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Q07108

- CD69_HUMAN

UniProt

Q07108 - CD69_HUMAN

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Protein
Early activation antigen CD69
Gene
CD69, CLEC2C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl
  2. carbohydrate binding Source: InterPro
  3. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. cellular response to drug Source: Ensembl
  2. signal transduction Source: GOC
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Early activation antigen CD69
Alternative name(s):
Activation inducer molecule
Short name:
AIM
BL-AC/P26
C-type lectin domain family 2 member C
EA1
Early T-cell activation antigen p60
GP32/28
Leukocyte surface antigen Leu-23
MLR-3
CD_antigen: CD69
Gene namesi
Name:CD69
Synonyms:CLEC2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:1694. CD69.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei41 – 6121Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini62 – 199138Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Early activation antigen CD69
PRO_0000046583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 – 68Interchain Inferred
Disulfide bondi85 ↔ 963 Publications
Disulfide bondi113 ↔ 1943 Publications
Glycosylationi166 – 1661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi173 ↔ 1863 Publications

Post-translational modificationi

Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ07108.
PaxDbiQ07108.
PRIDEiQ07108.

PTM databases

PhosphoSiteiQ07108.

Expressioni

Tissue specificityi

Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.

Developmental stagei

Earliest inducible cell surface glycoprotein acquired during lymphoid activation.

Inductioni

By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells.

Gene expression databases

ArrayExpressiQ07108.
BgeeiQ07108.
CleanExiHS_CD69.
GenevestigatoriQ07108.

Organism-specific databases

HPAiCAB002503.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.3 Publications

Protein-protein interaction databases

DIPiDIP-60426N.
IntActiQ07108. 1 interaction.
MINTiMINT-4656238.
STRINGi9606.ENSP00000228434.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi90 – 923
Beta strandi95 – 995
Helixi106 – 1149
Turni115 – 1173
Helixi126 – 13611
Beta strandi141 – 1477
Beta strandi153 – 1553
Beta strandi168 – 1703
Beta strandi172 – 1776
Beta strandi180 – 1845
Beta strandi190 – 1978

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E87X-ray1.50A82-199[»]
1E8IX-ray1.95A/B82-199[»]
1FM5X-ray2.27A1-199[»]
3CCKX-ray1.80A/B82-199[»]
3HUPX-ray1.37A/B70-199[»]
DisProtiDP00306.
ProteinModelPortaliQ07108.
SMRiQ07108. Positions 79-199.

Miscellaneous databases

EvolutionaryTraceiQ07108.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 195104C-type lectin
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276386.
HOGENOMiHOG000111491.
HOVERGENiHBG005288.
InParanoidiQ07108.
KOiK06502.
OMAiVGQYNCP.
OrthoDBiEOG793B96.
PhylomeDBiQ07108.
TreeFamiTF351467.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07108-1 [UniParc]FASTAAdd to Basket

« Hide

MSSENCFVAE NSSLHPESGQ ENDATSPHFS TRHEGSFQVP VLCAVMNVVF    50
ITILIIALIA LSVGQYNCPG QYTFSMPSDS HVSSCSEDWV GYQRKCYFIS 100
TVKRSWTSAQ NACSEHGATL AVIDSEKDMN FLKRYAGREE HWVGLKKEPG 150
HPWKWSNGKE FNNWFNVTGS DKCVFLKNTE VSSMECEKNL YWICNKPYK 199
Length:199
Mass (Da):22,559
Last modified:October 1, 1994 - v1
Checksum:i172E2699D2FB8DFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07555 mRNA. Translation: AAB46359.1.
Z22576 mRNA. Translation: CAA80298.1.
Z30426
, Z30430, Z30427, Z30429, Z30428 Genomic DNA. Translation: CAA83017.1.
BC007037 mRNA. Translation: AAH07037.1.
CCDSiCCDS8604.1.
PIRiJH0822.
RefSeqiNP_001772.1. NM_001781.2.
UniGeneiHs.208854.

Genome annotation databases

EnsembliENST00000228434; ENSP00000228434; ENSG00000110848.
GeneIDi969.
KEGGihsa:969.
UCSCiuc001qwk.3. human.

Polymorphism databases

DMDMi584906.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD69

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07555 mRNA. Translation: AAB46359.1 .
Z22576 mRNA. Translation: CAA80298.1 .
Z30426
, Z30430 , Z30427 , Z30429 , Z30428 Genomic DNA. Translation: CAA83017.1 .
BC007037 mRNA. Translation: AAH07037.1 .
CCDSi CCDS8604.1.
PIRi JH0822.
RefSeqi NP_001772.1. NM_001781.2.
UniGenei Hs.208854.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1E87 X-ray 1.50 A 82-199 [» ]
1E8I X-ray 1.95 A/B 82-199 [» ]
1FM5 X-ray 2.27 A 1-199 [» ]
3CCK X-ray 1.80 A/B 82-199 [» ]
3HUP X-ray 1.37 A/B 70-199 [» ]
DisProti DP00306.
ProteinModelPortali Q07108.
SMRi Q07108. Positions 79-199.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60426N.
IntActi Q07108. 1 interaction.
MINTi MINT-4656238.
STRINGi 9606.ENSP00000228434.

PTM databases

PhosphoSitei Q07108.

Polymorphism databases

DMDMi 584906.

Proteomic databases

MaxQBi Q07108.
PaxDbi Q07108.
PRIDEi Q07108.

Protocols and materials databases

DNASUi 969.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000228434 ; ENSP00000228434 ; ENSG00000110848 .
GeneIDi 969.
KEGGi hsa:969.
UCSCi uc001qwk.3. human.

Organism-specific databases

CTDi 969.
GeneCardsi GC12M010256.
HGNCi HGNC:1694. CD69.
HPAi CAB002503.
MIMi 107273. gene.
neXtProti NX_Q07108.
PharmGKBi PA26233.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276386.
HOGENOMi HOG000111491.
HOVERGENi HBG005288.
InParanoidi Q07108.
KOi K06502.
OMAi VGQYNCP.
OrthoDBi EOG793B96.
PhylomeDBi Q07108.
TreeFami TF351467.

Miscellaneous databases

EvolutionaryTracei Q07108.
GeneWikii CD69.
GenomeRNAii 969.
NextBioi 4056.
PROi Q07108.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q07108.
Bgeei Q07108.
CleanExi HS_CD69.
Genevestigatori Q07108.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain."
    Hamann J., Fiebig H., Strauss M.
    J. Immunol. 150:4920-4927(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  2. "Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors."
    Lopez-Cabrera M., Santis A.G., Fernandez-Ruiz E., Blacher R., Esch F., Sanchez-Mateos P., Sanchez-Madrid F.
    J. Exp. Med. 178:537-547(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 96-103; 128-146 AND 189-199.
    Tissue: Blood.
  3. "Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens."
    Ziegler S.F., Ramsdell F., Hjerrild K.A., Armitage R.J., Grabstein K.H., Hennen K.B., Farrah T., Fanslow W.C., Shevach E.M., Alderson M.R.
    Eur. J. Immunol. 23:1643-1648(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors."
    Santis A., Lopez-Cabrera M., Hamann J., Strauss M., Sanchez-Madrid F.
    Eur. J. Immunol. 24:1692-1697(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  6. "Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells."
    Natarajan K., Sawicki M.W., Margulies D.H., Mariuzza R.A.
    Biochemistry 39:14779-14786(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS), SUBUNIT, DISULFIDE BONDS.
  7. "Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69."
    Llera A.S., Viedma F., Sanchez-Madrid F., Tormo J.
    J. Biol. Chem. 276:7312-7319(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 82-199, SUBUNIT, DISULFIDE BONDS.
  8. "Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice."
    Vanek O., Nalezkova M., Kavan D., Borovickova I., Pompach P., Novak P., Kumar V., Vannucci L., Hudecek J., Hofbauerova K., Kopecky V. Jr., Brynda J., Kolenko P., Dohnalek J., Kaderavek P., Chmelik J., Gorcik L., Zidek L., Sklenar V., Bezouska K.
    FEBS J. 275:5589-5606(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 82-199, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiCD69_HUMAN
AccessioniPrimary (citable) accession number: Q07108
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 9, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi