Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q07113

- MPRI_MOUSE

UniProt

Q07113 - MPRI_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cation-independent mannose-6-phosphate receptor

Gene

Igf2r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.By similarity

GO - Molecular functioni

  1. glycoprotein binding Source: UniProtKB
  2. G-protein coupled receptor activity Source: Ensembl
  3. insulin-like growth factor binding Source: MGI
  4. mannose binding Source: MGI
  5. phosphoprotein binding Source: UniProtKB
  6. retinoic acid binding Source: Ensembl
  7. transporter activity Source: InterPro

GO - Biological processi

  1. liver development Source: Ensembl
  2. organ regeneration Source: Ensembl
  3. positive regulation of apoptotic process Source: Ensembl
  4. post-embryonic development Source: Ensembl
  5. response to retinoic acid Source: Ensembl
  6. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_232671. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-independent mannose-6-phosphate receptor
Short name:
CI Man-6-P receptor
Short name:
CI-MPR
Short name:
M6PR
Alternative name(s):
300 kDa mannose 6-phosphate receptor
Short name:
MPR 300
Insulin-like growth factor 2 receptor
Insulin-like growth factor II receptor
Short name:
IGF-II receptor
M6P/IGF2 receptor
Short name:
M6P/IGF2R
CD_antigen: CD222
Gene namesi
Name:Igf2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:96435. Igf2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 22952260LumenalSequence AnalysisAdd
BLAST
Transmembranei2296 – 231621HelicalSequence AnalysisAdd
BLAST
Topological domaini2317 – 2483167CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. clathrin coat Source: Ensembl
  3. endocytic vesicle Source: UniProtKB
  4. endosome Source: MGI
  5. extracellular space Source: Ensembl
  6. extracellular vesicular exosome Source: Ensembl
  7. integral component of membrane Source: UniProtKB-KW
  8. late endosome Source: Ensembl
  9. lysosome Source: UniProtKB-KW
  10. membrane Source: MGI
  11. nuclear envelope lumen Source: MGI
  12. nucleus Source: MGI
  13. perinuclear region of cytoplasm Source: Ensembl
  14. plasma membrane Source: Ensembl
  15. trans-Golgi network transport vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 24832448Cation-independent mannose-6-phosphate receptorPRO_0000019230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 64PROSITE-ProRule annotation
Disulfide bondi72 ↔ 79PROSITE-ProRule annotation
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 144PROSITE-ProRule annotation
Disulfide bondi129 ↔ 156PROSITE-ProRule annotation
Disulfide bondi169 ↔ 207PROSITE-ProRule annotation
Disulfide bondi223 ↔ 230PROSITE-ProRule annotation
Disulfide bondi270 ↔ 301PROSITE-ProRule annotation
Disulfide bondi283 ↔ 313PROSITE-ProRule annotation
Disulfide bondi323 ↔ 361PROSITE-ProRule annotation
Disulfide bondi369 ↔ 377PROSITE-ProRule annotation
Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi415 ↔ 449PROSITE-ProRule annotation
Disulfide bondi429 ↔ 461PROSITE-ProRule annotation
Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi537 – 5371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi575 – 5751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi621 ↔ 658PROSITE-ProRule annotation
Disulfide bondi666 ↔ 673PROSITE-ProRule annotation
Disulfide bondi724 ↔ 753PROSITE-ProRule annotation
Glycosylationi740 – 7401N-linked (GlcNAc...)1 Publication
Glycosylationi864 – 8641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi944 – 9441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1157 – 11571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1239 – 12391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1305 – 13051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1358 – 13581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1423 – 14231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1509 ↔ 1546PROSITE-ProRule annotation
Glycosylationi1532 – 15321N-linked (GlcNAc...)2 Publications
Disulfide bondi1552 ↔ 1559PROSITE-ProRule annotation
Disulfide bondi1591 ↔ 1627PROSITE-ProRule annotation
Disulfide bondi1607 ↔ 1639PROSITE-ProRule annotation
Disulfide bondi1645 ↔ 1688PROSITE-ProRule annotation
Glycosylationi1649 – 16491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1699 ↔ 1706PROSITE-ProRule annotation
Disulfide bondi1743 ↔ 1776PROSITE-ProRule annotation
Glycosylationi1750 – 17501N-linked (GlcNAc...)1 Publication
Disulfide bondi1759 ↔ 1788PROSITE-ProRule annotation
Disulfide bondi1797 ↔ 1832PROSITE-ProRule annotation
Glycosylationi1809 – 18091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1843 ↔ 1849PROSITE-ProRule annotation
Disulfide bondi1886 ↔ 1968PROSITE-ProRule annotation
Disulfide bondi1896 ↔ 1920PROSITE-ProRule annotation
Disulfide bondi1910 ↔ 1935PROSITE-ProRule annotation
Disulfide bondi1950 ↔ 1980PROSITE-ProRule annotation
Disulfide bondi1987 ↔ 2022PROSITE-ProRule annotation
Disulfide bondi2032 ↔ 2039PROSITE-ProRule annotation
Disulfide bondi2075 ↔ 2106PROSITE-ProRule annotation
Glycosylationi2078 – 20781N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2089 ↔ 2118PROSITE-ProRule annotation
Glycosylationi2129 – 21291N-linked (GlcNAc...)Sequence Analysis
Modified residuei2342 – 23421N6-acetyllysineBy similarity
Modified residuei2401 – 24011Phosphoserine2 Publications
Modified residuei2471 – 24711Phosphoserine1 Publication
Modified residuei2476 – 24761Phosphoserine4 Publications

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ07113.
PaxDbiQ07113.
PRIDEiQ07113.

PTM databases

PhosphoSiteiQ07113.

Expressioni

Gene expression databases

BgeeiQ07113.
CleanExiMM_IGF2R.
ExpressionAtlasiQ07113. baseline and differential.
GenevestigatoriQ07113.

Interactioni

Subunit structurei

Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3. Binds HA-I and HA-II plasma membrane adapters (By similarity).By similarity

Protein-protein interaction databases

BioGridi200550. 1 interaction.
IntActiQ07113. 4 interactions.
MINTiMINT-200350.

Structurei

3D structure databases

ProteinModelPortaliQ07113.
SMRiQ07113. Positions 43-2159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati35 – 1841501Add
BLAST
Repeati185 – 3391552Add
BLAST
Repeati340 – 4841453Add
BLAST
Repeati485 – 6371534Add
BLAST
Repeati638 – 7761395Add
BLAST
Repeati777 – 9431676Add
BLAST
Repeati945 – 10921487Add
BLAST
Repeati1093 – 12361448Add
BLAST
Repeati1237 – 13771419Add
BLAST
Repeati1378 – 152514810Add
BLAST
Repeati1526 – 165913411Add
BLAST
Repeati1660 – 181315412Add
BLAST
Repeati1814 – 200118813Add
BLAST
Domaini1891 – 193747Fibronectin type-IIPROSITE-ProRule annotationAdd
BLAST
Repeati2002 – 213012914Add
BLAST
Repeati2158 – 228212515Add
BLAST

Domaini

Sequence similaritiesi

Belongs to the MRL1/IGF2R family.Curated
Contains 1 fibronectin type-II domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260109.
GeneTreeiENSGT00390000013943.
HOGENOMiHOG000113638.
HOVERGENiHBG000334.
InParanoidiQ07113.
KOiK06564.
OMAiVDCQVTD.
OrthoDBiEOG74BJRG.
PhylomeDBiQ07113.
TreeFamiTF328963.

Family and domain databases

Gene3Di2.10.10.10. 1 hit.
2.70.130.10. 16 hits.
InterProiIPR000479. CIMR.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
[Graphical view]
PfamiPF00878. CIMR. 14 hits.
PF00040. fn2. 1 hit.
[Graphical view]
SMARTiSM00059. FN2. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 16 hits.
SSF57440. SSF57440. 1 hit.
PROSITEiPS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07113-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRAVQLGPVP SGPRVALLPP LLLLLLLAAA GSAQAQAVDL DALCSYTWEA
60 70 80 90 100
VDSKNNAVYK INVCGNVGIS SCGPTSAICM CDLKTENCRS VGDSLLRSSA
110 120 130 140 150
RSLLEFNTTM GCQPSDSQHR IQTSITFLCG KTLGTPEFVT ATDCVHYFEW
160 170 180 190 200
RTTAACKKDI FKADKEVPCY AFDDKLQKHD LNPLIKLNGG YLVDDSDPDT
210 220 230 240 250
SLFINVCRDI DSLRDPSTQL RVCPAGTAAC LLKGNQAFDV GRPKEGLKLL
260 270 280 290 300
SKDRLVLTYV KEEGEKPDFC NGHSPAVTVT FVCPSERREG TIPKLTAKSN
310 320 330 340 350
CRYEVEWITE YACHRDYLQS ESCSLSSEQH DITIDLSPLA QYGGSPYVSD
360 370 380 390 400
GREYTFFINV CGDTKVSLCN NKEAAVCQEK KADSTQVKIA GRHQNQTLRY
410 420 430 440 450
SDGDLTLIYS GGDECSSGFQ RMSVINFECN KTAGKDGRGE PVFTGEVDCT
460 470 480 490 500
YFFTWDTKYA CIKEKEDLLC GAINGKKRYD LSVLARHSES EQNWEAVDGS
510 520 530 540 550
QAESEKYFFI NVCHRVLQEG KARNCPEDAA VCAVDKNGSK NLGKFVSSPT
560 570 580 590 600
KEKGHIQLSY TDGDDCGSDK KISTNITLVC KPGDLESAPV LRAARSDGCF
610 620 630 640 650
YEFEWHTAAA CVLSKTEGEN CTVLDAQAGF SFDLSLLTKK NGAYKVETEK
660 670 680 690 700
YDFYINVCGP VSMDPCQSNS GACQVAKSGK SWNLGLSSTK LTYYDGMIQL
710 720 730 740 750
SYRNGTPYNN EKHTPRATLI TFLCDRDAGV GFPEYQEEDN STYNFRWYTS
760 770 780 790 800
YACPEEPLEC MVTDPSMMEQ YDLSSLVKSE GGSGGNWYAM ENSREHVTRR
810 820 830 840 850
KYYLNVCRPL NPVPGCDRYA SACQMKYENH EGSLAETVSI SNLGVAKIGP
860 870 880 890 900
VVEESGSLLL EYVNGSACTT SDGQLTTYST RIHLVCGRGF MNSHPIFTFN
910 920 930 940 950
WECVVSFLWN TEAACPIQTI TETDQACSIR DPSSGFVFNL SPLNDSAQGH
960 970 980 990 1000
VVLGIGKTFV FNICGAMPAC GTVAGKPAYG CEAETQIEDI KDLRPQRPVG
1010 1020 1030 1040 1050
MERSLQLSAE GFLTLTYKGS SPSDRGTAFI IRFICNDDIY PGAPKFLHQD
1060 1070 1080 1090 1100
IDSTRGIRNT YFEFETALAC TPSLVDCQVT DPAGNEYDLS ALSMVRKPWT
1110 1120 1130 1140 1150
AVDTSAYGKR RHFYLSVCNP LPYIPGCHGI ALGSCMVSED NSFNLGVVQI
1160 1170 1180 1190 1200
SPQATGNGSL SILYVNGDRC GDQRFSTRIV FECAQTSGSP MFQFVNNCEY
1210 1220 1230 1240 1250
VFVWRTVEAC PVIREEGDNC QVKDPRHGNL YDLKPLGLND TIVSVGEYTY
1260 1270 1280 1290 1300
YLRVCGKLSS DVCSAHDGSK AVSSCQEKKG PQGFQKVAGL LSQKLTFENG
1310 1320 1330 1340 1350
LLKMNYTGGD TCHKVYQRST TIYFYCDRTT QKPVFLKETS DCSYMFEWRT
1360 1370 1380 1390 1400
QYACPPFNVT ECSVQDAAGN SIDLSSLSRY SDNWEAVTRT GATEHYLINV
1410 1420 1430 1440 1450
CKSLSPHAGT EPCPPEAAVC LLNGSKPVNL GKVRDGPQWT DGVTVLQYVD
1460 1470 1480 1490 1500
GDLCPDKIRR RSTIIRFTCS DNQVNSRPLF ISAVQDCEYT FSWPTPSACP
1510 1520 1530 1540 1550
VKSNTHDDCQ VTNPSTGHLF DLSSLSGRAG INASYSEKGL VFMSICEENE
1560 1570 1580 1590 1600
NCGPGVGACF GQTRISVGKA SKRLSYKDQV LQLVYENGSP CPSLSDLRYK
1610 1620 1630 1640 1650
SVISFVCRPE AGPTNRPMLI SLDKQTCTLF FSWHTPLACE QATECTVRNG
1660 1670 1680 1690 1700
SSIIDLSPLI HRTGGYEAYD ESEDDTSDTT PDFYINICQP LNPMHGVPCP
1710 1720 1730 1740 1750
AGASVCKVPV DGPPIDIGRV TGPPIFNPVA NEVYLNFESS THCLADRYMN
1760 1770 1780 1790 1800
YTSLITFHCK RGVSMGTPKL IRTNDCDFVF EWETPIVCPD EVKTQGCAVT
1810 1820 1830 1840 1850
DEQLLYSFNL TSLSTSTFKV TRDARTYSIG VCTAAAGLGQ EGCKDGGVCL
1860 1870 1880 1890 1900
LSGNKGASFG RLASMQLDYR HQDEAVILSY VNGDPCPPET DDGEPCVFPF
1910 1920 1930 1940 1950
IYKGKSYDEC VLEGRAKLWC SKTANYDRDH EWGFCRQTNS YRMSAIIFTC
1960 1970 1980 1990 2000
DESEDIGRPQ VFSEDRGCEV TFEWKTKVVC PPKKMECKFV QKHKTYDLRL
2010 2020 2030 2040 2050
LSSLTGSWDF VHEGNSYFIN LCQRVYKGPL DCSERASICK KSATGQVQVL
2060 2070 2080 2090 2100
GLVHTQKLEV IDETVIVTYS KGYPCGGNKT ASSVIELTCA KTVGRPAFKR
2110 2120 2130 2140 2150
FDSVSCTYYF YWYSRAACAV RPQEVTMVNG TLTNPVTGKS FSLGEIYFKL
2160 2170 2180 2190 2200
FSASGDMRTN GDNYLYEIQL SSITSSSYPA CAGANICQVK PNDQHFSRKV
2210 2220 2230 2240 2250
GTSDMTKYYV QDGDLDVVFT SSSKCGKDKT KSVSSTIFFH CDPLVKDGIP
2260 2270 2280 2290 2300
EFSHETADCQ YLFSWYTSAV CPLGVDFEDE SAGPEYKGLS ERSQAVGAVL
2310 2320 2330 2340 2350
SLLLVALTGC LLALLLHKKE RRETVINKLT SCCRRSSGVS YKYSKVSKEE
2360 2370 2380 2390 2400
ETDENETEWL MEEIQVPAPR LGKDGQENGH ITTKAVKAEA LSSLHGDDQD
2410 2420 2430 2440 2450
SEDEVLTVPE VKVHSGRGAE VESSQPLRNP QRKVLKEREG ERLGLVRGEK
2460 2470 2480
ARKGKFRPGQ RKPTAPAKLV SFHDDSDEDL LHI
Length:2,483
Mass (Da):273,815
Last modified:October 1, 1996 - v1
Checksum:i8F64F6189FD05CD1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 112PS → RP(PubMed:8194771)Curated
Sequence conflicti13 – 131Missing(PubMed:8194771)Curated
Sequence conflicti209 – 2091D → V in AAA19568. (PubMed:8194771)Curated
Sequence conflicti456 – 4572DT → VS(PubMed:8194771)Curated
Sequence conflicti1626 – 16316TCTLFF → GSTFFS in CAA42940. 1 PublicationCurated
Sequence conflicti1694 – 16952MH → TC in CAA42940. 1 PublicationCurated
Sequence conflicti1699 – 16991C → R in CAA42940. 1 PublicationCurated
Sequence conflicti1759 – 17591C → Y in AAA19568. (PubMed:8194771)Curated
Sequence conflicti2028 – 20281G → V in CAA42940. 1 PublicationCurated
Sequence conflicti2032 – 20321C → S in CAA42940. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22143
, L22096, L22097, L22098, L22099, L22100, L22101, L22102, L22103, L22104, L22105, L22106, L22107, L22108, L22109, L22110, L22111, L22112, L22113, L22114, L22115, L22116, L22117, L22118, L22119, L22120, L22121, L22122, L22123, L22124, L22125, L22126, L22127, L22128, L22129, L22130, L22131, L22132, L22133, L22134, L22135, L22136, L22137, L22138, L22139, L22140, L22141, L22142 Genomic DNA. Translation: AAA39320.1.
U04710 mRNA. Translation: AAA19568.1.
L06445 Genomic DNA. Translation: AAA37921.1.
L06446 Genomic DNA. Translation: AAA37922.1.
U26348 Genomic DNA. Translation: AAA98844.1.
M58586 Genomic DNA. Translation: AAA39483.1.
X60389 mRNA. Translation: CAA42940.1.
L19500 mRNA. Translation: AAA16037.1.
CCDSiCCDS37436.1.
PIRiA49617.
I48922.
RefSeqiNP_034645.2. NM_010515.2.
UniGeneiMm.26553.

Genome annotation databases

EnsembliENSMUST00000024599; ENSMUSP00000024599; ENSMUSG00000023830.
GeneIDi16004.
KEGGimmu:16004.
UCSCiuc008aky.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22143
, L22096 , L22097 , L22098 , L22099 , L22100 , L22101 , L22102 , L22103 , L22104 , L22105 , L22106 , L22107 , L22108 , L22109 , L22110 , L22111 , L22112 , L22113 , L22114 , L22115 , L22116 , L22117 , L22118 , L22119 , L22120 , L22121 , L22122 , L22123 , L22124 , L22125 , L22126 , L22127 , L22128 , L22129 , L22130 , L22131 , L22132 , L22133 , L22134 , L22135 , L22136 , L22137 , L22138 , L22139 , L22140 , L22141 , L22142 Genomic DNA. Translation: AAA39320.1 .
U04710 mRNA. Translation: AAA19568.1 .
L06445 Genomic DNA. Translation: AAA37921.1 .
L06446 Genomic DNA. Translation: AAA37922.1 .
U26348 Genomic DNA. Translation: AAA98844.1 .
M58586 Genomic DNA. Translation: AAA39483.1 .
X60389 mRNA. Translation: CAA42940.1 .
L19500 mRNA. Translation: AAA16037.1 .
CCDSi CCDS37436.1.
PIRi A49617.
I48922.
RefSeqi NP_034645.2. NM_010515.2.
UniGenei Mm.26553.

3D structure databases

ProteinModelPortali Q07113.
SMRi Q07113. Positions 43-2159.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200550. 1 interaction.
IntActi Q07113. 4 interactions.
MINTi MINT-200350.

PTM databases

PhosphoSitei Q07113.

Proteomic databases

MaxQBi Q07113.
PaxDbi Q07113.
PRIDEi Q07113.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024599 ; ENSMUSP00000024599 ; ENSMUSG00000023830 .
GeneIDi 16004.
KEGGi mmu:16004.
UCSCi uc008aky.1. mouse.

Organism-specific databases

CTDi 3482.
MGIi MGI:96435. Igf2r.

Phylogenomic databases

eggNOGi NOG260109.
GeneTreei ENSGT00390000013943.
HOGENOMi HOG000113638.
HOVERGENi HBG000334.
InParanoidi Q07113.
KOi K06564.
OMAi VDCQVTD.
OrthoDBi EOG74BJRG.
PhylomeDBi Q07113.
TreeFami TF328963.

Enzyme and pathway databases

Reactomei REACT_232671. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

NextBioi 288798.
PROi Q07113.
SOURCEi Search...

Gene expression databases

Bgeei Q07113.
CleanExi MM_IGF2R.
ExpressionAtlasi Q07113. baseline and differential.
Genevestigatori Q07113.

Family and domain databases

Gene3Di 2.10.10.10. 1 hit.
2.70.130.10. 16 hits.
InterProi IPR000479. CIMR.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
[Graphical view ]
Pfami PF00878. CIMR. 14 hits.
PF00040. fn2. 1 hit.
[Graphical view ]
SMARTi SM00059. FN2. 1 hit.
[Graphical view ]
SUPFAMi SSF50911. SSF50911. 16 hits.
SSF57440. SSF57440. 1 hit.
PROSITEi PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse insulin-like growth factor II/cation-independent mannose 6-phosphate (IGF-II/MPR) receptor gene: molecular cloning and genomic organization."
    Szebenyi G., Rotwein P.
    Genomics 19:120-129(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning and sequencing of cDNAs encoding the full-length mouse mannose 6-phosphate/insulin-like growth factor II receptor."
    Ludwig T., Tenscher K., Remmler J., Hoflack B., Lobel P.
    Gene 142:311-312(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  3. "Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal."
    Stoger R., Kubicka P., Liu C.G., Kafri T., Razin A., Cedar H., Barlow D.P.
    Cell 73:61-71(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44 AND 93-106.
    Strain: 129 and C57BL/6.
  4. "Control of insulin-like growth factor-II/mannose 6-phosphate receptor gene transcription by proximal promoter elements."
    Liu Z., Mittanck D.W., Kim S., Rotwein P.
    Mol. Endocrinol. 9:1477-1487(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44.
    Strain: 129/Sv.
  5. "Differential regulation of mannose 6-phosphate receptors and their ligands during the myogenic development of C2 cells."
    Szebenyi G., Rotwein P.
    J. Biol. Chem. 266:5534-5539(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 435-488.
    Tissue: Liver.
  6. Matzner U.
    Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1625-2045.
    Strain: C57BL/6.
  7. "Mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor. A consensus casein kinase II site followed by 2 leucines near the carboxyl terminus is important for intracellular targeting of lysosomal enzymes."
    Chen H.J., Remmler J., Delaney J.C., Messner D.J., Lobel P.
    J. Biol. Chem. 268:22338-22346(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2249-2483.
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2401 AND SER-2476, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2476, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2471 AND SER-2476, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1532.
    Tissue: Myoblast.
  12. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2401 AND SER-2476, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  13. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-740; ASN-1532 AND ASN-1750.

Entry informationi

Entry nameiMPRI_MOUSE
AccessioniPrimary (citable) accession number: Q07113
Secondary accession number(s): Q61822, Q6LED1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3