGS 500
    QAESEKYFFI NVCHRVLQEG KARNCPEDAA VCAVDKNGSK NLGKFVSSPT 550
    KEKGHIQLSY TDGDDCGSDK KISTNITLVC KPGDLESAPV LRAARSDGCF 600
    YEFEWHTAAA CVLSKTEGEN CTVLDAQAGF SFDLSLLTKK NGAYKVETEK 650
    YDFYINVCGP VSMDPCQSNS GACQVAKSGK SWNLGLSSTK LTYYDGMIQL 700
    SYRNGTPYNN EKHTPRATLI TFLCDRDAGV GFPEYQEEDN STYNFRWYTS 750
    YACPEEPLEC MVTDPSMMEQ YDLSSLVKSE GGSGGNWYAM ENSREHVTRR 800
    KYYLNVCRPL NPVPGCDRYA SACQMKYENH EGSLAETVSI SNLGVAKIGP 850
    VVEESGSLLL EYVNGSACTT SDGQLTTYST RIHLVCGRGF MNSHPIFTFN 900
    WECVVSFLWN TEAACPIQTI TETDQACSIR DPSSGFVFNL SPLNDSAQGH 950
    VVLGIGKTFV FNICGAMPAC GTVAGKPAYG CEAETQIEDI KDLRPQRPVG 1000
    MERSLQLSAE GFLTLTYKGS SPSDRGTAFI IRFICNDDIY PGAPKFLHQD 1050
    IDSTRGIRNT YFEFETALAC TPSLVDCQVT DPAGNEYDLS ALSMVRKPWT 1100
    AVDTSAYGKR RHFYLSVCNP LPYIPGCHGI ALGSCMVSED NSFNLGVVQI 1150
    SPQATGNGSL SILYVNGDRC GDQRFSTRIV FECAQTSGSP MFQFVNNCEY 1200
    VFVWRTVEAC PVIREEGDNC QVKDPRHGNL YDLKPLGLND TIVSVGEYTY 1250
    YLRVCGKLSS DVCSAHDGSK AVSSCQEKKG PQGFQKVAGL LSQKLTFENG 1300
    LLKMNYTGGD TCHKVYQRST TIYFYCDRTT QKPVFLKETS DCSYMFEWRT 1350
    QYACPPFNVT ECSVQDAAGN SIDLSSLSRY SDNWEAVTRT GATEHYLINV 1400
    CKSLSPHAGT EPCPPEAAVC LLNGSKPVNL GKVRDGPQWT DGVTVLQYVD 1450
    GDLCPDKIRR RSTIIRFTCS DNQVNSRPLF ISAVQDCEYT FSWPTPSACP 1500
    VKSNTHDDCQ VTNPSTGHLF DLSSLSGRAG INASYSEKGL VFMSICEENE 1550
    NCGPGVGACF GQTRISVGKA SKRLSYKDQV LQLVYENGSP CPSLSDLRYK 1600
    SVISFVCRPE AGPTNRPMLI SLDKQTCTLF FSWHTPLACE QATECTVRNG 1650
    SSIIDLSPLI HRTGGYEAYD ESEDDTSDTT PDFYINICQP LNPMHGVPCP 1700
    AGASVCKVPV DGPPIDIGRV TGPPIFNPVA NEVYLNFESS THCLADRYMN 1750
    YTSLITFHCK RGVSMGTPKL IRTNDCDFVF EWETPIVCPD EVKTQGCAVT 1800
    DEQLLYSFNL TSLSTSTFKV TRDARTYSIG VCTAAAGLGQ EGCKDGGVCL 1850
    LSGNKGASFG RLASMQLDYR HQDEAVILSY VNGDPCPPET DDGEPCVFPF 1900
    IYKGKSYDEC VLEGRAKLWC SKTANYDRDH EWGFCRQTNS YRMSAIIFTC 1950
    DESEDIGRPQ VFSEDRGCEV TFEWKTKVVC PPKKMECKFV QKHKTYDLRL 2000
    LSSLTGSWDF VHEGNSYFIN LCQRVYKGPL DCSERASICK KSATGQVQVL 2050
    GLVHTQKLEV IDETVIVTYS KGYPCGGNKT ASSVIELTCA KTVGRPAFKR 2100
    FDSVSCTYYF YWYSRAACAV RPQEVTMVNG TLTNPVTGKS FSLGEIYFKL 2150
    FSASGDMRTN GDNYLYEIQL SSITSSSYPA CAGANICQVK PNDQHFSRKV 2200
    GTSDMTKYYV QDGDLDVVFT SSSKCGKDKT KSVSSTIFFH CDPLVKDGIP 2250
    EFSHETADCQ YLFSWYTSAV CPLGVDFEDE SAGPEYKGLS ERSQAVGAVL 2300
    SLLLVALTGC LLALLLHKKE RRETVINKLT SCCRRSSGVS YKYSKVSKEE 2350
    ETDENETEWL MEEIQVPAPR LGKDGQENGH ITTKAVKAEA LSSLHGDDQD 2400
    SEDEVLTVPE VKVHSGRGAE VESSQPLRNP QRKVLKEREG ERLGLVRGEK 2450
    ARKGKFRPGQ RKPTAPAKLV SFHDDSDEDL LHI 2483
    Length:2,483
    Mass (Da):273,815
    Last modified:October 1, 1996 - v1
    Checksum:i8F64F6189FD05CD1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 112PS → RP(PubMed:8194771)Curated
    Sequence conflicti13 – 131Missing(PubMed:8194771)Curated
    Sequence conflicti209 – 2091D → V in AAA19568. (PubMed:8194771)Curated
    Sequence conflicti456 – 4572DT → VS(PubMed:8194771)Curated
    Sequence conflicti1626 – 16316TCTLFF → GSTFFS in CAA42940. 1 PublicationCurated
    Sequence conflicti1694 – 16952MH → TC in CAA42940. 1 PublicationCurated
    Sequence conflicti1699 – 16991C → R in CAA42940. 1 PublicationCurated
    Sequence conflicti1759 – 17591C → Y in AAA19568. (PubMed:8194771)Curated
    Sequence conflicti2028 – 20281G → V in CAA42940. 1 PublicationCurated
    Sequence conflicti2032 – 20321C → S in CAA42940. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22143
    , L22096, L22097, L22098, L22099, L22100, L22101, L22102, L22103, L22104, L22105, L22106, L22107, L22108, L22109, L22110, L22111, L22112, L22113, L22114, L22115, L22116, L22117, L22118, L22119, L22120, L22121, L22122, L22123, L22124, L22125, L22126, L22127, L22128, L22129, L22130, L22131, L22132, L22133, L22134, L22135, L22136, L22137, L22138, L22139, L22140, L22141, L22142 Genomic DNA. Translation: AAA39320.1.
    U04710 mRNA. Translation: AAA19568.1.
    L06445 Genomic DNA. Translation: AAA37921.1.
    L06446 Genomic DNA. Translation: AAA37922.1.
    U26348 Genomic DNA. Translation: AAA98844.1.
    M58586 Genomic DNA. Translation: AAA39483.1.
    X60389 mRNA. Translation: CAA42940.1.
    L19500 mRNA. Translation: AAA16037.1.
    CCDSiCCDS37436.1.
    PIRiA49617.
    I48922.
    RefSeqiNP_034645.2. NM_010515.2.
    UniGeneiMm.26553.

    Genome annotation databases

    EnsembliENSMUST00000024599; ENSMUSP00000024599; ENSMUSG00000023830.
    GeneIDi16004.
    KEGGimmu:16004.
    UCSCiuc008aky.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22143
    , L22096 , L22097 , L22098 , L22099 , L22100 , L22101 , L22102 , L22103 , L22104 , L22105 , L22106 , L22107 , L22108 , L22109 , L22110 , L22111 , L22112 , L22113 , L22114 , L22115 , L22116 , L22117 , L22118 , L22119 , L22120 , L22121 , L22122 , L22123 , L22124 , L22125 , L22126 , L22127 , L22128 , L22129 , L22130 , L22131 , L22132 , L22133 , L22134 , L22135 , L22136 , L22137 , L22138 , L22139 , L22140 , L22141 , L22142 Genomic DNA. Translation: AAA39320.1 .
    U04710 mRNA. Translation: AAA19568.1 .
    L06445 Genomic DNA. Translation: AAA37921.1 .
    L06446 Genomic DNA. Translation: AAA37922.1 .
    U26348 Genomic DNA. Translation: AAA98844.1 .
    M58586 Genomic DNA. Translation: AAA39483.1 .
    X60389 mRNA. Translation: CAA42940.1 .
    L19500 mRNA. Translation: AAA16037.1 .
    CCDSi CCDS37436.1.
    PIRi A49617.
    I48922.
    RefSeqi NP_034645.2. NM_010515.2.
    UniGenei Mm.26553.

    3D structure databases

    ProteinModelPortali Q07113.
    SMRi Q07113. Positions 43-2159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200550. 1 interaction.
    IntActi Q07113. 4 interactions.
    MINTi MINT-200350.

    PTM databases

    PhosphoSitei Q07113.

    Proteomic databases

    MaxQBi Q07113.
    PaxDbi Q07113.
    PRIDEi Q07113.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024599 ; ENSMUSP00000024599 ; ENSMUSG00000023830 .
    GeneIDi 16004.
    KEGGi mmu:16004.
    UCSCi uc008aky.1. mouse.

    Organism-specific databases

    CTDi 3482.
    MGIi MGI:96435. Igf2r.

    Phylogenomic databases

    eggNOGi NOG260109.
    GeneTreei ENSGT00390000013943.
    HOGENOMi HOG000113638.
    HOVERGENi HBG000334.
    InParanoidi Q07113.
    KOi K06564.
    OMAi VDCQVTD.
    OrthoDBi EOG74BJRG.
    PhylomeDBi Q07113.
    TreeFami TF328963.

    Miscellaneous databases

    NextBioi 288798.
    PROi Q07113.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q07113.
    Bgeei Q07113.
    CleanExi MM_IGF2R.
    Genevestigatori Q07113.

    Family and domain databases

    Gene3Di 2.10.10.10. 1 hit.
    2.70.130.10. 16 hits.
    InterProi IPR000479. CIMR.
    IPR000562. FN_type2_col-bd.
    IPR013806. Kringle-like.
    IPR009011. Man6P_isomerase_rcpt-bd_dom.
    [Graphical view ]
    Pfami PF00878. CIMR. 14 hits.
    PF00040. fn2. 1 hit.
    [Graphical view ]
    SMARTi SM00059. FN2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50911. SSF50911. 16 hits.
    SSF57440. SSF57440. 1 hit.
    PROSITEi PS00023. FN2_1. 1 hit.
    PS51092. FN2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse insulin-like growth factor II/cation-independent mannose 6-phosphate (IGF-II/MPR) receptor gene: molecular cloning and genomic organization."
      Szebenyi G., Rotwein P.
      Genomics 19:120-129(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning and sequencing of cDNAs encoding the full-length mouse mannose 6-phosphate/insulin-like growth factor II receptor."
      Ludwig T., Tenscher K., Remmler J., Hoflack B., Lobel P.
      Gene 142:311-312(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    3. "Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal."
      Stoger R., Kubicka P., Liu C.G., Kafri T., Razin A., Cedar H., Barlow D.P.
      Cell 73:61-71(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44 AND 93-106.
      Strain: 129 and C57BL/6.
    4. "Control of insulin-like growth factor-II/mannose 6-phosphate receptor gene transcription by proximal promoter elements."
      Liu Z., Mittanck D.W., Kim S., Rotwein P.
      Mol. Endocrinol. 9:1477-1487(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44.
      Strain: 129/Sv.
    5. "Differential regulation of mannose 6-phosphate receptors and their ligands during the myogenic development of C2 cells."
      Szebenyi G., Rotwein P.
      J. Biol. Chem. 266:5534-5539(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 435-488.
      Tissue: Liver.
    6. Matzner U.
      Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1625-2045.
      Strain: C57BL/6.
    7. "Mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor. A consensus casein kinase II site followed by 2 leucines near the carboxyl terminus is important for intracellular targeting of lysosomal enzymes."
      Chen H.J., Remmler J., Delaney J.C., Messner D.J., Lobel P.
      J. Biol. Chem. 268:22338-22346(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2249-2483.
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2401 AND SER-2476, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    9. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2476, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    10. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2471 AND SER-2476, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1532.
      Tissue: Myoblast.
    12. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2401 AND SER-2476, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    13. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-740; ASN-1532 AND ASN-1750.

    Entry informationi

    Entry nameiMPRI_MOUSE
    AccessioniPrimary (citable) accession number: Q07113
    Secondary accession number(s): Q61822, Q6LED1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3