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Q07105

- GDF9_MOUSE

UniProt

Q07105 - GDF9_MOUSE

Protein

Growth/differentiation factor 9

Gene

Gdf9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Required for ovarian folliculogenesis.

    GO - Biological processi

    1. negative regulation of cell growth Source: MGI
    2. oocyte growth Source: MGI
    3. positive regulation of cell proliferation Source: Ensembl
    4. regulation of progesterone secretion Source: Ensembl

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth/differentiation factor 9
    Short name:
    GDF-9
    Gene namesi
    Name:Gdf9
    Synonyms:Gdf-9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:95692. Gdf9.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Propeptidei30 – 306277Sequence AnalysisPRO_0000033982Add
    BLAST
    Chaini307 – 441135Growth/differentiation factor 9PRO_0000033983Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi340 ↔ 406By similarity
    Disulfide bondi369 ↔ 438By similarity
    Disulfide bondi373 ↔ 440By similarity

    Post-translational modificationi

    Phosphorylated; phosphorylation is critical for GDF9 function.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ07105.

    PTM databases

    PhosphoSiteiQ07105.

    Expressioni

    Tissue specificityi

    Ovary.

    Gene expression databases

    BgeeiQ07105.
    CleanExiMM_GDF9.
    GenevestigatoriQ07105.

    Interactioni

    Subunit structurei

    Homodimer or heterodimer Potential. But, in contrast to other members of this family, cannot be disulfide-linked.Curated

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000018382.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07105.
    SMRiQ07105. Positions 340-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG261730.
    HOGENOMiHOG000073526.
    HOVERGENiHBG004660.
    InParanoidiQ07105.
    KOiK05498.
    OMAiDNWIVAP.
    OrthoDBiEOG70W3DJ.
    PhylomeDBiQ07105.
    TreeFamiTF351788.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR015617. Growth_differentiation_fac-9.
    IPR001839. TGF-b_C.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PTHR11848:SF19. PTHR11848:SF19. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07105-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPSNFLLG VCCFAWLCFL SSLSSQASTE ESQSGASENV ESEADPWSLL    50
    LPVDGTDRSG LLPPLFKVLS DRRGETPKLQ PDSRALYYMK KLYKTYATKE 100
    GVPKPSRSHL YNTVRLFSPC AQQEQAPSNQ VTGPLPMVDL LFNLDRVTAM 150
    EHLLKSVLLY TLNNSASSSS TVTCMCDLVV KEAMSSGRAP PRAPYSFTLK 200
    KHRWIEIDVT SLLQPLVTSS ERSIHLSVNF TCTKDQVPED GVFSMPLSVP 250
    PSLILYLNDT STQAYHSWQS LQSTWRPLQH PGQAGVAARP VKEEAIEVER 300
    SPRRRRGQKA IRSEAKGPLL TASFNLSEYF KQFLFPQNEC ELHDFRLSFS 350
    QLKWDNWIVA PHRYNPRYCK GDCPRAVRHR YGSPVHTMVQ NIIYEKLDPS 400
    VPRPSCVPGK YSPLSVLTIE PDGSIAYKEY EDMIATRCTC R 441
    Length:441
    Mass (Da):49,649
    Last modified:November 23, 2004 - v2
    Checksum:i43B47ADD41B99C29
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti296 – 2961I → T in AAA53035. (PubMed:8429021)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L06444 mRNA. Translation: AAA53035.1.
    X77112 Genomic DNA. No translation available.
    X77113 Genomic DNA. No translation available.
    CCDSiCCDS24679.1.
    PIRiS45284.
    RefSeqiNP_032136.2. NM_008110.2.
    UniGeneiMm.490461.
    Mm.9714.

    Genome annotation databases

    EnsembliENSMUST00000018382; ENSMUSP00000018382; ENSMUSG00000018238.
    GeneIDi14566.
    KEGGimmu:14566.
    UCSCiuc007iwa.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L06444 mRNA. Translation: AAA53035.1 .
    X77112 Genomic DNA. No translation available.
    X77113 Genomic DNA. No translation available.
    CCDSi CCDS24679.1.
    PIRi S45284.
    RefSeqi NP_032136.2. NM_008110.2.
    UniGenei Mm.490461.
    Mm.9714.

    3D structure databases

    ProteinModelPortali Q07105.
    SMRi Q07105. Positions 340-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000018382.

    PTM databases

    PhosphoSitei Q07105.

    Proteomic databases

    PRIDEi Q07105.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018382 ; ENSMUSP00000018382 ; ENSMUSG00000018238 .
    GeneIDi 14566.
    KEGGi mmu:14566.
    UCSCi uc007iwa.2. mouse.

    Organism-specific databases

    CTDi 2661.
    MGIi MGI:95692. Gdf9.

    Phylogenomic databases

    eggNOGi NOG261730.
    HOGENOMi HOG000073526.
    HOVERGENi HBG004660.
    InParanoidi Q07105.
    KOi K05498.
    OMAi DNWIVAP.
    OrthoDBi EOG70W3DJ.
    PhylomeDBi Q07105.
    TreeFami TF351788.

    Miscellaneous databases

    ChiTaRSi GDF9. mouse.
    NextBioi 286274.
    PROi Q07105.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q07105.
    CleanExi MM_GDF9.
    Genevestigatori Q07105.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR015617. Growth_differentiation_fac-9.
    IPR001839. TGF-b_C.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    PTHR11848:SF19. PTHR11848:SF19. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines."
      McPherron A.C., Lee S.-J.
      J. Biol. Chem. 268:3444-3449(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure of the mouse growth/differentiation factor 9 gene."
      Incerti B., Dong J., Borsani G., Matzuk M.M.
      Biochim. Biophys. Acta 1222:125-128(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvEv.
    3. "The ratio of growth differentiation factor 9: bone morphogenetic protein 15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates."
      Crawford J.L., McNatty K.P.
      Mol. Cell. Endocrinol. 348:339-343(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SPECIES-SPECIFIC OVULATION RATE DETERMINATION.

    Entry informationi

    Entry nameiGDF9_MOUSE
    AccessioniPrimary (citable) accession number: Q07105
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3