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Q07103 (FDH_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate dehydrogenase

EC=1.2.1.2
Alternative name(s):
NAD-dependent formate dehydrogenase
Short name=FDH
Gene names
Name:fdh
ORF Names:99H12.160, NCU03813
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Formate + NAD+ = CO2 + NADH.

Subunit structure

Homodimer By similarity.

Developmental stage

Developmentally regulated. Expressed only during conidiation and early germination.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Formate dehydrogenase
PRO_0000076026

Regions

Nucleotide binding175 – 1762NAD By similarity
Nucleotide binding257 – 2593NAD By similarity
Nucleotide binding312 – 3154NAD By similarity
Compositional bias364 – 37411Ala-rich

Sites

Active site2591 By similarity
Active site3121Proton donor By similarity
Binding site2831NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07103 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 3073CB95FB204968

FASTA37540,957
        10         20         30         40         50         60 
MVKVLAVLYD GGKHGEEVPE LLGTIQNELG LRKWLEDQGH TLVTTCDKDG ENSTFDKELE 

        70         80         90        100        110        120 
DAEIIITTPF HPGYLTAERL ARAKKLKLAV TAGIGSDHVD LNAANKTNGG ITVAEVTGSN 

       130        140        150        160        170        180 
VVSVAEHVLM TILVLVRNFV PAHEQIQEGR WDVAEAAKNE FDLEGKVVGT VGVGRIGERV 

       190        200        210        220        230        240 
LRRLKPFDCK ELLYYDYQPL SAEKEAEIGC RRVADLEEML AQCDVVTINC PLHEKTQGLF 

       250        260        270        280        290        300 
NKELISKMKK GSWLVNTARG AIVVKEDVAE ALKSGHLRGY GGDVWFPQPA PQDHPLRYAK 

       310        320        330        340        350        360 
NPFGGGNAMV PHMSGTSLDA QKRYAAGTKA IIESYLSGKH DYRPEDLIVY GGDYATKSYG 

       370 
ERERAKAAAA AAKSA 

« Hide

References

« Hide 'large scale' references
[1]"Developmental regulation of the gene for formate dehydrogenase in Neurospora crassa."
Chow C.M., RajBhandary U.L.
J. Bacteriol. 175:3703-3709(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[2]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13964 Genomic DNA. Translation: AAA99900.1.
AL451018 Genomic DNA. Translation: CAC18252.1.
CM002240 Genomic DNA. Translation: EAA31966.1.
PIRA47117.
RefSeqXP_961202.1. XM_956109.2.
UniGeneNcr.7835.

3D structure databases

ProteinModelPortalQ07103.
SMRQ07103. Positions 3-354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU03813.1.

Proteomic databases

PRIDEQ07103.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000003500; EFNCRP00000003500; EFNCRG00000003496.
GeneID3877330.
KEGGncr:NCU03813.

Phylogenomic databases

eggNOGCOG1052.
HOGENOMHOG000136703.
KOK00122.
OMAGCRRVEN.
OrthoDBEOG769ZV3.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDH_NEUCR
AccessionPrimary (citable) accession number: Q07103
Secondary accession number(s): Q7RVC9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families