Reviewed,
UniProtKB/Swiss-Prot Q07108 (CD69_HUMAN)
Last modified
November 25, 2008.
Version 85.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Early activation antigen CD69 Alternative name(s): Early T-cell activation antigen p60 GP32/28 Leu-23 MLR-3 EA1 BL-AC/P26 Activation inducer molecule Short name=AIM CD_antigen=CD69 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 199 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. |
| Subunit structure | Homodimer; disulfide-linked. |
| Subcellular location | |
| Tissue specificity | Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets. |
| Developmental stage | Earliest inducible cell surface glycoprotein acquired during lymphoid activation. |
| Induction | By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells. |
| Post-translational modification | Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes. |
| Sequence similarities | Contains 1 C-type lectin domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal-anchor Transmembrane |
| Ligand | Lectin |
| PTM | Glycoprotein Phosphoprotein |
| Technical term | 3D-structure Direct protein sequencing |
Gene Ontology (GO) | |
| Cellular component | integral to plasma membrane Ref.2 Traceable author statement. Source: ProtInc |
| Molecular function | sugar binding Inferred from electronic annotation. Source: InterPro transmembrane receptor activity Ref.2Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 199 | 199 | Early activation antigen CD69 | PRO_0000046583 | |||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||
| Topological domain | 1 – 40 | 40 | Cytoplasmic Potential | ||||||||||||||||||||||||
| Transmembrane | 41 – 61 | 21 | Signal-anchor for type II membrane protein Potential | ||||||||||||||||||||||||
| Topological domain | 62 – 199 | 138 | Extracellular Potential | ||||||||||||||||||||||||
| Domain | 92 – 195 | 104 | C-type lectin | ||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||
| Glycosylation | 166 | 1 | N-linked (GlcNAc...) Potential | ||||||||||||||||||||||||
| Disulfide bond | 113 ↔ 194 | By similarity | |||||||||||||||||||||||||
| Disulfide bond | 173 ↔ 186 | By similarity | |||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||
| Beta strand | 89 – 92 | 4 | |||||||||||||||||||||||||
| Beta strand | 95 – 99 | 5 | |||||||||||||||||||||||||
| Helix | 106 – 115 | 10 | |||||||||||||||||||||||||
| Helix | 126 – 136 | 11 | |||||||||||||||||||||||||
| Beta strand | 141 – 146 | 6 | |||||||||||||||||||||||||
| Beta strand | 168 – 170 | 3 | |||||||||||||||||||||||||
| Beta strand | 172 – 177 | 6 | |||||||||||||||||||||||||
| Beta strand | 180 – 184 | 5 | |||||||||||||||||||||||||
| Beta strand | 190 – 197 | 8 | |||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain." Hamann J., Fiebig H., Strauss M. J. Immunol. 150:4920-4927(1993) [PubMed: 8496594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood. |
| [2] | "Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors." Lopez-Cabrera M., Santis A.G., Fernandez-Ruiz E., Blacher R., Esch F., Sanchez-Mateos P., Sanchez-Madrid F. J. Exp. Med. 178:537-547(1993) [PubMed: 8340758] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 96-103; 128-146 AND 189-199. Tissue: Blood. |
| [3] | "Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens." Ziegler S.F., Ramsdell F., Hjerrild K.A., Armitage R.J., Grabstein K.H., Hennen K.B., Farrah T., Fanslow W.C., Shevach E.M., Alderson M.R. Eur. J. Immunol. 23:1643-1648(1993) [PubMed: 8100776] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. |
| [4] | "Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors." Santis A., Lopez-Cabrera M., Hamann J., Strauss M., Sanchez-Madrid F. Eur. J. Immunol. 24:1692-1697(1994) [PubMed: 8026529] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| L07555 mRNA. Translation: AAB46359.1. Z22576 mRNA. Translation: CAA80298.1. Z30426 Z30428 Genomic DNA. Translation: CAA83017.1. BC007037 mRNA. Translation: AAH07037.1. | |||||||||||||||||||||||||
| PIR | JH0822. | ||||||||||||||||||||||||
| RefSeq | NP_001772.1. | ||||||||||||||||||||||||
| UniGene | Hs.208854 | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
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| DisProt | DP00306. | ||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENSG00000110848. Homo sapiens. [Contig view] | ||||||||||||||||||||||||
| GeneID | 969. | ||||||||||||||||||||||||
| KEGG | hsa:969. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| H-InvDB | HIX0010418. | ||||||||||||||||||||||||
| HGNC | HGNC:1694. CD69. | ||||||||||||||||||||||||
| HPA | CAB002503. | ||||||||||||||||||||||||
| MIM | 107273. gene. | ||||||||||||||||||||||||
| PharmGKB | PA26233. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
| GeneCards | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| HOGENOM | Q07108. | ||||||||||||||||||||||||
| HOVERGEN | Q07108. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | Q07108. | ||||||||||||||||||||||||
| CleanEx | HS_CD69. | ||||||||||||||||||||||||
| GermOnline | ENSG00000110848. Homo sapiens. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR002353. AntifreezeII. IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. [Graphical view] | ||||||||||||||||||||||||
| Gene3D | G3DSA:3.10.100.10. C-type_lectin-like. 1 hit. | ||||||||||||||||||||||||
| Pfam | PF00059. Lectin_C. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| PRINTS | PR00356. ANTIFREEZEII. | ||||||||||||||||||||||||
| SMART | SM00034. CLECT. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| PROSITE | PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||
| NextBio | 4056. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | CD69_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q07108 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


