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Q07113 (MPRI_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cation-independent mannose-6-phosphate receptor

Short name=CI Man-6-P receptor
Short name=CI-MPR
Short name=M6PR
Alternative name(s):
300 kDa mannose 6-phosphate receptor
Short name=MPR 300
Insulin-like growth factor 2 receptor
Insulin-like growth factor II receptor
Short name=IGF-II receptor
M6P/IGF2 receptor
Short name=M6P/IGF2R
CD_antigen=CD222
Gene names
Name:Igf2r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2483 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a positive regulator of T-cell coactivation, by binding DPP4 By similarity. Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.

Subunit structure

Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3. Binds HA-I and HA-II plasma membrane adapters By similarity.

Subcellular location

Lysosome membrane; Single-pass type I membrane protein.

Domain

Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.

Sequence similarities

Belongs to the MRL1/IGF2R family.

Contains 1 fibronectin type-II domain.

Ontologies

Keywords
   Biological processTransport
   Cellular componentLysosome
Membrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMAcetylation
Disulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processliver development

Inferred from electronic annotation. Source: Ensembl

organ regeneration

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

post-embryonic development

Inferred from electronic annotation. Source: Ensembl

response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell surface

Inferred from sequence or structural similarity. Source: UniProtKB

clathrin coat

Inferred from electronic annotation. Source: Ensembl

endocytic vesicle

Inferred from sequence or structural similarity. Source: UniProtKB

endosome

Inferred from sequence orthology PubMed 15078902. Source: MGI

extracellular space

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

late endosome

Inferred from electronic annotation. Source: Ensembl

lysosomal membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from direct assay PubMed 2963825. Source: MGI

nuclear envelope lumen

Inferred from direct assay PubMed 12729502. Source: MGI

nucleus

Inferred from direct assay PubMed 12729502. Source: MGI

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

trans-Golgi network transport vesicle

Inferred from sequence orthology PubMed 15078902. Source: MGI

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: Ensembl

glycoprotein binding

Inferred from sequence or structural similarity. Source: UniProtKB

insulin-like growth factor binding

Inferred from physical interaction PubMed 14566968. Source: MGI

mannose binding

Inferred from direct assay PubMed 2963825. Source: MGI

phosphoprotein binding

Inferred from sequence or structural similarity. Source: UniProtKB

retinoic acid binding

Inferred from electronic annotation. Source: Ensembl

transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Chain36 – 24832448Cation-independent mannose-6-phosphate receptor
PRO_0000019230

Regions

Topological domain36 – 22952260Lumenal Potential
Transmembrane2296 – 231621Helical; Potential
Topological domain2317 – 2483167Cytoplasmic Potential
Repeat35 – 1841501
Repeat185 – 3391552
Repeat340 – 4841453
Repeat485 – 6371534
Repeat638 – 7761395
Repeat777 – 9431676
Repeat945 – 10921487
Repeat1093 – 12361448
Repeat1237 – 13771419
Repeat1378 – 152514810
Repeat1526 – 165913411
Repeat1660 – 181315412
Repeat1814 – 200118813
Domain1891 – 193747Fibronectin type-II
Repeat2002 – 213012914
Repeat2158 – 228212515

Amino acid modifications

Modified residue23421N6-acetyllysine By similarity
Modified residue24011Phosphoserine Ref.8 Ref.12
Modified residue24711Phosphoserine Ref.10
Modified residue24761Phosphoserine Ref.8 Ref.9 Ref.10 Ref.12
Glycosylation1071N-linked (GlcNAc...) Potential
Glycosylation3951N-linked (GlcNAc...) Potential
Glycosylation4301N-linked (GlcNAc...) Potential
Glycosylation5371N-linked (GlcNAc...) Potential
Glycosylation5751N-linked (GlcNAc...) Potential
Glycosylation6201N-linked (GlcNAc...) Potential
Glycosylation7401N-linked (GlcNAc...) Ref.13
Glycosylation8641N-linked (GlcNAc...) Potential
Glycosylation9441N-linked (GlcNAc...) Potential
Glycosylation11571N-linked (GlcNAc...) Potential
Glycosylation12391N-linked (GlcNAc...) Potential
Glycosylation13051N-linked (GlcNAc...) Potential
Glycosylation13581N-linked (GlcNAc...) Potential
Glycosylation14231N-linked (GlcNAc...) Potential
Glycosylation15321N-linked (GlcNAc...) Ref.11 Ref.13
Glycosylation16491N-linked (GlcNAc...) Potential
Glycosylation17501N-linked (GlcNAc...) Ref.13
Glycosylation18091N-linked (GlcNAc...) Potential
Glycosylation20781N-linked (GlcNAc...) Potential
Glycosylation21291N-linked (GlcNAc...) Potential
Disulfide bond44 ↔ 64 By similarity
Disulfide bond72 ↔ 79 By similarity
Disulfide bond112 ↔ 144 By similarity
Disulfide bond129 ↔ 156 By similarity
Disulfide bond169 ↔ 207 By similarity
Disulfide bond223 ↔ 230 By similarity
Disulfide bond270 ↔ 301 By similarity
Disulfide bond283 ↔ 313 By similarity
Disulfide bond323 ↔ 361 By similarity
Disulfide bond369 ↔ 377 By similarity
Disulfide bond415 ↔ 449 By similarity
Disulfide bond429 ↔ 461 By similarity
Disulfide bond621 ↔ 658 By similarity
Disulfide bond666 ↔ 673 By similarity
Disulfide bond724 ↔ 753 By similarity
Disulfide bond1509 ↔ 1546 By similarity
Disulfide bond1552 ↔ 1559 By similarity
Disulfide bond1591 ↔ 1627 By similarity
Disulfide bond1607 ↔ 1639 By similarity
Disulfide bond1645 ↔ 1688 By similarity
Disulfide bond1699 ↔ 1706 By similarity
Disulfide bond1743 ↔ 1776 By similarity
Disulfide bond1759 ↔ 1788 By similarity
Disulfide bond1797 ↔ 1832 By similarity
Disulfide bond1843 ↔ 1849 By similarity
Disulfide bond1886 ↔ 1968 By similarity
Disulfide bond1896 ↔ 1920 By similarity
Disulfide bond1910 ↔ 1935 By similarity
Disulfide bond1950 ↔ 1980 By similarity
Disulfide bond1987 ↔ 2022 By similarity
Disulfide bond2032 ↔ 2039 By similarity
Disulfide bond2075 ↔ 2106 By similarity
Disulfide bond2089 ↔ 2118 By similarity

Experimental info

Sequence conflict10 – 112PS → RP Ref.2
Sequence conflict131Missing Ref.2
Sequence conflict2091D → V in AAA19568. Ref.2
Sequence conflict456 – 4572DT → VS Ref.2
Sequence conflict1626 – 16316TCTLFF → GSTFFS in CAA42940. Ref.6
Sequence conflict1694 – 16952MH → TC in CAA42940. Ref.6
Sequence conflict16991C → R in CAA42940. Ref.6
Sequence conflict17591C → Y in AAA19568. Ref.2
Sequence conflict20281G → V in CAA42940. Ref.6
Sequence conflict20321C → S in CAA42940. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q07113 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 8F64F6189FD05CD1

FASTA2,483273,815
        10         20         30         40         50         60 
MRAVQLGPVP SGPRVALLPP LLLLLLLAAA GSAQAQAVDL DALCSYTWEA VDSKNNAVYK 

        70         80         90        100        110        120 
INVCGNVGIS SCGPTSAICM CDLKTENCRS VGDSLLRSSA RSLLEFNTTM GCQPSDSQHR 

       130        140        150        160        170        180 
IQTSITFLCG KTLGTPEFVT ATDCVHYFEW RTTAACKKDI FKADKEVPCY AFDDKLQKHD 

       190        200        210        220        230        240 
LNPLIKLNGG YLVDDSDPDT SLFINVCRDI DSLRDPSTQL RVCPAGTAAC LLKGNQAFDV 

       250        260        270        280        290        300 
GRPKEGLKLL SKDRLVLTYV KEEGEKPDFC NGHSPAVTVT FVCPSERREG TIPKLTAKSN 

       310        320        330        340        350        360 
CRYEVEWITE YACHRDYLQS ESCSLSSEQH DITIDLSPLA QYGGSPYVSD GREYTFFINV 

       370        380        390        400        410        420 
CGDTKVSLCN NKEAAVCQEK KADSTQVKIA GRHQNQTLRY SDGDLTLIYS GGDECSSGFQ 

       430        440        450        460        470        480 
RMSVINFECN KTAGKDGRGE PVFTGEVDCT YFFTWDTKYA CIKEKEDLLC GAINGKKRYD 

       490        500        510        520        530        540 
LSVLARHSES EQNWEAVDGS QAESEKYFFI NVCHRVLQEG KARNCPEDAA VCAVDKNGSK 

       550        560        570        580        590        600 
NLGKFVSSPT KEKGHIQLSY TDGDDCGSDK KISTNITLVC KPGDLESAPV LRAARSDGCF 

       610        620        630        640        650        660 
YEFEWHTAAA CVLSKTEGEN CTVLDAQAGF SFDLSLLTKK NGAYKVETEK YDFYINVCGP 

       670        680        690        700        710        720 
VSMDPCQSNS GACQVAKSGK SWNLGLSSTK LTYYDGMIQL SYRNGTPYNN EKHTPRATLI 

       730        740        750        760        770        780 
TFLCDRDAGV GFPEYQEEDN STYNFRWYTS YACPEEPLEC MVTDPSMMEQ YDLSSLVKSE 

       790        800        810        820        830        840 
GGSGGNWYAM ENSREHVTRR KYYLNVCRPL NPVPGCDRYA SACQMKYENH EGSLAETVSI 

       850        860        870        880        890        900 
SNLGVAKIGP VVEESGSLLL EYVNGSACTT SDGQLTTYST RIHLVCGRGF MNSHPIFTFN 

       910        920        930        940        950        960 
WECVVSFLWN TEAACPIQTI TETDQACSIR DPSSGFVFNL SPLNDSAQGH VVLGIGKTFV 

       970        980        990       1000       1010       1020 
FNICGAMPAC GTVAGKPAYG CEAETQIEDI KDLRPQRPVG MERSLQLSAE GFLTLTYKGS 

      1030       1040       1050       1060       1070       1080 
SPSDRGTAFI IRFICNDDIY PGAPKFLHQD IDSTRGIRNT YFEFETALAC TPSLVDCQVT 

      1090       1100       1110       1120       1130       1140 
DPAGNEYDLS ALSMVRKPWT AVDTSAYGKR RHFYLSVCNP LPYIPGCHGI ALGSCMVSED 

      1150       1160       1170       1180       1190       1200 
NSFNLGVVQI SPQATGNGSL SILYVNGDRC GDQRFSTRIV FECAQTSGSP MFQFVNNCEY 

      1210       1220       1230       1240       1250       1260 
VFVWRTVEAC PVIREEGDNC QVKDPRHGNL YDLKPLGLND TIVSVGEYTY YLRVCGKLSS 

      1270       1280       1290       1300       1310       1320 
DVCSAHDGSK AVSSCQEKKG PQGFQKVAGL LSQKLTFENG LLKMNYTGGD TCHKVYQRST 

      1330       1340       1350       1360       1370       1380 
TIYFYCDRTT QKPVFLKETS DCSYMFEWRT QYACPPFNVT ECSVQDAAGN SIDLSSLSRY 

      1390       1400       1410       1420       1430       1440 
SDNWEAVTRT GATEHYLINV CKSLSPHAGT EPCPPEAAVC LLNGSKPVNL GKVRDGPQWT 

      1450       1460       1470       1480       1490       1500 
DGVTVLQYVD GDLCPDKIRR RSTIIRFTCS DNQVNSRPLF ISAVQDCEYT FSWPTPSACP 

      1510       1520       1530       1540       1550       1560 
VKSNTHDDCQ VTNPSTGHLF DLSSLSGRAG INASYSEKGL VFMSICEENE NCGPGVGACF 

      1570       1580       1590       1600       1610       1620 
GQTRISVGKA SKRLSYKDQV LQLVYENGSP CPSLSDLRYK SVISFVCRPE AGPTNRPMLI 

      1630       1640       1650       1660       1670       1680 
SLDKQTCTLF FSWHTPLACE QATECTVRNG SSIIDLSPLI HRTGGYEAYD ESEDDTSDTT 

      1690       1700       1710       1720       1730       1740 
PDFYINICQP LNPMHGVPCP AGASVCKVPV DGPPIDIGRV TGPPIFNPVA NEVYLNFESS 

      1750       1760       1770       1780       1790       1800 
THCLADRYMN YTSLITFHCK RGVSMGTPKL IRTNDCDFVF EWETPIVCPD EVKTQGCAVT 

      1810       1820       1830       1840       1850       1860 
DEQLLYSFNL TSLSTSTFKV TRDARTYSIG VCTAAAGLGQ EGCKDGGVCL LSGNKGASFG 

      1870       1880       1890       1900       1910       1920 
RLASMQLDYR HQDEAVILSY VNGDPCPPET DDGEPCVFPF IYKGKSYDEC VLEGRAKLWC 

      1930       1940       1950       1960       1970       1980 
SKTANYDRDH EWGFCRQTNS YRMSAIIFTC DESEDIGRPQ VFSEDRGCEV TFEWKTKVVC 

      1990       2000       2010       2020       2030       2040 
PPKKMECKFV QKHKTYDLRL LSSLTGSWDF VHEGNSYFIN LCQRVYKGPL DCSERASICK 

      2050       2060       2070       2080       2090       2100 
KSATGQVQVL GLVHTQKLEV IDETVIVTYS KGYPCGGNKT ASSVIELTCA KTVGRPAFKR 

      2110       2120       2130       2140       2150       2160 
FDSVSCTYYF YWYSRAACAV RPQEVTMVNG TLTNPVTGKS FSLGEIYFKL FSASGDMRTN 

      2170       2180       2190       2200       2210       2220 
GDNYLYEIQL SSITSSSYPA CAGANICQVK PNDQHFSRKV GTSDMTKYYV QDGDLDVVFT 

      2230       2240       2250       2260       2270       2280 
SSSKCGKDKT KSVSSTIFFH CDPLVKDGIP EFSHETADCQ YLFSWYTSAV CPLGVDFEDE 

      2290       2300       2310       2320       2330       2340 
SAGPEYKGLS ERSQAVGAVL SLLLVALTGC LLALLLHKKE RRETVINKLT SCCRRSSGVS 

      2350       2360       2370       2380       2390       2400 
YKYSKVSKEE ETDENETEWL MEEIQVPAPR LGKDGQENGH ITTKAVKAEA LSSLHGDDQD 

      2410       2420       2430       2440       2450       2460 
SEDEVLTVPE VKVHSGRGAE VESSQPLRNP QRKVLKEREG ERLGLVRGEK ARKGKFRPGQ 

      2470       2480 
RKPTAPAKLV SFHDDSDEDL LHI 

« Hide

References

« Hide 'large scale' references
[1]"The mouse insulin-like growth factor II/cation-independent mannose 6-phosphate (IGF-II/MPR) receptor gene: molecular cloning and genomic organization."
Szebenyi G., Rotwein P.
Genomics 19:120-129(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning and sequencing of cDNAs encoding the full-length mouse mannose 6-phosphate/insulin-like growth factor II receptor."
Ludwig T., Tenscher K., Remmler J., Hoflack B., Lobel P.
Gene 142:311-312(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
Tissue: Liver.
[3]"Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal."
Stoger R., Kubicka P., Liu C.G., Kafri T., Razin A., Cedar H., Barlow D.P.
Cell 73:61-71(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44 AND 93-106.
Strain: 129 and C57BL/6.
[4]"Control of insulin-like growth factor-II/mannose 6-phosphate receptor gene transcription by proximal promoter elements."
Liu Z., Mittanck D.W., Kim S., Rotwein P.
Mol. Endocrinol. 9:1477-1487(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44.
Strain: 129/Sv.
[5]"Differential regulation of mannose 6-phosphate receptors and their ligands during the myogenic development of C2 cells."
Szebenyi G., Rotwein P.
J. Biol. Chem. 266:5534-5539(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 435-488.
Tissue: Liver.
[6]Matzner U.
Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1625-2045.
Strain: C57BL/6.
[7]"Mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor. A consensus casein kinase II site followed by 2 leucines near the carboxyl terminus is important for intracellular targeting of lysosomal enzymes."
Chen H.J., Remmler J., Delaney J.C., Messner D.J., Lobel P.
J. Biol. Chem. 268:22338-22346(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2249-2483.
Strain: C57BL/6 X CBA.
Tissue: Liver.
[8]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2401 AND SER-2476, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[9]"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2476, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[10]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2471 AND SER-2476, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1532.
Tissue: Myoblast.
[12]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2401 AND SER-2476, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
[13]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-740; ASN-1532 AND ASN-1750.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L22143 expand/collapse EMBL AC list , L22096, L22097, L22098, L22099, L22100, L22101, L22102, L22103, L22104, L22105, L22106, L22107, L22108, L22109, L22110, L22111, L22112, L22113, L22114, L22115, L22116, L22117, L22118, L22119, L22120, L22121, L22122, L22123, L22124, L22125, L22126, L22127, L22128, L22129, L22130, L22131, L22132, L22133, L22134, L22135, L22136, L22137, L22138, L22139, L22140, L22141, L22142 Genomic DNA. Translation: AAA39320.1.
U04710 mRNA. Translation: AAA19568.1.
L06445 Genomic DNA. Translation: AAA37921.1.
L06446 Genomic DNA. Translation: AAA37922.1.
U26348 Genomic DNA. Translation: AAA98844.1.
M58586 Genomic DNA. Translation: AAA39483.1.
X60389 mRNA. Translation: CAA42940.1.
L19500 mRNA. Translation: AAA16037.1.
PIRA49617.
I48922.
RefSeqNP_034645.2. NM_010515.2.
UniGeneMm.26553.

3D structure databases

ProteinModelPortalQ07113.
SMRQ07113. Positions 43-2274.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200550. 1 interaction.
IntActQ07113. 4 interactions.
MINTMINT-200350.

PTM databases

PhosphoSiteQ07113.

Proteomic databases

PaxDbQ07113.
PRIDEQ07113.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000024599; ENSMUSP00000024599; ENSMUSG00000023830.
GeneID16004.
KEGGmmu:16004.
UCSCuc008aky.1. mouse.

Organism-specific databases

CTD3482.
MGIMGI:96435. Igf2r.

Phylogenomic databases

eggNOGNOG260109.
GeneTreeENSGT00390000013943.
HOGENOMHOG000113638.
HOVERGENHBG000334.
InParanoidQ07113.
KOK06564.
OMANTEAACP.
OrthoDBEOG74BJRG.
PhylomeDBQ07113.
TreeFamTF328963.

Gene expression databases

ArrayExpressQ07113.
BgeeQ07113.
CleanExMM_IGF2R.
GenevestigatorQ07113.

Family and domain databases

Gene3D2.10.10.10. 1 hit.
2.70.130.10. 16 hits.
InterProIPR000479. CIMR.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
[Graphical view]
PfamPF00878. CIMR. 14 hits.
PF00040. fn2. 1 hit.
[Graphical view]
SMARTSM00059. FN2. 1 hit.
[Graphical view]
SUPFAMSSF50911. SSF50911. 16 hits.
SSF57440. SSF57440. 1 hit.
PROSITEPS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288798.
PROQ07113.
SOURCESearch...

Entry information

Entry nameMPRI_MOUSE
AccessionPrimary (citable) accession number: Q07113
Secondary accession number(s): Q61822, Q6LED1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot