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Protein

Head-specific guanylate cyclase

Gene

Gycalpha99B

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a role in phototransduction. A second subunit may be required for enzyme activity.1 Publication

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • guanylate cyclase activity Source: FlyBase
  • heme binding Source: InterPro

GO - Biological processi

  • cGMP biosynthetic process Source: FlyBase
  • intracellular signal transduction Source: InterPro
  • positive phototaxis Source: FlyBase
  • rhodopsin mediated signaling pathway Source: FlyBase
  • visual perception Source: UniProtKB-KW

Keywordsi

Molecular functionLyase
Biological processcGMP biosynthesis, Sensory transduction, Vision
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Head-specific guanylate cyclase (EC:4.6.1.2)
Alternative name(s):
Gycalpha99B
Gene namesi
Name:Gycalpha99B
Synonyms:dgc1, GYC, GYC-ALPHA-63A, Gyc99B
ORF Names:CG1912
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013972 Gycalpha99B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000741211 – 676Head-specific guanylate cyclaseAdd BLAST676

Proteomic databases

PaxDbiQ07093
PRIDEiQ07093

Expressioni

Tissue specificityi

Head, where it is preferentially expressed in the CNS and the retina. Not found in bodies.1 Publication

Gene expression databases

BgeeiFBgn0013972
ExpressionAtlasiQ07093 differential
GenevisibleiQ07093 DM

Interactioni

Subunit structurei

Dimer.Curated

Protein-protein interaction databases

BioGridi683571 interactor.
STRINGi7227.FBpp0084819

Structurei

3D structure databases

ProteinModelPortaliQ07093
SMRiQ07093
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini466 – 593Guanylate cyclasePROSITE-ProRule annotationAdd BLAST128

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4171 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000118959
InParanoidiQ07093
KOiK12318
OMAiQNWPNIH
OrthoDBiEOG091G04KV
PhylomeDBiQ07093

Family and domain databases

Gene3Di3.30.70.12301 hit
3.90.1520.101 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR038158 H-NOX_domain_sf
IPR011644 Heme_NO-bd
IPR011645 HNOB_dom_associated
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
PF07700 HNOB, 1 hit
PF07701 HNOBA, 2 hits
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q07093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACPFFRRAD SLTRQPSVIA EPGGHWALED EELSDDALTL THLQMAIQLL
60 70 80 90 100
TAPSNEDLNT AVTSLVAKYR QNWPNIHKLK LDPQTFKSCA NYDYLADIQE
110 120 130 140 150
LLLKMDEASA SEILVLLGEE LITCCCTGII ERAFRCLGTD LQEFLGSLDG
160 170 180 190 200
VYDVLKLQEE DVTDTGFVCA GEGELIFTSE RPVIAWLLLG SLKALTRMLY
210 220 230 240 250
KVDVNIKIEP VEGDARRYRY LFSLVKDNSQ TMLMGRPTSV SKTIPETVQR
260 270 280 290 300
SNSSNASDLQ MNSSSFCKMF PWHFIMNEQL ELVQLGRGFS KLYKPYMADF
310 320 330 340 350
GCQATTYFDF KRPKGLTMKF RDIVRRTYTP FLIGLNNPPG AVDFPAIGLE
360 370 380 390 400
IKGQMVHCPE SNSLLFIGSP FLDGLDGLTC NGLFISDIPL HDATREVILV
410 420 430 440 450
GEQARAQDGL RRRMDKIKNS IEEANSAVTK ERKKNVSLLH LIFPAEIAEK
460 470 480 490 500
LWLGSSIDAK TYPDVTILFS DIVGFTSICS RATPFMVISM LEGLYKDFDE
510 520 530 540 550
FCDFFDVYKV ETIGDAYCVA SGLHRASIYD AHKVAWMALK MIDACSKHIT
560 570 580 590 600
HDGEQIKMRI GLHTGTVLAG VVGRKMPRYC LFGHSVTIAN KFESGSEALK
610 620 630 640 650
INVSPTTKDW LTKHEGFEFE LQPRDPSFLP KEFPNPGGTE TCYFLESFRN
660 670
PALDSELPLV EHINVSMKTI SEGGDA
Length:676
Mass (Da):75,663
Last modified:June 21, 2005 - v2
Checksum:iCE8097E1EC3787F8
GO

Sequence cautioni

The sequence AAB25820 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S57126 mRNA Translation: AAB25820.1 Frameshift.
U27117 mRNA Translation: AAA87940.1
AE014297 Genomic DNA Translation: AAF56917.1
AY060654 mRNA Translation: AAL28202.1
PIRiJH0810
RefSeqiNP_477088.2, NM_057740.4
UniGeneiDm.3968

Genome annotation databases

EnsemblMetazoaiFBtr0085453; FBpp0084819; FBgn0013972
GeneIDi43493
KEGGidme:Dmel_CG1912

Similar proteinsi

Entry informationi

Entry nameiGCYH_DROME
AccessioniPrimary (citable) accession number: Q07093
Secondary accession number(s): Q24085, Q95SQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 21, 2005
Last modified: March 28, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome