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Protein

Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

Gene

PP2A2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Manganese 1By similarity1
Metal bindingi56Manganese 1By similarity1
Metal bindingi82Manganese 1By similarity1
Metal bindingi82Manganese 2By similarity1
Metal bindingi114Manganese 2By similarity1
Active sitei115Proton donorBy similarity1
Metal bindingi164Manganese 2By similarity1
Metal bindingi238Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular protein localization Source: TAIR
  • chloroplast avoidance movement Source: TAIR
  • protein dephosphorylation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-113501. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
R-ATH-198753. ERK/MAPK targets.
R-ATH-202670. ERKs are inactivated.
R-ATH-69231. Cyclin D associated events in G1.
R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2A isoform 2
Gene namesi
Name:PP2A2
Synonyms:PP2A1
Ordered Locus Names:At1g10430
ORF Names:T10O24.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G10430.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • cytosol Source: TAIR
  • nucleus Source: TAIR
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588521 – 306Serine/threonine-protein phosphatase PP2A-2 catalytic subunitAdd BLAST306

Proteomic databases

PaxDbiQ07098.

Expressioni

Gene expression databases

GenevisibleiQ07098. AT.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (subunit A), that associates with a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families).

Protein-protein interaction databases

BioGridi22823. 3 interactors.
IntActiQ07098. 1 interactor.
STRINGi3702.AT1G10430.1.

Structurei

3D structure databases

ProteinModelPortaliQ07098.
SMRiQ07098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
HOGENOMiHOG000172696.
InParanoidiQ07098.
KOiK04382.
OMAiAQFNHNN.
OrthoDBiEOG09360EXD.
PhylomeDBiQ07098.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSNGDLDRQ IEQLMECKPL SEADVRTLCD QARAILVEEY NVQPVKCPVT
60 70 80 90 100
VCGDIHGQFY DLIELFRIGG NAPDTNYLFM GDYVDRGYYS VETVSLLVAL
110 120 130 140 150
KVRYRDRLTI LRGNHESRQI TQVYGFYDEC LRKYGNANVW KYFTDLFDYL
160 170 180 190 200
PLTALIESQV FCLHGGLSPS LDTLDNIRSL DRIQEVPHEG PMCDLLWSDP
210 220 230 240 250
DDRCGWGISP RGAGYTFGQD IAAQFNHNNG LSLISRAHQL VMEGFNWCQD
260 270 280 290 300
KNVVTVFSAP NYCYRCGNMA AILEIGENME QNFLQFDPAP RQVEPDTTRK

TPDYFL
Length:306
Mass (Da):34,934
Last modified:October 1, 1994 - v1
Checksum:iB2DCB1B3C2CDD54F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96733 mRNA. Translation: AAA32848.1.
AC007067 Genomic DNA. Translation: AAD39564.1.
CP002684 Genomic DNA. Translation: AEE28579.1.
AY059847 mRNA. Translation: AAL24329.1.
AY093267 mRNA. Translation: AAM13266.1.
PIRiS31162.
RefSeqiNP_172514.1. NM_100918.3.
UniGeneiAt.21842.

Genome annotation databases

EnsemblPlantsiAT1G10430.1; AT1G10430.1; AT1G10430.
GeneIDi837583.
GrameneiAT1G10430.1; AT1G10430.1; AT1G10430.
KEGGiath:AT1G10430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96733 mRNA. Translation: AAA32848.1.
AC007067 Genomic DNA. Translation: AAD39564.1.
CP002684 Genomic DNA. Translation: AEE28579.1.
AY059847 mRNA. Translation: AAL24329.1.
AY093267 mRNA. Translation: AAM13266.1.
PIRiS31162.
RefSeqiNP_172514.1. NM_100918.3.
UniGeneiAt.21842.

3D structure databases

ProteinModelPortaliQ07098.
SMRiQ07098.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi22823. 3 interactors.
IntActiQ07098. 1 interactor.
STRINGi3702.AT1G10430.1.

Proteomic databases

PaxDbiQ07098.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G10430.1; AT1G10430.1; AT1G10430.
GeneIDi837583.
GrameneiAT1G10430.1; AT1G10430.1; AT1G10430.
KEGGiath:AT1G10430.

Organism-specific databases

TAIRiAT1G10430.

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
HOGENOMiHOG000172696.
InParanoidiQ07098.
KOiK04382.
OMAiAQFNHNN.
OrthoDBiEOG09360EXD.
PhylomeDBiQ07098.

Enzyme and pathway databases

ReactomeiR-ATH-113501. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
R-ATH-198753. ERK/MAPK targets.
R-ATH-202670. ERKs are inactivated.
R-ATH-69231. Cyclin D associated events in G1.
R-ATH-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiQ07098.

Gene expression databases

GenevisibleiQ07098. AT.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP2A2_ARATH
AccessioniPrimary (citable) accession number: Q07098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.