Serine/threonine-protein phosphatase PP2A-2 catalytic subunit - Arabidopsis thaliana (Mouse-ear cress)

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Q07098 (PP2A2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 99. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
EC=3.1.3.16

Alternative name(s):
Protein phosphatase 2A isoform 2

Gene names

Name:	PP2A2
Synonyms:	PP2A1
Ordered Locus Names:	At1g10430
ORF Names:	T10O24.4

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H₂O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Subunit structure	PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (subunit A), that associates with a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families).
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular protein localization Inferred from mutant phenotype PubMed 22642987. Source: TAIR chloroplast avoidance movement Inferred from mutant phenotype PubMed 22642987. Source: TAIR protein dephosphorylation Inferred from mutant phenotype PubMed 22642987. Source: TAIR
Cellular_component	cytosol Inferred from direct assay PubMed 22404109. Source: TAIR nucleus Inferred from direct assay PubMed 15469496 PubMed 22404109. Source: TAIR plasma membrane Inferred from direct assay PubMed 17317660 PubMed 17644812. Source: TAIR
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 306

306

Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

PRO_0000058852

Sites

Active site

115

Proton donor By similarity

Metal binding

Iron By similarity

Metal binding

Iron By similarity

Metal binding

Iron By similarity

Metal binding

Manganese By similarity

Metal binding

114

Manganese By similarity

Metal binding

164

Manganese By similarity

Metal binding

238

Manganese By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q07098 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: B2DCB1B3C2CDD54F
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FASTA

306

34,934

        10         20         30         40         50         60 
MPSNGDLDRQ IEQLMECKPL SEADVRTLCD QARAILVEEY NVQPVKCPVT VCGDIHGQFY 

        70         80         90        100        110        120 
DLIELFRIGG NAPDTNYLFM GDYVDRGYYS VETVSLLVAL KVRYRDRLTI LRGNHESRQI 

       130        140        150        160        170        180 
TQVYGFYDEC LRKYGNANVW KYFTDLFDYL PLTALIESQV FCLHGGLSPS LDTLDNIRSL 

       190        200        210        220        230        240 
DRIQEVPHEG PMCDLLWSDP DDRCGWGISP RGAGYTFGQD IAAQFNHNNG LSLISRAHQL 

       250        260        270        280        290        300 
VMEGFNWCQD KNVVTVFSAP NYCYRCGNMA AILEIGENME QNFLQFDPAP RQVEPDTTRK 


TPDYFL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Protein phosphatases in higher plants: multiplicity of type 2A phosphatases in Arabidopsis thaliana." Arino J., Perez-Callejon E., Cunillera N., Camps M., Posas F., Ferrer A. Plant Mol. Biol. 21:475-485(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia GL1.
[2]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"Molecular characterization of the B' regulatory subunit gene family of Arabidopsis protein phosphatase 2A." Haynes J.G., Hartung A.J., Hendershot J.D. III, Passingham R.S., Rundle S.J. Eur. J. Biochem. 260:127-136(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AALPHA.
[6]	"Arabidopsis PPP family of serine/threonine phosphatases." Farkas I., Dombradi V., Miskei M., Szabados L., Koncz C. Trends Plant Sci. 12:169-176(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M96733 mRNA. Translation: AAA32848.1. AC007067 Genomic DNA. Translation: AAD39564.1. CP002684 Genomic DNA. Translation: AEE28579.1. AY059847 mRNA. Translation: AAL24329.1. AY093267 mRNA. Translation: AAM13266.1.
IPI	IPI00533423.
PIR	S31162.
RefSeq	NP_172514.1. NM_100918.2.
UniGene	At.21842.
3D structure databases
ProteinModelPortal	Q07098.
SMR	Q07098. Positions 6-290.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q07098. 1 interaction.
STRING	3702.AT1G10430.1-P.
Proteomic databases
PaxDb	Q07098.
PRIDE	Q07098.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G10430.1; AT1G10430.1; AT1G10430.
GeneID	837583.
KEGG	ath:AT1G10430.
Organism-specific databases
TAIR	At1g10430.
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HOG000172696.
InParanoid	Q07098.
KO	K04382.
OMA	DVRTLCD.
PhylomeDB	Q07098.
ProtClustDB	CLSN2679580.
Gene expression databases
Genevestigator	Q07098.
GermOnline	AT1G10430. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PP2A2_ARATH

Accession

Primary (citable) accession number: Q07098

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents