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Protein

Growth/differentiation factor 9

Gene

Gdf9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for ovarian folliculogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 9
Short name:
GDF-9
Gene namesi
Name:Gdf9
Synonyms:Gdf-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95692. Gdf9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000003398230 – 306Sequence analysisAdd BLAST277
ChainiPRO_0000033983307 – 441Growth/differentiation factor 9Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Glycosylationi229N-linked (GlcNAc...)Sequence analysis1
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi340 ↔ 406By similarity
Disulfide bondi369 ↔ 438By similarity
Disulfide bondi373 ↔ 440By similarity

Post-translational modificationi

Phosphorylated; phosphorylation is critical for GDF9 function.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ07105.
PRIDEiQ07105.

PTM databases

iPTMnetiQ07105.
PhosphoSitePlusiQ07105.

Expressioni

Tissue specificityi

Ovary.

Gene expression databases

BgeeiENSMUSG00000018238.
CleanExiMM_GDF9.
ExpressionAtlasiQ07105. baseline and differential.
GenevisibleiQ07105. MM.

Interactioni

Subunit structurei

Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.Curated

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ07105. 1 interactor.
STRINGi10090.ENSMUSP00000018382.

Structurei

3D structure databases

ProteinModelPortaliQ07105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000073526.
HOVERGENiHBG004660.
InParanoidiQ07105.
KOiK05498.
OMAiSQLKWDN.
OrthoDBiEOG091G09RN.
PhylomeDBiQ07105.
TreeFamiTF351788.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR015617. Growth_differentiation_fac-9.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 4 hits.
PTHR11848:SF19. PTHR11848:SF19. 4 hits.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPSNFLLG VCCFAWLCFL SSLSSQASTE ESQSGASENV ESEADPWSLL
60 70 80 90 100
LPVDGTDRSG LLPPLFKVLS DRRGETPKLQ PDSRALYYMK KLYKTYATKE
110 120 130 140 150
GVPKPSRSHL YNTVRLFSPC AQQEQAPSNQ VTGPLPMVDL LFNLDRVTAM
160 170 180 190 200
EHLLKSVLLY TLNNSASSSS TVTCMCDLVV KEAMSSGRAP PRAPYSFTLK
210 220 230 240 250
KHRWIEIDVT SLLQPLVTSS ERSIHLSVNF TCTKDQVPED GVFSMPLSVP
260 270 280 290 300
PSLILYLNDT STQAYHSWQS LQSTWRPLQH PGQAGVAARP VKEEAIEVER
310 320 330 340 350
SPRRRRGQKA IRSEAKGPLL TASFNLSEYF KQFLFPQNEC ELHDFRLSFS
360 370 380 390 400
QLKWDNWIVA PHRYNPRYCK GDCPRAVRHR YGSPVHTMVQ NIIYEKLDPS
410 420 430 440
VPRPSCVPGK YSPLSVLTIE PDGSIAYKEY EDMIATRCTC R
Length:441
Mass (Da):49,649
Last modified:November 23, 2004 - v2
Checksum:i43B47ADD41B99C29
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296I → T in AAA53035 (PubMed:8429021).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06444 mRNA. Translation: AAA53035.1.
X77112 Genomic DNA. No translation available.
X77113 Genomic DNA. No translation available.
CCDSiCCDS24679.1.
PIRiS45284.
RefSeqiNP_032136.2. NM_008110.2.
UniGeneiMm.490461.
Mm.9714.

Genome annotation databases

EnsembliENSMUST00000018382; ENSMUSP00000018382; ENSMUSG00000018238.
GeneIDi14566.
KEGGimmu:14566.
UCSCiuc007iwa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06444 mRNA. Translation: AAA53035.1.
X77112 Genomic DNA. No translation available.
X77113 Genomic DNA. No translation available.
CCDSiCCDS24679.1.
PIRiS45284.
RefSeqiNP_032136.2. NM_008110.2.
UniGeneiMm.490461.
Mm.9714.

3D structure databases

ProteinModelPortaliQ07105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ07105. 1 interactor.
STRINGi10090.ENSMUSP00000018382.

PTM databases

iPTMnetiQ07105.
PhosphoSitePlusiQ07105.

Proteomic databases

PaxDbiQ07105.
PRIDEiQ07105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018382; ENSMUSP00000018382; ENSMUSG00000018238.
GeneIDi14566.
KEGGimmu:14566.
UCSCiuc007iwa.2. mouse.

Organism-specific databases

CTDi2661.
MGIiMGI:95692. Gdf9.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000073526.
HOVERGENiHBG004660.
InParanoidiQ07105.
KOiK05498.
OMAiSQLKWDN.
OrthoDBiEOG091G09RN.
PhylomeDBiQ07105.
TreeFamiTF351788.

Miscellaneous databases

ChiTaRSiGdf9. mouse.
PROiQ07105.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018238.
CleanExiMM_GDF9.
ExpressionAtlasiQ07105. baseline and differential.
GenevisibleiQ07105. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR015617. Growth_differentiation_fac-9.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 4 hits.
PTHR11848:SF19. PTHR11848:SF19. 4 hits.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGDF9_MOUSE
AccessioniPrimary (citable) accession number: Q07105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.