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Protein

Early activation antigen CD69

Gene

CD69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

GO - Molecular functioni

  • calcium ion binding Source: Ensembl
  • carbohydrate binding Source: UniProtKB-KW
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110848-MONOMER.
SIGNORiQ07108.

Names & Taxonomyi

Protein namesi
Recommended name:
Early activation antigen CD69
Alternative name(s):
Activation inducer molecule
Short name:
AIM
BL-AC/P26
C-type lectin domain family 2 member C
EA1
Early T-cell activation antigen p60
GP32/28
Leukocyte surface antigen Leu-23
MLR-3
CD_antigen: CD69
Gene namesi
Name:CD69
Synonyms:CLEC2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:1694. CD69.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini62 – 199ExtracellularSequence analysisAdd BLAST138

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi969.
OpenTargetsiENSG00000110848.
PharmGKBiPA26233.

Polymorphism and mutation databases

BioMutaiCD69.
DMDMi584906.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465831 – 199Early activation antigen CD69Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68InterchainCurated
Disulfide bondi85 ↔ 96
Disulfide bondi113 ↔ 194
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi173 ↔ 186

Post-translational modificationi

Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ07108.
PeptideAtlasiQ07108.
PRIDEiQ07108.

PTM databases

iPTMnetiQ07108.
PhosphoSitePlusiQ07108.
SwissPalmiQ07108.

Expressioni

Tissue specificityi

Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.

Developmental stagei

Earliest inducible cell surface glycoprotein acquired during lymphoid activation.

Inductioni

By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells.

Gene expression databases

BgeeiENSG00000110848.
CleanExiHS_CD69.
ExpressionAtlasiQ07108. baseline and differential.
GenevisibleiQ07108. HS.

Organism-specific databases

HPAiCAB002503.
HPA050525.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TMEM190Q8WZ595EBI-2836595,EBI-10278423

Protein-protein interaction databases

BioGridi107407. 6 interactors.
DIPiDIP-60426N.
IntActiQ07108. 2 interactors.
MINTiMINT-4656238.
STRINGi9606.ENSP00000228434.

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi90 – 92Combined sources3
Beta strandi95 – 99Combined sources5
Helixi106 – 114Combined sources9
Turni115 – 117Combined sources3
Helixi126 – 136Combined sources11
Beta strandi141 – 147Combined sources7
Beta strandi153 – 155Combined sources3
Beta strandi168 – 170Combined sources3
Beta strandi172 – 177Combined sources6
Beta strandi180 – 184Combined sources5
Beta strandi190 – 197Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E87X-ray1.50A82-199[»]
1E8IX-ray1.95A/B82-199[»]
1FM5X-ray2.27A64-199[»]
3CCKX-ray1.80A/B82-199[»]
3HUPX-ray1.37A/B70-199[»]
DisProtiDP00306.
ProteinModelPortaliQ07108.
SMRiQ07108.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07108.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 195C-type lectinPROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00710000106527.
HOGENOMiHOG000111491.
HOVERGENiHBG005288.
InParanoidiQ07108.
KOiK06502.
OMAiVGQYNCP.
OrthoDBiEOG091G0PON.
PhylomeDBiQ07108.
TreeFamiTF351467.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSENCFVAE NSSLHPESGQ ENDATSPHFS TRHEGSFQVP VLCAVMNVVF
60 70 80 90 100
ITILIIALIA LSVGQYNCPG QYTFSMPSDS HVSSCSEDWV GYQRKCYFIS
110 120 130 140 150
TVKRSWTSAQ NACSEHGATL AVIDSEKDMN FLKRYAGREE HWVGLKKEPG
160 170 180 190
HPWKWSNGKE FNNWFNVTGS DKCVFLKNTE VSSMECEKNL YWICNKPYK
Length:199
Mass (Da):22,559
Last modified:October 1, 1994 - v1
Checksum:i172E2699D2FB8DFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07555 mRNA. Translation: AAB46359.1.
Z22576 mRNA. Translation: CAA80298.1.
Z30426
, Z30430, Z30427, Z30429, Z30428 Genomic DNA. Translation: CAA83017.1.
BC007037 mRNA. Translation: AAH07037.1.
CCDSiCCDS8604.1.
PIRiJH0822.
RefSeqiNP_001772.1. NM_001781.2.
UniGeneiHs.208854.

Genome annotation databases

EnsembliENST00000228434; ENSP00000228434; ENSG00000110848.
GeneIDi969.
KEGGihsa:969.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07555 mRNA. Translation: AAB46359.1.
Z22576 mRNA. Translation: CAA80298.1.
Z30426
, Z30430, Z30427, Z30429, Z30428 Genomic DNA. Translation: CAA83017.1.
BC007037 mRNA. Translation: AAH07037.1.
CCDSiCCDS8604.1.
PIRiJH0822.
RefSeqiNP_001772.1. NM_001781.2.
UniGeneiHs.208854.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E87X-ray1.50A82-199[»]
1E8IX-ray1.95A/B82-199[»]
1FM5X-ray2.27A64-199[»]
3CCKX-ray1.80A/B82-199[»]
3HUPX-ray1.37A/B70-199[»]
DisProtiDP00306.
ProteinModelPortaliQ07108.
SMRiQ07108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107407. 6 interactors.
DIPiDIP-60426N.
IntActiQ07108. 2 interactors.
MINTiMINT-4656238.
STRINGi9606.ENSP00000228434.

PTM databases

iPTMnetiQ07108.
PhosphoSitePlusiQ07108.
SwissPalmiQ07108.

Polymorphism and mutation databases

BioMutaiCD69.
DMDMi584906.

Proteomic databases

PaxDbiQ07108.
PeptideAtlasiQ07108.
PRIDEiQ07108.

Protocols and materials databases

DNASUi969.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228434; ENSP00000228434; ENSG00000110848.
GeneIDi969.
KEGGihsa:969.

Organism-specific databases

CTDi969.
DisGeNETi969.
GeneCardsiCD69.
HGNCiHGNC:1694. CD69.
HPAiCAB002503.
HPA050525.
MIMi107273. gene.
neXtProtiNX_Q07108.
OpenTargetsiENSG00000110848.
PharmGKBiPA26233.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00710000106527.
HOGENOMiHOG000111491.
HOVERGENiHBG005288.
InParanoidiQ07108.
KOiK06502.
OMAiVGQYNCP.
OrthoDBiEOG091G0PON.
PhylomeDBiQ07108.
TreeFamiTF351467.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110848-MONOMER.
SIGNORiQ07108.

Miscellaneous databases

ChiTaRSiCD69. human.
EvolutionaryTraceiQ07108.
GeneWikiiCD69.
GenomeRNAii969.
PROiQ07108.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110848.
CleanExiHS_CD69.
ExpressionAtlasiQ07108. baseline and differential.
GenevisibleiQ07108. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD69_HUMAN
AccessioniPrimary (citable) accession number: Q07108
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.