Reviewed, UniProtKB/Swiss-Prot Q070J7 (PAP1_CPRV)

Names and origin

Protein names

Recommended name:
    Poly(A) polymerase catalytic subunit
    EC=2.7.7.19
Alternative name(s):
    Poly(A) polymerase large subunit
      Short name=PAP-L

Gene names

Name:	PAPL
Ordered Locus Names:	CRV054

Organism

Crocodilepox virus (CRV)

Taxonomic identifier

368445 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › unclassified Chordopoxvirinae

Virus host

Crocodylidae (crocodilians) [TaxID: 8493]

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Polymerase that creates the 3'-poly(A) tail of mRNA's.
Catalytic activity	ATP + RNA(n) = diphosphate + RNA(n+1).
Subunit structure	Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit By similarity.
Sequence similarities	Belongs to the poxviridae poly(A) polymerase catalytic subunit family.

Ontologies

Keywords
Biological process	Transcription mRNA processing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Gene Ontology (GO)
Biological process	mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW polynucleotide adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Poly(A) polymerase catalytic subunit		PRO_0000308929
Sites
	Active site	193	1	By similarity
	Active site	195	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q070J7-1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: 2145D9F31671CCA1	FASTA	473	54,062
	10 20 30 40 50 60 MNNRELINRY LGKTADQPIY YALFHKVGKI KQILNFDLNV FLKLLLKNRD RFLRENKQPT 70 80 90 100 110 120 AEIKRRLTHY FTKQHRVRKV GKILSIVEFQ HVIVTTFTRV LGVLTIDNRR VSKMYSSTAI 130 140 150 160 170 180 LDYAAHEDYV EAMLRSYRVT DGAGPPKGRN KVSDLVGYVI SMLKEYLKRH NKSAFCHGSY 190 200 210 220 230 240 SLHLLNPAIE YGDIDMLQTN SRTFLINLAF LIYCNTGRVT TMMKIPYLLN YIVMFDEEQA 250 260 270 280 290 300 HIVDSFQVSQ EIFDRIPKIL INDIYIIDPC VQLLNGIKMF SQVDRLDDLH TKFEKLRARF 310 320 330 340 350 360 CTLLEYVLYD YDMRIGEGSG AGALRRSRFA YSERVATVEA GALGEDLSPA RWVAFMDNAA 370 380 390 400 410 420 LDARIGASTR QAADFGPVTN SRFLEEDGCL YGYFSNTLLL TPDGAPHPVS CNALAAHFLM 430 440 450 460 470 YFVMTGAPCK PQLACLLNSL VVPEAREFTL VPRDKKLGDH VILSIDHDVF IDF

References

[1]	"Genome of crocodilepox virus." Afonso C.L., Tulman E.R., Delhon G., Lu Z., Viljoen G.J., Wallace D.B., Kutish G.F., Rock D.L. J. Virol. 80:4978-4991(2006) [PubMed: 16641289] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ356948 Genomic DNA. Translation: ABJ08945.1.
RefSeq	YP_784244.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4363317.
Enzyme and pathway databases
BRENDA	2.7.7.19. 299196.
Family and domain databases
InterPro	IPR004976. PolyA_pol_cat_poxviral. [Graphical view]
Pfam	PF03296. Pox_polyA_pol. 1 hit. [Graphical view]
PIRSF	PIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PAP1_CPRV

Accession

Primary (citable) accession number: Q070J7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 31, 2006
Last modified:	June 16, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)