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Protein

Formate dehydrogenase

Gene

fdh

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the NAD+-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.UniRule annotation

Catalytic activityi

Formate + NAD+ = CO2 + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94Substrate; via amide nitrogenUniRule annotation1
Binding sitei120SubstrateUniRule annotation1
Binding sitei196NADUniRule annotation1
Binding sitei257NAD; via carbonyl oxygenUniRule annotation1
Sitei259Important for catalytic activityUniRule annotation1
Binding sitei283NADUniRule annotation1
Sitei312Important for catalytic activityUniRule annotation1
Binding sitei358NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi175 – 176NADUniRule annotation2
Nucleotide bindingi231 – 235NADUniRule annotation5
Nucleotide bindingi312 – 315NADUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase1 PublicationUniRule annotation (EC:1.17.1.9UniRule annotation)
Short name:
FDHUniRule annotation
Alternative name(s):
NAD-dependent formate dehydrogenaseUniRule annotation
Gene namesi
Name:fdh1 Publication
ORF Names:99H12.160, NCU03813
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 2, Linkage Group V

Organism-specific databases

EuPathDBiFungiDB:NCU03813

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760261 – 375Formate dehydrogenaseAdd BLAST375

Proteomic databases

PRIDEiQ07103

Expressioni

Developmental stagei

Developmentally regulated. Expressed only during conidiation and early germination.1 Publication

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ07103
SMRiQ07103
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3 – 120CatalyticUniRule annotationAdd BLAST118
Regioni121 – 313Coenzyme-bindingUniRule annotationAdd BLAST193
Regioni314 – 359CatalyticUniRule annotationAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi364 – 374Ala-richAdd BLAST11

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000136703
InParanoidiQ07103
KOiK00122
OMAiEVTYCNS
OrthoDBiEOG092C30ZL

Family and domain databases

CDDicd05302 FDH, 1 hit
HAMAPiMF_03210 Formate_dehydrogenase, 1 hit
InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR029752 D-isomer_DH_CS1
IPR006140 D-isomer_DH_NAD-bd
IPR033689 FDH_NAD-dep
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00065 D_2_HYDROXYACID_DH_1, 1 hit
PS00670 D_2_HYDROXYACID_DH_2, 1 hit
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q07103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKVLAVLYD GGKHGEEVPE LLGTIQNELG LRKWLEDQGH TLVTTCDKDG
60 70 80 90 100
ENSTFDKELE DAEIIITTPF HPGYLTAERL ARAKKLKLAV TAGIGSDHVD
110 120 130 140 150
LNAANKTNGG ITVAEVTGSN VVSVAEHVLM TILVLVRNFV PAHEQIQEGR
160 170 180 190 200
WDVAEAAKNE FDLEGKVVGT VGVGRIGERV LRRLKPFDCK ELLYYDYQPL
210 220 230 240 250
SAEKEAEIGC RRVADLEEML AQCDVVTINC PLHEKTQGLF NKELISKMKK
260 270 280 290 300
GSWLVNTARG AIVVKEDVAE ALKSGHLRGY GGDVWFPQPA PQDHPLRYAK
310 320 330 340 350
NPFGGGNAMV PHMSGTSLDA QKRYAAGTKA IIESYLSGKH DYRPEDLIVY
360 370
GGDYATKSYG ERERAKAAAA AAKSA
Length:375
Mass (Da):40,957
Last modified:February 1, 1995 - v1
Checksum:i3073CB95FB204968
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13964 Genomic DNA Translation: AAA99900.1
AL451018 Genomic DNA Translation: CAC18252.1
CM002240 Genomic DNA Translation: EAA31966.1
PIRiA47117
RefSeqiXP_961202.1, XM_956109.3

Genome annotation databases

EnsemblFungiiEAA31966; EAA31966; NCU03813
GeneIDi3877330
KEGGincr:NCU03813

Similar proteinsi

Entry informationi

Entry nameiFDH_NEUCR
AccessioniPrimary (citable) accession number: Q07103
Secondary accession number(s): Q7RVC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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