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Q07105

- GDF9_MOUSE

UniProt

Q07105 - GDF9_MOUSE

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Protein

Growth/differentiation factor 9

Gene

Gdf9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Required for ovarian folliculogenesis.

GO - Biological processi

  1. negative regulation of cell growth Source: MGI
  2. oocyte growth Source: MGI
  3. positive regulation of cell proliferation Source: Ensembl
  4. regulation of progesterone secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 9
Short name:
GDF-9
Gene namesi
Name:Gdf9
Synonyms:Gdf-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:95692. Gdf9.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Propeptidei30 – 306277Sequence AnalysisPRO_0000033982Add
BLAST
Chaini307 – 441135Growth/differentiation factor 9PRO_0000033983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi340 ↔ 406By similarity
Disulfide bondi369 ↔ 438By similarity
Disulfide bondi373 ↔ 440By similarity

Post-translational modificationi

Phosphorylated; phosphorylation is critical for GDF9 function.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ07105.

PTM databases

PhosphoSiteiQ07105.

Expressioni

Tissue specificityi

Ovary.

Gene expression databases

BgeeiQ07105.
CleanExiMM_GDF9.
ExpressionAtlasiQ07105. baseline.
GenevestigatoriQ07105.

Interactioni

Subunit structurei

Homodimer or heterodimer Potential. But, in contrast to other members of this family, cannot be disulfide-linked.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018382.

Structurei

3D structure databases

ProteinModelPortaliQ07105.
SMRiQ07105. Positions 340-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG261730.
HOGENOMiHOG000073526.
HOVERGENiHBG004660.
InParanoidiQ07105.
KOiK05498.
OMAiDNWIVAP.
OrthoDBiEOG70W3DJ.
PhylomeDBiQ07105.
TreeFamiTF351788.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR015617. Growth_differentiation_fac-9.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PTHR11848:SF19. PTHR11848:SF19. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07105-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALPSNFLLG VCCFAWLCFL SSLSSQASTE ESQSGASENV ESEADPWSLL
60 70 80 90 100
LPVDGTDRSG LLPPLFKVLS DRRGETPKLQ PDSRALYYMK KLYKTYATKE
110 120 130 140 150
GVPKPSRSHL YNTVRLFSPC AQQEQAPSNQ VTGPLPMVDL LFNLDRVTAM
160 170 180 190 200
EHLLKSVLLY TLNNSASSSS TVTCMCDLVV KEAMSSGRAP PRAPYSFTLK
210 220 230 240 250
KHRWIEIDVT SLLQPLVTSS ERSIHLSVNF TCTKDQVPED GVFSMPLSVP
260 270 280 290 300
PSLILYLNDT STQAYHSWQS LQSTWRPLQH PGQAGVAARP VKEEAIEVER
310 320 330 340 350
SPRRRRGQKA IRSEAKGPLL TASFNLSEYF KQFLFPQNEC ELHDFRLSFS
360 370 380 390 400
QLKWDNWIVA PHRYNPRYCK GDCPRAVRHR YGSPVHTMVQ NIIYEKLDPS
410 420 430 440
VPRPSCVPGK YSPLSVLTIE PDGSIAYKEY EDMIATRCTC R
Length:441
Mass (Da):49,649
Last modified:November 23, 2004 - v2
Checksum:i43B47ADD41B99C29
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti296 – 2961I → T in AAA53035. (PubMed:8429021)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L06444 mRNA. Translation: AAA53035.1.
X77112 Genomic DNA. No translation available.
X77113 Genomic DNA. No translation available.
CCDSiCCDS24679.1.
PIRiS45284.
RefSeqiNP_032136.2. NM_008110.2.
UniGeneiMm.490461.
Mm.9714.

Genome annotation databases

EnsembliENSMUST00000018382; ENSMUSP00000018382; ENSMUSG00000018238.
GeneIDi14566.
KEGGimmu:14566.
UCSCiuc007iwa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L06444 mRNA. Translation: AAA53035.1 .
X77112 Genomic DNA. No translation available.
X77113 Genomic DNA. No translation available.
CCDSi CCDS24679.1.
PIRi S45284.
RefSeqi NP_032136.2. NM_008110.2.
UniGenei Mm.490461.
Mm.9714.

3D structure databases

ProteinModelPortali Q07105.
SMRi Q07105. Positions 340-441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000018382.

PTM databases

PhosphoSitei Q07105.

Proteomic databases

PRIDEi Q07105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000018382 ; ENSMUSP00000018382 ; ENSMUSG00000018238 .
GeneIDi 14566.
KEGGi mmu:14566.
UCSCi uc007iwa.2. mouse.

Organism-specific databases

CTDi 2661.
MGIi MGI:95692. Gdf9.

Phylogenomic databases

eggNOGi NOG261730.
HOGENOMi HOG000073526.
HOVERGENi HBG004660.
InParanoidi Q07105.
KOi K05498.
OMAi DNWIVAP.
OrthoDBi EOG70W3DJ.
PhylomeDBi Q07105.
TreeFami TF351788.

Miscellaneous databases

ChiTaRSi GDF9. mouse.
NextBioi 286274.
PROi Q07105.
SOURCEi Search...

Gene expression databases

Bgeei Q07105.
CleanExi MM_GDF9.
ExpressionAtlasi Q07105. baseline.
Genevestigatori Q07105.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR015617. Growth_differentiation_fac-9.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
PTHR11848:SF19. PTHR11848:SF19. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines."
    McPherron A.C., Lee S.-J.
    J. Biol. Chem. 268:3444-3449(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of the mouse growth/differentiation factor 9 gene."
    Incerti B., Dong J., Borsani G., Matzuk M.M.
    Biochim. Biophys. Acta 1222:125-128(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvEv.
  3. "The ratio of growth differentiation factor 9: bone morphogenetic protein 15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates."
    Crawford J.L., McNatty K.P.
    Mol. Cell. Endocrinol. 348:339-343(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SPECIES-SPECIFIC OVULATION RATE DETERMINATION.

Entry informationi

Entry nameiGDF9_MOUSE
AccessioniPrimary (citable) accession number: Q07105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3