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Q07098 (PP2A2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

EC=3.1.3.16
Alternative name(s):
Protein phosphatase 2A isoform 2
Gene names
Name:PP2A2
Synonyms:PP2A1
Ordered Locus Names:At1g10430
ORF Names:T10O24.4
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Subunit structure

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (subunit A), that associates with a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families).

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the PPP phosphatase family. PP-2A subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
PRO_0000058852

Sites

Active site1151Proton donor By similarity
Metal binding541Iron By similarity
Metal binding561Iron By similarity
Metal binding821Iron By similarity
Metal binding821Manganese By similarity
Metal binding1141Manganese By similarity
Metal binding1641Manganese By similarity
Metal binding2381Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07098 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: B2DCB1B3C2CDD54F

FASTA30634,934
        10         20         30         40         50         60 
MPSNGDLDRQ IEQLMECKPL SEADVRTLCD QARAILVEEY NVQPVKCPVT VCGDIHGQFY 

        70         80         90        100        110        120 
DLIELFRIGG NAPDTNYLFM GDYVDRGYYS VETVSLLVAL KVRYRDRLTI LRGNHESRQI 

       130        140        150        160        170        180 
TQVYGFYDEC LRKYGNANVW KYFTDLFDYL PLTALIESQV FCLHGGLSPS LDTLDNIRSL 

       190        200        210        220        230        240 
DRIQEVPHEG PMCDLLWSDP DDRCGWGISP RGAGYTFGQD IAAQFNHNNG LSLISRAHQL 

       250        260        270        280        290        300 
VMEGFNWCQD KNVVTVFSAP NYCYRCGNMA AILEIGENME QNFLQFDPAP RQVEPDTTRK 


TPDYFL 

« Hide

References

« Hide 'large scale' references
[1]"Protein phosphatases in higher plants: multiplicity of type 2A phosphatases in Arabidopsis thaliana."
Arino J., Perez-Callejon E., Cunillera N., Camps M., Posas F., Ferrer A.
Plant Mol. Biol. 21:475-485(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Columbia GL1.
[2]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Molecular characterization of the B' regulatory subunit gene family of Arabidopsis protein phosphatase 2A."
Haynes J.G., Hartung A.J., Hendershot J.D. III, Passingham R.S., Rundle S.J.
Eur. J. Biochem. 260:127-136(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH AALPHA.
[6]"Arabidopsis PPP family of serine/threonine phosphatases."
Farkas I., Dombradi V., Miskei M., Szabados L., Koncz C.
Trends Plant Sci. 12:169-176(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M96733 mRNA. Translation: AAA32848.1.
AC007067 Genomic DNA. Translation: AAD39564.1.
CP002684 Genomic DNA. Translation: AEE28579.1.
AY059847 mRNA. Translation: AAL24329.1.
AY093267 mRNA. Translation: AAM13266.1.
PIRS31162.
RefSeqNP_172514.1. NM_100918.2.
UniGeneAt.21842.

3D structure databases

ProteinModelPortalQ07098.
SMRQ07098. Positions 6-290.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid22823. 3 interactions.
IntActQ07098. 1 interaction.
STRING3702.AT1G10430.1-P.

Proteomic databases

PaxDbQ07098.
PRIDEQ07098.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G10430.1; AT1G10430.1; AT1G10430.
GeneID837583.
KEGGath:AT1G10430.

Organism-specific databases

TAIRAT1G10430.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172696.
InParanoidQ07098.
KOK04382.
OMADVRTLCD.
PhylomeDBQ07098.
ProtClustDBCLSN2679580.

Enzyme and pathway databases

BioCycARA:AT1G10430-MONOMER.

Gene expression databases

GenevestigatorQ07098.

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP2A2_ARATH
AccessionPrimary (citable) accession number: Q07098
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names