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Q07105 (GDF9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Growth/differentiation factor 9

Short name=GDF-9
Gene names
Name:Gdf9
Synonyms:Gdf-9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for ovarian folliculogenesis.

Subunit structure

Homodimer or heterodimer Potential. But, in contrast to other members of this family, cannot be disulfide-linked.

Subcellular location

Secreted By similarity.

Tissue specificity

Ovary.

Post-translational modification

Phosphorylated; phosphorylation is critical for GDF9 function By similarity.

Miscellaneous

Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to Ref.3, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.

Sequence similarities

Belongs to the TGF-beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Propeptide30 – 306277 Potential
PRO_0000033982
Chain307 – 441135Growth/differentiation factor 9
PRO_0000033983

Amino acid modifications

Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential
Glycosylation2581N-linked (GlcNAc...) Potential
Glycosylation3251N-linked (GlcNAc...) Potential
Disulfide bond340 ↔ 406 By similarity
Disulfide bond369 ↔ 438 By similarity
Disulfide bond373 ↔ 440 By similarity

Experimental info

Sequence conflict2961I → T in AAA53035. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q07105 [UniParc].

Last modified November 23, 2004. Version 2.
Checksum: 43B47ADD41B99C29

FASTA44149,649
        10         20         30         40         50         60 
MALPSNFLLG VCCFAWLCFL SSLSSQASTE ESQSGASENV ESEADPWSLL LPVDGTDRSG 

        70         80         90        100        110        120 
LLPPLFKVLS DRRGETPKLQ PDSRALYYMK KLYKTYATKE GVPKPSRSHL YNTVRLFSPC 

       130        140        150        160        170        180 
AQQEQAPSNQ VTGPLPMVDL LFNLDRVTAM EHLLKSVLLY TLNNSASSSS TVTCMCDLVV 

       190        200        210        220        230        240 
KEAMSSGRAP PRAPYSFTLK KHRWIEIDVT SLLQPLVTSS ERSIHLSVNF TCTKDQVPED 

       250        260        270        280        290        300 
GVFSMPLSVP PSLILYLNDT STQAYHSWQS LQSTWRPLQH PGQAGVAARP VKEEAIEVER 

       310        320        330        340        350        360 
SPRRRRGQKA IRSEAKGPLL TASFNLSEYF KQFLFPQNEC ELHDFRLSFS QLKWDNWIVA 

       370        380        390        400        410        420 
PHRYNPRYCK GDCPRAVRHR YGSPVHTMVQ NIIYEKLDPS VPRPSCVPGK YSPLSVLTIE 

       430        440 
PDGSIAYKEY EDMIATRCTC R 

« Hide

References

[1]"GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines."
McPherron A.C., Lee S.-J.
J. Biol. Chem. 268:3444-3449(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure of the mouse growth/differentiation factor 9 gene."
Incerti B., Dong J., Borsani G., Matzuk M.M.
Biochim. Biophys. Acta 1222:125-128(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvEv.
[3]"The ratio of growth differentiation factor 9: bone morphogenetic protein 15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates."
Crawford J.L., McNatty K.P.
Mol. Cell. Endocrinol. 348:339-343(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: SPECIES-SPECIFIC OVULATION RATE DETERMINATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L06444 mRNA. Translation: AAA53035.1.
X77112 Genomic DNA. No translation available.
X77113 Genomic DNA. No translation available.
PIRS45284.
RefSeqNP_032136.2. NM_008110.2.
UniGeneMm.490461.
Mm.9714.

3D structure databases

ProteinModelPortalQ07105.
SMRQ07105. Positions 340-441.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000018382.

PTM databases

PhosphoSiteQ07105.

Proteomic databases

PRIDEQ07105.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000018382; ENSMUSP00000018382; ENSMUSG00000018238.
GeneID14566.
KEGGmmu:14566.
UCSCuc007iwa.2. mouse.

Organism-specific databases

CTD2661.
MGIMGI:95692. Gdf9.

Phylogenomic databases

eggNOGNOG261730.
HOGENOMHOG000073526.
HOVERGENHBG004660.
InParanoidQ07105.
KOK05498.
OMAYEDMIAT.
OrthoDBEOG70W3DJ.
PhylomeDBQ07105.
TreeFamTF351788.

Gene expression databases

BgeeQ07105.
CleanExMM_GDF9.
GenevestigatorQ07105.

Family and domain databases

InterProIPR015617. Growth_differentiation_fac-9.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PTHR11848:SF19. PTHR11848:SF19. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGDF9. mouse.
NextBio286274.
PROQ07105.
SOURCESearch...

Entry information

Entry nameGDF9_MOUSE
AccessionPrimary (citable) accession number: Q07105
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot