Reviewed, UniProtKB/Swiss-Prot Q07103 (FDH_NEUCR)

Names and origin

Protein names

Recommended name:
    Formate dehydrogenase
    EC=1.2.1.2
Alternative name(s):
    NAD-dependent formate dehydrogenase
      Short name=FDH

Gene names

Name:	fdh
ORF Names:	99H12.160, NCU03813

Organism

Neurospora crassa [Complete proteome]

Taxonomic identifier

5141 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Formate + NAD+ = CO2 + NADH.
Subunit structure	Homodimer By similarity.
Developmental stage	Developmentally regulated. Expressed only during conidiation and early germination.
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro formate dehydrogenase activity Inferred from electronic annotation. Source: EC oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Formate dehydrogenase		PRO_0000076026
Regions
	Compositional bias	364 – 374	11	Ala-rich
Sites
	Active site	259	1	By similarity
	Active site	312	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q07103-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 3073CB95FB204968	FASTA	375	40,957
	10 20 30 40 50 60 MVKVLAVLYD GGKHGEEVPE LLGTIQNELG LRKWLEDQGH TLVTTCDKDG ENSTFDKELE 70 80 90 100 110 120 DAEIIITTPF HPGYLTAERL ARAKKLKLAV TAGIGSDHVD LNAANKTNGG ITVAEVTGSN 130 140 150 160 170 180 VVSVAEHVLM TILVLVRNFV PAHEQIQEGR WDVAEAAKNE FDLEGKVVGT VGVGRIGERV 190 200 210 220 230 240 LRRLKPFDCK ELLYYDYQPL SAEKEAEIGC RRVADLEEML AQCDVVTINC PLHEKTQGLF 250 260 270 280 290 300 NKELISKMKK GSWLVNTARG AIVVKEDVAE ALKSGHLRGY GGDVWFPQPA PQDHPLRYAK 310 320 330 340 350 360 NPFGGGNAMV PHMSGTSLDA QKRYAAGTKA IIESYLSGKH DYRPEDLIVY GGDYATKSYG 370 ERERAKAAAA AAKSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Developmental regulation of the gene for formate dehydrogenase in Neurospora crassa." Chow C.M., RajBhandary U.L. J. Bacteriol. 175:3703-3709(1993) [PubMed: 8509325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[2]	"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence." Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U. Nucleic Acids Res. 31:1944-1954(2003) [PubMed: 12655011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]	"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L13964 Genomic DNA. Translation: AAA99900.1. AL451018 Genomic DNA. Translation: CAC18252.1. AABX02000011 Genomic DNA. Translation: EAA31966.1.
PIR	A47117.
RefSeq	XP_961202.1.
3D structure databases
HSSP	HSSP built from PDB template 2NAC based on UniProtKB P33160.
ModBase	Search...
Genome annotation databases
GeneID	3877330.
KEGG	ncr:NCU03813.
NMPDR	fig|5141.1.peg.1047.
Enzyme and pathway databases
BioCyc	NCRA-XX3-01:NCRA-XX3-01-007561-MON.
BRENDA	1.2.1.2. 266.
Family and domain databases
InterPro	IPR006139. D-isomer_2_OHA_DH. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view]
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FDH_NEUCR

Accession

Primary (citable) accession number: Q07103
Secondary accession number(s): Q7RVC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	June 16, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)