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Q07103

- FDH_NEUCR

UniProt

Q07103 - FDH_NEUCR

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Protein

Formate dehydrogenase

Gene

fdh

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei259 – 2591By similarity
Binding sitei283 – 2831NADBy similarity
Active sitei312 – 3121Proton donorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 1762NADBy similarity
Nucleotide bindingi257 – 2593NADBy similarity
Nucleotide bindingi312 – 3154NADBy similarity

GO - Molecular functioni

  1. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro
  3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase (EC:1.2.1.2)
Alternative name(s):
NAD-dependent formate dehydrogenase
Short name:
FDH
Gene namesi
Name:fdh
ORF Names:99H12.160, NCU03813
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 2, Linkage Group V

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: EnsemblFungi
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Formate dehydrogenasePRO_0000076026Add
BLAST

Proteomic databases

PRIDEiQ07103.

Expressioni

Developmental stagei

Developmentally regulated. Expressed only during conidiation and early germination.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5141.NCU03813.1.

Structurei

3D structure databases

ProteinModelPortaliQ07103.
SMRiQ07103. Positions 3-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi364 – 37411Ala-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136703.
InParanoidiQ07103.
KOiK00122.
OMAiGCRRVEN.
OrthoDBiEOG769ZV3.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07103-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKVLAVLYD GGKHGEEVPE LLGTIQNELG LRKWLEDQGH TLVTTCDKDG
60 70 80 90 100
ENSTFDKELE DAEIIITTPF HPGYLTAERL ARAKKLKLAV TAGIGSDHVD
110 120 130 140 150
LNAANKTNGG ITVAEVTGSN VVSVAEHVLM TILVLVRNFV PAHEQIQEGR
160 170 180 190 200
WDVAEAAKNE FDLEGKVVGT VGVGRIGERV LRRLKPFDCK ELLYYDYQPL
210 220 230 240 250
SAEKEAEIGC RRVADLEEML AQCDVVTINC PLHEKTQGLF NKELISKMKK
260 270 280 290 300
GSWLVNTARG AIVVKEDVAE ALKSGHLRGY GGDVWFPQPA PQDHPLRYAK
310 320 330 340 350
NPFGGGNAMV PHMSGTSLDA QKRYAAGTKA IIESYLSGKH DYRPEDLIVY
360 370
GGDYATKSYG ERERAKAAAA AAKSA
Length:375
Mass (Da):40,957
Last modified:February 1, 1995 - v1
Checksum:i3073CB95FB204968
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13964 Genomic DNA. Translation: AAA99900.1.
AL451018 Genomic DNA. Translation: CAC18252.1.
CM002240 Genomic DNA. Translation: EAA31966.1.
PIRiA47117.
RefSeqiXP_961202.1. XM_956109.2.
UniGeneiNcr.7835.

Genome annotation databases

EnsemblFungiiEFNCRT00000003500; EFNCRP00000003500; EFNCRG00000003496.
GeneIDi3877330.
KEGGincr:NCU03813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13964 Genomic DNA. Translation: AAA99900.1 .
AL451018 Genomic DNA. Translation: CAC18252.1 .
CM002240 Genomic DNA. Translation: EAA31966.1 .
PIRi A47117.
RefSeqi XP_961202.1. XM_956109.2.
UniGenei Ncr.7835.

3D structure databases

ProteinModelPortali Q07103.
SMRi Q07103. Positions 3-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU03813.1.

Proteomic databases

PRIDEi Q07103.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000003500 ; EFNCRP00000003500 ; EFNCRG00000003496 .
GeneIDi 3877330.
KEGGi ncr:NCU03813.

Phylogenomic databases

eggNOGi COG1052.
HOGENOMi HOG000136703.
InParanoidi Q07103.
KOi K00122.
OMAi GCRRVEN.
OrthoDBi EOG769ZV3.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view ]
PROSITEi PS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Developmental regulation of the gene for formate dehydrogenase in Neurospora crassa."
    Chow C.M., RajBhandary U.L.
    J. Bacteriol. 175:3703-3709(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  3. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiFDH_NEUCR
AccessioniPrimary (citable) accession number: Q07103
Secondary accession number(s): Q7RVC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3